1 mec-15 Encodes an F-box Protein Required for Touch
... Selective protein degradation is a key regulator of neuronal development and synaptogenesis. Complexes that target proteins for degradation often contain F-box proteins. Here we characterize MEC-15, an F-box protein with WD repeats, that is required for the development and function of C. elegans tou ...
... Selective protein degradation is a key regulator of neuronal development and synaptogenesis. Complexes that target proteins for degradation often contain F-box proteins. Here we characterize MEC-15, an F-box protein with WD repeats, that is required for the development and function of C. elegans tou ...
File - Alexis Kezirian
... represent methylated cytosine sites in the region of interest. White circles are unmethylated cytosine sites in the region of interest. Each row of circle represents a different individual. b) In Figure 2A, the inverted transgene results in most of the paternallyinherited cysteine sites being unmeth ...
... represent methylated cytosine sites in the region of interest. White circles are unmethylated cytosine sites in the region of interest. Each row of circle represents a different individual. b) In Figure 2A, the inverted transgene results in most of the paternallyinherited cysteine sites being unmeth ...
Molecular Pathology/Molecular Diagnostics/Genetic Testing
... Men rarely develop breast cancer and, thus, there may not be an affected first -degree relative, and the size of the family may not permit analysis of possible autosomal dominant inheritance. In patients with breast or ovarian cancer who are from high-risk families without a known BRCA1 or BRCA2 gen ...
... Men rarely develop breast cancer and, thus, there may not be an affected first -degree relative, and the size of the family may not permit analysis of possible autosomal dominant inheritance. In patients with breast or ovarian cancer who are from high-risk families without a known BRCA1 or BRCA2 gen ...
Slide 1
... physical genetic material be What methods would you use? disadvantageous for fern evolution? Could it be related to slow speciation 2. Why is the fate of most duplicate genes to rates, compared to angiosperms? Or, on eventually become silenced? Could the other hand, could the silenced genes mutation ...
... physical genetic material be What methods would you use? disadvantageous for fern evolution? Could it be related to slow speciation 2. Why is the fate of most duplicate genes to rates, compared to angiosperms? Or, on eventually become silenced? Could the other hand, could the silenced genes mutation ...
Screening of Gene Markers for Forensic Identification of Vaginal
... the 500 µl of Buffer RLT Plus (provided by the kit), placing two swabs into each tube. Sterile razor blade was used to cut the cotton swab just up from the swab cotton area. Incubated these swabs in eppendorf tubes for 15 minutes on ice and then for 15 minutes at room temperature with occasional vor ...
... the 500 µl of Buffer RLT Plus (provided by the kit), placing two swabs into each tube. Sterile razor blade was used to cut the cotton swab just up from the swab cotton area. Incubated these swabs in eppendorf tubes for 15 minutes on ice and then for 15 minutes at room temperature with occasional vor ...
Diagnosing Mitochondrial Disorder
... Neither parent carries the disorder. A random gene mutation occurs for unknown reasons. ...
... Neither parent carries the disorder. A random gene mutation occurs for unknown reasons. ...
TILLING. Traditional Mutagenesis Meets
... Large-scale DNA sequencing projects have changed the way that biology is performed. The traditional pursuit of a gene starting with a phenotype has given way to the opposite situation: most of the genes are known from sequence, but most of the phenotypes are obscure. Thus, reverse genetics has becom ...
... Large-scale DNA sequencing projects have changed the way that biology is performed. The traditional pursuit of a gene starting with a phenotype has given way to the opposite situation: most of the genes are known from sequence, but most of the phenotypes are obscure. Thus, reverse genetics has becom ...
Male-Specific Diseases
... What kind of biological mechanisms lie behind the formation of the different genders? Some scientists now conclude that cells from male and female organisms differ in ways that result from chromosomes, not hormones, and believe that every organ in the body — not just those related to reproduction — ...
... What kind of biological mechanisms lie behind the formation of the different genders? Some scientists now conclude that cells from male and female organisms differ in ways that result from chromosomes, not hormones, and believe that every organ in the body — not just those related to reproduction — ...
