Pharmacological Significance of Synthetic Heterocycles
... Two hundred years ago, the chemical science was an undivided field; around 1900 a division into inorganic, organic and physical chemistry became necessary. The increase of factual material enforced a progressive segmentation into sub disciplines. A map shows countries and regions neatly separated; s ...
... Two hundred years ago, the chemical science was an undivided field; around 1900 a division into inorganic, organic and physical chemistry became necessary. The increase of factual material enforced a progressive segmentation into sub disciplines. A map shows countries and regions neatly separated; s ...
5-country RAR report
... New Psychoactive Substances (NPS) are becoming a major challenge to public health and drug policies in Europe and have become a high priority in Europe. The “new psychoactive substances in Europe” project ...
... New Psychoactive Substances (NPS) are becoming a major challenge to public health and drug policies in Europe and have become a high priority in Europe. The “new psychoactive substances in Europe” project ...
Evaluation of different mycobacterial species for drug discovery and
... used for anti-Tb drug high-throughput screening (HTS), and to use this model to identify a novel candidate anti-tubercular drug and its cognate cellular target. A sensitive growth inhibition assay was set up with a GFP-labelled Tb vaccine strain, M. bovis BCG, using standard first and second line an ...
... used for anti-Tb drug high-throughput screening (HTS), and to use this model to identify a novel candidate anti-tubercular drug and its cognate cellular target. A sensitive growth inhibition assay was set up with a GFP-labelled Tb vaccine strain, M. bovis BCG, using standard first and second line an ...
... preparations. In addition, tramadol and paracetamol were found to reduce the severity of pain and photophobia associated with moderate-to-severe migraine headache [97]. Intra-operative studies showed tramadol did not antagonise the hypnotic effects of volatile inhalational agents (such as isoflurane ...
The Safety of Citrus aurantium (Bitter Orange) and its
... listed by Consumer Reports (Anon, 2010) as being possibly unsafe and a dietary supplement ‘to avoid’. The assumption is generally made that, because of structural similarities with sympathomimetic agents as ephedrine and nor‐epinephrine, p‐synephrine can be expected to exert central nervous system ( ...
... listed by Consumer Reports (Anon, 2010) as being possibly unsafe and a dietary supplement ‘to avoid’. The assumption is generally made that, because of structural similarities with sympathomimetic agents as ephedrine and nor‐epinephrine, p‐synephrine can be expected to exert central nervous system ( ...
6. Kelly CP. A 76-year-old man with recurrent
... Adverse Effects Reference books and package inserts provide extensive lists of adverse effects associated with and/or caused by a drug, but these information sources seldom quantify how likely it is that a specific adverse effect will occur or which patients are at risk. Clinicians want to know what ...
... Adverse Effects Reference books and package inserts provide extensive lists of adverse effects associated with and/or caused by a drug, but these information sources seldom quantify how likely it is that a specific adverse effect will occur or which patients are at risk. Clinicians want to know what ...
Targeting the Bacterial Division Protein FtsZ
... and polymerization into the Z-ring at mid-cell65 (Figure 2B). In the Gram-positive pathogen Streptococcus pneumoniae, MapZ localizes at the division site prior to FtsZ, interacts directly with FtsZ, and guides positioning of the Z-ring66 (Figure 2B). MapZ is a single-passage transmembrane protein th ...
... and polymerization into the Z-ring at mid-cell65 (Figure 2B). In the Gram-positive pathogen Streptococcus pneumoniae, MapZ localizes at the division site prior to FtsZ, interacts directly with FtsZ, and guides positioning of the Z-ring66 (Figure 2B). MapZ is a single-passage transmembrane protein th ...
Theracurmin | Information Sheet
... subjects were not taking any medications before or during this study. Both curcumin powder and Theracurmin in liquid form were administered orally at a dose of 30 mg of curcumin. Subjects were randomly assigned to dose groups, with 7 subjects in each treatment group. Blood samples were collected bef ...
... subjects were not taking any medications before or during this study. Both curcumin powder and Theracurmin in liquid form were administered orally at a dose of 30 mg of curcumin. Subjects were randomly assigned to dose groups, with 7 subjects in each treatment group. Blood samples were collected bef ...
Autonomic Dysfunction - Internal Medicine of Northern Virginia
... Anatomy/Physiology-BRIEF Overview Potential etiologies Systems impacted ...
