Slide 1
... Concept Navigator: Features that I liked about V1 and is missing in V2 1. Domain/collection switching 2. A dual window system 3. Terms extracted and displayed and can be selected to form a new ...
... Concept Navigator: Features that I liked about V1 and is missing in V2 1. Domain/collection switching 2. A dual window system 3. Terms extracted and displayed and can be selected to form a new ...
Eukaryotic Genomes - Building Directory
... All cells in an organism contain an identical genome (set of genes) However, the genes expressed in the cells of each type are unique Most of the DNA in eukaryotic genomes are noncoding – unsure of its purpose 25,000 genes in humans Only about 1.5% codes for protein The expression of specific ge ...
... All cells in an organism contain an identical genome (set of genes) However, the genes expressed in the cells of each type are unique Most of the DNA in eukaryotic genomes are noncoding – unsure of its purpose 25,000 genes in humans Only about 1.5% codes for protein The expression of specific ge ...
Regulation of Gene Expression
... Stability may change in response to regulatory signals and is thought to be a major regulatory control point. ...
... Stability may change in response to regulatory signals and is thought to be a major regulatory control point. ...
File
... The Comparative Models of Regeneration Database (RegenDB) provides a systems-level view of tissue regeneration models to advance knowledge of regenerative biology and stem cell self-renewal. Scientists can use RegenDB to analyze integrated functional genomic datasets of regenerative processes to ide ...
... The Comparative Models of Regeneration Database (RegenDB) provides a systems-level view of tissue regeneration models to advance knowledge of regenerative biology and stem cell self-renewal. Scientists can use RegenDB to analyze integrated functional genomic datasets of regenerative processes to ide ...
Gene Expression
... • Conditions tightly controlled – Lactose must be high, but no other sugar present – [Lactose] and [glucose] ...
... • Conditions tightly controlled – Lactose must be high, but no other sugar present – [Lactose] and [glucose] ...
“bDNA for gene expression in plant and animal tissue”
... “bDNA for gene expression in plant and animal tissue” December 2nd, 2014 at 12:00-1:00pm Genomics bldg. Room 1102A Speaker: Harry Vacek, Quantigene Specialist Please RSVP to [email protected] food will be provided for RSVPs Measure up to 80 genes or 4 RNA targets in 1 sample Imagine if you c ...
... “bDNA for gene expression in plant and animal tissue” December 2nd, 2014 at 12:00-1:00pm Genomics bldg. Room 1102A Speaker: Harry Vacek, Quantigene Specialist Please RSVP to [email protected] food will be provided for RSVPs Measure up to 80 genes or 4 RNA targets in 1 sample Imagine if you c ...
Diapositive 1
... Perturbed genotypes in cancer can now be identified by whole genome sequencing of large number of diverse tumor samples, and observed gene mutations can be used for prognosis and classification of cancer subtypes. Although mutations in a few causative genes are directly linked to key signaling pathw ...
... Perturbed genotypes in cancer can now be identified by whole genome sequencing of large number of diverse tumor samples, and observed gene mutations can be used for prognosis and classification of cancer subtypes. Although mutations in a few causative genes are directly linked to key signaling pathw ...
SBI 4U Genetics 5
... repressor protein and changes the shape of it so it can no longer bind onto the operator. Then the CAP activator can bind on and controls how fast the transcription works. The lac operon is known as an inducible operon because transcription is induced when lactose is present. ...
... repressor protein and changes the shape of it so it can no longer bind onto the operator. Then the CAP activator can bind on and controls how fast the transcription works. The lac operon is known as an inducible operon because transcription is induced when lactose is present. ...
Controlling the genes
... – Homodomain motif - 3 linked alpha helices of the protein make intimate contact with the DNA – Zinc-finger motif - a molecule of zinc stabilizes a alpha helix and a beta sheet structure of the protein. – Leucine zipper motif - two alpha helices, each from different protein molecules come together t ...
