Unit 8 Molecular Genetics: Chp 12 Mutations Notes PPT
... • Recall what happens when a strand of mRNA is transcribed from DNA. • What might happen if one base is deleted from the DNA? • The transcribed mRNA would also be affected. ...
... • Recall what happens when a strand of mRNA is transcribed from DNA. • What might happen if one base is deleted from the DNA? • The transcribed mRNA would also be affected. ...
Mutations - Lakeland Regional High School / Overview
... • Part of a chromosome becomes oriented in reverse of its usual direction • Ex. TAGTAGTAG-•TAGTAGGAT ...
... • Part of a chromosome becomes oriented in reverse of its usual direction • Ex. TAGTAGTAG-•TAGTAGGAT ...
Genetic changes - Southington Public Schools
... Mutations in gametes will be passed to the offspring. Types of mutations 1. Point mutations—a change in a single base of a DNA chain. This results in a different “message.” Example: normal sequence THE DOG BIT THE CAT mutation THE DOG BIT THE CAR Sense mutation: the changed codon makes a differe ...
... Mutations in gametes will be passed to the offspring. Types of mutations 1. Point mutations—a change in a single base of a DNA chain. This results in a different “message.” Example: normal sequence THE DOG BIT THE CAT mutation THE DOG BIT THE CAR Sense mutation: the changed codon makes a differe ...
Mutations - The Super Heroes of Biology
... • One nucleotide is replaced by another but it still codes for the same amino acid ...
... • One nucleotide is replaced by another but it still codes for the same amino acid ...
Smurfs, Trolls & Elves
... • As railroads and development swept through, the blue Fugates started moving out of Troublesome Creek and marrying other people • The inherited blue began to disappear as the recessive gene spread to families where it is unlikely to be paired to a similar gene ...
... • As railroads and development swept through, the blue Fugates started moving out of Troublesome Creek and marrying other people • The inherited blue began to disappear as the recessive gene spread to families where it is unlikely to be paired to a similar gene ...
MUTATIONS • Mutations are errors made in the DNA sequence that
... nonsense mutation involves a change in the DNA sequence that causes a stop codon to replace a codon for an aa; only the part of the protein prior to the stop codon will be produced. they are often lethal to the cell. ...
... nonsense mutation involves a change in the DNA sequence that causes a stop codon to replace a codon for an aa; only the part of the protein prior to the stop codon will be produced. they are often lethal to the cell. ...
Frameshift mutation
A frameshift mutation (also called a framing error or a reading frame shift) is a genetic mutation caused by indels (insertions or deletions) of a number of nucleotides in a DNA sequence that is not divisible by three. Due to the triplet nature of gene expression by codons, the insertion or deletion can change the reading frame (the grouping of the codons), resulting in a completely different translation from the original. The earlier in the sequence the deletion or insertion occurs, the more altered the protein. A frameshift mutation is not the same as a single-nucleotide polymorphism in which a nucleotide is replaced, rather than inserted or deleted. A frameshift mutation will in general cause the reading of the codons after the mutation to code for different amino acids. The frameshift mutation will also alter the first stop codon (""UAA"", ""UGA"" or ""UAG"") encountered in the sequence. The polypeptide being created could be abnormally short or abnormally long, and will most likely not be functional.Frameshift mutations are apparent in severe genetic diseases such as Tay-Sachs disease and Cystic Fibrosis; they increase susceptibility to certain cancers and classes of familial hypercholesterolaemia; in 1997, a frameshift mutation was linked to resistance to infection by the HIV retrovirus. Frameshift mutations have been proposed as a source of biological novelty, as with the alleged creation of nylonase, however, this interpretation is controversial. A study by Negoro et al (2006) found that a frameshift mutation was unlikely to have been the cause and that rather a two amino acid substitution in the catalytic cleft of an ancestral esterase amplified Ald-hydrolytic activity.