... Anatomy/Physiology-BRIEF Overview Potential etiologies Systems impacted ...
DATA SHEET Tramal Capsules Solution for Injection
... The analgesic effect is dose-dependant, but the relationship between serum concentrations and analgesic effect varies considerably between individuals. In one study, the median serum concentration of tramadol required for effective post-operative analgesia was 300 ng/mL, with individual values rangi ...
... The analgesic effect is dose-dependant, but the relationship between serum concentrations and analgesic effect varies considerably between individuals. In one study, the median serum concentration of tramadol required for effective post-operative analgesia was 300 ng/mL, with individual values rangi ...
MDMA in humans: factors which affect the neuropsychobiological
... (2003) found that the proportion of recreational users who complained of ecstasy-attributed problems, increased significantly in parallel with lifetime dosage. Future studies might usefully employ objective and subjective measures in parallel. This would address the topic of their relative sensitivi ...
... (2003) found that the proportion of recreational users who complained of ecstasy-attributed problems, increased significantly in parallel with lifetime dosage. Future studies might usefully employ objective and subjective measures in parallel. This would address the topic of their relative sensitivi ...
Chloramphenicol
... Chloramphenicol palmitate ester is inactive, and is hydrolysed to active chloramphenicol in the small intestine. There is no difference in bioavailability between chloramphenicol and chloramphenicol palmitate. The intravenous (IV) preparation of chloramphenicol is the succinate ester, because pure c ...
... Chloramphenicol palmitate ester is inactive, and is hydrolysed to active chloramphenicol in the small intestine. There is no difference in bioavailability between chloramphenicol and chloramphenicol palmitate. The intravenous (IV) preparation of chloramphenicol is the succinate ester, because pure c ...
Full-Text PDF
... To fill up this gap, various new biomarkers are under consideration that hopefully will have a specificity and sensitivity high enough to out-perform and replace in the future traditional LTs [20–40]. However, it seems that none of the biomarkers listed under early recognition of liver injury fulfil ...
... To fill up this gap, various new biomarkers are under consideration that hopefully will have a specificity and sensitivity high enough to out-perform and replace in the future traditional LTs [20–40]. However, it seems that none of the biomarkers listed under early recognition of liver injury fulfil ...
Ewrramt~amm=nts I
... has been done on aspirin’s side effects. For example, it is well known that aspirin can upset the stomach. The manner in which aspirin breaks the gastric mucosal barrier was first outlined in 1964 by physiologist Horace W. Davenport, University of Michigan. 10 Davenport published a Citation Classic ...
... has been done on aspirin’s side effects. For example, it is well known that aspirin can upset the stomach. The manner in which aspirin breaks the gastric mucosal barrier was first outlined in 1964 by physiologist Horace W. Davenport, University of Michigan. 10 Davenport published a Citation Classic ...
PREZISTA® (darunavir) oral suspension PREZISTA® (darunavir
... PREZISTA, co-administered with ritonavir (PREZISTA/ritonavir), and with other antiretroviral agents, is indicated for the treatment of HIV-1 infection in pediatric patients 3 years of age and older [see Use in Specific Populations (8.4)]. The indication for treatment-experienced pediatric patients 3 ...
... PREZISTA, co-administered with ritonavir (PREZISTA/ritonavir), and with other antiretroviral agents, is indicated for the treatment of HIV-1 infection in pediatric patients 3 years of age and older [see Use in Specific Populations (8.4)]. The indication for treatment-experienced pediatric patients 3 ...
Ulipristal acetate - Therapeutic Goods Administration
... This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and reta ...
... This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and reta ...
BAX 855, a PEGylated rFVIII product with prolonged half-life
... to yield a rFVIII conjugate with a low PEGylation degree of about 2 moles PEG per FVIII molecule. This optimised modification degree resulted in an improved PK profile for rFVIII without compromising its specific activity. PEGylation sites were identified by employing various HPLC- and MS-based meth ...
... to yield a rFVIII conjugate with a low PEGylation degree of about 2 moles PEG per FVIII molecule. This optimised modification degree resulted in an improved PK profile for rFVIII without compromising its specific activity. PEGylation sites were identified by employing various HPLC- and MS-based meth ...
