Nicotinamide adenine dinucleotide, a metabolic regulator of
... complex I, isolated from type 2 diabetes patients exhibits lower activity [44]. These studies suggest that the ability to regulate NAD : NADH ratio is lower in diabetes patients, since mitochondrial NADH dehydrogenase is the major site for re-oxidising NAD. It is therefore likely that NAD may also p ...
... complex I, isolated from type 2 diabetes patients exhibits lower activity [44]. These studies suggest that the ability to regulate NAD : NADH ratio is lower in diabetes patients, since mitochondrial NADH dehydrogenase is the major site for re-oxidising NAD. It is therefore likely that NAD may also p ...
Metabolic engineering of Escherichia coli and Corynebacterium glutamicum for the -threonine
... impetus to further improve productivity of the bioconversion and reduce its costs. The most efficient solution is to develop more productive bacterial strains with reduced growth retardation. Strains surviving multiple rounds of mutation are genetically undefined and vulnerable to further changes, occ ...
... impetus to further improve productivity of the bioconversion and reduce its costs. The most efficient solution is to develop more productive bacterial strains with reduced growth retardation. Strains surviving multiple rounds of mutation are genetically undefined and vulnerable to further changes, occ ...
Characterization of the Phosphoenolpyruvate Carboxykinase Gene
... 610 amino acids with an Mr of 66,874. The gene is preceded by a typical ribosomal binding site (GGAGA). Centered 47 bp downstream of the pck stop codon, a region of dyad symmetry followed by several T residues similar to rhoindependent transcription terminators was found. The mRNA hairpin loop predi ...
... 610 amino acids with an Mr of 66,874. The gene is preceded by a typical ribosomal binding site (GGAGA). Centered 47 bp downstream of the pck stop codon, a region of dyad symmetry followed by several T residues similar to rhoindependent transcription terminators was found. The mRNA hairpin loop predi ...
- VU Research Repository
... Gene array analysis was used to study gene expression in Saccharomyces cerevisiae during acclimatisation to non-lethal ethanol stress, in the presence and absence of acetaldehyde. Acetaldehyde caused significant changes in gene expression in ethanol-stressed yeast. For example, many genes associated ...
... Gene array analysis was used to study gene expression in Saccharomyces cerevisiae during acclimatisation to non-lethal ethanol stress, in the presence and absence of acetaldehyde. Acetaldehyde caused significant changes in gene expression in ethanol-stressed yeast. For example, many genes associated ...
- UEA Digital Repository
... Figure 1.7 Key processes in the microbial nitrogen cycle ...................................................... 15 Figure 1.8 Nitrogen fractions within the total fixed nitrogen pool ......................................... 17 Figure 1.9 Typical nitrogen components in dissolved and particulate nitro ...
... Figure 1.7 Key processes in the microbial nitrogen cycle ...................................................... 15 Figure 1.8 Nitrogen fractions within the total fixed nitrogen pool ......................................... 17 Figure 1.9 Typical nitrogen components in dissolved and particulate nitro ...
Potassium starvation responses in yeast highlight novel potassium-related functions
... reason, potassium homeostasis is tightly controlled by several transporters, that allow the cation uptake, intracellular traffic and efflux, and by a set of proteins regulating these processes. In spite of the importance of potassium for yeast physiology, not all relevant functional potassium-relate ...
... reason, potassium homeostasis is tightly controlled by several transporters, that allow the cation uptake, intracellular traffic and efflux, and by a set of proteins regulating these processes. In spite of the importance of potassium for yeast physiology, not all relevant functional potassium-relate ...
Glutamate Dehydrogenases: Enzymology, Physiological
... trimers of subunits stacked directly on top of each other [61-63]. Some GDHs such as that from bovine liver, which is the best-characterized enzyme [1], may have higher order multimeric structures. This enzyme, which is a hexamer in solution, aggregates to form a high molecular weight species and th ...
... trimers of subunits stacked directly on top of each other [61-63]. Some GDHs such as that from bovine liver, which is the best-characterized enzyme [1], may have higher order multimeric structures. This enzyme, which is a hexamer in solution, aggregates to form a high molecular weight species and th ...
02_whole - Massey Research Online
... restriction sites are unique to each individual MD-AeO sequence. Genomic Southern analysis, using probes spanning the 3 '-UTR and the 3 '-end of the coding region confirmed that MD A e03 is encoded by a distinct gene. However, while the distinction between MD-A eO] and MD-A e02 is not as definitive ...
