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Oxidation of Alcohols
Oxidation of Alcohols

... Primary Alcohol • With gentle heating, a primary alcohol can be oxidised to produce an aldehyde. • With strong heating and excess [o] a carboxylic acid is formed. • Reflux apparatus is generally used to produce carboxylic acids. • Aldehydes must be distilled as they are formed to prevent further ox ...
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Making Macromolecule Activity - Mercer Island School District
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... In this activity, students will mimic the reactions which create organic macromolecules. In the process they will learn about the structure of biomolecules and the chemical processes by which they are metabolized. Background: You will use a molecular modeling kit to construct models of carbohydrate, ...
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Section 7.5~7.6 - www .alexandria .k12 .mn .us
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Petasis reaction



The Petasis reaction (alternatively called the Petasis borono–Mannich (PBM) reaction) is the chemical reaction of an amine, aldehyde, and vinyl- or aryl-boronic acid to form substituted amines.Reported in 1993 by Nicos Petasis as a practical method towards the synthesis of a geometrically pure antifungal agent, naftifine, the Petasis reaction can be described as a variation of the Mannich reaction. Rather than generating an enolate to form the substituted amine product, in the Petasis reaction, the vinyl group of the organoboronic acid serves as the nucleophile. In comparison to other methods of generating allyl amines, the Petasis reaction tolerates a multifunctional scaffold, with a variety of amines and organoboronic acids as potential starting materials. Additionally, the reaction does not require anhydrous or inert conditions. As a mild, selective synthesis, the Petasis reaction is useful in generating α-amino acids, and is utilized in combinatorial chemistry and drug discovery.
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