E.Publication
... could be expensive. Should government pay for it? Maybe you say yes. However, the cost of this treatment for people who are albino may increase government’s expenditure on health for everyone. Would that change your answer? Think about the choices Fahim’s mother would have to make. If she loves Fahi ...
... could be expensive. Should government pay for it? Maybe you say yes. However, the cost of this treatment for people who are albino may increase government’s expenditure on health for everyone. Would that change your answer? Think about the choices Fahim’s mother would have to make. If she loves Fahi ...
Immunome database for marsupials and monotremes Open Access
... built from a variety of sources, including EST projects and expert-curated gene predictions generated through a variety of methods including chained-BLAST and sensitive HMMER searches. To facilitate systems-based research we have grouped sequences based on broad Gene Ontology categories as well as b ...
... built from a variety of sources, including EST projects and expert-curated gene predictions generated through a variety of methods including chained-BLAST and sensitive HMMER searches. To facilitate systems-based research we have grouped sequences based on broad Gene Ontology categories as well as b ...
Expression of the Hox gene complex in the indirect development of
... after embryogenesis is complete, by a separate process occurring within imaginal tissues set aside in the larva. The single Hox gene complex of Strongylocentrotus purpuratus contains 10 genes, and expression of eight of these genes was measured by quantitative methods during both embryonic and larva ...
... after embryogenesis is complete, by a separate process occurring within imaginal tissues set aside in the larva. The single Hox gene complex of Strongylocentrotus purpuratus contains 10 genes, and expression of eight of these genes was measured by quantitative methods during both embryonic and larva ...
Ribosome reinitiation at leader peptides increases translation of
... distance in known operons has been made. In Escherichia coli the distance between two consecutive genes peaks at around 10 nt. While it might support authors’ hypothesis (and there is a glimpse of such discussion in the text), there is no discussion of other mechanisms putatively involved. Response: ...
... distance in known operons has been made. In Escherichia coli the distance between two consecutive genes peaks at around 10 nt. While it might support authors’ hypothesis (and there is a glimpse of such discussion in the text), there is no discussion of other mechanisms putatively involved. Response: ...
Correction of copy number induced false positives in
... positive hits in regions of high copy number amplifications. In this report, we describe two methods, Local Drop Out (LDO) and General Additive Model (GAM), to correct for this copy number bias, thereby enabling the identification of true positive hits while reducing false positives substantially. I ...
... positive hits in regions of high copy number amplifications. In this report, we describe two methods, Local Drop Out (LDO) and General Additive Model (GAM), to correct for this copy number bias, thereby enabling the identification of true positive hits while reducing false positives substantially. I ...
Your Genes, Your Choices
... knows that since the disease is inherited, she has a strong chance of getting it herself. Priya just learned about a test she can take. The test will tell if she carries the gene for Huntington’s disease. She is tempted to take the test. She thinks that if she could find out once and for all whether ...
... knows that since the disease is inherited, she has a strong chance of getting it herself. Priya just learned about a test she can take. The test will tell if she carries the gene for Huntington’s disease. She is tempted to take the test. She thinks that if she could find out once and for all whether ...
Relative Rates of Nucleotide Substitution in Frogs
... scnDNA substitution rates (Rand 1994). Alternatively, the ratio of substitution rates may be more or less constant across divergent taxa, implying that evolution has arrived at some fundamental constant determined by the balance between error minimization and energy investment. Although recent studi ...
... scnDNA substitution rates (Rand 1994). Alternatively, the ratio of substitution rates may be more or less constant across divergent taxa, implying that evolution has arrived at some fundamental constant determined by the balance between error minimization and energy investment. Although recent studi ...
Volume 16 - Number 1 January 2012 Atlas of Genetics and Cytogenetics
... the principal responsible for HER2 shedding in HER2 over-expressing breast cancer. The cleavage of HER2 liberates the extracellular domain of HER2 leaving a p95 fragment containing the transmembrane domain as well as the intracellular domain. This p95 fragment presents constitutive kinase activation ...