... restriction sites are unique to each individual MD-AeO sequence. Genomic Southern analysis, using probes spanning the 3 '-UTR and the 3 '-end of the coding region confirmed that MD A e03 is encoded by a distinct gene. However, while the distinction between MD-A eO] and MD-A e02 is not as definitive ...
endoglucanase in cellulose biosynthesis is not very clear
... Instead, the plant gene was identified by sequencing random cDNAs from a cotton fiber library and analyzing the derived amino acid sequences for presence of the conserved features identified in the bacterial cellulose synthase and other processive β-glycosyltransferases. Mutant analysis, specificall ...
... Instead, the plant gene was identified by sequencing random cDNAs from a cotton fiber library and analyzing the derived amino acid sequences for presence of the conserved features identified in the bacterial cellulose synthase and other processive β-glycosyltransferases. Mutant analysis, specificall ...
attached paper highlights
... PGC-1a expression is greatly enhanced in the developing mouse heart immediately before the burst of mitochondrial biogenesis that precedes birth.19 Constitutive cardiospecific PGC-1a overexpression in mice results in uncontrolled mitochondrial proliferation, leading to dilated cardiomyopathy.19 Durin ...
... PGC-1a expression is greatly enhanced in the developing mouse heart immediately before the burst of mitochondrial biogenesis that precedes birth.19 Constitutive cardiospecific PGC-1a overexpression in mice results in uncontrolled mitochondrial proliferation, leading to dilated cardiomyopathy.19 Durin ...
pdf
... hypothetical proteins. A transposase (Noc_A0021), phage integrase (Noc_A0015), and a small number of other phagerelated genes along with restriction modification systems are also found on this replicon. A possible replication protein (Noc_A0039) whose only putative homologue (56% similar over 80% of ...
... hypothetical proteins. A transposase (Noc_A0021), phage integrase (Noc_A0015), and a small number of other phagerelated genes along with restriction modification systems are also found on this replicon. A possible replication protein (Noc_A0039) whose only putative homologue (56% similar over 80% of ...
Analysis of the genetic potential of the spongederived fungus
... lab and for introducing me into the puzzling world of polyketides. I am grateful for all suggestions that I got from him during the practical work in the lab, as well as for the writing of my thesis. Moreover, I want to thank him for his trust and unique experience in building up a laboratory togeth ...
... lab and for introducing me into the puzzling world of polyketides. I am grateful for all suggestions that I got from him during the practical work in the lab, as well as for the writing of my thesis. Moreover, I want to thank him for his trust and unique experience in building up a laboratory togeth ...
Identification and expression of GH
... (Tanabe et al., 2003) and M. chitosanitabida (Yun et al., 2005) are involved in a retaining mechanism in which one of the two essential residues functions as a nucleophile and the other as a general acid/base. Knowledge of the 3D structures and amino acid sequences of chitosanases has led to the ide ...
... (Tanabe et al., 2003) and M. chitosanitabida (Yun et al., 2005) are involved in a retaining mechanism in which one of the two essential residues functions as a nucleophile and the other as a general acid/base. Knowledge of the 3D structures and amino acid sequences of chitosanases has led to the ide ...
Minimal metabolic pathway structure is consistent with
... same transcription factor (TF). We compared MinSpan pathways to PPI and genetic interactions in S. cerevisiae and the TRN of E. coli as the datasets are most complete for those particular organisms (Fig 2C). By testing for significant Spearman correlation coefficients of cooccurrence or co-absence o ...
... same transcription factor (TF). We compared MinSpan pathways to PPI and genetic interactions in S. cerevisiae and the TRN of E. coli as the datasets are most complete for those particular organisms (Fig 2C). By testing for significant Spearman correlation coefficients of cooccurrence or co-absence o ...
meme
... present in all of the sequences. * anr — Any Number of Repetitions MEME assumes each sequence may contain any number of non-overlapping occurrences of each motif. This option is useful when you suspect that motifs repeat multiple times within a single sequence. In that case, the motifs found will be ...
... present in all of the sequences. * anr — Any Number of Repetitions MEME assumes each sequence may contain any number of non-overlapping occurrences of each motif. This option is useful when you suspect that motifs repeat multiple times within a single sequence. In that case, the motifs found will be ...
Chlamydia Exploit the Mammalian Tryptophan-Depletion
... distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academ ...
... distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academ ...
Practical Aspects of Estimating Energy Components in
... Supplemental Text 1: SNP report of the rs2403254 locus. The report contains knowledge of all genes within a 500 kbp distance of rs2403254, as retrieved from NCBI-Gene, ConsensusPathDB, UniProtKB, OMIM, Gene Ontology, TCDB, ExPASy and KEGG database. --------------------------------------------------- ...
... Supplemental Text 1: SNP report of the rs2403254 locus. The report contains knowledge of all genes within a 500 kbp distance of rs2403254, as retrieved from NCBI-Gene, ConsensusPathDB, UniProtKB, OMIM, Gene Ontology, TCDB, ExPASy and KEGG database. --------------------------------------------------- ...
