name of the candidate and address
... increase in body temperature at rest was due to an increase in heat production during the first day of wakefulness followed by a lower evaporative heat loss during the second day [3, 4] in non-heat acclimatised males. The inhibition of GABA release following Modafinil ingestion increased sympathetic ...
... increase in body temperature at rest was due to an increase in heat production during the first day of wakefulness followed by a lower evaporative heat loss during the second day [3, 4] in non-heat acclimatised males. The inhibition of GABA release following Modafinil ingestion increased sympathetic ...
Study protocol
... in patients with essential hypertension Ilkka Tikkanen, Per Omvik* and Henrik Æ. Jensen† for the Scandinavian Study Group‡ Objective: To evaluate the blood pressure lowering efficacy as well as tolerability and safety of the angiotensin II antagonist losartan compared with that of the angiotensin co ...
... in patients with essential hypertension Ilkka Tikkanen, Per Omvik* and Henrik Æ. Jensen† for the Scandinavian Study Group‡ Objective: To evaluate the blood pressure lowering efficacy as well as tolerability and safety of the angiotensin II antagonist losartan compared with that of the angiotensin co ...
Cocaine and Alcohol Interactions in Humans
... Recoveries (mean 6 S.D.) were 98.0 6 2.0% for cocaine, 80.1 6 2.4% for benzoylecgonine, 81.7 6 5.0% for ecgoninemethylester, 78.8 6 9.6% for norcocaine, 97.1 6 1.7% for cocaethylene and 71.8 6 18.8% for norcocaethylene. Intra-assay coefficients of variation (50 ng/ml for cocaine and benzoylecgonine; ...
... Recoveries (mean 6 S.D.) were 98.0 6 2.0% for cocaine, 80.1 6 2.4% for benzoylecgonine, 81.7 6 5.0% for ecgoninemethylester, 78.8 6 9.6% for norcocaine, 97.1 6 1.7% for cocaethylene and 71.8 6 18.8% for norcocaethylene. Intra-assay coefficients of variation (50 ng/ml for cocaine and benzoylecgonine; ...
Guidelines for the Biological Treatment of Substance Use and
... Objectives. To develop evidence-based practice guidelines for the pharmacological treatment of opioid abuse and dependence. Methods. An international task force of the World Federation of Societies of Biological Psychiatry (WFSBP) developed these practice guidelines after a systematic review of the ...
... Objectives. To develop evidence-based practice guidelines for the pharmacological treatment of opioid abuse and dependence. Methods. An international task force of the World Federation of Societies of Biological Psychiatry (WFSBP) developed these practice guidelines after a systematic review of the ...
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington
... Copyright © 2014 by Mosby, an imprint of Elsevier Inc. ...
... Copyright © 2014 by Mosby, an imprint of Elsevier Inc. ...
A Critical Review of ADHD Neuroimaging Research
... “The effect of methylphenidate on D 2 receptor levels in patients with ADHD is similar to that observed in healthy adults: a downregulation phenomenon within 0 to 30%” (p. 755). The stimulant-specific findings briefly reviewed above illustrate the general point that, when striving to establish wheth ...
... “The effect of methylphenidate on D 2 receptor levels in patients with ADHD is similar to that observed in healthy adults: a downregulation phenomenon within 0 to 30%” (p. 755). The stimulant-specific findings briefly reviewed above illustrate the general point that, when striving to establish wheth ...
PRODUCT MONOGRAPH PrLUVOX
... Epidemiological studies show an increased risk of bone fractures following exposure to some antidepressants, including SSRIs and serotonin / norepinephrine reuptake inhibitors (SNRIs). The risks appear to be greater at the initial stages of treatment, but significant increased risks were also observ ...
... Epidemiological studies show an increased risk of bone fractures following exposure to some antidepressants, including SSRIs and serotonin / norepinephrine reuptake inhibitors (SNRIs). The risks appear to be greater at the initial stages of treatment, but significant increased risks were also observ ...
Resistance to First-Line Anti-TB Drugs is Associated with Reduced Nitric Oxide
... a C strain cluster defined by IS6110-based strain-typing [20], and the genotypes G1, G2, S2, U [24]). Since the acid has a bactericidal effect in itself and actually potentiates the effect of NO [38], it has been acknowledged that the new generation NO donors (DETA/NO) can better mimic a prolonged r ...
... a C strain cluster defined by IS6110-based strain-typing [20], and the genotypes G1, G2, S2, U [24]). Since the acid has a bactericidal effect in itself and actually potentiates the effect of NO [38], it has been acknowledged that the new generation NO donors (DETA/NO) can better mimic a prolonged r ...