Gene Section ETV6 (ETS variant gene 6 (TEL oncogene))
... respectively. HLH domain is encoded by exons 3 and 4 and has also been referred to as the pointed or sterile alpha motif (SAM) domain. It is responsible for heteroand homodimerization with other ETV6 proteins and possibly other ets family members. The ETS domain is encoded by exons 6 through 8 and i ...
... respectively. HLH domain is encoded by exons 3 and 4 and has also been referred to as the pointed or sterile alpha motif (SAM) domain. It is responsible for heteroand homodimerization with other ETV6 proteins and possibly other ets family members. The ETS domain is encoded by exons 6 through 8 and i ...
Brian Yu - Comparison of Microarrayc and RNA-Seq Analysis Methods for Single Cell Transcriptiomics
... precursor RNA, and the reads are short with possibly many isoforms. To combat these difficulties, two approaches have been developed referred to as the genome-guided reconstruction and genome-independent reconstruction. Genome-guided reconstruction relies on a reference genome to which all reads are ...
... precursor RNA, and the reads are short with possibly many isoforms. To combat these difficulties, two approaches have been developed referred to as the genome-guided reconstruction and genome-independent reconstruction. Genome-guided reconstruction relies on a reference genome to which all reads are ...
Genome Databases and Open Access Resources
... • Three types of genome databases: • Databases which collect data of all sequenced genomes (Entrez_Genomes; EBI_genomes) • Databases which collect data of a category of organisms with sequenced genomes (Microbial Genomes at TIGR) • Databases specific for one organism with sequenced genomes (Flybase ...
... • Three types of genome databases: • Databases which collect data of all sequenced genomes (Entrez_Genomes; EBI_genomes) • Databases which collect data of a category of organisms with sequenced genomes (Microbial Genomes at TIGR) • Databases specific for one organism with sequenced genomes (Flybase ...
Lec-GenomeAllignment2010
... Figure 1. The difference between positional homology alignment and glocal alignment. Three example linear genomes are broken into genes labeled A,B,C,D, and R. R is a multicopy (repetitive) gene, with different copies labeled using numeric subscripts. Each copy of R is assumed to be identical in se ...
... Figure 1. The difference between positional homology alignment and glocal alignment. Three example linear genomes are broken into genes labeled A,B,C,D, and R. R is a multicopy (repetitive) gene, with different copies labeled using numeric subscripts. Each copy of R is assumed to be identical in se ...
De novo Structure Variations of the Y Chromosome in a 47,XXY
... unknown. Although the possibility that the genetic material from the Y chromosome perturbs the normal function of the ovaries should not be ruled out, it is necessary to explore the potential genetic factors of the patient’s ...
... unknown. Although the possibility that the genetic material from the Y chromosome perturbs the normal function of the ovaries should not be ruled out, it is necessary to explore the potential genetic factors of the patient’s ...
Congenital hyperinsulinism caused by a de novo mutation in the
... mutation in a recessively-inherited disease (2). Rapid, high-throughput techniques for analysis of candidate genes have helped the care of patients with CHI. Genotyping guides further investigation of the patient and, because of the strong genotype-phenotype correlation, also the therapy (10,11). Th ...
... mutation in a recessively-inherited disease (2). Rapid, high-throughput techniques for analysis of candidate genes have helped the care of patients with CHI. Genotyping guides further investigation of the patient and, because of the strong genotype-phenotype correlation, also the therapy (10,11). Th ...
Exercises Biological databases PART ensembl
... A popup window appears showing details on the transcript. It says that the transcript is confirmed by both ensemble and Havana annotation, so it is a highly relevant transcript. Green transcripts are referred to as resulting from the consensus coding sequence project and they are confirmed by Havana ...
... A popup window appears showing details on the transcript. It says that the transcript is confirmed by both ensemble and Havana annotation, so it is a highly relevant transcript. Green transcripts are referred to as resulting from the consensus coding sequence project and they are confirmed by Havana ...
Slide 1
... Use RNAi to characterize regulatory function in protein secretion areA is a positively acting regulatory gene which has been shown to be essential for activating genes encoding enzymes, permeases, needed to acquire nitrogen for the environment areA has recently been shown in Aspergillus to play a p ...
