Nuclear Genes That Encode Mitochondrial Proteins
... An extensive survey of the Arabidopsis genome for genes that might be involved in mitochondrial genome maintenance functions revealed the presence of a number of genes on chromosome III that appeared to encode mitochondrial proteins based on their prokaryotic sequence homology and targeting capacity ...
... An extensive survey of the Arabidopsis genome for genes that might be involved in mitochondrial genome maintenance functions revealed the presence of a number of genes on chromosome III that appeared to encode mitochondrial proteins based on their prokaryotic sequence homology and targeting capacity ...
CHAPTER 16 Advanced Gene Mapping in Eukaryotes
... a. Parental-ditype (PD) tetrad has only the two parental types (a+ b+ and a b). A PD tetrad results either if no crossing-over occurs between the two genes, or if a double crossover involving the same two chromatids occurs. b. Tetratype (T) has two parentals (a+ b+ and a b) and two recombinants (a+ ...
... a. Parental-ditype (PD) tetrad has only the two parental types (a+ b+ and a b). A PD tetrad results either if no crossing-over occurs between the two genes, or if a double crossover involving the same two chromatids occurs. b. Tetratype (T) has two parentals (a+ b+ and a b) and two recombinants (a+ ...
Oligogenic basis of isolated gonadotropin
... was to have isolated GnRH deficiency manifested as IHH as opposed to a milder or partial phenotype, such as delayed puberty, anosmia, or cleft lip/palate (Fig. S2A, pedigrees I and II; Fig. S2B, pedigrees IV–VIII). For example, in pedigree IV, nIHH was present only in the two digenic subjects with on ...
... was to have isolated GnRH deficiency manifested as IHH as opposed to a milder or partial phenotype, such as delayed puberty, anosmia, or cleft lip/palate (Fig. S2A, pedigrees I and II; Fig. S2B, pedigrees IV–VIII). For example, in pedigree IV, nIHH was present only in the two digenic subjects with on ...
How Does Replication-Associated Mutational Pressure Influence
... other and disappear, leaving the effect of asymmetry introduced by other mechanisms (see Methods for details). In contrast, the asymmetry in ORFs resulting from their coding function or transcription is of the same sign independent of their location on leading or lagging strands. Thus, the addition ...
... other and disappear, leaving the effect of asymmetry introduced by other mechanisms (see Methods for details). In contrast, the asymmetry in ORFs resulting from their coding function or transcription is of the same sign independent of their location on leading or lagging strands. Thus, the addition ...
Gene Section WWP1 (WW domain containing E3 ubiquitin protein ligase 1)
... WWP1 may play a pro-survival role in several tumor types including breast (Chen et al., 2007b) and prostate (Chen et al., 2007a). WWP1 has also shown to promote virus budding (Martin-Serrano et al., 2005; Heidecker et al., 2007). ...
... WWP1 may play a pro-survival role in several tumor types including breast (Chen et al., 2007b) and prostate (Chen et al., 2007a). WWP1 has also shown to promote virus budding (Martin-Serrano et al., 2005; Heidecker et al., 2007). ...
Genes for Cognitive Function: Developments on the X
... Since the publication of MRX1 (Suthers et al. 1988), a significant resource of mapped MRX families has been established, and additions remain ongoing. In the recent past this was the point when the family study was abandoned. The gene localization determined by linkage in single families was too bro ...
... Since the publication of MRX1 (Suthers et al. 1988), a significant resource of mapped MRX families has been established, and additions remain ongoing. In the recent past this was the point when the family study was abandoned. The gene localization determined by linkage in single families was too bro ...
Unit 1 Topic 4 - Holy Cross Collegiate
... rays, and some chemicals are called mutagens because they cause in this disaster were the mutations. Sometimes mutations have little or no effect on an organism, clean-up crew. Later, some of the clean-up but often they can disrupt the complex interactions of chemicals and crew had children. It is c ...
