Basic Bioinformatics - NIU Department of Biological Sciences
... – E-values for good hits are usually written something like: 3e-42, which is the same as 3 x 10-42 , a very small number – Bad hits are very common, and they have e-values in a more familiar form: for example, 0.004 or 1.2 – A really good e-values is less than 1e-180, which underflows the computer’s ...
... – E-values for good hits are usually written something like: 3e-42, which is the same as 3 x 10-42 , a very small number – Bad hits are very common, and they have e-values in a more familiar form: for example, 0.004 or 1.2 – A really good e-values is less than 1e-180, which underflows the computer’s ...
Basic Bioinformatics
... – E-values for good hits are usually written something like: 3e-42, which is the same as 3 x 10-42 , a very small number – Bad hits are very common, and they have e-values in a more familiar form: for example, 0.004 or 1.2 – A really good e-values is less than 1e-180, which underflows the computer’s ...
... – E-values for good hits are usually written something like: 3e-42, which is the same as 3 x 10-42 , a very small number – Bad hits are very common, and they have e-values in a more familiar form: for example, 0.004 or 1.2 – A really good e-values is less than 1e-180, which underflows the computer’s ...
simultaneous detection of colorectal cancer mutations in stool
... it is non-invasive, requires no unpleasant cathartic preparation and allows for off-site collection of samples (6). The most common pathway of CRC development is the chromosomal instability (CIN) pathway, which includes point mutations that occur within Kras/BRAF, APC and TP53 genes (4, 7). The CIN ...
... it is non-invasive, requires no unpleasant cathartic preparation and allows for off-site collection of samples (6). The most common pathway of CRC development is the chromosomal instability (CIN) pathway, which includes point mutations that occur within Kras/BRAF, APC and TP53 genes (4, 7). The CIN ...
Creating mutant flies
... Small pieces of DNA that can move from one site in the genome to another - ALL organisms have them (about 45% of our genome: transposon remnants!) - Jumping genes, Selfish DNA - Mechanism for evolutionary change ...
... Small pieces of DNA that can move from one site in the genome to another - ALL organisms have them (about 45% of our genome: transposon remnants!) - Jumping genes, Selfish DNA - Mechanism for evolutionary change ...
From DNA to Proteins
... The double helix shape of DNA, together with Chargaff’s rules, led to a better understanding of DNA. DNA, as a nucleic acid, is made from nucleotide monomers, and the DNA double helix consists of two polynucleotide chains. Each nucleotide consists of a sugar (deoxyribose), a phosphate group, and a n ...
... The double helix shape of DNA, together with Chargaff’s rules, led to a better understanding of DNA. DNA, as a nucleic acid, is made from nucleotide monomers, and the DNA double helix consists of two polynucleotide chains. Each nucleotide consists of a sugar (deoxyribose), a phosphate group, and a n ...
Microbial Genetics - Austin Community College
... in the chromosome called the origin of replication. • Because prokaryotes have a circular chromosome replication can proceed bi-directionally or rolling circle. – Bi-directional means that replication starts at the origin of replication and proceeds right and left on both ...
... in the chromosome called the origin of replication. • Because prokaryotes have a circular chromosome replication can proceed bi-directionally or rolling circle. – Bi-directional means that replication starts at the origin of replication and proceeds right and left on both ...
DNA / RNA / PROTEIN SYNTHESIS / AP Biology
... mRNA Strand (from above) a. b. c. DNA Strand (from above) a. b. c. 6) Using your Amino Acids, mRNA from #5 above: a. What change (Amino Acids produced) would take place if an “A” was inserted before the first codon on “a” ? Write down the new Amino Acids from this mutation in the table below. What t ...
... mRNA Strand (from above) a. b. c. DNA Strand (from above) a. b. c. 6) Using your Amino Acids, mRNA from #5 above: a. What change (Amino Acids produced) would take place if an “A” was inserted before the first codon on “a” ? Write down the new Amino Acids from this mutation in the table below. What t ...
Genes and Proteins
... DNA, Genes & Proteins The relationship of Chromosomes, Genes, DNA & Proteins ...
... DNA, Genes & Proteins The relationship of Chromosomes, Genes, DNA & Proteins ...
The I148T CFTR allele occurs on multiple haplotypes: A
... in CF patients.25 In the ethnically diverse US population reported here, the I148T allele is 100-fold more frequent in carriers than in CF patients. Additional evidence for the variable phenotypic effect of a mutation is the occurrence of the same putative genotype in healthy individuals and CF pati ...
... in CF patients.25 In the ethnically diverse US population reported here, the I148T allele is 100-fold more frequent in carriers than in CF patients. Additional evidence for the variable phenotypic effect of a mutation is the occurrence of the same putative genotype in healthy individuals and CF pati ...