... – Homodomain motif - 3 linked alpha helices of the protein make intimate contact with the DNA – Zinc-finger motif - a molecule of zinc stabilizes a alpha helix and a beta sheet structure of the protein. – Leucine zipper motif - two alpha helices, each from different protein molecules come together t ...
Nutritional Genomics and Genetics
... Controllability of complex networks • Naturally occurring networks, such as those involving gene regulation, are surprisingly hard to control. • To fully control a gene regulatory network, roughly 80% of the nodes should be driver nodes. (in contrast to social networks) • To a certain extent this ...
... Controllability of complex networks • Naturally occurring networks, such as those involving gene regulation, are surprisingly hard to control. • To fully control a gene regulatory network, roughly 80% of the nodes should be driver nodes. (in contrast to social networks) • To a certain extent this ...
IntroNetworksandGenes
... for proteins. The rest is……RNA regulatory network? Human genes are also segmented into Exon and Introns, with alternative splicing, significantly increasing the actual number of protein ...
... for proteins. The rest is……RNA regulatory network? Human genes are also segmented into Exon and Introns, with alternative splicing, significantly increasing the actual number of protein ...
«題目»
... Abstract The molecular basis of epigenetics involves modifications to DNA and histone proteins that associate with the regulation of gene expression but that do not result from mutation or changes to the DNA sequence. The four core histone proteins are subject to post-translational modifications, su ...
... Abstract The molecular basis of epigenetics involves modifications to DNA and histone proteins that associate with the regulation of gene expression but that do not result from mutation or changes to the DNA sequence. The four core histone proteins are subject to post-translational modifications, su ...
Gene expression
... of DNA base pairs, is made into a functional gene product, such as protein or RNA ...
... of DNA base pairs, is made into a functional gene product, such as protein or RNA ...
Ch 15 - .Gene Regulation
... allows differential protein expression dependent on specialized function of cell. ...
... allows differential protein expression dependent on specialized function of cell. ...
The genetic engineers toolkit
... • Agriculture and conservation. Eg. Checking that closely related endangered animals are not mated together. • To establish how closely related different seed stocks are • To place a suspect at the crime scene in forensic science. ...
... • Agriculture and conservation. Eg. Checking that closely related endangered animals are not mated together. • To establish how closely related different seed stocks are • To place a suspect at the crime scene in forensic science. ...
BIOL1020 Core Concepts Introduction to evolution as a common
... Introduction to evolution as a common theme in biology: Common ancestor concept, Taxonomy intro, Evolutionary processes intro Cells: definition, structure, types, cytoskeleton DNA and RNA: structure and composition, double helical structure implications/parallel/anti-parallel DNA replication Macromo ...
... Introduction to evolution as a common theme in biology: Common ancestor concept, Taxonomy intro, Evolutionary processes intro Cells: definition, structure, types, cytoskeleton DNA and RNA: structure and composition, double helical structure implications/parallel/anti-parallel DNA replication Macromo ...
Timing and Development of Growth
... • Temp and water availability determine seed germination and embryo growth. ...
... • Temp and water availability determine seed germination and embryo growth. ...
Regulation of Gene Expression
... A general relaxation of the DNA in the vicinity of the gene is required for transcription to occur o Histone acetylation can destabilize the nucleosome structure o Some transcription factors have acetyltransferase activity o Deacetylation can restore chromatin repression o Other chemical modificatio ...
... A general relaxation of the DNA in the vicinity of the gene is required for transcription to occur o Histone acetylation can destabilize the nucleosome structure o Some transcription factors have acetyltransferase activity o Deacetylation can restore chromatin repression o Other chemical modificatio ...
Regulation of Gene Expression
... • Post-translational Control: after synthesizing the polypeptide the cell can modify it chemically or vary the rate at whish the polypeptide becomes a functional protein ...
... • Post-translational Control: after synthesizing the polypeptide the cell can modify it chemically or vary the rate at whish the polypeptide becomes a functional protein ...
