Genomics Glossary - College of American Pathologists
... The fundamental physical and functional unit of heredity. A gene is an ordered sequence of nucleotides located in a particular position on a particular chromosome that encodes a specific functional product (i.e., a protein or RNA molecule). Gene expression: The process by which a gene's coded inform ...
... The fundamental physical and functional unit of heredity. A gene is an ordered sequence of nucleotides located in a particular position on a particular chromosome that encodes a specific functional product (i.e., a protein or RNA molecule). Gene expression: The process by which a gene's coded inform ...
screening and selection for recombinants
... Nucleic acid hybridization Detection of an individual clone in a library can be achieved by employing strategies of nucleic acid hybridization in which short chemically synthesized labeled oligonucleotides (probes) are used to detect complementary sequences in individual cells or phages containing a ...
... Nucleic acid hybridization Detection of an individual clone in a library can be achieved by employing strategies of nucleic acid hybridization in which short chemically synthesized labeled oligonucleotides (probes) are used to detect complementary sequences in individual cells or phages containing a ...
IntroducTon to Biological sequences
... the four leRers: A, C, G, U • RNA is single stranded – More flexible than DNA – Can double back and form loops – Such structures can be more stable ...
... the four leRers: A, C, G, U • RNA is single stranded – More flexible than DNA – Can double back and form loops – Such structures can be more stable ...
ChIP-seq - The Fenyo Lab
... • tens to hundreds of thousands of sites • large binding region (~2kb) • tags not oriented • signal may be scaled • associated w/ almost all transcribed genes ...
... • tens to hundreds of thousands of sites • large binding region (~2kb) • tags not oriented • signal may be scaled • associated w/ almost all transcribed genes ...
DNA Replication
... entire strand is copied Result is two strands of DNA Semi-Conservative Replication - Each strand is 50% new and 50% old DNA ...
... entire strand is copied Result is two strands of DNA Semi-Conservative Replication - Each strand is 50% new and 50% old DNA ...
Presented
... Mutation is when there is a change in information content of a DNA molecule due to replication error or damage. Mutations do not affect the fitness of an organism to the same degree. Natural selection causes many to be lost from the gene pool and the changes that remain are referred to as substituti ...
... Mutation is when there is a change in information content of a DNA molecule due to replication error or damage. Mutations do not affect the fitness of an organism to the same degree. Natural selection causes many to be lost from the gene pool and the changes that remain are referred to as substituti ...
Molecular Biology
... range of different polymers can be produced from the basic molecule by varying the number of carbons in the side chain. The molecule is constructed from units which are present in plants. It is possible to take those three genes from the soil bacterium and localise them in the chloroplasts of Arabid ...
... range of different polymers can be produced from the basic molecule by varying the number of carbons in the side chain. The molecule is constructed from units which are present in plants. It is possible to take those three genes from the soil bacterium and localise them in the chloroplasts of Arabid ...
VCE BIOLOGY 2013–2016 Introduction
... range of different polymers can be produced from the basic molecule by varying the number of carbons in the side chain. The molecule is constructed from units which are present in plants. It is possible to take those three genes from the soil bacterium and localise them in the chloroplasts of Arabid ...
... range of different polymers can be produced from the basic molecule by varying the number of carbons in the side chain. The molecule is constructed from units which are present in plants. It is possible to take those three genes from the soil bacterium and localise them in the chloroplasts of Arabid ...
Transcriptional interference among the murine β
... large, intact, wild-type human b-globin YAC transgenes can occasionally have little or no expression11,12 or experience some degree of variegation at a higher frequency,13 concerns remain that the YACs do not, in fact, harbor the full cis-regulatory requirements of the endogenous human locus. Theref ...
... large, intact, wild-type human b-globin YAC transgenes can occasionally have little or no expression11,12 or experience some degree of variegation at a higher frequency,13 concerns remain that the YACs do not, in fact, harbor the full cis-regulatory requirements of the endogenous human locus. Theref ...
PROTEIN SYNTHESIS
... eyes while the normal form (allele) of the gene caused brown eyes. It was discovered that the mutant blue-eye colour was the result of any mutation in the DNA causing three of the SAME amino acid to be produced side by side in the polypeptide sequence. Amazingly, it did not matter which amino acid w ...
... eyes while the normal form (allele) of the gene caused brown eyes. It was discovered that the mutant blue-eye colour was the result of any mutation in the DNA causing three of the SAME amino acid to be produced side by side in the polypeptide sequence. Amazingly, it did not matter which amino acid w ...
Challenge:
... b. Conserved sequence c. Phylogenic tree When we have DNA or protein sequences from many organisms, we can compare them to one another in order to determine which organisms are more closely related. It is inferred that species sharing similar sequences share a common evolutionary ancestor Certain ge ...
... b. Conserved sequence c. Phylogenic tree When we have DNA or protein sequences from many organisms, we can compare them to one another in order to determine which organisms are more closely related. It is inferred that species sharing similar sequences share a common evolutionary ancestor Certain ge ...
