
Iodomethylzinc_iodid.. - Groupe Charette
... reported.25 Vinyl boronates derived from tartaric esters or amides were shown to undergo highly diastereoselective cyclopropanations upon treatment with CH2 I2 /Zn–Cu couple. These adducts were conveniently converted to enantiomerically enriched cyclopropanols. The carbohydrate 2-hydroxy-3,4,6-tri-O ...
... reported.25 Vinyl boronates derived from tartaric esters or amides were shown to undergo highly diastereoselective cyclopropanations upon treatment with CH2 I2 /Zn–Cu couple. These adducts were conveniently converted to enantiomerically enriched cyclopropanols. The carbohydrate 2-hydroxy-3,4,6-tri-O ...
Chapter 22 Summary - McGraw Hill Higher Education
... Quaternary ammonium salts, compounds of the type R4N X, find application in a technique called phase-transfer catalysis. A small amount of a quaternary ammonium salt promotes the transfer of an anion from aqueous solution, where it is highly solvated, to an organic solvent, where it is much less s ...
... Quaternary ammonium salts, compounds of the type R4N X, find application in a technique called phase-transfer catalysis. A small amount of a quaternary ammonium salt promotes the transfer of an anion from aqueous solution, where it is highly solvated, to an organic solvent, where it is much less s ...
Exam 3 - Napa Valley College
... mean that you would get a lot of by-products but you would end up getting more product also (SN1 major, E1 minor). 4) There are a number of ways of substituting a halogen for an alcohol group, but some ways are better than others. What advantage is there in using PCl3 rather than HCl in the chloride ...
... mean that you would get a lot of by-products but you would end up getting more product also (SN1 major, E1 minor). 4) There are a number of ways of substituting a halogen for an alcohol group, but some ways are better than others. What advantage is there in using PCl3 rather than HCl in the chloride ...
C - Deans Community High School
... Ethanol is formed industrially from ethene. The reaction conditions are 300oC , high pressure of 60 atmospheres and phosphoric acid catalyst. Correct because ……………….. ...
... Ethanol is formed industrially from ethene. The reaction conditions are 300oC , high pressure of 60 atmospheres and phosphoric acid catalyst. Correct because ……………….. ...
Aminoketone Rearrangements. 11. The Rearrangement of Phenyl a
... When the aminoketone I I a was heated with methylamine and methanol, i t was partially converted into the unconjugated aminoketone IIIa, as shown by infrared analysis. These are the same conditions under which these aminoketones were formed in the original epoxyether reaction. This indicated that I ...
... When the aminoketone I I a was heated with methylamine and methanol, i t was partially converted into the unconjugated aminoketone IIIa, as shown by infrared analysis. These are the same conditions under which these aminoketones were formed in the original epoxyether reaction. This indicated that I ...
Organometallic Chemistry between organic and inorganic
... Metal-carbon multiple bonds • Many transition metals form not only M-C single bonds but also M=C and (more rare) even M≡C bonds. • Complexes containing an M=C bond are called carbene complexes – The ligand without the metal would be a free carbene ...
... Metal-carbon multiple bonds • Many transition metals form not only M-C single bonds but also M=C and (more rare) even M≡C bonds. • Complexes containing an M=C bond are called carbene complexes – The ligand without the metal would be a free carbene ...
Chapter 7: Alkene reactions
... Dehydration is a common biochemical reaction in carbohydrate and fatty acid metabolism and terpene biosynthesis – it’s catalyzed in vivo by specific enzymes. In the lab, dehydration is an acid-catalyzed elimination reaction. The mechanism involves formation of a carbocation intermediate (more on eli ...
... Dehydration is a common biochemical reaction in carbohydrate and fatty acid metabolism and terpene biosynthesis – it’s catalyzed in vivo by specific enzymes. In the lab, dehydration is an acid-catalyzed elimination reaction. The mechanism involves formation of a carbocation intermediate (more on eli ...
Alcohols and Phenols
... • To aldehyde: pyridinium chlorochromate (PCC, C5H6NCrO3Cl) in dichloromethane • Other reagents produce carboxylic acids ...
... • To aldehyde: pyridinium chlorochromate (PCC, C5H6NCrO3Cl) in dichloromethane • Other reagents produce carboxylic acids ...
Lorell Thesis Final Version in PDF S
... Figure 22. 13C and 1H NMR of syn-(S,S)-90d. ........................................................ 68 Figure 23. 31P NMR of CDA derivative of 90d. ........................................................ 69 Figure 24. 13C and 1H NMR of syn-(R,R)-90e. ............................................... ...