... the principal responsible for HER2 shedding in HER2 over-expressing breast cancer. The cleavage of HER2 liberates the extracellular domain of HER2 leaving a p95 fragment containing the transmembrane domain as well as the intracellular domain. This p95 fragment presents constitutive kinase activation ...
Chapter 18 Regulation of Gene Expression Multiple-Choice
... genome and the genomes of many other multicellular eukaryotes. There was surprise expressed by many that the number of protein-coding sequences is much smaller than they had expected. Which of the following accounts for most of the rest? A) ʺjunkʺ DNA that serves no possible purpose B) rRNA and tRNA ...
... genome and the genomes of many other multicellular eukaryotes. There was surprise expressed by many that the number of protein-coding sequences is much smaller than they had expected. Which of the following accounts for most of the rest? A) ʺjunkʺ DNA that serves no possible purpose B) rRNA and tRNA ...
cns neoplasms module - Michigan State University
... primary CNS lymphoma, germ cell tumors and pineal parenchymal tumors. 7. Discuss the neurocutaneous syndromes (phakomatoses) in terms of associated lesions and genetic defect. 8. Discuss metastasis of tumors to CNS from primary sites outside of the CNS, including morphology (gross and microscopic), ...
... primary CNS lymphoma, germ cell tumors and pineal parenchymal tumors. 7. Discuss the neurocutaneous syndromes (phakomatoses) in terms of associated lesions and genetic defect. 8. Discuss metastasis of tumors to CNS from primary sites outside of the CNS, including morphology (gross and microscopic), ...
Ledbetter Presentation 8/15/05
... CGH-arrays since we detected 100% of all imbalances (n=17) identified by FISH; ...
... CGH-arrays since we detected 100% of all imbalances (n=17) identified by FISH; ...
McElwain, Mark: A Critical Review of Gene Prediction Software
... the abovementioned FGENEH and GRAIL 2 on a set of 570 sequences (Burset and Guigo, 1996). They found that, at the nucleotide level, FGENEH performed with sensitivity = 0.77 and specificity = 0.88, while GRAIL 2 performed with sensitivity = 0.72 and specificity = 0.87. At the exon level, FGENEH perfo ...
... the abovementioned FGENEH and GRAIL 2 on a set of 570 sequences (Burset and Guigo, 1996). They found that, at the nucleotide level, FGENEH performed with sensitivity = 0.77 and specificity = 0.88, while GRAIL 2 performed with sensitivity = 0.72 and specificity = 0.87. At the exon level, FGENEH perfo ...
Survival of the Sickest Reading Guide
... 46. Describe the life cycle of the guinea worm. 47. Describe the life cycle of Toxoplasma Gondii. 48. How does streptococcus cause your body to attack itself? 49. Define xenophobia and how does it affect the spread of disease? 50. What is virulence? 51. Describe three ways microbes move from host to ...
... 46. Describe the life cycle of the guinea worm. 47. Describe the life cycle of Toxoplasma Gondii. 48. How does streptococcus cause your body to attack itself? 49. Define xenophobia and how does it affect the spread of disease? 50. What is virulence? 51. Describe three ways microbes move from host to ...
Using credibility intervals instead of hypothesis tests in SAGE analysis
... a priori, k = 20 000, and q = 0.95. Frame (a) and (b) show results for Beta random variates (stage i of the algorithm described in the text). Solid lines are the theoretically known distribution. Frame (c) shows result for Q distribution. Solid line is the Kernel Density estimation (algorithm’s stag ...
... a priori, k = 20 000, and q = 0.95. Frame (a) and (b) show results for Beta random variates (stage i of the algorithm described in the text). Solid lines are the theoretically known distribution. Frame (c) shows result for Q distribution. Solid line is the Kernel Density estimation (algorithm’s stag ...
Why Sex? — Monte Carlo Simulations of Survival After Catastrophes
... second string of the baby. The sex of the baby is then randomly chosen. When only deleterious mutations are considered, and this is our case, whenever a 1 bit is randomly chosen in the parent genome, it remains equal to 1 in the offspring genome (no mutation occurs). However, if the randomly chosen ...