DNA Replication and Protein Synthesis-New
... – This entire process is called protein synthesis and begins with the DNA that makes up the chromatin/chromosomes in the nucleus. ...
... – This entire process is called protein synthesis and begins with the DNA that makes up the chromatin/chromosomes in the nucleus. ...
Soggy, a spermatocyte-specific gene, lies 3.8 kb
... Although mSgy mRNA was clearly expressed in vivo (see below; 8), it was possible that the mSgy gene existed at multiple genomic loci and that the copy located upstream of mTEAD-2 was a pseudogene. Therefore, to determine whether or not mSgy exists as a single copy gene, mouse genomic DNA was digeste ...
... Although mSgy mRNA was clearly expressed in vivo (see below; 8), it was possible that the mSgy gene existed at multiple genomic loci and that the copy located upstream of mTEAD-2 was a pseudogene. Therefore, to determine whether or not mSgy exists as a single copy gene, mouse genomic DNA was digeste ...
SNCURS OPTED ETC POSTER_PPTX
... In conclusion, there was seen a correlation to the progression of Osteoarthritis to the age of the mice (since, OA is closely associated with age). When the results from the initial experiment came back, the younger mice appeared to have more up regulation (i.e. more genes are expressed; the older t ...
... In conclusion, there was seen a correlation to the progression of Osteoarthritis to the age of the mice (since, OA is closely associated with age). When the results from the initial experiment came back, the younger mice appeared to have more up regulation (i.e. more genes are expressed; the older t ...
7-Tumor Suppressor genes, Oncogenes and Development The
... contribute in the development of tumor. – Activator transcription factors: e.g.; SMAD family that are activated by TGF-β, leading to inhibition of cell proliferation . P53: that produces P21 that has the same action of P16 in inhibiting the action of cdk/cyclin. ...
... contribute in the development of tumor. – Activator transcription factors: e.g.; SMAD family that are activated by TGF-β, leading to inhibition of cell proliferation . P53: that produces P21 that has the same action of P16 in inhibiting the action of cdk/cyclin. ...
Greg Thor - gthor eportfolio
... requires special approval before planting them even though “Both the United States Food and Drug Administration and the European Food Safety Agency say that there is no scientific evidence that eating MON810 corn is dangerous. But there is greater disagreement on how genetically modified plants affe ...
... requires special approval before planting them even though “Both the United States Food and Drug Administration and the European Food Safety Agency say that there is no scientific evidence that eating MON810 corn is dangerous. But there is greater disagreement on how genetically modified plants affe ...
Genetic engineering – stepping stones
... Genetic engineering – stepping stones Draw a path across the stepping stones in the correct order for each process. 1) Dolly the sheep – cloning technique ...
... Genetic engineering – stepping stones Draw a path across the stepping stones in the correct order for each process. 1) Dolly the sheep – cloning technique ...
Biochemistry and Molecular Biology
... function) and optimal control of living matter (animal, plant and microorganism). After a survey of the molecular building blocks and of the macromolecules of the living cell, the properties and kinetics of enzymes as biocatalysts are covered. Finally, the principles and major pathways of the centra ...
... function) and optimal control of living matter (animal, plant and microorganism). After a survey of the molecular building blocks and of the macromolecules of the living cell, the properties and kinetics of enzymes as biocatalysts are covered. Finally, the principles and major pathways of the centra ...
Abeer Gene Therapy P..
... Genes can also make the cancerous cells unstable. Usually cancer cells do not allow the faulty DNA to repair which results in the rapid growth of abnormal cells. ...
... Genes can also make the cancerous cells unstable. Usually cancer cells do not allow the faulty DNA to repair which results in the rapid growth of abnormal cells. ...
Specialties: Microbial Diversity and Bacterial Membrane Proteins
... permease subsequently leads to a conformational change and releases them into the cytoplasm. Hence, permeases must display a high degree of specificity in substrate recognition in order to discriminate between different molecules presented to the cell. However, the precise mechanisms of these import ...
... permease subsequently leads to a conformational change and releases them into the cytoplasm. Hence, permeases must display a high degree of specificity in substrate recognition in order to discriminate between different molecules presented to the cell. However, the precise mechanisms of these import ...
introductory slides
... Excision of “SWR peptide” from Lipin gene 1. Cut dLipin gene with restriction enzymes on either side of conserved sequence and remove excised sequence 2. Insert short DNA sequence to restore open reading frame (ORF) and ligate 3. Transform modified gene into bacteria 4. Select clones that harbor co ...
... Excision of “SWR peptide” from Lipin gene 1. Cut dLipin gene with restriction enzymes on either side of conserved sequence and remove excised sequence 2. Insert short DNA sequence to restore open reading frame (ORF) and ligate 3. Transform modified gene into bacteria 4. Select clones that harbor co ...
Promoter (genetics)
In genetics, a promoter is a region of DNA that initiates transcription of a particular gene. Promoters are located near the transcription start sites of genes, on the same strand and upstream on the DNA (towards the 5' region of the sense strand).Promoters can be about 100–1000 base pairs long.