Development of a New Method to Prioritise Gene Analysis in
... • More genes tend to be excluded when more distantly related individuals such as first cousins or aunt/niece, nephew pairs are considered, rather than more closely related sibs • GLEAM can be used to determine the order in which genes are sequenced in heterogeneous disorders ...
... • More genes tend to be excluded when more distantly related individuals such as first cousins or aunt/niece, nephew pairs are considered, rather than more closely related sibs • GLEAM can be used to determine the order in which genes are sequenced in heterogeneous disorders ...
Mutation Rates
... In the real case, we cannot count the number of independent mutation events the occurred in each culture; we can only distinguish among the cultures in which no mutation had occurred (zero mutants) from all the others. Thus, the 20 cultures that were tested for phage T1 resistance can be divided amo ...
... In the real case, we cannot count the number of independent mutation events the occurred in each culture; we can only distinguish among the cultures in which no mutation had occurred (zero mutants) from all the others. Thus, the 20 cultures that were tested for phage T1 resistance can be divided amo ...
DNA.Protein.Synthesis Notes
... Elongation adds amino acids to the polypeptide chain until a stop codon terminates translation – Once initiation is complete amino acids are added one by one to the first amino acid – The mRNA moves a codon at a time • A tRNA with a complementary anticodon pairs with each codon, adding its amino ac ...
... Elongation adds amino acids to the polypeptide chain until a stop codon terminates translation – Once initiation is complete amino acids are added one by one to the first amino acid – The mRNA moves a codon at a time • A tRNA with a complementary anticodon pairs with each codon, adding its amino ac ...
Chapter 6
... protein (with its twenty-letter alphabet of amino acids). Each amino acid has a central carbon atom (Figure 6.10) flanked by an amino group (NH2) and a carboxyl group (COOH); one of twenty possible side chains is also attached to the central carbon. Ribosomes, with tRNA (Figure 6.9), decode the mess ...
... protein (with its twenty-letter alphabet of amino acids). Each amino acid has a central carbon atom (Figure 6.10) flanked by an amino group (NH2) and a carboxyl group (COOH); one of twenty possible side chains is also attached to the central carbon. Ribosomes, with tRNA (Figure 6.9), decode the mess ...
DNA WebQuest
... Carefully view and read each part of this animation. Complete the statements and questions below: 1. Protein Synthesis is the making of __________________ from instructions coded for in the DNA. 2. There are many types of proteins and a variety of functions which include: hormones (send signals), tr ...
... Carefully view and read each part of this animation. Complete the statements and questions below: 1. Protein Synthesis is the making of __________________ from instructions coded for in the DNA. 2. There are many types of proteins and a variety of functions which include: hormones (send signals), tr ...
Biotechnology PPT
... Lab AP Lab 6 #88 V 8231 Any transformation will work. Connie Wood (East Meck) suggests using Carolina Biological’s “Outbreak” activity. She gets free DNA for this. ...
... Lab AP Lab 6 #88 V 8231 Any transformation will work. Connie Wood (East Meck) suggests using Carolina Biological’s “Outbreak” activity. She gets free DNA for this. ...
Biology 30 - Patricia Schwandt Courses
... DNA has only four kinds of nucleotides, but must code for 20 different amino acids used to build polypeptides. Just as a specific series of dots and dashes is used to represent one letter in Morse code, a specific series of nucleotides is used as the code for each amino acid. This series of nucleoti ...
... DNA has only four kinds of nucleotides, but must code for 20 different amino acids used to build polypeptides. Just as a specific series of dots and dashes is used to represent one letter in Morse code, a specific series of nucleotides is used as the code for each amino acid. This series of nucleoti ...
Io mo0 - Journal of Medical Genetics
... predicted CFTR polypeptide. This is homologous to a putative cystic fibrosis causing mutation (R297Q) reported in a Northern Ireland family.9 Interestingly, the arginine (R297) residue lies in the first membrane spanning domain of the predicted CFTR protein, specifically part of the cytoplasmic loop ...
... predicted CFTR polypeptide. This is homologous to a putative cystic fibrosis causing mutation (R297Q) reported in a Northern Ireland family.9 Interestingly, the arginine (R297) residue lies in the first membrane spanning domain of the predicted CFTR protein, specifically part of the cytoplasmic loop ...
Shprintzen-Goldberg Craniosynostosis Syndrome
... Involuntary movements of the head started from three months of age. When she was nine months, a brain MRI scan showed slight general brain atrophy with delayed myelinization. At two years, she displayed the SGS dysmorphism, progressive microcephaly, palpebral fissures, a flat occiput, short philtrum ...
