Can genes create sexual preferences?
... organisms, most genes are expressed, but, in complex organisms, only about 10-15% are expressed in any one organ. For example, genes coding for proteins involved in the development and function of the eye will be repressed in cells in the region of the toenail. The pattern of proteins produced depen ...
... organisms, most genes are expressed, but, in complex organisms, only about 10-15% are expressed in any one organ. For example, genes coding for proteins involved in the development and function of the eye will be repressed in cells in the region of the toenail. The pattern of proteins produced depen ...
Insertion of liver enriched transcription
... targeted gene delivery. The strategy involved the design of new synthetic promoters/enhancers, upstream of a gene of interest, using regulatory elements associated with the expression of a specific target tissue/organ. The goal of such gene delivery was to correct either an inherited genetic or meta ...
... targeted gene delivery. The strategy involved the design of new synthetic promoters/enhancers, upstream of a gene of interest, using regulatory elements associated with the expression of a specific target tissue/organ. The goal of such gene delivery was to correct either an inherited genetic or meta ...
Gene ORGANizer: linking genes to the organs they
... data collected rarely capture the entire temporal and structural variation of organs. Third, expression analyses generally focus on specific cell types or tissues (e.g. cardiomyocytes), rather than on whole organs (e.g. heart), systems (e.g. the cardiovascular), or anatomical regions (e.g. the thora ...
... data collected rarely capture the entire temporal and structural variation of organs. Third, expression analyses generally focus on specific cell types or tissues (e.g. cardiomyocytes), rather than on whole organs (e.g. heart), systems (e.g. the cardiovascular), or anatomical regions (e.g. the thora ...
The silence of genes
... The current favourite is the sexual conflict theory, which was first suggested by David Haig, an evolutionary biologist and geneticist at Harvard University (Cambridge, MA, USA). He proposed that imprinting specific genes is the result of a conflict of interest between the father and mother, if the ...
... The current favourite is the sexual conflict theory, which was first suggested by David Haig, an evolutionary biologist and geneticist at Harvard University (Cambridge, MA, USA). He proposed that imprinting specific genes is the result of a conflict of interest between the father and mother, if the ...
ABCA3 Gene Mutations in Newborns with Fatal
... 4, viral pneumonia in 3, acinar dysplasia in 2, pulmonary lymphangiectasia in 1, and mucopolysaccharidosis type II in 1. In 47 infants (14 percent), hereditary deficiency of surfactant protein B was identified as the basis of the lung disease, as determined by the identification of loss-of-function ...
... 4, viral pneumonia in 3, acinar dysplasia in 2, pulmonary lymphangiectasia in 1, and mucopolysaccharidosis type II in 1. In 47 infants (14 percent), hereditary deficiency of surfactant protein B was identified as the basis of the lung disease, as determined by the identification of loss-of-function ...
Ryanodine Myopathies Without Central Cores-Clinical
... stains, without a clear core formation. Endomysial fibrosis and adipose substitution, as found in the biopsy of Patient 2, are characteristics more commonly associated with dystrophies and are less specific traits, but they have also been described in RYR1-related myopathies.7,12 Concerning molecular ...
... stains, without a clear core formation. Endomysial fibrosis and adipose substitution, as found in the biopsy of Patient 2, are characteristics more commonly associated with dystrophies and are less specific traits, but they have also been described in RYR1-related myopathies.7,12 Concerning molecular ...
Ge´nie: literature-based gene prioritization at multi genomic scale
... to screen for genes associated with particular properties, which can then be further used to design new experiments or to prioritize analysis (1). Classically, the literature dealing with genes, as stored in the MEDLINE database of biomedical references (2), has been used to do this prioritization ( ...
... to screen for genes associated with particular properties, which can then be further used to design new experiments or to prioritize analysis (1). Classically, the literature dealing with genes, as stored in the MEDLINE database of biomedical references (2), has been used to do this prioritization ( ...
fog-1, a Regulatory Gene Required for Specification of
... gamma-rays (7000 R). After allowing these animals to mate for 24 hr they were transferred to Petri dishes containing 1 mM aldicarb (Chem Service, Inc., Westchester, PA) in agar. Rand Mutations in unc-11 confer resistance to aldicarb and C. Johnson, personal communication); therefore, only those anim ...
... gamma-rays (7000 R). After allowing these animals to mate for 24 hr they were transferred to Petri dishes containing 1 mM aldicarb (Chem Service, Inc., Westchester, PA) in agar. Rand Mutations in unc-11 confer resistance to aldicarb and C. Johnson, personal communication); therefore, only those anim ...
Convergent evolution of genes controlling mitonuclear
... and assigned to ortholog groups by best-bidirectional blast against N. furzeri. Then, for each N. furzeri isoform the most similar isoform of each other species were determined by pairwise comparison. These sequences were required to have additionally at least a similarity of 70% with N. furzeri and ...
... and assigned to ortholog groups by best-bidirectional blast against N. furzeri. Then, for each N. furzeri isoform the most similar isoform of each other species were determined by pairwise comparison. These sequences were required to have additionally at least a similarity of 70% with N. furzeri and ...
Identification of helper T cell master regulator candidates using the
... 2009). The discovery of Th17 cells also links the differentiation of FOXP3+ regulatory T (Treg) cells to that of helper T phenotypes, because the set of cytokines inducing either Treg or Th17 cells overlaps. New Th phenotypes are currently being suggested, e.g. Th9 (Veldhoen et al., 2008), reviewed ...