Control of Gene Expression
... Cells are very different because each cell makes certain proteins and not others ...
... Cells are very different because each cell makes certain proteins and not others ...
Table S2. Summary of microarray data for genes with decreased
... Table S2. Summary of microarray data for genes with decreased expression levels. Numbers are fold changes in gene expression levels in the mutant pancreata as compared to wild-type controls. Genes that showed reduced expression levels by 4 fold or higher in at least one age group are shown. “-,” exp ...
... Table S2. Summary of microarray data for genes with decreased expression levels. Numbers are fold changes in gene expression levels in the mutant pancreata as compared to wild-type controls. Genes that showed reduced expression levels by 4 fold or higher in at least one age group are shown. “-,” exp ...
401Lecture8Sp2013post
... • Activators promote transcription and are modular proteins composed of a DNA binding domain and an activation domain • Repressors inhibit transcription and are modular proteins composed of a DNA binding domain and a repressor domain • Both repressor and activators recruit other proteins to affect g ...
... • Activators promote transcription and are modular proteins composed of a DNA binding domain and an activation domain • Repressors inhibit transcription and are modular proteins composed of a DNA binding domain and a repressor domain • Both repressor and activators recruit other proteins to affect g ...
A walk-through for the above site illustrating some of the possible
... Support value vector for a set #1 of orthologous genes ...
... Support value vector for a set #1 of orthologous genes ...
Gene regulatory network
A gene regulatory network or genetic regulatory network (GRN) is a collection of regulators thatinteract with each other and with other substances in the cell to govern the gene expression levels of mRNA and proteins.The regulator can be DNA, RNA, protein and their complex. The interaction can be direct or indirect (through their transcribed RNA or translated protein).In general, each mRNA molecule goes on to make a specific protein (or set of proteins). In some cases this protein will be structural, and will accumulate at the cell membrane or within the cell to give it particular structural properties. In other cases the protein will be an enzyme, i.e., a micro-machine that catalyses a certain reaction, such as the breakdown of a food source or toxin. Some proteins though serve only to activate other genes, and these are the transcription factors that are the main players in regulatory networks or cascades. By binding to the promoter region at the start of other genes they turn them on, initiating the production of another protein, and so on. Some transcription factors are inhibitory.In single-celled organisms, regulatory networks respond to the external environment, optimising the cell at a given time for survival in this environment. Thus a yeast cell, finding itself in a sugar solution, will turn on genes to make enzymes that process the sugar to alcohol. This process, which we associate with wine-making, is how the yeast cell makes its living, gaining energy to multiply, which under normal circumstances would enhance its survival prospects.In multicellular animals the same principle has been put in the service of gene cascades that control body-shape. Each time a cell divides, two cells result which, although they contain the same genome in full, can differ in which genes are turned on and making proteins. Sometimes a 'self-sustaining feedback loop' ensures that a cell maintains its identity and passes it on. Less understood is the mechanism of epigenetics by which chromatin modification may provide cellular memory by blocking or allowing transcription. A major feature of multicellular animals is the use of morphogen gradients, which in effect provide a positioning system that tells a cell where in the body it is, and hence what sort of cell to become. A gene that is turned on in one cell may make a product that leaves the cell and diffuses through adjacent cells, entering them and turning on genes only when it is present above a certain threshold level. These cells are thus induced into a new fate, and may even generate other morphogens that signal back to the original cell. Over longer distances morphogens may use the active process of signal transduction. Such signalling controls embryogenesis, the building of a body plan from scratch through a series of sequential steps. They also control and maintain adult bodies through feedback processes, and the loss of such feedback because of a mutation can be responsible for the cell proliferation that is seen in cancer. In parallel with this process of building structure, the gene cascade turns on genes that make structural proteins that give each cell the physical properties it needs.It has been suggested that, because biological molecular interactions are intrinsically stochastic, gene networks are the result of cellular processes and not their cause (i.e. cellular Darwinism). However, recent experimental evidence has favored the attractor view of cell fates.