... Involuntary movements of the head started from three months of age. When she was nine months, a brain MRI scan showed slight general brain atrophy with delayed myelinization. At two years, she displayed the SGS dysmorphism, progressive microcephaly, palpebral fissures, a flat occiput, short philtrum ...
Understanding Genetic Cancer Risk: BRCA1 and 2
... bodies: one from our mother and one from our father. Each gene has a specific job to do. When a gene has a mistake or “mutation,” it does not work like it should. Everyone has two copies of BRCA1 and two copies of BRCA2. A single mistake in one of the copies increases the risk for cancer of the brea ...
... bodies: one from our mother and one from our father. Each gene has a specific job to do. When a gene has a mistake or “mutation,” it does not work like it should. Everyone has two copies of BRCA1 and two copies of BRCA2. A single mistake in one of the copies increases the risk for cancer of the brea ...
Here
... and father who do have this green gene. This is an ancient method of creating new plants (and animals), but today we are doing this in very scientific manner. We first identify the gene that bestows a plant with drought tolerance, then we sequence the DNA of various plants to determine which one of ...
... and father who do have this green gene. This is an ancient method of creating new plants (and animals), but today we are doing this in very scientific manner. We first identify the gene that bestows a plant with drought tolerance, then we sequence the DNA of various plants to determine which one of ...
Genome Research - University of Oxford
... assumed in phylogenetic and phylogeographic analyses can be explicitly assumed in a coalescent framework, alternative demographies may be assumed, or may be ...
... assumed in phylogenetic and phylogeographic analyses can be explicitly assumed in a coalescent framework, alternative demographies may be assumed, or may be ...
Transcription and Translation Review Lesson Plan
... Explain how messenger RNA, ribosomal RNA, and transfer RNA are involved in the transcription and translation of genes. Describe how the code of DNA is translated into messenger RNA and is utilized to synthesize a particular protein. Content Standards: Illinois State Science Standard 12.A.4a Ex ...
... Explain how messenger RNA, ribosomal RNA, and transfer RNA are involved in the transcription and translation of genes. Describe how the code of DNA is translated into messenger RNA and is utilized to synthesize a particular protein. Content Standards: Illinois State Science Standard 12.A.4a Ex ...
Genetics Wow!
... •Good communication skills such as listening, empathy and attending to the patient’s agenda will maximise the interaction •Giving a diagnosis of a genetic susceptibility or condition can have the same impact as giving any other ‘bad news’ to an individual •It is important to understand issues of con ...
... •Good communication skills such as listening, empathy and attending to the patient’s agenda will maximise the interaction •Giving a diagnosis of a genetic susceptibility or condition can have the same impact as giving any other ‘bad news’ to an individual •It is important to understand issues of con ...
Test # 1. Which of the following is not an electron acceptor or carrier?
... Which RNA has an “anticodon,” that is complementary to a specific codon, is attached to a specific amino acid in a process called “charging,” and works with other RNA’s to position amino acids for chemical bonding to one another? a) m-RNA. b) t-RNA. c) r-RNA. ...
... Which RNA has an “anticodon,” that is complementary to a specific codon, is attached to a specific amino acid in a process called “charging,” and works with other RNA’s to position amino acids for chemical bonding to one another? a) m-RNA. b) t-RNA. c) r-RNA. ...
Frameshift mutation
A frameshift mutation (also called a framing error or a reading frame shift) is a genetic mutation caused by indels (insertions or deletions) of a number of nucleotides in a DNA sequence that is not divisible by three. Due to the triplet nature of gene expression by codons, the insertion or deletion can change the reading frame (the grouping of the codons), resulting in a completely different translation from the original. The earlier in the sequence the deletion or insertion occurs, the more altered the protein. A frameshift mutation is not the same as a single-nucleotide polymorphism in which a nucleotide is replaced, rather than inserted or deleted. A frameshift mutation will in general cause the reading of the codons after the mutation to code for different amino acids. The frameshift mutation will also alter the first stop codon (""UAA"", ""UGA"" or ""UAG"") encountered in the sequence. The polypeptide being created could be abnormally short or abnormally long, and will most likely not be functional.Frameshift mutations are apparent in severe genetic diseases such as Tay-Sachs disease and Cystic Fibrosis; they increase susceptibility to certain cancers and classes of familial hypercholesterolaemia; in 1997, a frameshift mutation was linked to resistance to infection by the HIV retrovirus. Frameshift mutations have been proposed as a source of biological novelty, as with the alleged creation of nylonase, however, this interpretation is controversial. A study by Negoro et al (2006) found that a frameshift mutation was unlikely to have been the cause and that rather a two amino acid substitution in the catalytic cleft of an ancestral esterase amplified Ald-hydrolytic activity.