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Genetics - MrGalusha.org
Genetics - MrGalusha.org

... about 40% of the individual differences that we observe in, say, shyness may in some way be attributable to genetic individual difference. • It does NOT mean that 40% of any person's shyness is due to his/her genes and the other 60% is due to his/her environment. ...
The Relationship Between XRCC1 and XRCC6 Genes
The Relationship Between XRCC1 and XRCC6 Genes

... XRCC genes play a momentous role in comprehension processes of DNA repair in mammals, especially in doublestrand break (DSB) repair (3). Therefore, normal activity of XRCC genes is a major factor for cancer prevention. On the other hand, approximately, 84400 new patients of renal cell carcinoma (RCC ...
3-8-heredity_and_environment
3-8-heredity_and_environment

... about 40% of the individual differences that we observe in, say, shyness may in some way be attributable to genetic individual difference. • It does NOT mean that 40% of any person's shyness is due to his/her genes and the other 60% is due to his/her environment. ...
Implications of the Human Genome Project for Medical
Implications of the Human Genome Project for Medical

... Though the working draft of the human sequence represents a major milestone, a vast amount of additional work remains to be done to understand its function. It is necessary to complete the sequence analysis by closing the gaps and resolving ambiguities. This finishing process already has been accomp ...
Assignment 4: The mutation
Assignment 4: The mutation

... gene we are after. When both alleles are normal, the individual can hear. When one of the alleles is mutated, the individual carrying it may become deaf in adulthood. ...
genes - School
genes - School

Supplementary Information (doc 7548K)
Supplementary Information (doc 7548K)

... Supplementary Table 1 | Clinical characteristics of CG-SH cell line and AML patients. Data include FAB, French-American-British classification of AML, and mutational status of nucleophosmin gene (NPM1), internal tandem duplications of FLT3 gene (FLT3-3-ITD) and point mutations in DNMT3A (R882H). Ave ...
HOX11L2/TLX3 is transcriptionally activated through T-cell
HOX11L2/TLX3 is transcriptionally activated through T-cell

Renal Cell Carcinoma - Dr Douglas Scherr Urologic Oncologist
Renal Cell Carcinoma - Dr Douglas Scherr Urologic Oncologist

Microbial Genetics
Microbial Genetics

Kelly Keough`s Story - Chris4Life Colon Cancer Foundation
Kelly Keough`s Story - Chris4Life Colon Cancer Foundation

... I was first diagnosed in 2008. We had gone on vacation to Topsail Beach and while we were unloading the car up 4 flights of stairs, I was having trouble breathing. Then the next week we were moving my oldest daughter from her house in Baltimore to an apartment and again, after a few flight of stairs ...
Molecular Biology – Final Laboratory Report
Molecular Biology – Final Laboratory Report

... including cyclins (Bednenko et al. 2009). Many of these proteins are specific to a single nucleus, as the events in each are very different, therefore the nuclei contain different transporters to move different proteins inside them (Malone et al. 2008). The two genomes are combined in a way reminisc ...
Meiosis and the Alternation of Generations
Meiosis and the Alternation of Generations

Lab/Activity: Prot
Lab/Activity: Prot

... gene. These types of mutations may cause only minor effects to the phenotype of an organism. But sometimes mutations can cause great changes to the gene and therefore greatly alter the protein that is made from that gene. This will likely have great effects on the organism, since the protein will no ...
The tumor pathology of Genetically Engineered Mice: a new
The tumor pathology of Genetically Engineered Mice: a new

ppt.document - NCSU Bioinformatics Research Center
ppt.document - NCSU Bioinformatics Research Center

... care based on our own predicted risk of disease as assessed by looking at our DNA. By then each of us will have had our genomes sequenced because it will cost less than $100 to do that. And this information will be part of our ...
Automatic annotation of organellar genomes with DOGMA
Automatic annotation of organellar genomes with DOGMA

... animal mitochondrial database, we downloaded the complete genomes for 243 organisms (the total number in GenBank at the time) and extracted the annotated genes to compile a database for each individual protein coding gene. Each database contains the amino acid sequence for a specific gene from each ...
Cure/Treatment
Cure/Treatment

... may play a role in cancer and aging ...
AP Biology - Cloudfront.net
AP Biology - Cloudfront.net

...  Translocation: chromosome breaks off and is added to a nonhomologous chrosomosome ...
Human Genetics
Human Genetics

... 1. Chromosomes contain the hereditary material 2. The Unit of heredity is the gene 3. diploid cells have homologous chromosomes 4. alleles are on homologous chromosomes 5. haploid cells (after meiosis) have 1 of each kind of chromosome 6. Independent Assortment of homologues 7. genes on the same chr ...
Single Gene Inheritance
Single Gene Inheritance

... • Outcome of a contiguous deletion of imprinted genes is dependent on the chromosomal parent of ...
Chapter 3 sample - Scion Publishing
Chapter 3 sample - Scion Publishing

... • be repeatedly and accurately replicated, in order to create new and viable cells • code for the development and function of cells as they grow and contribute to the maintenance of homeostasis • change (a process called mutation), producing variations between individuals in a population so that the ...
22 Fungal Genetics Newsletter bimD
22 Fungal Genetics Newsletter bimD

... Neurospora (and also in fission yeast); more specifically, that two types of excision repair are active, one being specific for UV dimers (Yajima et al. 1995 EMBO J 14:2393-2399) the other resembling yeast and human NER (Hatekayama et al. 1998 Curr. Genet. 33:276-283). Provided both processes can pa ...
No Slide Title
No Slide Title

... •75% of the XPA -/- mice developed at least one squamous cell carcinoma by week 25. • No cancers were observed in the other two phenotypes ...
Leukaemia Section t(14;19)(q32;q13) in acute lymphoblastic leukaemia Atlas of Genetics and Cytogenetics
Leukaemia Section t(14;19)(q32;q13) in acute lymphoblastic leukaemia Atlas of Genetics and Cytogenetics

... The involvement of the IGH gene located at 14q32 has been demonstrated via FISH using the LSI IGH Dual Colour Break Apart Rearrangement Probe in all cases tested. Metaphase and interphase FISH using probes flanking the BCL3 gene have ruled out the involvement of this gene; thus distinguishing it fro ...
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Oncogenomics



Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.
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