CalbiCyc, Metabolic Pathways at the Candida Genome Database
... The tools are quite different, and the process is distinct, from the usual gene-centric curation we do, curators need to “switch gears” for pathway curation. Found that it was easier to make progress by making a focused “project” out of pathway curation. ...
... The tools are quite different, and the process is distinct, from the usual gene-centric curation we do, curators need to “switch gears” for pathway curation. Found that it was easier to make progress by making a focused “project” out of pathway curation. ...
Gene Section POU4F1 (POU class 4 homeobox 1) in Oncology and Haematology
... whilst antagonising p53 mediated expression of proapoptotic target genes, Bax and Noxa. Brn-3a other interacting partner includes Rin1 (on target gene, Egr1), HIPK1 (alters TrkA expression), EWS - Fli1 fusion protein (represses Brn-3a mediated effects on survival / differentiation genes). In additio ...
... whilst antagonising p53 mediated expression of proapoptotic target genes, Bax and Noxa. Brn-3a other interacting partner includes Rin1 (on target gene, Egr1), HIPK1 (alters TrkA expression), EWS - Fli1 fusion protein (represses Brn-3a mediated effects on survival / differentiation genes). In additio ...
1. Telomeres 2. Centromeric Repeats 3. Retrotransposons (Class I
... Three of the Tos family (Tos10, Tos17, Tos19) have been shown to be active under tissue culture conditions Tos17 was found to only have two copies in the Nipponbare genome Tos17, when activated, has a preference for insertion into low copy sequences in the rice genome Tos17 activation leads to a gra ...
... Three of the Tos family (Tos10, Tos17, Tos19) have been shown to be active under tissue culture conditions Tos17 was found to only have two copies in the Nipponbare genome Tos17, when activated, has a preference for insertion into low copy sequences in the rice genome Tos17 activation leads to a gra ...
The population genetics of beneficial mutations
... was gamma, with a shape parameter close to (but statistically distinguishable from) exponential. (The gamma distribution belongs to the Gumbel domain.) In both experiments, beneficial mutations of small effect were more common than those of large effect (similarly, see Imhof & Schlotterer 2001; Perf ...
... was gamma, with a shape parameter close to (but statistically distinguishable from) exponential. (The gamma distribution belongs to the Gumbel domain.) In both experiments, beneficial mutations of small effect were more common than those of large effect (similarly, see Imhof & Schlotterer 2001; Perf ...
- CSHL Institutional Repository
... information to the next sexual generation. Highly polyploid macronuclei express the genetic information but develop anew at each sexual generation, through extensive programmed rearrangements of the genome. ...
... information to the next sexual generation. Highly polyploid macronuclei express the genetic information but develop anew at each sexual generation, through extensive programmed rearrangements of the genome. ...
No Slide Title - Ohio University
... Facts about polyploidy and allopolyploids • Uncommon in animals but abundant (ancient and ancestral?) in plants • Recent genetic research shows allopolyploids far more common than autopolyploids—different from theory • Many allopolyploids found with multiple origins—contrary to evolutionary paradig ...
... Facts about polyploidy and allopolyploids • Uncommon in animals but abundant (ancient and ancestral?) in plants • Recent genetic research shows allopolyploids far more common than autopolyploids—different from theory • Many allopolyploids found with multiple origins—contrary to evolutionary paradig ...
Kinoshita, T et al.
... Due to the absence of evidence on imprinted gene clusters in flowering plants, it is not yet clear whether a long-distance control of genomic imprinting occurs. However, a recent report showed that the DNA methylation status of a 3 -tandem repeat about 2.5 kb downstream from the PHE1 locus affected ...
... Due to the absence of evidence on imprinted gene clusters in flowering plants, it is not yet clear whether a long-distance control of genomic imprinting occurs. However, a recent report showed that the DNA methylation status of a 3 -tandem repeat about 2.5 kb downstream from the PHE1 locus affected ...
Hereditary Angioedema
... airway. Laryngeal swellings can result in death. As with many rare conditions, there is unfortunately often a delay to diagnosis during which time patients do not receive appropriate treatment. The vast majority of cases result from mutations affecting SERPING1 which encodes C1 esterase inhibitor (C ...
... airway. Laryngeal swellings can result in death. As with many rare conditions, there is unfortunately often a delay to diagnosis during which time patients do not receive appropriate treatment. The vast majority of cases result from mutations affecting SERPING1 which encodes C1 esterase inhibitor (C ...
Genetic mapping and manipulation: Chapter 8
... haploinsufficiency, one can directly examine animals that are heterozygous for a chromosomal deficiency that removes the entire gene (as well as a number of other genes presumably). Alternatively, if a deletion or null allele of the gene exists, placing this mutation over the wild-type chromosome co ...
... haploinsufficiency, one can directly examine animals that are heterozygous for a chromosomal deficiency that removes the entire gene (as well as a number of other genes presumably). Alternatively, if a deletion or null allele of the gene exists, placing this mutation over the wild-type chromosome co ...
The knockout of miR-143 and -145 alters smooth muscle cell
... Mechanisms controlling vascular smooth muscle cell (VSMC) plasticity and renewal still remain to be elucidated completely. A class of small RNAs called microRNAs (miRs) regulate gene expression at the post-transcriptional level. Here, we show a critical role of the miR-143/145 cluster in SMC differe ...