... 2009). The discovery of Th17 cells also links the differentiation of FOXP3+ regulatory T (Treg) cells to that of helper T phenotypes, because the set of cytokines inducing either Treg or Th17 cells overlaps. New Th phenotypes are currently being suggested, e.g. Th9 (Veldhoen et al., 2008), reviewed ...
Globozoospermia is mainly due to DPY19L2 deletion via non
... identify mutations in two genes, SPATA16 and DPY19L2 (11,12). The deletion of exon 4 in SPATA16 was found in an Ashkenazi Jewish family with three affected brothers. No other mutations were identified in a screen of 21 patients. A large deletion of 200 kb encompassing the entire DPY19L2 locus was d ...
... identify mutations in two genes, SPATA16 and DPY19L2 (11,12). The deletion of exon 4 in SPATA16 was found in an Ashkenazi Jewish family with three affected brothers. No other mutations were identified in a screen of 21 patients. A large deletion of 200 kb encompassing the entire DPY19L2 locus was d ...
Genetic of Non-syndromic Cleft Lip and Palate
... developmental events, or environmental influences in utero. However, the highly increased monozygotic twin concordance does strongly support a major genetic component to orofacial clefting [1,3]. The advent of gene targeting technology and basic conventional techniques using animal models has led to ...
... developmental events, or environmental influences in utero. However, the highly increased monozygotic twin concordance does strongly support a major genetic component to orofacial clefting [1,3]. The advent of gene targeting technology and basic conventional techniques using animal models has led to ...
Simulating evolution by gene duplication of protein features that
... a gene to mutate and explore genetic space while the other copy continues to fulfill the original function. Models of the process often implicitly assume that a single mutation to the duplicated gene can confer a new selectable property. Yet some protein features, such as disulfide bonds or ligand b ...
... a gene to mutate and explore genetic space while the other copy continues to fulfill the original function. Models of the process often implicitly assume that a single mutation to the duplicated gene can confer a new selectable property. Yet some protein features, such as disulfide bonds or ligand b ...
Transmission & maternal effects
... Seen in a wide array of taxa including plants, insects and mammals ...
... Seen in a wide array of taxa including plants, insects and mammals ...
Gabriele Marras
... genome or genes. Additionally, standard GWAS is prone to return a certain proportion of spurious associations. We propose alternative and complementary approaches to association studies, that can make the detection of signals of association more robust: one is based on the p ...
... genome or genes. Additionally, standard GWAS is prone to return a certain proportion of spurious associations. We propose alternative and complementary approaches to association studies, that can make the detection of signals of association more robust: one is based on the p ...
Allele replacement: an application that permits rapid manipulation of
... LB plates containing 5% sucrose at the permissive temperature (Figure 3). At the permissive temperature, the plasmid origin is unstable in the BAC, and the plasmid is excised by homologous recombination at either crossover point 1 or 2 (Figure 3). This can result in exchange of the target allele wit ...
... LB plates containing 5% sucrose at the permissive temperature (Figure 3). At the permissive temperature, the plasmid origin is unstable in the BAC, and the plasmid is excised by homologous recombination at either crossover point 1 or 2 (Figure 3). This can result in exchange of the target allele wit ...
Identification of the 5T‐12TG allele of the cystic fibrosis
... into account. On the other hand, only further clinical follow-up of these subjects will be able to define how many of them will go on to develop a CF phenotype. In conclusion, we identified a further phenotype caused by the 5T-12TG allele when in trans with a CFTR mutation: neonatal persistent hyper ...
... into account. On the other hand, only further clinical follow-up of these subjects will be able to define how many of them will go on to develop a CF phenotype. In conclusion, we identified a further phenotype caused by the 5T-12TG allele when in trans with a CFTR mutation: neonatal persistent hyper ...
Genetic Testing in Male Infertility
... infertility and idiopathic RSA as DNA damage in the sperm can be transmitted to the offspring and may potentially increase the risk for transgenerational infertility or other serious health problems such as congenital malformations and childhood cancer [4]. Genetic screening includes cytogenetic ana ...
... infertility and idiopathic RSA as DNA damage in the sperm can be transmitted to the offspring and may potentially increase the risk for transgenerational infertility or other serious health problems such as congenital malformations and childhood cancer [4]. Genetic screening includes cytogenetic ana ...
Mendel`s Accountant: A New Population Genetics Simulation Tool
... an integer from which the mutation’s fitness effect can readily be computed, while a single multiplication yields the mutation’s location in the genome in terms of the linkage subunit on which the mutation resides. The mutations carried by each individual occur within its two versions of the haploid ...
... an integer from which the mutation’s fitness effect can readily be computed, while a single multiplication yields the mutation’s location in the genome in terms of the linkage subunit on which the mutation resides. The mutations carried by each individual occur within its two versions of the haploid ...
Document
... Figure 1 The CRISPR/Cas9 system.1 Clustered regularly interspaced palindromic repeats (CRISPR) refers to sequences in the bacterial genome. They afford protection against invading viruses, when combined with a series of CRISPR-associated (Cas) proteins. Cas9, one of the associated proteins, is an en ...
... Figure 1 The CRISPR/Cas9 system.1 Clustered regularly interspaced palindromic repeats (CRISPR) refers to sequences in the bacterial genome. They afford protection against invading viruses, when combined with a series of CRISPR-associated (Cas) proteins. Cas9, one of the associated proteins, is an en ...
Speciation
... • Even when they are created from a totally different source • Which implies that there is a real underlying relationship © Colin Frayn, 2008-2011 www.frayn.net ...
... • Even when they are created from a totally different source • Which implies that there is a real underlying relationship © Colin Frayn, 2008-2011 www.frayn.net ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.