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Azithromycin for Injection, USP
Azithromycin for Injection, USP

... The average CLt and Vd values were 10.18 mL/min/kg and 33.3 L/kg, respectively, in 18 normal volunteers receiving 1000 to 4000-mg doses given as 1 mg/mL over 2 hours. Comparison of the plasma pharmacokinetic parameters following the 1st and 5th daily doses of 500 mg intravenous azithromycin showed o ...
psychoactive substances
psychoactive substances

... sellers, which are mainly pharmacists. Most recognized drugs of misuse are controlled in this way, but are also subject to further more stringent legal controls. Medical Preparations (Control of Amphetamines) Regulations 1970 The Medical Preparations (Control of Amphetamines) Regulations 1970 prohib ...
biodegradable implants with different drug release - diss.fu
biodegradable implants with different drug release - diss.fu

... thermoplastic aliphatic poly(esters) (Jain 2000). These polymers are commercially available in different molecular weights, co-polymer ratios and chemical end groups. Interest in the use of these polymers for pharmaceutical applications and medical devices has increased extensively due to their biod ...
Comparison of Inhaled Corticosteroids: An Update
Comparison of Inhaled Corticosteroids: An Update

... Relative Potency of Inhaled Corticosteroids It has been well established that chemical changes in the basic corticosteroid molecule produce significant differences in potency, usually measured as binding affinity at the glucocorticoid receptor. The relative receptor affinities are provided in Table ...
Urinary Hydrocodone and Metabolite Distributions in
Urinary Hydrocodone and Metabolite Distributions in

... # The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: [email protected] ...
Carbamazepine ER Capsules, 300 mg 120 count
Carbamazepine ER Capsules, 300 mg 120 count

... measurement of drug serum levels may aid in determining the cause of toxicity when more than one medication is being used. ...
Effects of Temperature and Drugs on Frog Heart
Effects of Temperature and Drugs on Frog Heart

... Caffeine is 1,3,7-trimethylxanthine and is structurally related to uric acid. Caffeine is metabolized by demethylation and by oxidation7. The major pathway in man proceeds through the formation of paraxanthine (1,7-dimethylxanthine), leading to the principal urinary metabolites, l-methylxanthine, 1- ...
  Clinical pharmacology and abuse potential of   gamma‐hydroxybutyric acid (GHB)
  Clinical pharmacology and abuse potential of   gamma‐hydroxybutyric acid (GHB)

... decrease in GHB plasma concentrations. The three study drugs, GHB, flunitrazepam and ethanol,  although  known  sedate‐like  drugs,  they  all  induced  a  mixed  sedative‐stimulant  pattern.    GHB  tolerability  highly  differ  between  subjects  with  no  within‐subject  coincidence  of  positive ...
Concurrent Access to Nicotine and SucroseREVISION
Concurrent Access to Nicotine and SucroseREVISION

... automatically limits intake of the other. In other words, choice of one reinforcer in a discrete-trials procedure carries a high opportunity cost in terms of lost access to the other reinforcer. For this reason, discrete-trials procedures are well suited for determining the relative values of reinfo ...
Prescribing Information
Prescribing Information

... Caution should be exercised when PROVIGIL is given to patients with a history of psychosis, depression, or mania. Consideration should be given to the possible emergence or exacerbation of psychiatric symptoms in patients treated with PROVIGIL. If psychiatric symptoms develop in association with PRO ...
Original salbutamol versus similar salbutamol in
Original salbutamol versus similar salbutamol in

... Thirdly, the likelihood that the dose administered of both medicinal products was higher than necessary to obtain the maximum BDR should be taken into account.27 For similar salbutamol, the dosage is prescribed in drops based on the age and body weight; and for original salbutamol, in mg/kg of body ...
acetaminophen and codeine phosphate tablets
acetaminophen and codeine phosphate tablets

... Concentration-Efficacy Relationships – The minimum effective analgesic concentration will vary widely among patients, especially among patients who have been previously treated with potent agonist opioids. The minimum effective analgesic concentration of codeine for any individual patient may increa ...
Inderal (propranolol hydrochloride) Tablets Rx only
Inderal (propranolol hydrochloride) Tablets Rx only