... Figure 22. 13C and 1H NMR of syn-(S,S)-90d. ........................................................ 68 Figure 23. 31P NMR of CDA derivative of 90d. ........................................................ 69 Figure 24. 13C and 1H NMR of syn-(R,R)-90e. ............................................... ...
View/Open
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First palladium- and nickel-catalyzed oxidative
... ing either basic hydolysis, hydrogenolysis of acidic cleavage, respectively, affords free sulfamides, which can be converted to the free pyrrolidine-2-methylamines by LAH reduction. Alternatively, directly removal of both protection groups is feasible [14,15]. Recent efforts dealt with the developme ...
... ing either basic hydolysis, hydrogenolysis of acidic cleavage, respectively, affords free sulfamides, which can be converted to the free pyrrolidine-2-methylamines by LAH reduction. Alternatively, directly removal of both protection groups is feasible [14,15]. Recent efforts dealt with the developme ...
Document
... carcinogenic by-products (such as Cr3+). One methods uses a polymer supported Cr3+ reagent— Amberlyte A-26 resin-HCrO4—that avoids the use of strong acid, and forms a Cr3+ by-product that can easily be removed from the product by filtration. ...
... carcinogenic by-products (such as Cr3+). One methods uses a polymer supported Cr3+ reagent— Amberlyte A-26 resin-HCrO4—that avoids the use of strong acid, and forms a Cr3+ by-product that can easily be removed from the product by filtration. ...
22.4: Acidity of Phenols.
... Chapter 22: Phenols. Alcohols contain an OH group bonded to an sp3-hybridized carbon. Phenols contain an OH group bonded to an sp2-hybridized carbon of a benzene ring 22.1: Nomenclature (please read) 22.2: Structure and Bonding (please read) 22.3: Physical Properties (please read). Like other alcoho ...
... Chapter 22: Phenols. Alcohols contain an OH group bonded to an sp3-hybridized carbon. Phenols contain an OH group bonded to an sp2-hybridized carbon of a benzene ring 22.1: Nomenclature (please read) 22.2: Structure and Bonding (please read) 22.3: Physical Properties (please read). Like other alcoho ...
Orbitals
... Acetal and hemiacetal groups are common in carbohydrate chemistry • Glucose, a polyhydroxy aldehyde, undergoes intramolecular nucleophilic addition • Exists primarily as a cyclic hemiacetal ...
... Acetal and hemiacetal groups are common in carbohydrate chemistry • Glucose, a polyhydroxy aldehyde, undergoes intramolecular nucleophilic addition • Exists primarily as a cyclic hemiacetal ...
Ryoji Noyori - Nobel Lecture
... drawn on silk catalyzes asymmetric (heterogeneous) hydrogenation of oximes and oxazolones[13]. This pioneering work, though not effective synthetically, was already well known throughout Japan. In 1968, two years after our asymmetric cyclopropanation in 1966, W. S. Knowles (fellow Nobel laureate in ...
... drawn on silk catalyzes asymmetric (heterogeneous) hydrogenation of oximes and oxazolones[13]. This pioneering work, though not effective synthetically, was already well known throughout Japan. In 1968, two years after our asymmetric cyclopropanation in 1966, W. S. Knowles (fellow Nobel laureate in ...
... yield Percent yield ____________________ 100% theoretical yield 10. Describe four factors that may cause percent yields to be less than 100%. impure reactants, competing side reactions, loss of product during filtration or in transferring between containers, carelessly measuring reactants or pro ...
Discodermolide

(+)-Discodermolide is a polyketide natural product found to stabilize microtubule. (+)-discodermolide was isolated by Gunasekera and his co-workers at the Harbor Branch Oceanographic Institute from the deep-sea sponge Discodermia dissoluta in 1990. (+)-Discodermolide was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines. (+)-discodermolide also shows some unique characters, including a linear backbone structure, immunosuppressive properties both in vitro and in vivo, potent induction of an accelerated senescence phenotype, and synergistic antiproliferative activity in combination with paclitaxel. Discodermolide was recognized as one of the most potent natural promoters of tubulin assembly. A large number of efforts toward the total synthesis of (+)-discodermolide were directed by its interesting biological activities and extreme scarcity of natural sources (0.002% w/w from frozen marine sponge). The compound supply necessary for complete clinical trials cannot be met by harvesting, isolation, and purification. As of 2005, attempts at synthesis or semi-synthesis by fermentation have proven unsuccessful. As a result, all discodermolide used in preclinical studies and clinical trials has come from large-scale total synthesis.