Temporal modulation of the dynamics of neuronal networks with
... This dissertation re ects in rst place the in uence of the many people who, throughout my life, have shaped and nurtured my mind. Among them were rst my parents and my grand-parents, but also the many teachers who have been giving me the tools to think, and to express my thoughts. I would like to ...
... This dissertation re ects in rst place the in uence of the many people who, throughout my life, have shaped and nurtured my mind. Among them were rst my parents and my grand-parents, but also the many teachers who have been giving me the tools to think, and to express my thoughts. I would like to ...
THE ELECTRODE-TISSUE INTERFACE DURING RECORDING
... such an amazing friend and for helping me through all of this. Dr. B. thanks for being a great advisor and friend. I have learned a lot from you and I appreciate that you still help me to this day. Maybe one day we can actually estimate cell membrane capacitance. ...
... such an amazing friend and for helping me through all of this. Dr. B. thanks for being a great advisor and friend. I have learned a lot from you and I appreciate that you still help me to this day. Maybe one day we can actually estimate cell membrane capacitance. ...
Relative Contributions of Specific Activity Histories and
... Indeed, overwhelming experimental evidence supports the idea that synaptic properties are affected by the history of their activation. What is less established and often ignored is the "flip side" of synaptic plasticity: that is, the implicit supposition that synapses, when not driven to change thei ...
... Indeed, overwhelming experimental evidence supports the idea that synaptic properties are affected by the history of their activation. What is less established and often ignored is the "flip side" of synaptic plasticity: that is, the implicit supposition that synapses, when not driven to change thei ...
Zebrafish Get Connected: Investigating Neurotransmission Targets
... pathways are highlighted. We also review techniques for evaluating neurological function, including the measurement of neurotransmitter levels, assessment of gene expression through transcriptomic analysis, and the recording of neurobehavior. Finally examples of chemical toxicity studies evaluating ...
... pathways are highlighted. We also review techniques for evaluating neurological function, including the measurement of neurotransmitter levels, assessment of gene expression through transcriptomic analysis, and the recording of neurobehavior. Finally examples of chemical toxicity studies evaluating ...
Modulation of premotor circuits controlling locomotor activity by
... effortless to the point that many movements are almost executed unconsciously. Indeed, the generation of sophisticated motor behaviors relies on the complex interplay between supraspinal brain structures and circuits in the spinal cord. Understanding how the central nervous system generates a large ...
... effortless to the point that many movements are almost executed unconsciously. Indeed, the generation of sophisticated motor behaviors relies on the complex interplay between supraspinal brain structures and circuits in the spinal cord. Understanding how the central nervous system generates a large ...
Muscle tone regulation during REM sleep
... vlPAG-LPT and SLD in rats (Lu et al., 2006). As the vlPAG-LPT GABAergic neurons project to the cLDT-SLD, and GABAergic neurons in the cLDTSLD express cFos following enhanced REM sleep, we proposed that these two neuronal populations inhibit each other, and that this mutual inhibition produces state ...
... vlPAG-LPT and SLD in rats (Lu et al., 2006). As the vlPAG-LPT GABAergic neurons project to the cLDT-SLD, and GABAergic neurons in the cLDTSLD express cFos following enhanced REM sleep, we proposed that these two neuronal populations inhibit each other, and that this mutual inhibition produces state ...
Potential switch from eupnea to fictive gasping after blockade of
... 21, 49), activates persistent sodium channels (13, 15, 17), and induces an augmentation of the extracellular concentration of potassium ions (24). Previous experimental and computational studies have demonstrated that an increase in the external potassium concentration may release endogenous pacemak ...
... 21, 49), activates persistent sodium channels (13, 15, 17), and induces an augmentation of the extracellular concentration of potassium ions (24). Previous experimental and computational studies have demonstrated that an increase in the external potassium concentration may release endogenous pacemak ...
Axonal degeneration as a therapeutic target in the CNS | SpringerLink
... neurotraumatic disorders. We discuss the basic morphological and temporal modalities of axonal degeneration (acute, chronic and focal axonal degeneration and Wallerian degeneration). Based on the mechanistic concepts, we then delineate in detail the major molecular mechanisms that underlie the degen ...
... neurotraumatic disorders. We discuss the basic morphological and temporal modalities of axonal degeneration (acute, chronic and focal axonal degeneration and Wallerian degeneration). Based on the mechanistic concepts, we then delineate in detail the major molecular mechanisms that underlie the degen ...
Electroencephalography - Department of Computational and
... fMRI have time resolution between seconds and minutes. EEG measures the brain's electrical activity directly, while other methods record changes in blood flow (e.g., SPECT, fMRI) or metabolic activity (e.g., PET), which are indirect markers of brain electrical activity. EEG can be used simultaneousl ...
... fMRI have time resolution between seconds and minutes. EEG measures the brain's electrical activity directly, while other methods record changes in blood flow (e.g., SPECT, fMRI) or metabolic activity (e.g., PET), which are indirect markers of brain electrical activity. EEG can be used simultaneousl ...
