• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Summary – Consumer Products
Summary – Consumer Products

... Alcohol can be quickly absorbed into the bloodstream where it can interfere with some of the chemical reactions in the body. Alcohol slows reaction time down. In small quantities it can relax a person, but in larger quantities it can slow reactions so much that a person can have trouble speaking, m ...
functional groups 2. PPT
functional groups 2. PPT

... (Not IUPAC) ...
Level 3: Organics Part I
Level 3: Organics Part I

Alcohols
Alcohols

... The longest chain contains six carbon atoms, but it does not contain the carbon bonded to the hydroxyl group. The longest chain containing the carbon bonded to the —OH group is the one outlined by the green box, containing five carbon atoms. This chain is numbered from right to left in order to give ...
Mixtures & Organic Compounds
Mixtures & Organic Compounds

... have their original properties.  A mixture is a combination of substance in which the individual ...
File
File

Topic 10. Organic chemistry
Topic 10. Organic chemistry

... The starting compound has to be converted into the desired product using as few steps as possible and each step should have the highest possible yield. The reaction pathway describes this sequence of several steps between the starting material and the product. ...
Chapter 6-student notes
Chapter 6-student notes

... 2. Potassium hydroxide reacts with hydrogen phosphate to produce potassium phosphate and hydrogen gas. ...
Balancing Chemical Equations
Balancing Chemical Equations

... Introduction: The equation H2 + O2  H2O is unbalanced because there are two oxygen atoms on the reactants side of the equation, and only one on the products side of the equation. To balance the equation, you cannot change the structure of any of the molecules, but you can change the number of molec ...
Ch. 16: Solutions - Quynh Nguyen Official Website
Ch. 16: Solutions - Quynh Nguyen Official Website

...  They tend to have much lower bps than alcohols, because alcohols are much more polar  Aldehydes and ketones of 5 C atoms or less are soluble in water ...
syllabus for entrance examination - NTU.edu
syllabus for entrance examination - NTU.edu

... Group II The elements magnesium, calcium, strontium and barium. A group of reactive metals which are essentially similar to each other with only gradual changes as their atomic numbers increase. (a) ...
Final Exam, Chem 111 2012 Study Guide (labs)
Final Exam, Chem 111 2012 Study Guide (labs)

... 1. Be familiar with the structure and nomenclature of organic compounds. a. Explain the origin of steric repulsion, with examples (e.g., eclipsed vs staggered) b. Explain how to tell when two structures are different conformations of the same molecule, vs when they are different constitutional isome ...
Science-M2-Basic-Che..
Science-M2-Basic-Che..

... It may be useful to draw a carbon atom and one other atom to illustrate the difference between elements. You can use the carbon atom to show its atomic number and mass and then elicit the atomic number and mass of the other atom. Finally, draw an isotope of carbon (perhaps carbon 14) and one of the ...
Partial Pressures of Gases
Partial Pressures of Gases

... First, balance atoms that are not in polyatomic ions, and are not O or H. (Oxygen and hydrogen atoms may be constituents of many compounds in a reaction. Balancing O and H early could be a waste of time, because they might need to be rebalanced again at a later stage.) In this case, we can start wit ...
The Nature of Chemical Reactions
The Nature of Chemical Reactions

... mass of what you start with has to be equal to the mass of what you end with This is why equations must be balanced!!! A balanced equation says the number of atoms you started with has to be equal to the number of atoms you end with ...
Organic Halides
Organic Halides

... Hemiacetals can be converted acetals:  Hemiacetal + alcohol +acid(catalyst) acetal + water An aldehyde dissolved in water exists in equilibrium with low concentrations of its hydrate, R-CH(OH)2. Similarly, in excess alcohol, the aldehyde, its hemiacetal, and its acetal all exist in solution. Hemiac ...
1 Atomic structure
1 Atomic structure

...  Chlorine also disproportionates in cold, aqueous sodium hydroxide to form sodium chloride, sodium chlorate(I) and water.  Chlorine is used to kill germs in water supplies, but is also toxic to humans at higher doses.  Halide ions are detected with silver(I) nitrate solution and the subsequent re ...
naming using more functional groups
naming using more functional groups

FOUNDATION MODULE 2012
FOUNDATION MODULE 2012

... Fructose, Glucose, mannose, and galactose are all isomers of each other, having the same chemical formula , C6 H12 O6. Carbon satisfied with four different atoms/groups of atoms is called chiral/asymmetric carbon ...
Document
Document

... R Note: for asymmetric alkenes, Markovnikov’s rule is used • Hydrogen will bond to the carbon that is richest in hydrogens already -This allows for the most stable carbocation to form ...
Reaction of Alkenes
Reaction of Alkenes

... The bromonium ion is opened by the nucleophilic water at the  higher‐substituted carbon because the partial positive charge is  more stabilized (hyperconjugation): more stabilized (hyperconjugation): ...
Chapter 18 - people.vcu.edu
Chapter 18 - people.vcu.edu

...  This reaction doesn’t happen to a large degree with most ketones  It happens a little more with aldehydes  Keq for formaldehyde is 40 Formation of Cyanohydrins o HCN is a toxic gas, so most often it is made in situ from excess NaCN and HCl. o Step one: cyanide ion attacks the carbonyl. ...
Paper
Paper

File - cpprashanths Chemistry
File - cpprashanths Chemistry

... (b)(i)CH3COCH3+[H]/Ni→CH3CH(OH)CH3+Con.H2SO4→CH3CH=CH2(1) (ii)C6H5COOH+SOCl2→C6H5COCl +H2 /PdBaSO4 →C6H5CHO (1) (iii)2CH3CH2OH +Mild oxidation (KMnO4 )→2CH3OH +NaOH→CH3CH3 (OH)CH2CHO (1) OR a) i) Aldol condensation; give the equation. ii) Acetone is treated with methyl magnesium bromide followed by ...
Aldehid dan Keton
Aldehid dan Keton

... Nucleophilic Addition of H2O: Hydration Aldehydes and ketones react reversibly with water to give ...
< 1 ... 270 271 272 273 274 275 276 277 278 ... 333 >

Strychnine total synthesis



Strychnine total synthesis in chemistry describes the total synthesis of the complex biomolecule strychnine. The first reported method by the group of Robert Burns Woodward in 1954 is considered a classic in this research field. At the time it formed the natural conclusion to an elaborate process of molecular structure elucidation that started with the isolation of strychnine from the beans of Strychnos ignatii by Pierre Joseph Pelletier and Joseph Bienaimé Caventou in 1818. Major contributors to the entire effort were Sir Robert Robinson with over 250 publications and Hermann Leuchs with another 125 papers in a time span of 40 years. Robinson was awarded the Nobel Prize in Chemistry in 1947 for his work on alkaloids, strychnine included. The process of chemical identification was completed with publications in 1946 by Robinson and later confirmed by Woodward in 1947. X-ray structures establishing the absolute configuration became available between 1947 and 1951 with publications from J. M. Bijvoet and J.H. Robertson .Woodward published a very brief account on the strychnine synthesis in 1954 (just 3 pages) and a lengthy one (42 pages) in 1963.Many more methods exist and reported by the research groups of Magnus, Overman, Kuehne, Rawal, Bosch, Vollhardt, Mori, Shibasaki, Li, Fukuyama Vanderwal and MacMillan. Synthetic (+)-strychnine is also known. Racemic synthesises were published by Padwa in 2007 and in 2010 by Andrade and by Reissig.In his 1963 publication Woodward quoted Sir Robert Robinson who said for its molecular size it is the most complex substance known.
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report