Beyond the ABCs - Information for Professionals: Amphetamines
... central nervous system (CNS). Some of these drugs are produced naturally by plants; others, like amphetamines, are the result of chemical synthesis. The amphetamines include methamphetamine, dextroamphetamine, levoamphetamine, and others. Amphetamine, the original drug of this group, is a mixture o ...
... central nervous system (CNS). Some of these drugs are produced naturally by plants; others, like amphetamines, are the result of chemical synthesis. The amphetamines include methamphetamine, dextroamphetamine, levoamphetamine, and others. Amphetamine, the original drug of this group, is a mixture o ...
Opiate Abuse 2011
... "We urgently need to take action," echoed Thomas R. Frieden, MD, MPH, director of the CDC in Atlanta, Georgia, in the same statement. "[ED] visits involving non-medical use of these prescription drugs are now as common as [ED] visits for use of illicit drugs. These prescription medicines help many p ...
... "We urgently need to take action," echoed Thomas R. Frieden, MD, MPH, director of the CDC in Atlanta, Georgia, in the same statement. "[ED] visits involving non-medical use of these prescription drugs are now as common as [ED] visits for use of illicit drugs. These prescription medicines help many p ...
Drugs Used in Tuberculosis and Leprosy
... Streptomycin, an aminoglycoside antibiotic (see Chapter 46), was the first drug shown to reduce tuberculosis mortality. Streptomycin is bactericidal against M. tuberculosis in vitro but is inactive against intracellular organisms. Most M. tuberculosis strains and nontuberculosis species, such as M. ...
... Streptomycin, an aminoglycoside antibiotic (see Chapter 46), was the first drug shown to reduce tuberculosis mortality. Streptomycin is bactericidal against M. tuberculosis in vitro but is inactive against intracellular organisms. Most M. tuberculosis strains and nontuberculosis species, such as M. ...
November 2014 - Deferrals
... Therapeutics looks forward to meeting and working with the PBAC to find a rapid and commercially feasible solution to achieve equitable access to Iclusig for all Australians. The PBAC decided to defer its decision on trastuzumab emtansine (TDM1), noting uncertainties in the economic model by omittin ...
... Therapeutics looks forward to meeting and working with the PBAC to find a rapid and commercially feasible solution to achieve equitable access to Iclusig for all Australians. The PBAC decided to defer its decision on trastuzumab emtansine (TDM1), noting uncertainties in the economic model by omittin ...
Document
... Although more than 40 000 clients are receiving OST in Australia,56 it has been estimated that between 10 000–30 000 people are unable to access treatment.45 Attempts to make treatment more accessible through provision from general medical practice and community pharmacies have struggled due to low ...
... Although more than 40 000 clients are receiving OST in Australia,56 it has been estimated that between 10 000–30 000 people are unable to access treatment.45 Attempts to make treatment more accessible through provision from general medical practice and community pharmacies have struggled due to low ...
Newborn Screening - Lower Hudson Valley Perinatal Network
... – Can a HLA match be found for every patient screened positive? – What is the longterm outcome of treatment? – Who will pay? ...
... – Can a HLA match be found for every patient screened positive? – What is the longterm outcome of treatment? – Who will pay? ...
PPT File - Abdel Hamid Derm Atlas
... using selective serotonin reuptake inhibitors (SSRIs) which were developed initially to treat psychiatric disorders , are being increasingly used as unlicensed treatment of premature ejaculation based on their side effect of delayed ejaculation ( Medascape news, MNT today) .Some tricyclic antidepres ...
... using selective serotonin reuptake inhibitors (SSRIs) which were developed initially to treat psychiatric disorders , are being increasingly used as unlicensed treatment of premature ejaculation based on their side effect of delayed ejaculation ( Medascape news, MNT today) .Some tricyclic antidepres ...
A Brief History of Great Discoveries in Pharmacology: In Celebration
... because it had the broadest of implications for humankind. I have also limited the number of references cited in order not to detract from the concepts and/or ideas that I hoped to convey. The personal anecdotes and vignettes embedded in these essays are meant to express a reverence for the gifted s ...
... because it had the broadest of implications for humankind. I have also limited the number of references cited in order not to detract from the concepts and/or ideas that I hoped to convey. The personal anecdotes and vignettes embedded in these essays are meant to express a reverence for the gifted s ...
September 30, 2004
... • Alcohol is rapidly absorbed unaltered from the GI tract (mostly small intestine) • Rate of absorption is affected by – Type of beverage – Stomach contents – Absorbed into blood and transported directly to the liver ...