... rays, and some chemicals are called mutagens because they cause in this disaster were the mutations. Sometimes mutations have little or no effect on an organism, clean-up crew. Later, some of the clean-up but often they can disrupt the complex interactions of chemicals and crew had children. It is c ...
Introducing:
... •Numerical mutations will affect the number of genes by either removing one copy or providing extra copies. •During the Human Genome Project (which aimed to map the entire human genome) analysis of this chromosome revealed 127 known genes, 98 predicted genes, and 59 pseudogenes. Pseudogenes are sect ...
... •Numerical mutations will affect the number of genes by either removing one copy or providing extra copies. •During the Human Genome Project (which aimed to map the entire human genome) analysis of this chromosome revealed 127 known genes, 98 predicted genes, and 59 pseudogenes. Pseudogenes are sect ...
PDF
... et al., 2003) to group putative orthologs and paralogs (OrthoMCL with BLASTP < 1e 5), we identified orthologs that are conserved among Brachypodium, Oryza, Sorghum and Zizania, and those that are Zizania-specific genes (Figure 1b). As expected, Zizania appears to share more orthologous groups with O ...
... et al., 2003) to group putative orthologs and paralogs (OrthoMCL with BLASTP < 1e 5), we identified orthologs that are conserved among Brachypodium, Oryza, Sorghum and Zizania, and those that are Zizania-specific genes (Figure 1b). As expected, Zizania appears to share more orthologous groups with O ...
Somatic MEN1 gene mutation does not contribute
... were assessed in 35 sporadic tumours of the anterior pituitary (9 prolactin-secreting, 8 GH-secreting, 3 TSH-secreting, 2 TSH/GH-secreting, 4 Cushing, 9 silent). Thirty-one tumours were found to be heterozygous for at least one MEN1 intragenic polymorphism (25 cases) or for a flanking gene polymorph ...
... were assessed in 35 sporadic tumours of the anterior pituitary (9 prolactin-secreting, 8 GH-secreting, 3 TSH-secreting, 2 TSH/GH-secreting, 4 Cushing, 9 silent). Thirty-one tumours were found to be heterozygous for at least one MEN1 intragenic polymorphism (25 cases) or for a flanking gene polymorph ...
activator
... • The regulatory “switch” is a segment of DNA called an operator usually positioned within the promoter • An operon is the entire stretch of DNA that includes the operator, the promoter, and the genes that they control Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings ...
... • The regulatory “switch” is a segment of DNA called an operator usually positioned within the promoter • An operon is the entire stretch of DNA that includes the operator, the promoter, and the genes that they control Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings ...
REVIEWS - Ken Wolfe`s
... The renewed interest in Ohno’s ideas stems from two lines of research that began to bear fruit in the late 1980s. The first was what is now called comparative genomics. Genetic map comparisons among mammals confirmed that they contain large segments4 of conserved SYNTENY with conserved gene order. A ...
... The renewed interest in Ohno’s ideas stems from two lines of research that began to bear fruit in the late 1980s. The first was what is now called comparative genomics. Genetic map comparisons among mammals confirmed that they contain large segments4 of conserved SYNTENY with conserved gene order. A ...
Polyploidy and genome evolution in plants
... Arabidopsis suecica, soybean, and tobacco, have become experimental systems for addressing questions in younger allopolyploids. Even more recent are allopolyploids in Tragopogon, Spartina and Senecio that were formed within the past 200 years [29,30,31,32]. These situations provide a rich opportun ...
... Arabidopsis suecica, soybean, and tobacco, have become experimental systems for addressing questions in younger allopolyploids. Even more recent are allopolyploids in Tragopogon, Spartina and Senecio that were formed within the past 200 years [29,30,31,32]. These situations provide a rich opportun ...
Appearances can be deceiving: phenotypes of
... uncommon occurrence upon generating null mutations in the mouse. It is difficult to estimate what proportion of mouse null mutants generated to date have no observable phenotype. This is because publishing ‘negative’ data is often difficult, accompanied by the fact that frequently a researcher will ...
