ELECTROPHILIC ADDITIONS OF ALKENES AS THE
... by the action of an oxidizing agent, resulting in more oxidized forms of carbon, such as aldehydes, ketones, and carboxylic acids. All these reactions are covered in chapter 8 of the Wade text, 4th ed. The following is a summary of the most important representative types of these reactions. For full ...
... by the action of an oxidizing agent, resulting in more oxidized forms of carbon, such as aldehydes, ketones, and carboxylic acids. All these reactions are covered in chapter 8 of the Wade text, 4th ed. The following is a summary of the most important representative types of these reactions. For full ...
Chapter 16: Ethers, Epoxides, and Sulfides
... 16.2: Structure and Bonding in Ethers and Epoxides The ether oxygen is sp3-hybridized and tetrahedral. In general, the C-O bonds of ethers have low reactivity. 16.3: Physical Properties of Ethers the O-H group of alcohols act as both an H-bond donor (Lewis acid) and H-bond acceptor (Lewis base). Eth ...
... 16.2: Structure and Bonding in Ethers and Epoxides The ether oxygen is sp3-hybridized and tetrahedral. In general, the C-O bonds of ethers have low reactivity. 16.3: Physical Properties of Ethers the O-H group of alcohols act as both an H-bond donor (Lewis acid) and H-bond acceptor (Lewis base). Eth ...
Ruthenium Half-Sandwich Complexes as Protein Kinase Inhibitors
... functional mimicry of these organometallic scaffolds (see also Figure 1).2e,5 However, at the same time, these new scaffolds have properties which are clearly distinct from their parent indolocarbazole alkaloids. For example, whereas staurosporine is a nanomolar inhibitor for most protein kinases, t ...
... functional mimicry of these organometallic scaffolds (see also Figure 1).2e,5 However, at the same time, these new scaffolds have properties which are clearly distinct from their parent indolocarbazole alkaloids. For example, whereas staurosporine is a nanomolar inhibitor for most protein kinases, t ...
Chapter 10 The Chemistry of Alcohols and Thiols
... with tosyl chloride and pyridine, and treat the resulting tosylate with sodium bromide in a polar aprotic solvent. This type of solvent suppresses carbocation formation. Also, PBr3 often gives satisfactory results with unbranched secondary alcohols. ...
... with tosyl chloride and pyridine, and treat the resulting tosylate with sodium bromide in a polar aprotic solvent. This type of solvent suppresses carbocation formation. Also, PBr3 often gives satisfactory results with unbranched secondary alcohols. ...
Chapter 7: Alkene reactions
... Stereospecific syn addition occurs to produce vicinal diols The positive charge on the metal attracts electrons and sets a pericyclic reaction in motion; π electrons form σ bonds As the organic functional group gets oxidized, the inorganic reagent gets reduced (by products: MnO2 or OsO3) KMn ...
... Stereospecific syn addition occurs to produce vicinal diols The positive charge on the metal attracts electrons and sets a pericyclic reaction in motion; π electrons form σ bonds As the organic functional group gets oxidized, the inorganic reagent gets reduced (by products: MnO2 or OsO3) KMn ...
Open Access
... Catalysts are often based on transition metals due to their ability to bind a wide variety of molecules. The catalysis of chemical processes is divided into two fields, homogeneous catalysis where the catalyst is dissolved in the same phase as the substrate and heterogeneous catalysis where the cat ...
... Catalysts are often based on transition metals due to their ability to bind a wide variety of molecules. The catalysis of chemical processes is divided into two fields, homogeneous catalysis where the catalyst is dissolved in the same phase as the substrate and heterogeneous catalysis where the cat ...
Reversible reaction
... In equilibrium, an atom may change from being part of the products to part of the reactants many times. But the overall concentrations of products and reactants stay the same. For chemical equilibrium to be maintained, the rates of the forward and reverse reactions must be equal. Arrows of equal ...
... In equilibrium, an atom may change from being part of the products to part of the reactants many times. But the overall concentrations of products and reactants stay the same. For chemical equilibrium to be maintained, the rates of the forward and reverse reactions must be equal. Arrows of equal ...
Origin of the Diastereoselection in the Indium
... We tentatively explain the high and opposite stereoselections for anti-3a and for syn-3n according to the R1 substituent of 1 using the model proposed by Hoffmann.10 Hoffmann connected the conformation of the complex between metal enolate and aldehyde to the stereochemistry of the aldol product thro ...
... We tentatively explain the high and opposite stereoselections for anti-3a and for syn-3n according to the R1 substituent of 1 using the model proposed by Hoffmann.10 Hoffmann connected the conformation of the complex between metal enolate and aldehyde to the stereochemistry of the aldol product thro ...
Ring-closing metathesis
Ring-closing metathesis, or RCM, is a widely used variation of olefin metathesis in organic chemistry for the synthesis of various unsaturated rings via the intramolecular metathesis of two terminal alkenes, which forms the cycloalkene as the E- or Z- isomers and volatile ethylene.The most commonly synthesized ring sizes are between 5-7 atoms; however, reported syntheses include 45- up to 90- membered macroheterocycles. These reactions are metal-catalyzed and proceed through a metallacyclobutane intermediate. It was first published by Dider Villemin in 1980 describing the synthesis of an Exaltolide precursor, and later become popularized by Robert H. Grubbs and Richard R. Schrock, who shared the Nobel Prize in Chemistry, along with Yves Chauvin, in 2005 for their combined work in olefin metathesis. RCM is a favorite among organic chemists due to its synthetic utility in the formation of rings, which were previously difficult to access efficiently, and broad substrate scope. Since the only major by-product is ethylene, these reactions may also be considered atom economic, an increasingly important concern in the development of green chemistry.There are several reviews published on ring-closing metathesis.