Answer key 2012
... a) They have an affinity for the agonist binding site on receptor b) They have no intrinsic activity c) They cause parallels rightward shift of the control dose response curve d) Maximum response of agonist cannot be achieved in their presence by increasing the concentration of the agonist Q.17 Atyp ...
... a) They have an affinity for the agonist binding site on receptor b) They have no intrinsic activity c) They cause parallels rightward shift of the control dose response curve d) Maximum response of agonist cannot be achieved in their presence by increasing the concentration of the agonist Q.17 Atyp ...
Pregnancy and Cardiovascular Disease
... focuses on RECOGNITION of condition and, ultimately, DELIVERY OF THE PLACENTA, which is curative. As proteinuria may be a late sign of preeclampsia, it should be suspected when de novo HPN is accompanied by symptoms (HA, visual disturbances, abdominal pain, or abnormal laboratory tests - low platele ...
... focuses on RECOGNITION of condition and, ultimately, DELIVERY OF THE PLACENTA, which is curative. As proteinuria may be a late sign of preeclampsia, it should be suspected when de novo HPN is accompanied by symptoms (HA, visual disturbances, abdominal pain, or abnormal laboratory tests - low platele ...
Dynacin Prescribing Information
... All tetracyclines form a stable calcium complex in any bone-forming tissue. A decrease in fibula growth rate has been observed in premature human infants given oral tetracycline in doses of 25 mg/kg every six hours. This reaction was shown to be reversible when the drug was discontinued. Results of ...
... All tetracyclines form a stable calcium complex in any bone-forming tissue. A decrease in fibula growth rate has been observed in premature human infants given oral tetracycline in doses of 25 mg/kg every six hours. This reaction was shown to be reversible when the drug was discontinued. Results of ...
Functional Activation of Cerebral Blood Flow Abolished by
... The rCBF response to vibrotactile stimulation that was abolished by systemic administration of scopolamine was recovered by administration of cholinesterase inhibitors (physostigmine, E2020 and tacrine) in the somatosensory cortex of unanesthetized monkeys. It is of interest that, when evaluated wit ...
... The rCBF response to vibrotactile stimulation that was abolished by systemic administration of scopolamine was recovered by administration of cholinesterase inhibitors (physostigmine, E2020 and tacrine) in the somatosensory cortex of unanesthetized monkeys. It is of interest that, when evaluated wit ...
Local Anaesthetic Agents In Clinical Use
... Rebound vasodilation occurs with both 1:50,000 and 1:100,000 epinephrine concentrations as the tissue concentration of epinephrine decreases. Minimum volumes of solution should be administered to provide excellent haemostasis. Signs and symptoms of lidocaine toxicity (overdose) may be the same (cent ...
... Rebound vasodilation occurs with both 1:50,000 and 1:100,000 epinephrine concentrations as the tissue concentration of epinephrine decreases. Minimum volumes of solution should be administered to provide excellent haemostasis. Signs and symptoms of lidocaine toxicity (overdose) may be the same (cent ...
Identification of the date-rape drug GHB and its precursor GBL by
... Figure 4 shows the Raman spectra of GHB in water at a range of the concentrations recorded on the Delta Nu Inspector Raman instrument. The spectra of GHB in water shows two bands, one at 946 cm−1 assigned to C-C stretching and the other at 1423 cm−1 assigned to C-O-C asymmetric stretch. As mentioned ...
... Figure 4 shows the Raman spectra of GHB in water at a range of the concentrations recorded on the Delta Nu Inspector Raman instrument. The spectra of GHB in water shows two bands, one at 946 cm−1 assigned to C-C stretching and the other at 1423 cm−1 assigned to C-O-C asymmetric stretch. As mentioned ...
Antiarrhythmic effect of the Ca(2+)
... blocker; however, new data indicate that it also increases the late sodium current [39]. IKr is conducted through hERG1 channels, which are expressed in both atria and ventricle [15, 27]. Unlike other antiarrhythmic agents, dofetilide does not increase mortality in patients with recent myocardial in ...
... blocker; however, new data indicate that it also increases the late sodium current [39]. IKr is conducted through hERG1 channels, which are expressed in both atria and ventricle [15, 27]. Unlike other antiarrhythmic agents, dofetilide does not increase mortality in patients with recent myocardial in ...
PDF - Innovare Academic Sciences
... Microemulsions have been widely studied to enhance the bioavailability of the poorly soluble drugs. These systems are known to enhance drug solubility, increase the stability, and modify drug release [3,4]. Microemulsion allows the incorporation of hydrophilic as well as lipophilic compound dependin ...
... Microemulsions have been widely studied to enhance the bioavailability of the poorly soluble drugs. These systems are known to enhance drug solubility, increase the stability, and modify drug release [3,4]. Microemulsion allows the incorporation of hydrophilic as well as lipophilic compound dependin ...