CHEWING GUM - International Journal of Pharmaceutical Sciences
... therapeutic agent is easily maintained during storage because of packaging that keeps it away from oxygen, light, and water. Gum chewing can have local effects in the mouth and also systemic effects after the active agents have been swallo ...
... therapeutic agent is easily maintained during storage because of packaging that keeps it away from oxygen, light, and water. Gum chewing can have local effects in the mouth and also systemic effects after the active agents have been swallo ...
CARBIDOPA AND LEVODOPA EXTENDED-RELEASE
... the treatment of Parkinson’s disease apparently because it does not cross the bloodbrain barrier. However, levodopa, the metabolic precursor of dopamine, does cross the blood-brain barrier, and presumably is converted to dopamine in the brain. This is thought to be the mechanism whereby levodopa rel ...
... the treatment of Parkinson’s disease apparently because it does not cross the bloodbrain barrier. However, levodopa, the metabolic precursor of dopamine, does cross the blood-brain barrier, and presumably is converted to dopamine in the brain. This is thought to be the mechanism whereby levodopa rel ...
PrDALACIN* C FLAVOURED GRANULES
... In patients with G-6-PD deficiency, the combination of clindamycin with primaquine may cause hemolytic reactions. Reference should also be made to the primaquine product monograph for other possible risk groups for other hematologic reactions (see ADVERSE REACTIONS). DALACIN C FLAVOURED GRANULES (cl ...
... In patients with G-6-PD deficiency, the combination of clindamycin with primaquine may cause hemolytic reactions. Reference should also be made to the primaquine product monograph for other possible risk groups for other hematologic reactions (see ADVERSE REACTIONS). DALACIN C FLAVOURED GRANULES (cl ...
NLA Task Force On Statin Safety - 2014 Update
... but may approach 10%. Real or perceived symptoms from statins may be an underappreciated cause of nonadherence to therapy. Data from the cross-sectional Understanding Statin use in America and Gaps in Patient Education (USAGE) study suggests that muscle symptoms may occur in up to 29% of patients in ...
... but may approach 10%. Real or perceived symptoms from statins may be an underappreciated cause of nonadherence to therapy. Data from the cross-sectional Understanding Statin use in America and Gaps in Patient Education (USAGE) study suggests that muscle symptoms may occur in up to 29% of patients in ...
PIPERINE, AN ALKALOID DERIVED FROM BLACK
... ability to improve circulating levels of drugs and nutrients. However, it is possible that there may be important distinctions between piperine’s effect on drugs and piperine’s effect on nutrients. Drugs, as examples of xenobiotics, are subject to biotransformation primarily in the epithelial cells ...
... ability to improve circulating levels of drugs and nutrients. However, it is possible that there may be important distinctions between piperine’s effect on drugs and piperine’s effect on nutrients. Drugs, as examples of xenobiotics, are subject to biotransformation primarily in the epithelial cells ...
Download CV
... Thomas AJ, Olkowski JH, Vornov JJ, Slusher BS. “Toxicity induced by a polyglutamated folate analog is attenuated by NAALADase inhibition.” Brain Research, 1999, 843, 48-52 Tiffany CW, Lapidus RG, Merion A, Calvin DC, Slusher BS. “Characterization of the enzymatic activity of PSM: Comparison with bra ...
... Thomas AJ, Olkowski JH, Vornov JJ, Slusher BS. “Toxicity induced by a polyglutamated folate analog is attenuated by NAALADase inhibition.” Brain Research, 1999, 843, 48-52 Tiffany CW, Lapidus RG, Merion A, Calvin DC, Slusher BS. “Characterization of the enzymatic activity of PSM: Comparison with bra ...
effect of cytochrome p450 2d6 and 3a enzyme inhibition on
... investigated, and the new aspects of its metabolism have been discovered only some years ago (Kalso 2005, Olkkola and Hagelberg 2009). After the introduction of immediate- and extended-release oral oxycodone into the market in the 1990s, the global use of oxycodone has increased rapidly (Coluzzi and ...
... investigated, and the new aspects of its metabolism have been discovered only some years ago (Kalso 2005, Olkkola and Hagelberg 2009). After the introduction of immediate- and extended-release oral oxycodone into the market in the 1990s, the global use of oxycodone has increased rapidly (Coluzzi and ...