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Regulation of Arabidopsis 14-3
Regulation of Arabidopsis 14-3

... In vivo reconstitution of aequorin and Ca2+ measurements Calcium measurements were carried out essentially as described by Knight, Trewavas & Knight (1996). Arabidopsis seedlings expressing aequorin (line RLD1.1; Polisensky & Braam 1996) were grown on MS agar plates with full strength nitrogen plus ...
Effects of signaling on subcellular localization of MITF
Effects of signaling on subcellular localization of MITF

... melanocytes and plays a crucial role in melanoma. MITF is known from the literature to be regulated by signaling, for example through the MAPK pathway which mediates signals with protein phosphorylations. The MAPK pathway is deregulated in at least 90% of all melanomas. When transcription factors ar ...
AN ABSTRACT OF THE THESIS OF Sara R. Fassio for the degree of
AN ABSTRACT OF THE THESIS OF Sara R. Fassio for the degree of

... responsible for inducing most of the cholera symptoms. Upon uptake into the cells, CT induces elevated levels of cyclic adenosine monophosphate (cAMP), which ultimately results in electrolyte and water loss as manifested by the watery diarrhea (15). Thus, CT reverses the normal physiology of the sma ...
The first true obligately syntrophic propionate
The first true obligately syntrophic propionate

... was used for phylogenetic analysis. PCR amplification of the 16S rRNA genes from nucleic acids isolated from this culture resulted in a product of the expected size of 1?4 kb. This fragment was digested with BamHI and PstI and ligated in pUC18 linearized with the same enzymes. The ligation products ...
3.2 Breeding of corn line DAS-40278-9
3.2 Breeding of corn line DAS-40278-9

... studies with the AAD-1 protein have confirmed the absence of any biologically significant amino acid sequence similarity to known protein toxins or allergens and digestibility studies have demonstrated that the protein would be rapidly degraded following ingestion, similar to other dietary proteins. ...
Crystal structure of mouse coronavirus receptor
Crystal structure of mouse coronavirus receptor

... The Coronaviridae family of large, enveloped, positive-stranded RNA viruses consists of at least three major genera or groups (Table S1). Aminopeptidase-N (APN) is the receptor for porcine transmissible gastroenteritis virus (TGEV), porcine respiratory coronavirus (PRCoV), and human coronavirus 229E ...
TFE3 contains two activation domains, one acidic and the other
TFE3 contains two activation domains, one acidic and the other

... is contained within the 102 amino acid C-terminal portion of TFE3 shown to be sufficient for activation (Fig. 1 A). Interestingly, although the proline content in the highly conserved region is low (3/38), all three prolines are perfectly conserved. The two TFE3 activation domains activate transcrip ...


... expression and covalent modifications of proteins. Research findings that have been generated by using molecular techniques have guided us into new territory, going way beyond classical nutrition studies such as characterization of clinical signs of nutrient deficiencies. Those nutritionists who inv ...
Characterisation of the novel proteins expressed in corn line 1507
Characterisation of the novel proteins expressed in corn line 1507

... carbohydrate, ash, fibre, fatty acids, amino acids, minerals and moisture) were similar in corn line 1507 and the non-transformed control corns. In addition, there were no observed differences in results from the analyses of four vitamins (Vitamins B1, B2, E and folate) measured in the transformed a ...
Gene Section GHRL (ghrelin/obestatin prepropeptide) Atlas of Genetics and Cytogenetics
Gene Section GHRL (ghrelin/obestatin prepropeptide) Atlas of Genetics and Cytogenetics

... As the endogenous ligand of the growth hormone secretagogues (GHS) receptor, Ghrelin/MTLRP is involved in the pulsatile secretion of Growth hormone. In addition to this role Ghrelin/MTLRP is in the regulation of feeding. In rodent In contrast to leptin, Ghrelin/MTLRP promotes food intake and obesity ...
The trimethoprim-resistant dihydrofolate reductase associated with
The trimethoprim-resistant dihydrofolate reductase associated with

... enzymes have exactly the same number of amino acid residues and 61 of the 78 amino acids are identical. The remaining 17 amino acids, for the most part, are conservative replacements, eight of which can be explained by transitions of single bases (amino acid residues 3,6,8,9,17,18, and 21; Fig. 4) a ...
Cloning and characterization of an eukaryotic initiation factor
Cloning and characterization of an eukaryotic initiation factor

... These fragments were subcloned and sequenced. The 1300bp fragment displayed 30% homology to human PKR gene and was used to screen a cDNA library from Bombyx fat body. About 400,000 plaques were screened and six positive clones were isolated. One of these clones was subcloned into pBlueScript SK( ) a ...
Trans-chalcone and quercetin down-regulate fatty acid synthase
Trans-chalcone and quercetin down-regulate fatty acid synthase

