The 2013 Thomas Hunt Morgan Medal Thomas Douglas
... was also here where Tom met Rosann Farber, a human geneticist who has been his wife, as well as occasional collaborator, for almost 40 years. Their two most notable collaborations are their daughters: Laura, a marine biologist at the National Oceanic and Atmospheric Administration and Diana, a yogur ...
... was also here where Tom met Rosann Farber, a human geneticist who has been his wife, as well as occasional collaborator, for almost 40 years. Their two most notable collaborations are their daughters: Laura, a marine biologist at the National Oceanic and Atmospheric Administration and Diana, a yogur ...
32 Fungal Genetics Newsletter Ursula Kües , Michaela J. Klaus
... data obtained with the monokaryons. Cotransformation frequencies of a second plasmid was detected at frequencies between 535%, of two additional plasmids at frequencies between 3-18% and of three additional plasmids at a frequency of 3% (Table 2). Thus, cotransformation frequencies of multiple plasm ...
... data obtained with the monokaryons. Cotransformation frequencies of a second plasmid was detected at frequencies between 535%, of two additional plasmids at frequencies between 3-18% and of three additional plasmids at a frequency of 3% (Table 2). Thus, cotransformation frequencies of multiple plasm ...
OMIM® – The Online Mendelian Inheritance in Man
... and then trying to determine how those samples related to each other, over time building up a map of related data points that could be used to pick out where on the genome the disease-causing mutation must lie. The advent of full-genome sequencing changed this immensely – geneticists now sequence DN ...
... and then trying to determine how those samples related to each other, over time building up a map of related data points that could be used to pick out where on the genome the disease-causing mutation must lie. The advent of full-genome sequencing changed this immensely – geneticists now sequence DN ...
bbr038online 474..484 - Oxford Academic
... conducted even by individual laboratories. However, this will yield more and more genome sequences that are not well assembled, and will hinder thorough annotation when no closely related reference genome is available. One of the challenging issues is the identification of protein-coding sequences s ...
... conducted even by individual laboratories. However, this will yield more and more genome sequences that are not well assembled, and will hinder thorough annotation when no closely related reference genome is available. One of the challenging issues is the identification of protein-coding sequences s ...
Caenorhabditis elegans: Genetic Portrait of a Simple Multicellular
... by cell membranes, which divide mitotically in a common core of cytoplasm (forming a syncytium). The nuclei move toward the other (proximal) end of the lobe, which terminates in the uterus. As they move toward the bend between the distal and proximal arms of the lobe, the nuclei enter into meiosis. ...
... by cell membranes, which divide mitotically in a common core of cytoplasm (forming a syncytium). The nuclei move toward the other (proximal) end of the lobe, which terminates in the uterus. As they move toward the bend between the distal and proximal arms of the lobe, the nuclei enter into meiosis. ...
Historical Development of the Concept of the Gene
... 1958; Yanofsky & Crawford, 1959). Thus, the cornerstone of the neoclassical view of the gene became the one cistron/one polypeptide hypothesis, which replaced the old one gene/one enzyme hypothesis. (An enzyme molecule can consist of a single polypeptide molecule, but usually it consists of several ...
... 1958; Yanofsky & Crawford, 1959). Thus, the cornerstone of the neoclassical view of the gene became the one cistron/one polypeptide hypothesis, which replaced the old one gene/one enzyme hypothesis. (An enzyme molecule can consist of a single polypeptide molecule, but usually it consists of several ...
Evolution of the defensin-like gene family in grass genomes
... within species and E ≤ 10−20 between species) (Sato et al. 2008), we considered that these members belonged to a duplicated block. Ultimately, we detect a total of 21 (41%) genes involved in large-scale duplication events, with a maximum number of seven in rice and a minimum number of four in brachy ...
... within species and E ≤ 10−20 between species) (Sato et al. 2008), we considered that these members belonged to a duplicated block. Ultimately, we detect a total of 21 (41%) genes involved in large-scale duplication events, with a maximum number of seven in rice and a minimum number of four in brachy ...
Hailey Spelman - Determining Cellular Fate: Pre- and Postnatal Methylation Effects on Gene Expression
... status. Many health centers are investing in technologies to track cancer growth through methylation concentration. For instance, in India, Reliance Life Sciences is working on a way to use the degree of methylation at known tumor suppressor genes to see how far an individual is from developing oral ...
... status. Many health centers are investing in technologies to track cancer growth through methylation concentration. For instance, in India, Reliance Life Sciences is working on a way to use the degree of methylation at known tumor suppressor genes to see how far an individual is from developing oral ...
Evolution on the X chromosome: unusual patterns and processes
... bird W chromosome have lower mutation rates than the autosomes, resulting in lower levels of neutral divergence at X- and W-chromosome loci. In Drosophila species, on the other hand, no such effect has been detected, as expected from the similar number of cell divisions estimated for male and female ...
... bird W chromosome have lower mutation rates than the autosomes, resulting in lower levels of neutral divergence at X- and W-chromosome loci. In Drosophila species, on the other hand, no such effect has been detected, as expected from the similar number of cell divisions estimated for male and female ...
Detection of cystic fibrosis transmembrane conductance regulator
... widely detected in infertile men with congenital bilateral absence of the vas deferens (CBAVD). Despite extensive analysis of the CFTR gene using varied screening methods, a number of cases remain unsolved and could be attributable to the presence of large gene rearrangements, as recently shown for ...
