Decreased cohesin in the brain leads to defective synapse
... expression analysis to identify the genes responsible for the phenotype, beginning with RNA-sequencing of cortical tissue samples from postnatal day 1 (P1) Smc3+/+ or Smc3+/− mice (Fig. 8 A and Table S1). We then focused on the time course of expression during dendritic formation (P1–P21). We found ...
... expression analysis to identify the genes responsible for the phenotype, beginning with RNA-sequencing of cortical tissue samples from postnatal day 1 (P1) Smc3+/+ or Smc3+/− mice (Fig. 8 A and Table S1). We then focused on the time course of expression during dendritic formation (P1–P21). We found ...
neuropathology of dopamine systems in schizophrenia
... dopaminergic neurons. This pigmentation is due to the presence of neuromelanin, which is a byproduct of the metabolism of dopamine, giving the SN its distinct dark color (Double et al., 2000; Zecca et al., 2008). Within this mesodiencephalic dopaminergic complex, the VTA is located medial to the SN, ...
... dopaminergic neurons. This pigmentation is due to the presence of neuromelanin, which is a byproduct of the metabolism of dopamine, giving the SN its distinct dark color (Double et al., 2000; Zecca et al., 2008). Within this mesodiencephalic dopaminergic complex, the VTA is located medial to the SN, ...
Mechanisms of Sleep Control - UCLA Integrative Center for
... In NREM sleep, the role of the raphe system, the midline serotonergic system of the brainstem, remains unclear. Depletion of serotonin with the synthesis inhibitor /7chlorophenylalanine (PCPA) produces insomnia that can be rapidly reversed by injection of the serotonin precursor tryptophan (Pujol et ...
... In NREM sleep, the role of the raphe system, the midline serotonergic system of the brainstem, remains unclear. Depletion of serotonin with the synthesis inhibitor /7chlorophenylalanine (PCPA) produces insomnia that can be rapidly reversed by injection of the serotonin precursor tryptophan (Pujol et ...
Curriculum Vitae - Laureate Institute for Brain Research
... I am a Professor in Residence in the Department of Psychiatry at the University of California San Diego (UCSD) and the Director of Telemental Health at the Veterans Affairs San Diego Health Care System (VASDHS). My research focuses on the interface between interoception, i.e. the processing of senso ...
... I am a Professor in Residence in the Department of Psychiatry at the University of California San Diego (UCSD) and the Director of Telemental Health at the Veterans Affairs San Diego Health Care System (VASDHS). My research focuses on the interface between interoception, i.e. the processing of senso ...
Rewarding properties of sildenafil citrate in mice
... and guanylyl cyclase inhibitor MB on sildenafilinduced place preference conditioning was assessed. In the first part of the experiment, animals received saline (10 ml/ kg, i.p.), MB (0.5, 1, and 2 mg/kg, i.p.), or L-NAME (1, 5, and 10 mg/kg, i.p.) 30 min before confinement to the conditioning appara ...
... and guanylyl cyclase inhibitor MB on sildenafilinduced place preference conditioning was assessed. In the first part of the experiment, animals received saline (10 ml/ kg, i.p.), MB (0.5, 1, and 2 mg/kg, i.p.), or L-NAME (1, 5, and 10 mg/kg, i.p.) 30 min before confinement to the conditioning appara ...
PDF - Bentham Open
... an exaggerated emotional response to threats [11, 32, 33]. For example, prior work has shown that participants with low trait anxiety exhibit greater vmPFC activation compared to participants with high trait anxiety during cued fear conditioning [34]. In contrast, individuals with high trait anxiety ...
... an exaggerated emotional response to threats [11, 32, 33]. For example, prior work has shown that participants with low trait anxiety exhibit greater vmPFC activation compared to participants with high trait anxiety during cued fear conditioning [34]. In contrast, individuals with high trait anxiety ...
Full-Text PDF
... inferior temporal cortex, and temporo-occipital area [47]. It is also associated with the insula [48], posterior parietal cortex [49], medial frontal cortex [49,50], superior temporal gyrus [51], and cingulate gyrus [50]. Most of these structures are involved in conscious processing of emotions and ...
... inferior temporal cortex, and temporo-occipital area [47]. It is also associated with the insula [48], posterior parietal cortex [49], medial frontal cortex [49,50], superior temporal gyrus [51], and cingulate gyrus [50]. Most of these structures are involved in conscious processing of emotions and ...