Potential Drug Interactions with Grapefruit Evidence and Advice You Can Trust... CHART: CHART
... Grapefruit juice does not normally inhibit the pharmacokinetics of medications administered intravenously. At usual doses it only affects enzymes in the gut wall. However, high consumption could inhibit liver CYP3A4 and prolong drug half-life.48 In addition to grapefruit juice, many researchers are ...
... Grapefruit juice does not normally inhibit the pharmacokinetics of medications administered intravenously. At usual doses it only affects enzymes in the gut wall. However, high consumption could inhibit liver CYP3A4 and prolong drug half-life.48 In addition to grapefruit juice, many researchers are ...
AusPAR: Perampanel (as hemisesquihydrate)
... neuronal firing usually accompanied by a reduction in awareness or by focal neurological symptoms. Seizures are usually classified into focal (‘partial’) seizures, which begin in one part of the brain, or primary generalised seizures, which involve the whole brain network from the onset of the seizu ...
... neuronal firing usually accompanied by a reduction in awareness or by focal neurological symptoms. Seizures are usually classified into focal (‘partial’) seizures, which begin in one part of the brain, or primary generalised seizures, which involve the whole brain network from the onset of the seizu ...
Drug-Induced Lupus Erythematosus
... The generation of autoantibodies and autoimmune diseases such as systemic lupus erythematosus has been associated with the use of certain drugs in humans. Early reports suggested that procainamide and hydralazine were associated with the highest risk of developing lupus, quinidine with a moderate ri ...
... The generation of autoantibodies and autoimmune diseases such as systemic lupus erythematosus has been associated with the use of certain drugs in humans. Early reports suggested that procainamide and hydralazine were associated with the highest risk of developing lupus, quinidine with a moderate ri ...
For effective and well-tolerated treatment
... The discovery of cyclosporine and its immunosuppressive activity represents one of the most significant breakthroughs in immunosuppressive therapy. It was first isolated from a soil-dwelling fungus, Tolypocladium inflatum, in 1972 and has since become a standard of care for maintenance immunosuppre ...
... The discovery of cyclosporine and its immunosuppressive activity represents one of the most significant breakthroughs in immunosuppressive therapy. It was first isolated from a soil-dwelling fungus, Tolypocladium inflatum, in 1972 and has since become a standard of care for maintenance immunosuppre ...
Product Monograph - Ask Novartis Pharma
... Blood dyscrasias: Blood dyscrasias (such as neutropenia, leukopenia, thrombocytopenia, aplastic anemia and agranulocytosis) associated with the use of NSAIDs are rare, but could occur with severe consequences. Anemia is sometimes seen in patients receiving NSAIDs, including VOLTAREN RAPIDE. This may ...
... Blood dyscrasias: Blood dyscrasias (such as neutropenia, leukopenia, thrombocytopenia, aplastic anemia and agranulocytosis) associated with the use of NSAIDs are rare, but could occur with severe consequences. Anemia is sometimes seen in patients receiving NSAIDs, including VOLTAREN RAPIDE. This may ...
Nanoparticles as `smart` pharmaceutical delivery
... nanoparticle delivery systems. In this review, we have also highlighted about the promising pharmaceutical deliveries like brain targeted delivery, ocular delivery, oral delivery, dermal and transdermal delivery, cancer chemotherapy, vaccine delivery, nucleic acids delivery and delivery system coupl ...
... nanoparticle delivery systems. In this review, we have also highlighted about the promising pharmaceutical deliveries like brain targeted delivery, ocular delivery, oral delivery, dermal and transdermal delivery, cancer chemotherapy, vaccine delivery, nucleic acids delivery and delivery system coupl ...
Diovan HCT Prescribing Information
... If hypotension occurs, the patient should be placed in the supine position and, if necessary, given an intravenous infusion of normal saline. A transient hypotensive response is not a contraindication to further treatment, which usually can be continued without difficulty once the blood pressure has ...
... If hypotension occurs, the patient should be placed in the supine position and, if necessary, given an intravenous infusion of normal saline. A transient hypotensive response is not a contraindication to further treatment, which usually can be continued without difficulty once the blood pressure has ...
NADPH-Diaphorase Activity Changes During Gangliogenesis and
... and in the apical ganglion of young juveniles. This ganglion is lost in advanced juveniles (Lin and Leise, 1996). Whether this occurs by apoptotic or necrotic cell death related to NO release or by the translocation of these cells into other ganglia is unknown. In the abalone Haliotis rufescens, cer ...
... and in the apical ganglion of young juveniles. This ganglion is lost in advanced juveniles (Lin and Leise, 1996). Whether this occurs by apoptotic or necrotic cell death related to NO release or by the translocation of these cells into other ganglia is unknown. In the abalone Haliotis rufescens, cer ...