... widely detected in infertile men with congenital bilateral absence of the vas deferens (CBAVD). Despite extensive analysis of the CFTR gene using varied screening methods, a number of cases remain unsolved and could be attributable to the presence of large gene rearrangements, as recently shown for ...
Genotype–phenotype characteristics and baseline natural
... (Shy et al., 2005b; Murphy et al., 2011a). Both have been validated for composite measurement of impairment and assess symptoms, signs and neurophysiology of CMT patients. CMTNSv1 and CMTNSv2 are both composed of nine assessments: symptoms (three items), signs (four items), and neurophysiology (two ...
... (Shy et al., 2005b; Murphy et al., 2011a). Both have been validated for composite measurement of impairment and assess symptoms, signs and neurophysiology of CMT patients. CMTNSv1 and CMTNSv2 are both composed of nine assessments: symptoms (three items), signs (four items), and neurophysiology (two ...
The new genes of rice: a closer look
... representative reference sample of bona fide non-coding rice DNA would not have been an easy task. By contrast, ...
... representative reference sample of bona fide non-coding rice DNA would not have been an easy task. By contrast, ...
Slides
... • Calculate P-values for each GO term’s association to a cluster, and choose those that are most significant. ...
... • Calculate P-values for each GO term’s association to a cluster, and choose those that are most significant. ...
The role of duplications in the evolution of genomes highlights the
... slower rates of amino acid substitution, insertion and deletion than single copy genes. However, authors concluded that it is still unclear whether fixation, maintenance, or both of these steps together cause the bias towards the preferential duplication and highlighted that the relative importance ...
... slower rates of amino acid substitution, insertion and deletion than single copy genes. However, authors concluded that it is still unclear whether fixation, maintenance, or both of these steps together cause the bias towards the preferential duplication and highlighted that the relative importance ...
The Modest Beginnings of One Genome Project
... suppressible mutants that appeared to saturate its genetic map, defining most of its 30 genes. In addition, using the recently invented slab gel electrophoresis system, he identified the proteins encoded by most of these genes (Studier 1969; Studier and Hausmann 1969; Studier and Maizel 1969). Throug ...
... suppressible mutants that appeared to saturate its genetic map, defining most of its 30 genes. In addition, using the recently invented slab gel electrophoresis system, he identified the proteins encoded by most of these genes (Studier 1969; Studier and Hausmann 1969; Studier and Maizel 1969). Throug ...
Section F
... Base excision repair (BER) • Base excision repair (BER): the lesion is removed by a specific DNA glycosylase, which cleave the N-glycosylic bond between the altered base and the sugar. This results AP site, then it is cleaved and expanded to a gap by ...
... Base excision repair (BER) • Base excision repair (BER): the lesion is removed by a specific DNA glycosylase, which cleave the N-glycosylic bond between the altered base and the sugar. This results AP site, then it is cleaved and expanded to a gap by ...
Click
... mber of probes to the gene RNA. RNA-seq gene expression as the fraction of aligned reads that can be assigned to the before expression e ...
... mber of probes to the gene RNA. RNA-seq gene expression as the fraction of aligned reads that can be assigned to the before expression e ...
... appear differently between the traits is increasing interested in genetic variation. In case of beef cattle industry DNA markers are available commercially. Thus, in Korean cattle(Hanwoo) the sufficient value is so strong at industrial level that means it should be very useful if we can develop the ...
Investigation of the role of the Inflammasome triggering HIN200
... AIM2, a unique cytosolic DNA sensor which instigates the formation of the inflammasome yielding cell death via IL-1β and IL-182. This project sought to develop a novel subcongenic mouse model containing the HIN 200 locus, B10.Yaa.Bxs3.Ifi to investigate the potential role of this gene family in SLE ...
... AIM2, a unique cytosolic DNA sensor which instigates the formation of the inflammasome yielding cell death via IL-1β and IL-182. This project sought to develop a novel subcongenic mouse model containing the HIN 200 locus, B10.Yaa.Bxs3.Ifi to investigate the potential role of this gene family in SLE ...
Why have organelles retained genomes?
... How do those predictions fare from the standpoint of today’s data? The first prediction involves the functions of genes expected to be encoded in organelles. We have compared the number of protein-coding genes per functional category that are present in the genomes of organelles and their free-livin ...
... How do those predictions fare from the standpoint of today’s data? The first prediction involves the functions of genes expected to be encoded in organelles. We have compared the number of protein-coding genes per functional category that are present in the genomes of organelles and their free-livin ...
Oligogenic basis of isolated gonadotropin
... was to have isolated GnRH deficiency manifested as IHH as opposed to a milder or partial phenotype, such as delayed puberty, anosmia, or cleft lip/palate (Fig. S2A, pedigrees I and II; Fig. S2B, pedigrees IV–VIII). For example, in pedigree IV, nIHH was present only in the two digenic subjects with on ...
... was to have isolated GnRH deficiency manifested as IHH as opposed to a milder or partial phenotype, such as delayed puberty, anosmia, or cleft lip/palate (Fig. S2A, pedigrees I and II; Fig. S2B, pedigrees IV–VIII). For example, in pedigree IV, nIHH was present only in the two digenic subjects with on ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.