Diapositive 1 - Institut Pasteur
... RNA sequence databases Protein sequence databases Structure Databases Genomics Databases (non-vertebrate) Metabolic and Signaling Pathways Human and other Vertebrate Genomes Human Genes and Diseases Microarray Data and other Gene Expression Databases Proteomics Resources Other Molecular Biology Data ...
... RNA sequence databases Protein sequence databases Structure Databases Genomics Databases (non-vertebrate) Metabolic and Signaling Pathways Human and other Vertebrate Genomes Human Genes and Diseases Microarray Data and other Gene Expression Databases Proteomics Resources Other Molecular Biology Data ...
Document
... Coordinately Controlled Genes in Eukaryotes • Unlike the genes of a prokaryotic operon, each of the co-expressed eukaryotic genes has a promoter and control elements • These genes can be scattered over different chromosomes, but each has the same combination of control elements • Copies of the acti ...
... Coordinately Controlled Genes in Eukaryotes • Unlike the genes of a prokaryotic operon, each of the co-expressed eukaryotic genes has a promoter and control elements • These genes can be scattered over different chromosomes, but each has the same combination of control elements • Copies of the acti ...
fgdfgdgsty - Latvijas universitāte
... Coagulase-negative staphylococci (CoNS) are major nosocomial pathogens known by their ability to form biofilm on the surfaces of foreign bodies introduced (implanted) into the organism. The accumulative phase of biofilm formation is linked to the production of polysaccharide intercellular adhesin (P ...
... Coagulase-negative staphylococci (CoNS) are major nosocomial pathogens known by their ability to form biofilm on the surfaces of foreign bodies introduced (implanted) into the organism. The accumulative phase of biofilm formation is linked to the production of polysaccharide intercellular adhesin (P ...
4.11 Repro Biol 053 Reik NEW
... most tangible during life in the womb1,8. One area for competition is in the placenta, over the control of the supply of nutrients. The placenta comprises two components: a fetal portion that develops from trophoblast derivatives (the first lineage specified in the early embryo) and a maternal porti ...
... most tangible during life in the womb1,8. One area for competition is in the placenta, over the control of the supply of nutrients. The placenta comprises two components: a fetal portion that develops from trophoblast derivatives (the first lineage specified in the early embryo) and a maternal porti ...
Illumina Infinium HumanMethylation450 BeadChip Data
... powerful embedded statistics and visualizations to yield deep biological interpretation. Going from raw data to biological interpretation has never been easier. ...
... powerful embedded statistics and visualizations to yield deep biological interpretation. Going from raw data to biological interpretation has never been easier. ...
Van, C., Williams, J.S., Kunkel, T.A., and
... monitoring the frequency of 5-FOA or canavanine resistance, respectively. Resistance to 5FOA in the pol3-L612M swr1Δ double mutant strain was 2-fold higher than for the pol3L612M single mutant strain (Fig. 1A). This difference is significant as indicated by no overlap in the 95% confidence intervals ...
... monitoring the frequency of 5-FOA or canavanine resistance, respectively. Resistance to 5FOA in the pol3-L612M swr1Δ double mutant strain was 2-fold higher than for the pol3L612M single mutant strain (Fig. 1A). This difference is significant as indicated by no overlap in the 95% confidence intervals ...
identifying parent-daughter relationships among duplicated genes1
... We used lineage specific duplications from the human genome for our analysis, with macaque as the outgroup species. The dataset of gene families constructed from six mammalian genomes, each with a phylogenetic tree, is described in Hahn et al. [3]. To find human specific duplicates, we collected the ...
... We used lineage specific duplications from the human genome for our analysis, with macaque as the outgroup species. The dataset of gene families constructed from six mammalian genomes, each with a phylogenetic tree, is described in Hahn et al. [3]. To find human specific duplicates, we collected the ...
Missing Value Estimation for Gene Expression Profile Data
... IV. Conclusions DNA microarray is a high-throughput technology that allows the recording of expression levels of thousands of genes simultaneously, giving a global view of gene expression. The data generated in a set of microarray experiments are usually gathered in a matrix with genes in rows and e ...
... IV. Conclusions DNA microarray is a high-throughput technology that allows the recording of expression levels of thousands of genes simultaneously, giving a global view of gene expression. The data generated in a set of microarray experiments are usually gathered in a matrix with genes in rows and e ...
Epigenetic differences arise during the lifetime of
... Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for thes ...
... Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for thes ...
genes associated with production and health in farm animals
... expression of the receptor for ECF18 bacteria. Two alpha (1,2) fucosyltransferase genes (FUT1, FUT2) on porcine chromosome 6q11 have been identified and are closely linked to the blood group inhibitor (S) and Escherichia coli F18 receptor (ECF18R) loci. The typical clinical symptoms of oedema disease ...
... expression of the receptor for ECF18 bacteria. Two alpha (1,2) fucosyltransferase genes (FUT1, FUT2) on porcine chromosome 6q11 have been identified and are closely linked to the blood group inhibitor (S) and Escherichia coli F18 receptor (ECF18R) loci. The typical clinical symptoms of oedema disease ...
1 How to use asci for obtaining double mutants of genes that show
... Double mutants were used to establish the sequence of gene action in the first biosynthetic pathway. Srb and Horowitz (1944) crossed a Neurospora strain that could use ornithine or citrulline or arginine by a strain that could use citrulline or arginine but not ornithine. The double mutant, obtained ...
