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Principles of Neural Science
Principles of Neural Science

... Electrical synaptic transmission was first described in the giant motor synapse of the crayfish, where the presynaptic fiber is much larger than the postsynaptic fiber (Figure 10-2A). An action potential generated in the presynaptic fiber produces a depolarizing post- synaptic potential that is ofte ...
Overview
Overview

... How does your nervous system function and why is it so important to protect our nervous system? ...
Mechanisms of Neuropathic Pain - International Association for the
Mechanisms of Neuropathic Pain - International Association for the

VI. The vertebrate nervous system is a hierarchy of structural and
VI. The vertebrate nervous system is a hierarchy of structural and

... branched to increase surface area where the cell is most likely to be stimulated. ⇒ Axons conduct impulses away from the cell body; are long, single processes. ◊ Vertebrate axons in PNS are wrapped in concentric layers of Schwann cells which form an insulating myelin sheath. ◊ Axons extend from the ...
Gene Section MST1R (Macrophage stimulating 1 receptor) Atlas of Genetics and Cytogenetics
Gene Section MST1R (Macrophage stimulating 1 receptor) Atlas of Genetics and Cytogenetics

... fraction of complement, but RON/MSP complex has a much broader spectrum of activity. Ligand-stimulated RON activates the pathways regulating cell adhesion and motility, growth and survival. STK (the mouse ortholog) is essential for peri-implantation development during gestation, as STK-deficient mic ...
Nervous System Outline
Nervous System Outline

... Action potentials, or nerve impulses, are: • Electrical impulses carried along the length of axons • Always the same regardless of stimulus • The underlying functional feature of the nervous system ...
Inquiry into Life, Eleventh Edition
Inquiry into Life, Eleventh Edition

... – Memories are stored in bits and pieces in association areas – Hippocampus pulls these all together to allow us to recall them all as a single event – Amygdala is responsible for emotions associated with some memories ...
Chapter 1
Chapter 1

... – Thermal pain receptors: respond to extreme heat/cold. – Mechanical pain receptors: respond to intense stimulation like pinching/cutting. – Polymodal pain receptors: activated by • both thermal and mechanical stimuli • chemicals released when tissue is injured. ...
Time cited
Time cited

... Abstract: Neurotrophic factors, such as nerve growth factor and brain-derived neurotrophic factor, are members of the structurally related neurotrophin family that play important roles in pain modulation. Although there are also indications for the involvement of glial cell line-derived neurotrophic ...
Making Sense Of Human Pheromones: Receptors, Physiology, and
Making Sense Of Human Pheromones: Receptors, Physiology, and

... with each other, which produces a specific reaction in the receptive animals. Many pheromones are divided by their functions, particularly how they induce the receptive animals to react to the chemosensory stimulation. In animal sexual pheromones, both sexes release pheromones that advertise their s ...
Structural Biochemistry/Cell Signaling Pathways/Nervous System
Structural Biochemistry/Cell Signaling Pathways/Nervous System

... The myelin sheath surrounding axons is critical to the propagation of action potentials. It essentially serves to maintain conductivity; without it, action potentials would travel much more slowly (so, for example, you would not be able to feel something hit you until after several seconds). This al ...
The Nervous System
The Nervous System

... They both have sensory and motor neurons. The PNS is divided into two systems that help to maintain 5 ...
Autonomic
Autonomic

...  digestion is ceased,  your liver ramps up glucose release,  your pupils dilate,  salivary production decreases,  sweat increases. ...
2/pg
2/pg

... • How can we determine if a neurotransmitter is used in a particular neural pathway? • Identify presence of synthetic enzyme Fig 1.8 • Technique: antibody labeling – immunocytochemistry – immunofluorescence ...
An octopaminergic system in the CNS of the snails, Lymnaea
An octopaminergic system in the CNS of the snails, Lymnaea

... feeding response of animals was monitored. Snails which received 25-50 mg/kg phentolamine did not start feeding in sucrose, and the same dose of NC-7 reduced the number of feeding animals by 80-90 percent 1-3 hours after injection. DCDM treatment reduced feeding by 20-60 percent. Additionally, both ...
Characterization of a conformationally sensitive TOAC spin
Characterization of a conformationally sensitive TOAC spin

... coupled to the receptor, and a high-affinity state, where the receptor is pre-coupled to the G-protein [25]. In addition, recent work in the b2 adernergic receptor and the neurokinin 2 receptor [37,51], show that GPCRs can adopt multiple ligandspecific conformations [14,25,26]. This feature provides ...
Area of Study 2: Detecting and Responding
Area of Study 2: Detecting and Responding

... Traditionally drugs have been discovered and improved through trial and error experimentation. Rational drug design, is the inventive process of finding new medications based on the knowledge of the biological target. The drug is most commonly an organic small molecule which activates or inhibits th ...
Dopaminergic Transmission and Wake
Dopaminergic Transmission and Wake

... Several groups of dopamine neurons are located in the hypothalamus (A11–A15) but little is known about them with regards to control of the sleep-wake cycle. One study suggested increased activity of the A11 cell group during REM sleep deprivation suggesting they are wake-active (Leger et al. 2010). ...
EGardner-pain path g..
EGardner-pain path g..