Extracellular Glutamate, Glutamine, and GABA in the Hippocampus
... patients) after their AEDs were tapered. The samples were analyzed with high performance liquid chromatography (HPLC) for glutamate, glutamine and GABA levels. Data were log-transformed and compared by ANOVA or multiple t-tests with a Bonferroni correction, where appropriate. In the cortex, glutamat ...
... patients) after their AEDs were tapered. The samples were analyzed with high performance liquid chromatography (HPLC) for glutamate, glutamine and GABA levels. Data were log-transformed and compared by ANOVA or multiple t-tests with a Bonferroni correction, where appropriate. In the cortex, glutamat ...
Circadian clocks in crustaceans: identified neuronal and cellular systems
... recordings from isolated brain-eyestalk preparations have demonstrated circadian multiunit activities and visual evoked potential ...
... recordings from isolated brain-eyestalk preparations have demonstrated circadian multiunit activities and visual evoked potential ...
1
... highlighted the importance of neurobiological factors in ADHD pathophysiology. In this sense, converging data from different studies point to ADHD abnormalities in fronto-striatal networks produced by dysfunctions in the DA system (Swanson et al. 2007). Structural neuroimaging studies partially supp ...
... highlighted the importance of neurobiological factors in ADHD pathophysiology. In this sense, converging data from different studies point to ADHD abnormalities in fronto-striatal networks produced by dysfunctions in the DA system (Swanson et al. 2007). Structural neuroimaging studies partially supp ...
... developmentally excessive levels of inattention, impulsivity and hyperactivity. ADHD occurs in 8 to 12% of school age children worldwide; the majority (60%-85%) continues to meet criteria for the disorder during their teenage years. Volumetric studies in children with Attention-Deficit/Hyperactivity ...
The Brain and Cranial Nerves
... – extends into ventricle from each side Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings ...
... – extends into ventricle from each side Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings ...
Document
... prostaglandins diffuse into interstitial fluid of brain and spinal cord Astrocytes control blood–brain barrier by releasing chemicals that control permeability of endothelium Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings ...
... prostaglandins diffuse into interstitial fluid of brain and spinal cord Astrocytes control blood–brain barrier by releasing chemicals that control permeability of endothelium Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings ...
Structure and Function of the Brain Serotonin System
... Before proceeding, it is important to obtain some general feeling for the numbers involved when we discuss 5-HT anatomy in the CNS. It may seem somewhat surprising that so much has been written about so little, i.e., the neurons in the entire mammalian CNS number in the billions, whereas serotonergi ...
... Before proceeding, it is important to obtain some general feeling for the numbers involved when we discuss 5-HT anatomy in the CNS. It may seem somewhat surprising that so much has been written about so little, i.e., the neurons in the entire mammalian CNS number in the billions, whereas serotonergi ...
The Anatomy of the Posterior Commissure
... to consist of long tracts connecting the visual areas of the occipital lobe with the anterior lobe, possibly playing a role in visual memory. We also observed in our study that the frontotemporooccipitopontine fibers connect with the posterior commissure. However, the anatomical differences between ...
... to consist of long tracts connecting the visual areas of the occipital lobe with the anterior lobe, possibly playing a role in visual memory. We also observed in our study that the frontotemporooccipitopontine fibers connect with the posterior commissure. However, the anatomical differences between ...
frontal functions, connectivity and neural efficiency underpinning
... This differential pattern between the two types of verbal fluency generation was replicated by Kallio et al. (2001). They also found that the reduction in fluency correlated positively with hypnotic susceptibility, and also with interference on the Stroop conflict task, a task also shown to involve ...
... This differential pattern between the two types of verbal fluency generation was replicated by Kallio et al. (2001). They also found that the reduction in fluency correlated positively with hypnotic susceptibility, and also with interference on the Stroop conflict task, a task also shown to involve ...
Idiom comprehension deficits in relation to corpus
... 1990), and congenital mental retardation (Ezell & Goldstein, 1991). Idiom comprehension deWcits have also been observed in children with more general, behaviorally deWned, cognitive and learning impairments, such as Language/Learning-Disability (Secord & Wiig, 1993). The diversity of idiom impairmen ...
... 1990), and congenital mental retardation (Ezell & Goldstein, 1991). Idiom comprehension deWcits have also been observed in children with more general, behaviorally deWned, cognitive and learning impairments, such as Language/Learning-Disability (Secord & Wiig, 1993). The diversity of idiom impairmen ...