... uncommon occurrence upon generating null mutations in the mouse. It is difficult to estimate what proportion of mouse null mutants generated to date have no observable phenotype. This is because publishing ‘negative’ data is often difficult, accompanied by the fact that frequently a researcher will ...
Mutations in type I collagen genes resulting in osteogenesis
... Functions associated with crucial versus noncrucial domains might include their role in thermal stability of collagen, its secretion from the cell or interactions with collagenous or noncollagenous molecules in the extracellular matrix. The genetic background and other modifiers appear to be importa ...
... Functions associated with crucial versus noncrucial domains might include their role in thermal stability of collagen, its secretion from the cell or interactions with collagenous or noncollagenous molecules in the extracellular matrix. The genetic background and other modifiers appear to be importa ...
Harvard Medical School - MGH-PGA
... Full-length cDNA clones of human genes involved in heart development and disease states Human tissue bank of 290 samples derived from cardiac transplantations or organ harvests ...
... Full-length cDNA clones of human genes involved in heart development and disease states Human tissue bank of 290 samples derived from cardiac transplantations or organ harvests ...
Relationship between chromosome fragility, aneuploidy and
... damage [9]. The recently cloned FANCD2 gene is the only FA gene conserved in evolution [8] and it is thought to be a key player downstream in the FA pathway where ubiquitinated isoform of FANCD2 moves to DNA damage-induced nuclear foci in association with the double strand break repair protein BRCA1 ...
... damage [9]. The recently cloned FANCD2 gene is the only FA gene conserved in evolution [8] and it is thought to be a key player downstream in the FA pathway where ubiquitinated isoform of FANCD2 moves to DNA damage-induced nuclear foci in association with the double strand break repair protein BRCA1 ...
Title PPAR interprets a chromatin signature of - DR-NTU
... Epigenetic post-transcriptional modifications of histone tails are thought to help in coordinating gene expression during development. An epigenetic signature is set in pluripotent cells and interpreted later at the onset of differentiation. In pluripotent cells, epigenetic marks normally associated ...
... Epigenetic post-transcriptional modifications of histone tails are thought to help in coordinating gene expression during development. An epigenetic signature is set in pluripotent cells and interpreted later at the onset of differentiation. In pluripotent cells, epigenetic marks normally associated ...
Bioinformatics Seminar 13/11/07
... Options can be in any order. Output can be redirected to a file as shown. A file of gene names could be used as input instead of a chromosome sequence range. gabos –help lists all options. ...
... Options can be in any order. Output can be redirected to a file as shown. A file of gene names could be used as input instead of a chromosome sequence range. gabos –help lists all options. ...
FMR1 low sub-genotype does not rescue BRCA1
... published by Weghofer et al. would have great implications for women undergoing an IVF procedure for fertility preservation or subsequent embryo selection by PGD. We aimed at testing their hypothesis in our BRCA1/2 population. We have also included males, to confirm the embryo rescue hypothesis, sinc ...
... published by Weghofer et al. would have great implications for women undergoing an IVF procedure for fertility preservation or subsequent embryo selection by PGD. We aimed at testing their hypothesis in our BRCA1/2 population. We have also included males, to confirm the embryo rescue hypothesis, sinc ...
RNA-Seq Tutorial - Gene Codes Corporation
... categories. The variable file is just a text file with one condition for each sample in the same order as the data file. • Highlight “gene_exp” and go to File > Import > Variable. • You need to import a Source File, click the button labeled … a ...
... categories. The variable file is just a text file with one condition for each sample in the same order as the data file. • Highlight “gene_exp” and go to File > Import > Variable. • You need to import a Source File, click the button labeled … a ...
Chapter 8 Patterns of Single-gene Inheritance
... A pedigree of polydactyly, showing the skipped generation because of Ⅱ3 who appeared phenotypically normal. ...
... A pedigree of polydactyly, showing the skipped generation because of Ⅱ3 who appeared phenotypically normal. ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.