... Mechanism of Action The mechanism of the antihypertensive effect of propranolol has not been established. Factors that may contribute to the antihypertensive action include: (1) decreased cardiac output, (2) inhibition of renin release by the kidneys, and (3) diminution of tonic sympathetic nerve o ...
Pharmacological and Pharmaceutical Profile of Valsartan: A Review
Pharmacological and Pharmaceutical Profile of Valsartan: A Review

... Angiotensin II Receptor type 1 antagonists have been widely used in treatment of diseases like hypertension, heart failure, myocardial infarction and diabetic nephropathy. Their beneficial effects are related to inhibition of Angiotensin II by blockade of AT1 receptor. Valsartan is an orally active ...
The use of Iboga[ine] in Equatorial African Ritual Context and the
The use of Iboga[ine] in Equatorial African Ritual Context and the

... in collectivity to Bwiti ritual practice. Neither approach thinks of itself as a “quick fix” (the searching for which is a characteristic behavior of the previous states of desultory confusion (Bwiti) or addiction (INTASH), but seeks a profound change of attitude toward physical, mental, and emotion ...
Jeopardy Powerpoint Template
Jeopardy Powerpoint Template

... How does that change the shape of the blood stain? GO TO ANSWER (question) ...
Bahauddin Zakariya University Multan Pakistan.
Bahauddin Zakariya University Multan Pakistan.

... supervision. No portion of this thesis work has formerly been offered for higher degree in this university or any other institute of learning and to best of the author’s knowledge, no material has been used in this thesis which is not his own work, except where due acknowledgement has been made. He ...
VP Anesthesiology Patel 2002 - University of British Columbia
VP Anesthesiology Patel 2002 - University of British Columbia

... not change from baseline to 4 h in the norepinephrine group. The vasopressin-induced increase in urine output was associated with a significantly increased creatinine clearance in the vasopressin group (P ⬍ 0.05; fig. 3) with no change in fractional excretion of sodium (table 4). Thus, vasopressin i ...
Platelet inhibitory activity and pharmacokinetics of prasugrel
Platelet inhibitory activity and pharmacokinetics of prasugrel

... pharmacokinetics of prasugrel (CS-747, LY640315), a novel thienopyridine antiplatelet agent in healthy volunteers. Twenty-four subjects were randomized into four groups of six in a double-blind, placebo-controlled trial. One subject in each group received placebo and five subjects received prasugrel ...
Losartan Potassium
Losartan Potassium

... the AT1 receptor with 10-fold greater affinity than its parent compound. E3174 is about 15 to 20 times more potent in inhibiting All-induced pressor and contactile responses, as shown in vitro and in vivo. Neither losartan potassium nor E3174 possess any agonist activity at the AT1 receptor. In pati ...
Pharmacy Compounding: Defining the New Landscape for Safe
Pharmacy Compounding: Defining the New Landscape for Safe

Tramadol - Medsafe
Tramadol - Medsafe

... (perspiration), "orthostatic dysregulation (tendency to collapse and cardiovascular collapse) and tachycardia" and "nausea/urge to vomit/vomiting" was significantly increased with rapid intravenous administration and also tended to be dose dependent. Drug abuse and dependence Although tramadol can p ...
Zolpidem Physical Dependence Assessed Across Increasing Doses
Zolpidem Physical Dependence Assessed Across Increasing Doses

... behavioral effects and possible physical-dependence-producing effects of zolpidem in baboons. The effects of a range of zolpidem doses (1.0 –32.0 mg/kg), delivered via the i.g. route, were compared with a vehicle condition, using a once-daily dosing regimen. The initial dose of zolpidem used in the ...
Effects of Acute Caffeine Administration on Adolescents
Effects of Acute Caffeine Administration on Adolescents

... completed a demographic questionnaire. Parents were then escorted from the room and participants provided a 3-ml saliva sample into a sterile tube that was analyzed for caffeine and steroid hormones. The participant then completed the Behavioral Checklist Questionnaire. He or she then had baseline b ...
Guideline for the Quality, Safety, and Efficacy Assurance of Follow
Guideline for the Quality, Safety, and Efficacy Assurance of Follow

... established, wherever possible. If such information is not available, literature and other information will be acceptable. Not only information about culture history but also the procedures for establishing the cell bank system and characterization of cell substrates are included in the requirements ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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