... Use RNAi to characterize regulatory function in protein secretion areA is a positively acting regulatory gene which has been shown to be essential for activating genes encoding enzymes, permeases, needed to acquire nitrogen for the environment areA has recently been shown in Aspergillus to play a p ...
Suppl. Material
... then purified and sequenced. The DNA sequences when BLAST searched against the database showed that the DNA sequences of the inserted DNA were identical to kdsA and waaG of P. aeruginosa (data not shown). Subcloning of kdsA306 and waaG507 gene fragments into suicide vector pFS100 In order to constru ...
... then purified and sequenced. The DNA sequences when BLAST searched against the database showed that the DNA sequences of the inserted DNA were identical to kdsA and waaG of P. aeruginosa (data not shown). Subcloning of kdsA306 and waaG507 gene fragments into suicide vector pFS100 In order to constru ...
Alisch RS, Wang T, Chopra P, Visootsak J, Conneely KN, Warren ST . Genome-wide analysis validates aberrant methylation in fragile X syndrome is specific to the FMR1 locus. BMC Med Genet. 2013 Jan 29;14:18. doi: 10.1186/1471-2350-14-18.
... Figure 1 FXS-associated differentially methylated loci. (A) Modified Manhattan plot of FXS-associated methylation levels in the peripheral blood: loci are displayed with the –log10(P-value) generated by the linear mixed-effect model (y-axis). Horizontal lines reflect cutoffs for FDR <0.05 (blue line ...
... Figure 1 FXS-associated differentially methylated loci. (A) Modified Manhattan plot of FXS-associated methylation levels in the peripheral blood: loci are displayed with the –log10(P-value) generated by the linear mixed-effect model (y-axis). Horizontal lines reflect cutoffs for FDR <0.05 (blue line ...
Variant ABO Blood Group Alleles, Secretor Status, and Risk of
... and no sugar residue, respectively, to an oligosaccharide acceptor, known as the H histo-blood group antigen, which is expressed on the surface of red blood cells, endothelial cells, and epithelial cells, including the gastrointestinal mucosa (2). Recent studies have shown an increased risk of pancr ...
... and no sugar residue, respectively, to an oligosaccharide acceptor, known as the H histo-blood group antigen, which is expressed on the surface of red blood cells, endothelial cells, and epithelial cells, including the gastrointestinal mucosa (2). Recent studies have shown an increased risk of pancr ...
Genetic analysis of a congenital nephrogenic diabetes insipidus
... formation of a truncated AVPR2 which showed significantly decreased cell surface expression and significantly reduced functionality.21-23 Moreover, Morello J. and his colleagues reported this truncated receptor was retained in the endoplasmic reticulum and never reached the Golgi compartment, which ...
... formation of a truncated AVPR2 which showed significantly decreased cell surface expression and significantly reduced functionality.21-23 Moreover, Morello J. and his colleagues reported this truncated receptor was retained in the endoplasmic reticulum and never reached the Golgi compartment, which ...
Gene Section EXT2 (exostoses (multiple) 2) Atlas of Genetics and Cytogenetics
... Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands (JVMGB) Published in Atlas Database: January 2000 Online updated version : http://AtlasGeneticsOncology.org/Genes/EXT2ID213.html ...
... Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands (JVMGB) Published in Atlas Database: January 2000 Online updated version : http://AtlasGeneticsOncology.org/Genes/EXT2ID213.html ...
Evaluation_ofDot - African Index Medicus
... proper management of patients, particularly those with multi-drug resistant tuberculosis (MDR-TB).(6) To facilitate rapid therapeutic decisions for patients, several relatively rapid, growth based, and molecular biological methods are available for antimicrobial susceptibility testing.(5) Use of liq ...
... proper management of patients, particularly those with multi-drug resistant tuberculosis (MDR-TB).(6) To facilitate rapid therapeutic decisions for patients, several relatively rapid, growth based, and molecular biological methods are available for antimicrobial susceptibility testing.(5) Use of liq ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.