... second string of the baby. The sex of the baby is then randomly chosen. When only deleterious mutations are considered, and this is our case, whenever a 1 bit is randomly chosen in the parent genome, it remains equal to 1 in the offspring genome (no mutation occurs). However, if the randomly chosen ...
RESEARCH ARTICLES
... from yeast. (A) Yeast clones containing a completely assembled synthetic genome were screened by multiplex PCR with a primer set that produces 11 amplicons; one at each of the 11 assembly junctions. Yeast clone sMmYCp235 (235) produced the 11 PCR products expected for a complete View larger version ...
... from yeast. (A) Yeast clones containing a completely assembled synthetic genome were screened by multiplex PCR with a primer set that produces 11 amplicons; one at each of the 11 assembly junctions. Yeast clone sMmYCp235 (235) produced the 11 PCR products expected for a complete View larger version ...
DNA helicase deficiencies associated with cancer
... Deficiency in a helicase of the RecQ family is found in at least three human genetic disorders associated with cancer predisposition and/or premature ageing. The RecQ helicases encoded by the BLM, WRN and RECQ4 genes are defective in Bloom’s, Werner’s and Rothmund–Thomson syndromes, respectively. Ce ...
... Deficiency in a helicase of the RecQ family is found in at least three human genetic disorders associated with cancer predisposition and/or premature ageing. The RecQ helicases encoded by the BLM, WRN and RECQ4 genes are defective in Bloom’s, Werner’s and Rothmund–Thomson syndromes, respectively. Ce ...
Gene Section PAX2 (Paired box gene 2) Atlas of Genetics and Cytogenetics
... PAX2 is overexpressed in a variety of cancers (see below). A detailed understanding of the mechanistic contribution mediated by PAX2 has yet to be established. However, inhibition of PAX2 expression in a number of cancer cell lines induces cell death, indicating a role for PAX2 in tumour cell surviv ...
... PAX2 is overexpressed in a variety of cancers (see below). A detailed understanding of the mechanistic contribution mediated by PAX2 has yet to be established. However, inhibition of PAX2 expression in a number of cancer cell lines induces cell death, indicating a role for PAX2 in tumour cell surviv ...
DNA-guided genome editing using the
... h, for Fig 3c: western blot (GFP,ACTIN). i, for Fig 3d: western blot (GFP,ACTIN). j, for Fig 4a: T7E1 (DYRK1A) . k, for Fig 4b: T7E1 (DYRK1A,EMX1,GRIN2B,GATA4,HBA2). ...
... h, for Fig 3c: western blot (GFP,ACTIN). i, for Fig 3d: western blot (GFP,ACTIN). j, for Fig 4a: T7E1 (DYRK1A) . k, for Fig 4b: T7E1 (DYRK1A,EMX1,GRIN2B,GATA4,HBA2). ...
Gene Section CASP8 (Caspase 8, Apoptosis-Related Cysteine Peptidase) Atlas of Genetics and Cytogenetics
... development was monitored. Although presence or lack of caspase-8 did not change primary tumor growth, metastasis was highly promoted in the tumors lacking caspase-8 due to impaired programmed cell death (Stupack et al., 2006). In a similar study, tumor cells additionally lacking caspase-3 were used ...
... development was monitored. Although presence or lack of caspase-8 did not change primary tumor growth, metastasis was highly promoted in the tumors lacking caspase-8 due to impaired programmed cell death (Stupack et al., 2006). In a similar study, tumor cells additionally lacking caspase-3 were used ...
Cancer Prone Disease Section Familial platelet disorder with predisposition to
... organizer, recruiting other lineage-specific transcription factors to their promoters. Expression: During embryogenesis, RUNX1 can be detected in hematopoietic stem cells and endothelial cells of the AGM region, while after organogenesis, RUNX1 is predominantly expressed in the hematopoietic system. ...
... organizer, recruiting other lineage-specific transcription factors to their promoters. Expression: During embryogenesis, RUNX1 can be detected in hematopoietic stem cells and endothelial cells of the AGM region, while after organogenesis, RUNX1 is predominantly expressed in the hematopoietic system. ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.