... • Alcohol is rapidly absorbed unaltered from the GI tract (mostly small intestine) • Rate of absorption is affected by – Type of beverage – Stomach contents – Absorbed into blood and transported directly to the liver ...
STABILITY INDICATING RPHPLC METHOD FOR THE DETERMINATION OF TELMISARTAN IN PURE AND PHARMACEUTICAL FORMULATION
... acceptance criteria for specificity, linearity, precision, recovery, ruggedness and robustness. The drug undergoes degradation under acidic, basic, Peroxide and thermal degradation conditions. All the peaks of degraded product were resolved from the active pharmaceutical i ...
... acceptance criteria for specificity, linearity, precision, recovery, ruggedness and robustness. The drug undergoes degradation under acidic, basic, Peroxide and thermal degradation conditions. All the peaks of degraded product were resolved from the active pharmaceutical i ...
Grafting Techniques towards Production of Peptide-Tethered
... The use of peptides as therapeutic agents is restricted by some of their physicochemical properties. The large molecular weight of peptides influences their diffusion through the epithelial layer, which leads to low bioavailability. Moreover, peptides are mostly hydrophilic so the transfer across bi ...
... The use of peptides as therapeutic agents is restricted by some of their physicochemical properties. The large molecular weight of peptides influences their diffusion through the epithelial layer, which leads to low bioavailability. Moreover, peptides are mostly hydrophilic so the transfer across bi ...
Pharmacovigilance of drug allergy and hypersensitivity using
... during ß-lactam treatment (35). The mechanisms involved in most nonimmediate reactions seem to be heterogeneous and are not yet all completely understood (36). However, clinical and immunohistological studies, as well as the analysis of drug-specific T-cell clones obtained from the circulating blood ...
... during ß-lactam treatment (35). The mechanisms involved in most nonimmediate reactions seem to be heterogeneous and are not yet all completely understood (36). However, clinical and immunohistological studies, as well as the analysis of drug-specific T-cell clones obtained from the circulating blood ...
FLURBIPROFEN FAST DISINTEGRATING TABLETS Research Article AMAL S. M. ABU EL-ENIN
... bioavailability. Fast Disintegrating Tablets (FDTs) are solid dosage form containing medicinal substances or active ingredients which disintegrates rapidly within few seconds when placed up on tongue. Some drugs are absorbed from the mouth, pharynx and esophagus as the saliva passes down into the st ...
... bioavailability. Fast Disintegrating Tablets (FDTs) are solid dosage form containing medicinal substances or active ingredients which disintegrates rapidly within few seconds when placed up on tongue. Some drugs are absorbed from the mouth, pharynx and esophagus as the saliva passes down into the st ...
Bridging Studies
... e.g., genetic polymorphism, age, gender, height, weight, lean body mass, body composition, and disease conditions, etc. Extrinsic Ethnic Factors are more social and cultural in nature e.g., environment, culture, medical practice, health insurance, practices in clinical trials or conduct ...
... e.g., genetic polymorphism, age, gender, height, weight, lean body mass, body composition, and disease conditions, etc. Extrinsic Ethnic Factors are more social and cultural in nature e.g., environment, culture, medical practice, health insurance, practices in clinical trials or conduct ...
CBS2005_AMJ - Center for Biological Sequence Analysis
... ….. Another method of biological activity prediction… Observations that modification of some parts of a ligand results in minor changes of activity, whereas modifications of other parts of the ligand result in large change of activity. Pharmacophore element: Atom or functional group essential for bi ...
... ….. Another method of biological activity prediction… Observations that modification of some parts of a ligand results in minor changes of activity, whereas modifications of other parts of the ligand result in large change of activity. Pharmacophore element: Atom or functional group essential for bi ...
St. Xavier`s College – Autonomous Mumbai Syllabus for 3 Semester
... LEARNING OBJECTIVES 1. To introduce students to the basic concepts involved in chemical bonding. 2. To help students to determine the shape of a molecule by applying VSEPR theory. 3. To encourage students to analyze and integrate concepts relevant to inorganic chemistry required to understand compou ...
... LEARNING OBJECTIVES 1. To introduce students to the basic concepts involved in chemical bonding. 2. To help students to determine the shape of a molecule by applying VSEPR theory. 3. To encourage students to analyze and integrate concepts relevant to inorganic chemistry required to understand compou ...
abstracts
... extensively by enzymes in the gastrointestinal tract (GIT). In addition, the large size and water soluble nature of these drugs prevent them from being absorbed through the GIT. For siRNA based therapeutics, another challenge to overcome is the inability of these negatively charge molecules to cross ...