The Role of Carbohydrate Response Element Binding Protein in
... mechanisms underlying intestinal and hepatic fructose metabolism will be beneficial for understanding the pathogenesis of not only obesity-related diseases, but also fructose malabsorption. We have analyzed the role of carbohydrate response element binding protein (ChREBP) in the pathogenesis of met ...
... mechanisms underlying intestinal and hepatic fructose metabolism will be beneficial for understanding the pathogenesis of not only obesity-related diseases, but also fructose malabsorption. We have analyzed the role of carbohydrate response element binding protein (ChREBP) in the pathogenesis of met ...
The Plant Cell
... coli resistance to a group of antimicrobial agents that are similar to but not overlapping with those to which NorM confers resistance. The significant reduction in norfloxacin accumulation in E. coli cells attributed to NorM expression can be eliminated rapidly by dissipation of the proton gradient ...
... coli resistance to a group of antimicrobial agents that are similar to but not overlapping with those to which NorM confers resistance. The significant reduction in norfloxacin accumulation in E. coli cells attributed to NorM expression can be eliminated rapidly by dissipation of the proton gradient ...
Cloning and sequencing of the kedarcidin biosynthetic
... The enediynes represent a steadily growing family of natural products with remarkable molecular architectures. Since the structural elucidation of neocarzinostatin (NCS)21 and calicheamicin (CAL),22 the first two members of the family, in the 1980s, 14 enediynes have now been structurally confirmed, ...
... The enediynes represent a steadily growing family of natural products with remarkable molecular architectures. Since the structural elucidation of neocarzinostatin (NCS)21 and calicheamicin (CAL),22 the first two members of the family, in the 1980s, 14 enediynes have now been structurally confirmed, ...
PhyPA: Phylogenetic method with pairwise sequence alignment
... designated as Sym (for symmetric tree) and Asym (for asymmetric tree), respectively, were used for sequence simulation. The scales of branch lengths indicated in Fig. 3 are for amino acid and codon sequences. The branch lengths of Sym and Asym trees for simulating nucleotide sequences are half as lo ...
... designated as Sym (for symmetric tree) and Asym (for asymmetric tree), respectively, were used for sequence simulation. The scales of branch lengths indicated in Fig. 3 are for amino acid and codon sequences. The branch lengths of Sym and Asym trees for simulating nucleotide sequences are half as lo ...
Structure, mechanism and regulation of pyruvate carboxylase
... Hanson [21] proposed the involvement of PC in the pathway of de novo fatty acid synthesis. PC participates in this pathway by providing oxaloacetate for conversion into citrate which is exported from the mitochondria and cleaved in the cytosol to form oxaloacetate and acetyl-CoA [21] (see Figure 1). ...
... Hanson [21] proposed the involvement of PC in the pathway of de novo fatty acid synthesis. PC participates in this pathway by providing oxaloacetate for conversion into citrate which is exported from the mitochondria and cleaved in the cytosol to form oxaloacetate and acetyl-CoA [21] (see Figure 1). ...
Unveiling the physiological and molecular basis of Mycobacterium
... role in mycobacteria physiology was also envisaged and advanced, but not fully completed in the scope of this work. Comparison of in vitro growth of wild-type and isogenic knock-out strains in batch assays and macrophage cell lines and, also in vivo using an animal model of infection, would enable u ...
... role in mycobacteria physiology was also envisaged and advanced, but not fully completed in the scope of this work. Comparison of in vitro growth of wild-type and isogenic knock-out strains in batch assays and macrophage cell lines and, also in vivo using an animal model of infection, would enable u ...
Specific and ubiquitous expression of different Zn finger protein
... specific DNA binding (31). Furthermore,they lack the conserved Phe and Leu residues in the finger loop and the H-C link peptide TGEKP. Interestingly, when Kruppel(Kr), the Drosophila segmentation gene of the gap class(32) was isolated and sequenced.it was found to contain 5 Zn fingers(5),thereby imp ...
... specific DNA binding (31). Furthermore,they lack the conserved Phe and Leu residues in the finger loop and the H-C link peptide TGEKP. Interestingly, when Kruppel(Kr), the Drosophila segmentation gene of the gap class(32) was isolated and sequenced.it was found to contain 5 Zn fingers(5),thereby imp ...
Promoter (genetics)
In genetics, a promoter is a region of DNA that initiates transcription of a particular gene. Promoters are located near the transcription start sites of genes, on the same strand and upstream on the DNA (towards the 5' region of the sense strand).Promoters can be about 100–1000 base pairs long.