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Final - lgh
Final - lgh

... acetylcholinesterases so their concentration in the synaptic cleft does not fall rapidly  Continuous end plate potential depolarization will leads to muscle relaxation  End plate cannot repolarized as long as depolarizing agent binds to Ach receptors  Recovery only occur when drug diffuses away f ...
-click here for handouts (full page)
-click here for handouts (full page)

... interaction between drugs and brain receptors.  Worked on ligands for the cannabinoid receptors.  The chemical compounds Huffman developed have been made into synthetic marijuana that is marketed as "Spice," "K-2," "Skunk" and similar products. ...
Choose the correct answer for questions (1-90: Question 1
Choose the correct answer for questions (1-90: Question 1

... e. Preanesthetic medications 32. Which of the following choices would be most appropriate in treating nausea and vomiting associated with motion sickness? a. Diphenhydramine b. Brompheniramine c. Ondansetron d. Omeprazole e. Ranitidine 33. Which of the following antiulcer medications is most likely ...
No Slide Title
No Slide Title

... Edwards et al. Parkinson’s disease and other movement disorders. Oxford University Press. 2008. pg 45-55 Parkinson’s Disease Society. The Professional’s Guide to Parkinson’s Disease; ...
An Introduction to Pharmacogenomics
An Introduction to Pharmacogenomics

... – What are the response rates for different classes of drugs? – How are doses determined? – Why does drug response vary? – Genetic variation • What is it? • How do you measure it? • How extensive is it? • Pharmacogenomics: genetic variation and drug response – Examples • Gefitinib • Warfarin – Pharm ...
Ocular_Pharmacology_&_Toxicology_Dr._Kharashi
Ocular_Pharmacology_&_Toxicology_Dr._Kharashi

... General Pharmacological Principles ...
Antibiotic
Antibiotic

...  Used in areas of the body that can flush away wastes of infection - kidneys  Long term use has resulted in resistance  Used in combination to increase action ...
Clinical Trials and Scientific Methods Chapter 0 Enrichment
Clinical Trials and Scientific Methods Chapter 0 Enrichment

... People in a clinical trial are given an experimental drug or another substance that is inactive and has no treatment value. The inactive substance is called a placebo. This is done as a way to assess a drug’s effectiveness. If an expected result occurs as often in the group receiving a placebo as it ...
Consciousness Day 2
Consciousness Day 2

... the culture you are in.  Often people act how they think they should act when on a certain drug.  Ex: Alcohol belief studies. ...
Deprenyl in Parkinson`s Disease: Mechanisms, Neuroprotective
Deprenyl in Parkinson`s Disease: Mechanisms, Neuroprotective

Chapter08
Chapter08

... entered the body, it is absorbed into the bloodstream and circulated throughout the body. Some drugs tend to concentrate in certain areas:  Pesticides in fatty tissue  Heavy metals: teeth, gums, hair  LSD and marijuana: brain Chapter 8 ...
Dr.A.K.AL-Yassari 2016-2017 Microbiology Year:third Antibiotics
Dr.A.K.AL-Yassari 2016-2017 Microbiology Year:third Antibiotics

... Antibiotics and Chemotherapeutic agents  Definitions  Antibiotic: antimicrobials of microbial origin, most of which are produced by fungi or by bacteria of the genus Streptomyces.  Antimicrobial: any substance with sufficient antimicrobial activity that it can be used in the treatment of infectio ...
Teacher notes and student sheets
Teacher notes and student sheets

... 2 Isolation of the chemical being tested is important so that it is clear which chemical is the ‘active ingredient’ of a drug. Sometimes new drugs are synthesised starting with the structure of an existing drug. ...
Special considerations for age groups
Special considerations for age groups

... Preparation and administration of medications to children • Calculated amt to be given in 24 hrs then divide by equal number of doses • Number of doses determined by recommended frequency of ...
Healthy volunteer studies for oncology drug development
Healthy volunteer studies for oncology drug development

... and commercialization rights to rociletinib, one of three product candidates in clinical development, which is currently in Phase II development for the treatment of non-small cell lung cancer. At ...
click here for presentation
click here for presentation

... their impact on treatment plans • Discuss new medications and their impact on  the elderly • Discuss new medications, adverse effects, or  restrictions for the general population ...
The impact of pharmacogenetics on the development and use of
The impact of pharmacogenetics on the development and use of

... The candidate genes The pharmacogenetics of antipsychotic drug action has concentrated primarily on investigation of common variations in the DNA sequence (polymorphisms) in genes that have been implicated by the known pharmacology and neurochemical mechanisms of these drugs (reviewed in [4]). The t ...
cyclobenzaprine (sye-kloe-ben-za-preen) - DavisPlus
cyclobenzaprine (sye-kloe-ben-za-preen) - DavisPlus

... anticholinergic effects with drugs possessing anticholinergic properties, including antihistamines, antidepressants, atropine, disopyramide, haloperidol, and phenothiazines. Avoid use within 14 days of MAO inhibitors (hyperpyretic crisis, seizures, and death may occur). Drugs that affect serotonergi ...
Example for Peginterferon alfa-2a
Example for Peginterferon alfa-2a

... bind to specific receptors on the cell surface, initiating intracellular signaling via a complex cascade of protein-protein interactions leading to rapid activation of gene transcription. Interferon inhibits viral entry into cells and inhibits viral replication, followed by activating natural killer ...
Anticonvulsive Effects of Sodium Phenobarbital Experimental purpose
Anticonvulsive Effects of Sodium Phenobarbital Experimental purpose

... the most widely prescribed drugs worldwide.  Major therapeutic use is to cause sedation or encourage sleep. Anxiety states and sleep disorder are common. ...
Heart Failure
Heart Failure

... •Vasoconstriction by (-) enantiomer is countered by (+) enatiomer and 2 agonist activity- ultimate result is a decrease in PVR and mild decrease in systemic blood pressure ...
NanoCarrier to Present at the American Association for Cancer
NanoCarrier to Present at the American Association for Cancer

... NanoCarrier to Present at the American Association for Cancer Research (AACR) Annual Meeting On April 22, 2015, NanoCarrier will present the results of the research on its next-generation technology named Antibody/Drug Conjugated Micelle (ADCM) at the American Association for Cancer Research (AACR) ...
Ocular Pharmacology
Ocular Pharmacology

... the penetration. e.g pilocarpine 1‐4% but limited by reflex tearing ...
Lectures 8 and 9
Lectures 8 and 9

...  Side effects caused when patient has eaten food which contains high levels of tyramine, e.g. cheese, wine, beer.  Ingested tyramine causes the release of noradrenaline (NA), which would normally be metabolised by MAOs.  But because these enzymes have been inhibited, the NA levels rise. As NA is ...
File - Wk 1-2
File - Wk 1-2

... Sorry… may have gone a little OTT with this one. Phase 1 reactions often introduce a reactive group, such as a hydroxyl into the molecule (termed ‘functionalisation’). This point later serves as the ‘point of attack’ to which the conjugating system in phase 2 can attach the glucuronide The P450 Mono ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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