... extensively by enzymes in the gastrointestinal tract (GIT). In addition, the large size and water soluble nature of these drugs prevent them from being absorbed through the GIT. For siRNA based therapeutics, another challenge to overcome is the inability of these negatively charge molecules to cross ...
Chapter 5 - Immune Assist Micron
... culture mycelium and culture broths. In general, there is normally a higher level and number of different polysaccharides extracted from fruit-bodies than from the other cultural sources. As discussed in Chapter 9 an important direction for future studies on mushroom polysaccharides will be by subme ...
... culture mycelium and culture broths. In general, there is normally a higher level and number of different polysaccharides extracted from fruit-bodies than from the other cultural sources. As discussed in Chapter 9 an important direction for future studies on mushroom polysaccharides will be by subme ...
Semester 4 - Vaal University of Technology
... of suitable work integrated learning as well as the prescribed University training must be successfully be completed. To assist the University in assessing the progress of your work integrated learning, you have to report on a continuing basis to the Head of Department: Chemistry The attached logboo ...
... of suitable work integrated learning as well as the prescribed University training must be successfully be completed. To assist the University in assessing the progress of your work integrated learning, you have to report on a continuing basis to the Head of Department: Chemistry The attached logboo ...
OVERVIEW OF CHIRALITY AND CHIRAL DRUGS
... biological matrices or drug targets such as proteins, nucleic acids, and biomembranes (e.g., phospholipids and glycolipids). These biological matrices display complex three-dimensional structures that are capable of recognizing specifically a drug molecule in only one of the many possible arrangemen ...
... biological matrices or drug targets such as proteins, nucleic acids, and biomembranes (e.g., phospholipids and glycolipids). These biological matrices display complex three-dimensional structures that are capable of recognizing specifically a drug molecule in only one of the many possible arrangemen ...
EA_QA312.3_levothyroxineseakelp
... thyroid disorders, mainly hypothyroidism and hyperthyroidism. This effect has been attributed to the iodine contained in these products (1, 2, 4-7). Several case reports about this association have been published (1, 4). Mechanism of Interaction The normal daily iodine requirement ranges from 100 to ...
... thyroid disorders, mainly hypothyroidism and hyperthyroidism. This effect has been attributed to the iodine contained in these products (1, 2, 4-7). Several case reports about this association have been published (1, 4). Mechanism of Interaction The normal daily iodine requirement ranges from 100 to ...
Selective Serotonin Reuptake Inhibitors (SSRIs) with Dual
... The strategy of designing virtual hybrid molecules combining the pharmacophoric profiles of 5-HT reuptake inhibition with 5HT1B/1D antagonism in one molecule can be conducted via: I) Modification of already existed hybrid molecules previously made by other research groups or II) the tethering techni ...
... The strategy of designing virtual hybrid molecules combining the pharmacophoric profiles of 5-HT reuptake inhibition with 5HT1B/1D antagonism in one molecule can be conducted via: I) Modification of already existed hybrid molecules previously made by other research groups or II) the tethering techni ...
List of projects (*, 98 Kb)
... clinical trials. The product is a medical preparation of patient’s blood, processed by a special technique, which is intended for stimulation of patient’s antitumor immune response. As a result of a project, a new method of personalized immune therapy of breast cancer will be introduced to the servi ...
... clinical trials. The product is a medical preparation of patient’s blood, processed by a special technique, which is intended for stimulation of patient’s antitumor immune response. As a result of a project, a new method of personalized immune therapy of breast cancer will be introduced to the servi ...
Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Later chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that have a desirable therapeutic effect in a process known as classical pharmacology. Since sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy.Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability. Once a compound that fulfills all of these requirements has been identified, it will begin the process of drug development prior to clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design. Modern drug discovery is thus usually a capital-intensive process that involves large investments by pharmaceutical industry corporations as well as national governments (who provide grants and loan guarantees). Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, ""expensive, difficult, and inefficient process"" with low rate of new therapeutic discovery. In 2010, the research and development cost of each new molecular entity (NME) was approximately US$1.8 billion. Drug discovery is done by pharmaceutical companies, with research assistance from universities. The ""final product"" of drug discovery is a patent on the potential drug. The drug requires very expensive Phase I, II and III clinical trials, and most of them fail. Small companies have a critical role, often then selling the rights to larger companies that have the resources to run the clinical trials.Discovering drugs that may be a commercial success, or a public health success, involves a complex interaction between investors, industry, academia, patent laws, regulatory exclusivity, marketing and the need to balance secrecy with communication. Meanwhile, for disorders whose rarity means that no large commercial success or public health effect can be expected, the orphan drug funding process ensures that people who experience those disorders can have some hope of pharmacotherapeutic advances.