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Covalently Bonded Platinum(II) Complexes of [alpha]
Covalently Bonded Platinum(II) Complexes of [alpha]

Grignard Reagents brochure
Grignard Reagents brochure

... easily with halosilanes like tetrachlorosilane, but usually the reaction leads to a mixture of several products. Nevertheless the reaction is a useful approach to access a great number of specialty silanes32 which cannot be produced otherwise. ...
ETHER
ETHER

... boiling points low. • The C-O-C bond angle in the functional group is about 110°. • Ethers are slightly polar, more polar than alkenes but not as polar as alcohols, esters, or amides. ...
Synthesis of alternating hydroxy-and methyl
Synthesis of alternating hydroxy-and methyl

... manner from such a long-range 1H-13Cshift correlation spectrum. By use of this method in combination with other recently developed technique^,'^.'^ complete and unambiguous 'H and I3Cassignments have been made. In a forthcoming publication20this reassignment will be reported, together with conformat ...
chm121 tutorial kit - Covenant University
chm121 tutorial kit - Covenant University

... (a) the two double bonds are joined by a single bond (b) a single carbon atom is common to two double bonds (c) the two double bonds are separated from each other by one or more sp3-hybridized C-atoms (d) two single carbon atoms are common to two double bonds ...
CHEMICAL REACTIVITY AND MECHANISMS, AND SUBSTITUTION REACTIONS  1.
CHEMICAL REACTIVITY AND MECHANISMS, AND SUBSTITUTION REACTIONS 1.

... Substrate: SN2 reactions are fastest for methyl substrates; rates are: CH3 > 1° > 2° >> 3° (this is a steric effect; larger groups interfere with the approaching nucleophile). SN1 reactions are faster for 3° substrates (because the more stable the carbocation, the faster the reaction; this means 3° ...
electrical energy and capacitance
electrical energy and capacitance

... LIMITING REACTANT Limiting reactants are compounds completely consumed in chemical reactions. THEORETICAL YIELD Theoretical yield is the amount of product that can be made in a chemical reaction. It is based on the amount of limiting reagent. ...
aldehyde group - Imperial Valley College Faculty Websites
aldehyde group - Imperial Valley College Faculty Websites

... Cyclic hemiacetals or hemiketals can form when the alcohol and the carbonyl group exist within the same molecule . ...
Protection (and Deprotection) of Functional Groups in Organic
Protection (and Deprotection) of Functional Groups in Organic

... limited thermal stability, whose manufacture generally is based on multistep synthesis performed in the liquid phase and frequently involving protectiondeprotection steps. The use of blocking functions in organic synthesis, developed for nearly 100 years, makes more complex the entire synthetic plan ...
For Peer Review Only
For Peer Review Only

Ethers and Epoxides
Ethers and Epoxides

... Naming these heterocyclic compounds depends on the ring size and number of oxygens. (It can be confusing at first…) ...
Carbohydrates: Occurrence, Structures and Chemistry
Carbohydrates: Occurrence, Structures and Chemistry

... closure corresponding to reaction between the aldehyde group and either the C-4-OH or C-5OH. Cyclization involving O-4 results in a fivemembered ring structurally related to furan and therefore designated as a furanose, whilst hemiacetal formation with O-5 gives rise to an essentially strain-free, h ...
Slide 1
Slide 1

... Elimination Reactions involving Amines Amines can under go two different types of elimination reactions that give alkenes. Hofmann elimination: An amine is exhaustively methylated to the quaternary ammonium salt. The halide salt is converted to the hydroxide salt by treatment with silver oxide. The ...
molecules
molecules

... was added to the solution. The mixture was stirred at 80 oC for 8 h. The mixture was cooled to room temperature, filtered, washed with water and acetone and dried. The polymer supported porphyrin is insoluble in common organic solvents. The reflectance spectrum clearly indicates a Soret band at 488 ...
View/Open - AURA - Alfred University
View/Open - AURA - Alfred University