... Double mutants were used to establish the sequence of gene action in the first biosynthetic pathway. Srb and Horowitz (1944) crossed a Neurospora strain that could use ornithine or citrulline or arginine by a strain that could use citrulline or arginine but not ornithine. The double mutant, obtained ...
Identification and functional analysis of novel genes
... respectively. Our data reveal a previously unanticipated role of mei-P26 in the maintenance of embryonic germ cell fate. We also demonstrated the requirement of sumoylation in GSC maintenance and differentiation. We performed systematic co-RNAi experiments in which we found a low rate of functional ...
... respectively. Our data reveal a previously unanticipated role of mei-P26 in the maintenance of embryonic germ cell fate. We also demonstrated the requirement of sumoylation in GSC maintenance and differentiation. We performed systematic co-RNAi experiments in which we found a low rate of functional ...
Download paper (PDF format)
... (Friedman and Koller, 2001). Friedman et al. (2000) evaluate the bootstrap approach in simulated data that matches the distributions observed in gene expression data. They note that the rate of false negatives is high. Thus, the fact that we do not detect a high confidence for a feature, does not me ...
... (Friedman and Koller, 2001). Friedman et al. (2000) evaluate the bootstrap approach in simulated data that matches the distributions observed in gene expression data. They note that the rate of false negatives is high. Thus, the fact that we do not detect a high confidence for a feature, does not me ...
The dawn of evolutionary genome engineering
... novel conditions remain a terra incognita. Most microbial experimental evolution studies focus on complex traits, such as nutrient limitation and heat stress3, in which mutations in hundreds of genes across the genome contribute to fitness. In these cases, it is difficult to disentangle beneficial m ...
... novel conditions remain a terra incognita. Most microbial experimental evolution studies focus on complex traits, such as nutrient limitation and heat stress3, in which mutations in hundreds of genes across the genome contribute to fitness. In these cases, it is difficult to disentangle beneficial m ...
File S1
... and substantial changes in expression. We assigned yellow (cerebellum), green (hippocampus), blue (neocortex), and red (hypothalamus). Genes are marked with blue if they are only present in the neocortex list. If one other region has differential expression of that gene, it is marked with the color ...
... and substantial changes in expression. We assigned yellow (cerebellum), green (hippocampus), blue (neocortex), and red (hypothalamus). Genes are marked with blue if they are only present in the neocortex list. If one other region has differential expression of that gene, it is marked with the color ...
reviews - Docentes
... that are frequently found to be in phylogenetic agreement with one another and those that are frequently found to be phylogenetically discordant. They found that the phylogenetically discordant genes group T. maritima among the Archaea as a sister group to the Pyrococci. By contrast, the concordant ...
... that are frequently found to be in phylogenetic agreement with one another and those that are frequently found to be phylogenetically discordant. They found that the phylogenetically discordant genes group T. maritima among the Archaea as a sister group to the Pyrococci. By contrast, the concordant ...
Monte Carlo Simulations of Biological Systems
... same species or to closed ones. Interaction among individuals is generally introduced through some global competition mechanism; ii) Models for coevolution - two or more species interact strongly in such a way that the survival of one species depends on the survival of the other; iii) Models for mac ...
... same species or to closed ones. Interaction among individuals is generally introduced through some global competition mechanism; ii) Models for coevolution - two or more species interact strongly in such a way that the survival of one species depends on the survival of the other; iii) Models for mac ...
Complete genome sequence of Roseophage vB_DshP
... Transcriptional modules of the phage vB_DshP-R1 contain three vRNAPs in its virion particles (predicted proteins with 3,555, 399 and 263 aa). vRNAP is a unique feature in N4phages [24]. Analysis of sequencing features of the large vRNAP using CLUSTALW suggested that the RNA polymerase of vB_DshP-R1 ...
... Transcriptional modules of the phage vB_DshP-R1 contain three vRNAPs in its virion particles (predicted proteins with 3,555, 399 and 263 aa). vRNAP is a unique feature in N4phages [24]. Analysis of sequencing features of the large vRNAP using CLUSTALW suggested that the RNA polymerase of vB_DshP-R1 ...
Conclude chromosomes and inheritance - April 9
... Breakage of a Chromosome • Deletions and duplications are common in meiosis. – Homologous chromatids may break and rejoin at incorrect places, such that one chromatid will lose more genes than it receives. • A diploid embryo that is homozygous for a large deletion or male with a large deletion to i ...
... Breakage of a Chromosome • Deletions and duplications are common in meiosis. – Homologous chromatids may break and rejoin at incorrect places, such that one chromatid will lose more genes than it receives. • A diploid embryo that is homozygous for a large deletion or male with a large deletion to i ...
... multimillion-dollar institutes are out to prove they’re just right. posals in hopes of leading to highly innovative technology and science. “They wanted 100 flowers to bloom to see what was successful,” as Roger Brent, director of a CEGS based at the Molecular Sciences Institute, puts it. The first ...
Presentazione standard di PowerPoint
... is dominated by T's (red circle), and that there are relatively few G's (outermost turquoise circle) and C's (pink circle), and a few Arich regions (green 2nd circle). There are many genes which overlap (the genes are indicated in the "annotation circle", which is the fifth circle from the outside - ...
... is dominated by T's (red circle), and that there are relatively few G's (outermost turquoise circle) and C's (pink circle), and a few Arich regions (green 2nd circle). There are many genes which overlap (the genes are indicated in the "annotation circle", which is the fifth circle from the outside - ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.