The basal forebrain cholinergic projection system in mice. In
... the basal forebrain and are divided into several subtypes based on their morphology, spontaneous or evoked firing pattern, and neuromodulatory function. Various CBPs are often co-expressed in a high percentage of GABAergic neurons in the cortex and hippocampus and serve to distinguish subpopulations ...
... the basal forebrain and are divided into several subtypes based on their morphology, spontaneous or evoked firing pattern, and neuromodulatory function. Various CBPs are often co-expressed in a high percentage of GABAergic neurons in the cortex and hippocampus and serve to distinguish subpopulations ...
The Basal Forebrain Cholinergic Projection
... the basal forebrain and are divided into several subtypes based on their morphology, spontaneous or evoked firing pattern, and neuromodulatory function. Various CBPs are often co-expressed in a high percentage of GABAergic neurons in the cortex and hippocampus and serve to distinguish subpopulations ...
... the basal forebrain and are divided into several subtypes based on their morphology, spontaneous or evoked firing pattern, and neuromodulatory function. Various CBPs are often co-expressed in a high percentage of GABAergic neurons in the cortex and hippocampus and serve to distinguish subpopulations ...
1 - Test Bank
... 39. Recent evidence suggests that glial cells and astrocytes may play an important role in ________. a. learning and memory b. endocrine functioning c. maturation and aging d. growth and metabolic regulation Answer: a Difficulty: 3 Page Reference: 43 Topic: Neurons: The Messengers Skill: F ...
... 39. Recent evidence suggests that glial cells and astrocytes may play an important role in ________. a. learning and memory b. endocrine functioning c. maturation and aging d. growth and metabolic regulation Answer: a Difficulty: 3 Page Reference: 43 Topic: Neurons: The Messengers Skill: F ...
Neural mechanism of rapid eye movement sleep generation
... REM sleep are apparently similar to that observed during wakefulness. The autonomic tone increases resulting in fast and irregular respiration, increased heart rate and elevated brain temperature. The brain glucose metabolism increases significantly in the thalamus, the limbic system and the pontine ...
... REM sleep are apparently similar to that observed during wakefulness. The autonomic tone increases resulting in fast and irregular respiration, increased heart rate and elevated brain temperature. The brain glucose metabolism increases significantly in the thalamus, the limbic system and the pontine ...
The physiological role of orexin/hypocretin neurons in the regulation
... and Aston-Jones, 2012). Given that inputs to orexin neurons are so anatomically varied and associated with multiple functions, it might be reasonable to hypothesize the existence of subgroups of orexin neurons. Indeed, anterograde tracers injected into the DR marked the lateral LHA preferentially, w ...
... and Aston-Jones, 2012). Given that inputs to orexin neurons are so anatomically varied and associated with multiple functions, it might be reasonable to hypothesize the existence of subgroups of orexin neurons. Indeed, anterograde tracers injected into the DR marked the lateral LHA preferentially, w ...
ATLAS OF FUNCTIONAL NEUROANATOMY
... color coding is included after the list of illustrations.) Much of the subject matter’s difficulty is terminology — complex, difficult to spell, sometimes inconsistent, with a Latin base, and sometimes with names of individuals (used often by neurologists, neurosurgeons, and neuroradiologists). A gl ...
... color coding is included after the list of illustrations.) Much of the subject matter’s difficulty is terminology — complex, difficult to spell, sometimes inconsistent, with a Latin base, and sometimes with names of individuals (used often by neurologists, neurosurgeons, and neuroradiologists). A gl ...
Curriculum Vitae - Laureate Institute for Brain Research
... I am a Professor in Residence in the Department of Psychiatry at the University of California San Diego (UCSD) and the Director of Telemental Health at the Veterans Affairs San Diego Health Care System (VASDHS). My research focuses on the interface between interoception, i.e. the processing of senso ...
... I am a Professor in Residence in the Department of Psychiatry at the University of California San Diego (UCSD) and the Director of Telemental Health at the Veterans Affairs San Diego Health Care System (VASDHS). My research focuses on the interface between interoception, i.e. the processing of senso ...
Cholinergic Cells and Pathways
... employing it successfully (see below, section C). Then an immunocytochemical method was developed for detection of ACh (Geffard et al., 1985); of course, this technique would be most useful in definitive identification of cholinergic neurons and pathways, but there was no follow-up with regard to its ...
... employing it successfully (see below, section C). Then an immunocytochemical method was developed for detection of ACh (Geffard et al., 1985); of course, this technique would be most useful in definitive identification of cholinergic neurons and pathways, but there was no follow-up with regard to its ...
1
... Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disease characterized by symptoms of inattention, hyperactivity and impulsivity. Converging data from different studies point to ADHD abnormalities in fronto-striatal circuits. Structural neuroimaging studies partially support f ...
... Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disease characterized by symptoms of inattention, hyperactivity and impulsivity. Converging data from different studies point to ADHD abnormalities in fronto-striatal circuits. Structural neuroimaging studies partially support f ...
Neurological characterization of mice deficient in GSK3α highlight
... with viability of GSK3α deficient mice [21]. This extreme difference in outcome demonstrates their non-redundant physiological functions, which still need to be detailed in vivo. Neurobiological analysis of GSK3α, particularly in AD remains fragmented and debated [22-25]. The contribution of GSK3β t ...
... with viability of GSK3α deficient mice [21]. This extreme difference in outcome demonstrates their non-redundant physiological functions, which still need to be detailed in vivo. Neurobiological analysis of GSK3α, particularly in AD remains fragmented and debated [22-25]. The contribution of GSK3β t ...
Extracellular Glutamate, Glutamine, and GABA in the Hippocampus
... Medication-Resistant Epilepsy: Drug-resistant epilepsy is a significant public health concern. It is associated with a mortality rate five times greater than the general population (4) and with psychiatric comorbidities, social disability, and a reduced quality of life (5). The type of epilepsy pred ...
... Medication-Resistant Epilepsy: Drug-resistant epilepsy is a significant public health concern. It is associated with a mortality rate five times greater than the general population (4) and with psychiatric comorbidities, social disability, and a reduced quality of life (5). The type of epilepsy pred ...
Mechanisms of Sleep Control - UCLA Integrative Center for
... Raphe—Locus ceruleus—Basal forebrain—Acetylcholine—Norepi-nephrine. ...
... Raphe—Locus ceruleus—Basal forebrain—Acetylcholine—Norepi-nephrine. ...
Corpus Callosum
... corpus callosum function definition anatomy body maps - the brain is divided into the right and left hemisphere and the two halves are connected by the corpus callosum this bundle of nerve tissue contains over 200, corpus callosum and brain function thoughtco - corpus callosum location directionally ...
... corpus callosum function definition anatomy body maps - the brain is divided into the right and left hemisphere and the two halves are connected by the corpus callosum this bundle of nerve tissue contains over 200, corpus callosum and brain function thoughtco - corpus callosum location directionally ...
View PDF - MRC Brain Network Dynamics Unit
... Electrical stimulation of the cortex and thalamus. Parallel, bipolar stimulating electrodes (constructed from nylon-coated stainless steel wires; California Fine Wire) with tip diameters of ⬃100 m, a tip separation of ⬃150 m, and an impedance of ⬃10 k⍀ were implanted into the ipsilateral frontal c ...
... Electrical stimulation of the cortex and thalamus. Parallel, bipolar stimulating electrodes (constructed from nylon-coated stainless steel wires; California Fine Wire) with tip diameters of ⬃100 m, a tip separation of ⬃150 m, and an impedance of ⬃10 k⍀ were implanted into the ipsilateral frontal c ...
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau
... propagating tau species via differential centrifugation and sizeexclusion chromatography (SEC), characterized it biochemically, and then studied its neuronal uptake in mouse primary cortical neurons and in vivo. For all different sources of tau, efficient uptake was only observed for high-molecular-w ...
... propagating tau species via differential centrifugation and sizeexclusion chromatography (SEC), characterized it biochemically, and then studied its neuronal uptake in mouse primary cortical neurons and in vivo. For all different sources of tau, efficient uptake was only observed for high-molecular-w ...
Apparent Loss and Hypertrophy of Interneurons in a Mouse Model
... Septal reg ion. The number of PV-expressing GABAergic neurons and ChAT-expressing cholinergic neurons in the septal region were determined in an unbiased manner using the optical dissector method in combination with the C avalieri method for estimating reference volume (West and Gundersen, 1990). Th ...
... Septal reg ion. The number of PV-expressing GABAergic neurons and ChAT-expressing cholinergic neurons in the septal region were determined in an unbiased manner using the optical dissector method in combination with the C avalieri method for estimating reference volume (West and Gundersen, 1990). Th ...
Connectome
A connectome is a comprehensive map of neural connections in the brain, and may be thought of as its ""wiring diagram"". More broadly, a connectome would include the mapping of all neural connections within an organism's nervous system.The production and study of connectomes, known as connectomics, may range in scale from a detailed map of the full set of neurons and synapses within part or all of the nervous system of an organism to a macro scale description of the functional and structural connectivity between all cortical areas and subcortical structures. The term ""connectome"" is used primarily in scientific efforts to capture, map, and understand the organization of neural interactions within the brain.Research has successfully constructed the full connectome of one animal: the roundworm C. elegans (White et al., 1986, Varshney et al., 2011). Partial connectomes of a mouse retina and mouse primary visual cortex have also been successfully constructed. Bock et al.'s complete 12TB data set is publicly available at Open Connectome Project.The ultimate goal of connectomics is to map the human brain. This effort is pursued by the Human Connectome Project, sponsored by the National Institutes of Health, whose focus is to build a network map of the human brain in healthy, living adults.