... Mechanisms controlling vascular smooth muscle cell (VSMC) plasticity and renewal still remain to be elucidated completely. A class of small RNAs called microRNAs (miRs) regulate gene expression at the post-transcriptional level. Here, we show a critical role of the miR-143/145 cluster in SMC differe ...
BIOL 106 Introduction to Cell Biology
... Describe cell division by comparing the genetic information in the chromosomes of typical daughter cells. Compare the cellular processes and cellular products of asexual and sexual reproduction. Describe the basic structure of a chromosome. Explain how and when chromosomes are duplicated. Describe t ...
... Describe cell division by comparing the genetic information in the chromosomes of typical daughter cells. Compare the cellular processes and cellular products of asexual and sexual reproduction. Describe the basic structure of a chromosome. Explain how and when chromosomes are duplicated. Describe t ...
BB - Life Science Classroom
... 2. Alleles are alternate forms of a gene located on the same locus of homologous chromosomes. 3. It seems that sometimes, one gene dominates the other of the pair. We say that the one gene is dominant, while the one that is dominated, is called the recessive gene (pg5). 4. A genotype Bb is called HE ...
... 2. Alleles are alternate forms of a gene located on the same locus of homologous chromosomes. 3. It seems that sometimes, one gene dominates the other of the pair. We say that the one gene is dominant, while the one that is dominated, is called the recessive gene (pg5). 4. A genotype Bb is called HE ...
Gene Section ID4 (inhibitor of DNA binding 4, dominant negative helix-loop-helix protein)
... significant risk factor for nodal metastasis (Umetani et al., 2006). In another study, BRCA1, ER (estrogen receptor), and ID4 were found expressed in breast cancer specimens from patients with invasive carcinomas. Most of the patients who expressed BRCA1 also expressed ER, but were negative for ID4, ...
... significant risk factor for nodal metastasis (Umetani et al., 2006). In another study, BRCA1, ER (estrogen receptor), and ID4 were found expressed in breast cancer specimens from patients with invasive carcinomas. Most of the patients who expressed BRCA1 also expressed ER, but were negative for ID4, ...
Mutations in type I collagen genes resulting in osteogenesis
... Functions associated with crucial versus noncrucial domains might include their role in thermal stability of collagen, its secretion from the cell or interactions with collagenous or noncollagenous molecules in the extracellular matrix. The genetic background and other modifiers appear to be importa ...
... Functions associated with crucial versus noncrucial domains might include their role in thermal stability of collagen, its secretion from the cell or interactions with collagenous or noncollagenous molecules in the extracellular matrix. The genetic background and other modifiers appear to be importa ...
Correlations Between Gene Expression and Gene Conservation in
... and C. elegans genomes. To confirm these results, we used a list of orphans that contains all fission yeast genes for which no homologs have been identified in any other organism (see Methods). This list of orphans should be more accurate, as it has been generated by careful manual curation and comp ...
... and C. elegans genomes. To confirm these results, we used a list of orphans that contains all fission yeast genes for which no homologs have been identified in any other organism (see Methods). This list of orphans should be more accurate, as it has been generated by careful manual curation and comp ...
Mutation frequencies for glycogen storage disease
... presence of a founder effect for the R83C mutation that has given rise to an elevated frequency of GSD1a in the AJ population. We note that this mutation frequency is comparable or greater than those for a number of diseases currently undergoing population screening in the AJ population, including N ...
... presence of a founder effect for the R83C mutation that has given rise to an elevated frequency of GSD1a in the AJ population. We note that this mutation frequency is comparable or greater than those for a number of diseases currently undergoing population screening in the AJ population, including N ...
Rate of Gene Transfer From Mitochondria to Nucleus
... Endosymbiotic theory states that mitochondria originated as bacterial intracellular symbionts, the size of the mitochondrial genome gradually reducing over a long period owing to, among other things, gene transfer from the mitochondria to the nucleus. Such gene transfer was observed in more genes in ...
... Endosymbiotic theory states that mitochondria originated as bacterial intracellular symbionts, the size of the mitochondrial genome gradually reducing over a long period owing to, among other things, gene transfer from the mitochondria to the nucleus. Such gene transfer was observed in more genes in ...
Presentation of Case: Our patient was a 32-year
... of the thorax and abdominal cavity are inverted. The pathogenic mechanisms of SIT have not been well elucidated. Some genetic patterns are involved, including an autosomal recessive gene located on chromosome 14 and deletions affecting chromosomes 7 or 8; 8 Recently, significant advancements in the ...
... of the thorax and abdominal cavity are inverted. The pathogenic mechanisms of SIT have not been well elucidated. Some genetic patterns are involved, including an autosomal recessive gene located on chromosome 14 and deletions affecting chromosomes 7 or 8; 8 Recently, significant advancements in the ...
Mutation of the p53 Gene Is Not a Typical Feature of Hodgkin and
... from single cells was performed by seminested PCR. The primers hybridized in the intronic sequences flanking the exons. Three segments of the p53 gene were amplified with different primer pairs, the first (E4) containing the downstream part of exon 4, the second (E5/6) containing exons 5 and 6, and ...
... from single cells was performed by seminested PCR. The primers hybridized in the intronic sequences flanking the exons. Three segments of the p53 gene were amplified with different primer pairs, the first (E4) containing the downstream part of exon 4, the second (E5/6) containing exons 5 and 6, and ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.