... C fibers (unmyelinated free nerve endings) Respond to heat, pinch and cold (HPC receptors) Express TRPV1, TRPA1 and other TRP receptors Respond to irritant chemicals ...
SCENTS AND SENSIBILITY: A MOLECULAR LOGIC OF OLFACTORY PERCEPTION
SCENTS AND SENSIBILITY: A MOLECULAR LOGIC OF OLFACTORY PERCEPTION

... The completed sequence of both the murine and human genome ultimately identified 1300 odorant receptors in the mouse (12,13) and 500 in humans (14,15,16). If mice possess 20,000 genes, then as much as 5% of the genome, one in 20 genes encodes the odorant receptors. A large family of odorant receptor ...
Common Neurotransmitters: Criteria for Neurotransmitters, Key
Common Neurotransmitters: Criteria for Neurotransmitters, Key

... Abstract: The criteria, key locations, classifications and functions of common neuro transmitters is reviewed and discussed. Neurotransmitters are the brain chemicals that communicate information throughout our brain and body. They relay signals between neurons. To be neurotransmitter the molecule m ...
10.6: Cell Membrane Potential
10.6: Cell Membrane Potential

... • If a neuron axon responds at all, it responds completely – with an action potential (nerve impulse) • A nerve impulse is conducted whenever a stimulus of threshold intensity or above is applied to an axon • All impulses carried on an axon are the same strength ...
Linking Genetically Defined Neurons to Behavior through a Broadly
Linking Genetically Defined Neurons to Behavior through a Broadly

... GFPtox and 5HT immunodetection (Figures 3A–3H and S4). Furthermore, immunocytochemical analyses revealed that the serotonin (5HT)-positive axon varicosities, typical of serotonergic neurons (Maley and Elde, 1982), were enlarged in triple transgenics as compared to controls (Figure 3H versus 3D, 5HT ...
Unit 1 – Nervous and Endocrine System
Unit 1 – Nervous and Endocrine System

... Topic 2 – Role of hormones in Homeostasis a. Explain the metabolic roles hormones may play in homeostasis; i.e., thyroxine in metabolism; insulin, glucagon and cortisol in blood sugar regulation; hGH in growth; ADH in water regulation; aldosterone in sodium ion regulation b. Explain how the endocrin ...
Dopamine: a potential substrate for synaptic plasticity and memory
Dopamine: a potential substrate for synaptic plasticity and memory

... 2.1. Pharmacological evidence for a modulatory dopamine input of different LTPs . . . . . . . . . . . . 2.1.1. The hippocampal formation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.1.2. Dopamine receptors and LTP in the striatum . . . . ...
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Endocannabinoid system

The endocannabinoid system is a group of neuromodulatory lipids and their receptors in the brain that are involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory; it mediates the psychoactive effects of cannabis and, broadly speaking, includes: The endogenous arachidonate-based lipids, anandamide (N-arachidonoylethanolamide, AEA) and 2-arachidonoylglycerol (2-AG); these are known as ""endocannabinoids"" and are physiological ligands for the cannabinoid receptors. Endocannabinoids are all eicosanoids. The enzymes that synthesize and degrade the endocannabinoids, such as fatty acid amide hydrolase or monoacylglycerol lipase. The cannabinoid receptors CB1 and CB2, two G protein-coupled receptors that are located in the central and peripheral nervous systems.The neurons, neural pathways, and other cells where these molecules, enzymes, and one or both cannabinoid receptor types are all colocalized form the endocannabinoid system.The endocannabinoid system has been studied using genetic and pharmacological methods. These studies have revealed that cannabinoids act as neuromodulators for a variety of processes, including motor learning, appetite, and pain sensation, among other cognitive and physical processes. The localization of the CB1 receptor in the endocannabinoid system has a very large degree of overlap with the orexinergic projection system, which mediates many of the same functions, both physical and cognitive. Moreover, CB1 is colocalized on orexin projection neurons in the lateral hypothalamus and many output structures of the orexin system, where the CB1 and orexin receptor 1 (OX1) receptors physically and functionally join together to form the CB1–OX1 receptor heterodimer.
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