... treat and there is only a limited number of antifungal drugs available for clinical use, especially when compared to the arsenal of antibacterial drugs [4,5]. Therefore, novel drugs with more specific and effective mechanisms of action against dermatophytes are urgently needed. In this respect, natu ...
Alternative routes of acetyl-CoA synthesis identified
Alternative routes of acetyl-CoA synthesis identified

... Fig. 1. Classification of orthologous oleaginous genes based on their relevant functions and metabolic processes. The bar chart shows the number of genes in each of five major classes, while the pie chart shows the percentage of genes devoted to different aspects of metabolism. ...
Genetic and biochemical identification of the
Genetic and biochemical identification of the

... State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China Environmental Microbiology and Biotechnology Research Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China ...
Sulfur Metabolism in Escherichia coli and Related Bacteria: Facts
Sulfur Metabolism in Escherichia coli and Related Bacteria: Facts

... to the metabolism of the first five elements, but much remains to be understood about sulfur metabolism. We review here the situation in Escherichia coli and related bacteria, where more than one hundred genes involved in sulfur metabolism have already been discovered in this organism. Examination o ...
Novel evolutionary lineages of the invertebrate oxytocin/vasopressin
Novel evolutionary lineages of the invertebrate oxytocin/vasopressin

... similarity of CTR2 and OPR to the OT receptor family is not so different from their similarity to VP receptors. When combined with these findings, the sequence analysis revealed that CTR2 and OPR are octopus counterparts for the OT/VP receptors. Several residues in the TM and extracellular domains a ...
Cambridge Workshop November 2008
Cambridge Workshop November 2008

... – Authors/researchers are the experts in their fields – Limited number of FlyBase curators, and increasing amount and variety of data being published – Improves FlyBase utility for everyone ...
Nucleotide Sequence of the Gene Coding for the
Nucleotide Sequence of the Gene Coding for the

... icant domainsor regions inthe nitrogenase proteins which are the atmosphere. Nitrogenase catalyzes the overall reaction: not conserved, and are these regions responsible for the obN2 3H2+ 2NH3; the detailsof its mechanism are notknown served differences in the nitrogenase proteins? If this is true, ...
a30 Study Questions for the Whole Course
a30 Study Questions for the Whole Course

... 5. Describe the differences in strength and composition of covalent, ionic, and hydrogen bonds. 6. What are the properties of water that make it especially suitable for biological life? What is the fundamental principle underlying most of the properties of water? 7. What is the relationship between ...
food produced from glyphosate tolerant sugar beet line 77
food produced from glyphosate tolerant sugar beet line 77

... not expected to be present in the final product due to the extensive refining that pulp undergoes if it is processed into refined dietary fibre. Thus exposure to the novel proteins is likely to be extremely low. The potential toxicity and allergenicity of the CP4 EPSPS and GUS proteins as well as th ...
food produced from glyphosate
food produced from glyphosate

... not expected to be present in the final product due to the extensive refining that pulp undergoes if it is processed into refined dietary fibre. Thus exposure to the novel proteins is likely to be extremely low. The potential toxicity and allergenicity of the CP4 EPSPS and GUS proteins as well as th ...
M261 MHC class I antigen presentation April 17, 2000
M261 MHC class I antigen presentation April 17, 2000

... translated in the ER and folded into the proper conformation. The MHC protein is stabilized by a protein, calnexin, a resident ER protein that binds to glycoproteins. MHC class I then binds to b2microglobulin (b2m) and calreticulin, a chaperone, that trafficks MHC class I to tapasin which stabilizes ...
Ketone Bodies Mimic the Life Span Extending
Ketone Bodies Mimic the Life Span Extending

... The longevity effect from mutation of genes in the IIS pathway was discovered in C. elegans. This longevity effect was also later found in fruit flies and mice. In C. elegans, the normal signaling pathway results in phosphorylation and sequestration in the cytosol of the forkhead box transcription f ...
Succinate Dehydrogenase of Saccharomyces cerevisiae
Succinate Dehydrogenase of Saccharomyces cerevisiae

... strong inhibitors. Mechanisms of inhibition by these compounds differ significantly because oxaloacetate, a competitive inhibitor of succinate dehydrogenase, bounds with a sulfhydryl group of the enzyme to abolish the enzyme activity [16]. It is known that SDH is sensitive to different thiol-binding ...
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Endogenous retrovirus



Endogenous retroviruses (ERVs) are endogenous viral elements in the genome that closely resemble and can be derived from retroviruses. They are abundant in the genomes of jawed vertebrates, and they comprise up to 5–8% of the human genome (lower estimates of ~1%). ERVs are a subclass of a type of gene called a transposon, which can be packaged and moved within the genome to serve a vital role in gene expression and in regulation. Researchers have suggested that retroviruses evolved from a type of transposable gene called a retrotransposon, which includes ERVs; these genes can mutate and instead of moving to another location in the genome they can become exogenous or pathogenic. This means that all ERVs may not have originated as an insertion by a retrovirus but that some may have been the source for the genetic information in the retroviruses they resemble.
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