Final Paper - The Oxbow School
... project was created to allow me to delve further into my fascination with this subject, and begin to understand the phenomenon that is synesthesia. This past year, I was tested for learning disorders, and found out that I have a prominent case of ADHD, which I had been learning to cope with for most ...
... project was created to allow me to delve further into my fascination with this subject, and begin to understand the phenomenon that is synesthesia. This past year, I was tested for learning disorders, and found out that I have a prominent case of ADHD, which I had been learning to cope with for most ...
Signal processing methods in Sleep Research
... Slow wave sleep predominates in the first third of the night and is linked to the initiation of sleep. REM sleep predominates in the last 3rd of the night. Wakefulness in sleep usually accounts for less than 5% of the night. N1 generally constitutes 2 to 5% of sleep. N2 generally constitutes 45 to 5 ...
... Slow wave sleep predominates in the first third of the night and is linked to the initiation of sleep. REM sleep predominates in the last 3rd of the night. Wakefulness in sleep usually accounts for less than 5% of the night. N1 generally constitutes 2 to 5% of sleep. N2 generally constitutes 45 to 5 ...
Here follows a list of recently published papers
... Raphe serotonin neuron-specific oxytocin receptor knockout reduces aggression without affecting anxie... http://ow.ly/2VxdNR " Neurons Constantly Rewrite Their DNA http://neurosciencenews.com/tet3-neuron-dna-genetics-2001 … ...
... Raphe serotonin neuron-specific oxytocin receptor knockout reduces aggression without affecting anxie... http://ow.ly/2VxdNR " Neurons Constantly Rewrite Their DNA http://neurosciencenews.com/tet3-neuron-dna-genetics-2001 … ...
A Critical Review of Secondary Neurodegeneration
... molecular structure that allows it to assume a large variety of configurations within the central nervous system, each of which appears to result in quite distinct biological effects [13,14]. This issue of specificity with respect to configuration state of amyloid-β is not simply academic matter for ...
... molecular structure that allows it to assume a large variety of configurations within the central nervous system, each of which appears to result in quite distinct biological effects [13,14]. This issue of specificity with respect to configuration state of amyloid-β is not simply academic matter for ...
Dokument_1 - KLUEDO - Technische Universität Kaiserslautern
... (review: Illing et al., 2000). It consists of several nuclei, and the main ones are the medial nucleus of the trapezoid body (MNTB), the medial superior olive (MSO), the lateral superior olive (LSO), and the superior paraolivary nucleus (SPN) (Fig. 1.2). The MNTB is one of the most prominent structu ...
... (review: Illing et al., 2000). It consists of several nuclei, and the main ones are the medial nucleus of the trapezoid body (MNTB), the medial superior olive (MSO), the lateral superior olive (LSO), and the superior paraolivary nucleus (SPN) (Fig. 1.2). The MNTB is one of the most prominent structu ...
Nicotine injections into the ventral tegmental area increase
... nicotinic receptor activation [3]. Nicotine has also been found to stimulate DA release from accumbal synaptosomes [40] and when directly administered into the NAc the drug has been found to increase extracellular concentrations of DA [26,32]. However, several studies indicate that stimulation of DA ...
... nicotinic receptor activation [3]. Nicotine has also been found to stimulate DA release from accumbal synaptosomes [40] and when directly administered into the NAc the drug has been found to increase extracellular concentrations of DA [26,32]. However, several studies indicate that stimulation of DA ...
Document
... dynamic, constantly changing environment. Only those organisms with the necessary attributes to adapt were able to reproduce successfully and spread their genes forward in the tree of life. Many of the challenges facing living organisms from those early days up to the present are due to chance and u ...
... dynamic, constantly changing environment. Only those organisms with the necessary attributes to adapt were able to reproduce successfully and spread their genes forward in the tree of life. Many of the challenges facing living organisms from those early days up to the present are due to chance and u ...
Paper
... then reconstructed into a 3D triangular mesh (Figure 1B), using the program CARET (Van Essen et al., 2001). The lateral view of this 3-dimensional model was then traced and smoothed in Illustrator, and overlaid with a 200 × 200 µm square grid, which was used as a template for plotting cells from eac ...
... then reconstructed into a 3D triangular mesh (Figure 1B), using the program CARET (Van Essen et al., 2001). The lateral view of this 3-dimensional model was then traced and smoothed in Illustrator, and overlaid with a 200 × 200 µm square grid, which was used as a template for plotting cells from eac ...