... alkylation takes place between toluene and the carbocation, which is putatively generated from the interaction between the PEDOT and the alcohol, making it an undesirable solvent.14 After testing a number of solvents, nitromethane was identified as an acceptable solvent. In addition to probing the s ...
New polyanion-based cathode materials for alkali
New polyanion-based cathode materials for alkali

... A number of new materials have been discovered through exploratory synthesis with the aim to be studied as the positive electrode (cathode) in Li-ion and Na-ion batteries. The focus has been set on the ease of synthesis, cost and availability of active ingredients in the battery, and decent cycle-li ...
New Exp8
New Exp8

... Limitations of E1 Reaction: Acid-Catalyzed Dehydrations Competition can occur with SN1 reaction if reaction conditions are not ‘controlled’ (when protic solvents, non-basic nucleophiles are used). Mixtures of products form with the E1 reaction (also SN1). Unsymmetrical reagents and rearrangements po ...
Alcohols - La Salle University
Alcohols - La Salle University

... called alcoholic myopathy (3 times more common than cirrhosis). ...
Alcohols and Phenols
Alcohols and Phenols

... To aldehyde: pyridinium chlorochromate (PCC, C5H6NCrO3Cl) in dichloromethane Other reagents produce carboxylic acids ...
Chapter 14 - Chemistry Solutions
Chapter 14 - Chemistry Solutions

... _ O + CH3CH2 CH3 ...
Ethers, Epoxides, and Sulfides
Ethers, Epoxides, and Sulfides

... _ O + CH3CH2 CH3 ...
PDF - Nanyang Technological University
PDF - Nanyang Technological University

HOMOLOGATION OF HETEROCYCLES BY A SEQUENTIAL REDUCTIVE OPENING LITHIATION – S
HOMOLOGATION OF HETEROCYCLES BY A SEQUENTIAL REDUCTIVE OPENING LITHIATION – S

... 04CRV2667) are of great interest in organic synthesis because polyfunctionalized molecules are obtained in a single synthetic operation by reaction with electrophilic reagents.(95MI5, 02MI6) Functionalized organolithium compounds can be prepared by halogen-lithium exchange, metal-lithium exchange, d ...
Aldehydes and Ketones - Belle Vernon Area School District
Aldehydes and Ketones - Belle Vernon Area School District

... *Acid chlorides look like aldehydes, but have a –Cl where the end –H is. (We will look at them more closely later) ...
Ir-catalysed formation of C− F bonds. From allylic alcohols to α
Ir-catalysed formation of C− F bonds. From allylic alcohols to α

... Since SelectF in THF/water mixtures successfully produced only one constitutional isomer of the product (i.e. 2a 0 was not formed), further screening on this system was performed (Table 2). The best results were obtained using a THF/water mixture of 5 : 1. Less water failed to dissolve SelectF, and ...
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Discodermolide



(+)-Discodermolide is a polyketide natural product found to stabilize microtubule. (+)-discodermolide was isolated by Gunasekera and his co-workers at the Harbor Branch Oceanographic Institute from the deep-sea sponge Discodermia dissoluta in 1990. (+)-Discodermolide was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines. (+)-discodermolide also shows some unique characters, including a linear backbone structure, immunosuppressive properties both in vitro and in vivo, potent induction of an accelerated senescence phenotype, and synergistic antiproliferative activity in combination with paclitaxel. Discodermolide was recognized as one of the most potent natural promoters of tubulin assembly. A large number of efforts toward the total synthesis of (+)-discodermolide were directed by its interesting biological activities and extreme scarcity of natural sources (0.002% w/w from frozen marine sponge). The compound supply necessary for complete clinical trials cannot be met by harvesting, isolation, and purification. As of 2005, attempts at synthesis or semi-synthesis by fermentation have proven unsuccessful. As a result, all discodermolide used in preclinical studies and clinical trials has come from large-scale total synthesis.
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