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... Click here for publications related to neuropeptides The long term goal of this project is to identify factors that regulate secretion of neuropeptides generally, and to determine how these peptides regulate behavior. The motivation for this project is two-fold. First, insulin secretion, and its mis ...
Evolution of Animal Neural Systems
Evolution of Animal Neural Systems

... molecular modules than is currently available. Thus, the next challenge to the field is to start putting the genomic data back into its physiological context, and this will involve developing comparative methods that explicitly take hierarchical systems into account. Because neurons are among the mo ...
Neurokinin B Signaling in the Female Rat: a Novel
Neurokinin B Signaling in the Female Rat: a Novel

... functional unit of which is considered to be the hypothalamic arcuate nucleus kisspeptin/neurokinin B/dynorphin A neurons. Agonists of the neurokinin B (NKB) receptor (NK3R) have been shown to suppress the GnRH pulse generator, in a dynorphin A (Dyn)-dependent fashion, under hypoestrogenic condition ...
Proceedings - Neuroscience Meetings
Proceedings - Neuroscience Meetings

... According to different studies, between 5% and 10% of people suffer a single isolated seizure at some time in their life. However, little is known about effects of a single seizure on the cognitive function, and clinical investigations of this issue are not easy to perform. The aim of our study was ...
Respiratory Physiology during Sleep
Respiratory Physiology during Sleep

... Central chemoreceptors • Central chemoreceptors, located primarily within the ventrolateral surface of medulla, respond to changes in brain extracellular fluid [H1] concentration. • Other receptors have been recently identified in the brainstem, hypothalamus, and the cerebellum. • These receptors ...
Sense Organs - mohamadtermos
Sense Organs - mohamadtermos

... - Include both exteroceptors and visceroceptors - Called nociceptors: receptors for pain - Also detect itching, tickling, touch, movement, and ...
Receptors in lateral hypothalamic area involved in - AJP
Receptors in lateral hypothalamic area involved in - AJP

... g/kg ip). During the experiment, anesthesia was maintained with urethan supplements (0.75 g/kg iv). Supplements were given on the first sign of withdrawal to pinching of the foot. Core temperature was maintained at 37°C with the use of a rectal thermometer, temperature controller, and heating pad. T ...
Self Assessment Chapter 14 - CM
Self Assessment Chapter 14 - CM

... sympathetic preganglionic axons and postganglionic neurons; postganglionic axons then transmit action potentials to target cell • At synapse with their target cells, postganglionic axons release one of three neurotransmitters: ACh, epinephrine (adrenalin), or norepinephrine (noradrenalin; most frequ ...
and “Wanting” Linked to Reward Deficiency
and “Wanting” Linked to Reward Deficiency

... over drug-seeking behavior. The three classical sets of craving and relapse triggers are reexposure to addictive drugs, stress, and reexposure to environmental cues (people, places, and things) previously associated with drug-taking behavior. Drug-triggered relapse involves the NAc and the neurotran ...
lecture i - Tripod.com
lecture i - Tripod.com

... - are either reversible or dissociable – or else you lose temporal specificity/resolution - TOXINS are not reversible – thus they decrease the number of active receptors Two types of receptors - ligand-gated ion channel – direct effect; rapid activation, not affected by voltage changes, but will aff ...
Chemical Senses
Chemical Senses

... be detected between two samples  This ...
Aminobutyric Acid (GABA)-A Function and Binding in
Aminobutyric Acid (GABA)-A Function and Binding in

... Abstract—The goal of this study was to determine whether ␥-aminobutyric acid (GABA)ergic transmission and GABA binding are altered in chronic renal-wrap hypertension. Three groups of hypertensive and sham-operated rats were prepared for separate protocols. Four weeks later, the animals were prepared ...
Lateral olfactory processing
Lateral olfactory processing

... mammalian olfactory bulb and its insect analog, the antennal lobe. These results are now beginning to elaborate which of these circuit motifs are operative in early olfactory processing and what role they play in odor coding (Aungst et al 2003; McGann et al. 2005; Olsen et al. 2007; Shang et al. 200 ...
optical imaging and control of genetically designated neurons in
optical imaging and control of genetically designated neurons in

... and controlling activity. At its core lie sensor proteins that report changes in the physiological states of neurons or synapses through the emission of light (Miesenböck & Rothman 1997, Miyawaki et al. 1997, Siegel & Isacoff 1997) and actuator proteins that effect such changes in response to exoge ...
Chapter 7 The Nervous System - Mrs. heninger
Chapter 7 The Nervous System - Mrs. heninger

...  1. Sensory input – gathering information  To monitor changes occurring inside and outside the body ...
May 30, 04copy.doc
May 30, 04copy.doc

... GABAA receptors subunits comprise a family of at least 17 subunits (Davies et al., 1997). Each subunit is expressed in a particular laminar pattern in SI and visual cortex (V1). For instance, in SI and V1, the α1 subunit, which is present in the majority of the GABAA receptors, is densest in layers ...
NeuroD2 Is Necessary for Development and Survival of Central
NeuroD2 Is Necessary for Development and Survival of Central

... Expression of NeuroD2-Driven lacZ Gene in Cerebellum and Cortex In an attempt to understand the reason for the early death and neurologic impairment of the neuroD2 mutant mice, we examined the expression pattern of the lacZ gene that had been used to replace the neuroD2 coding sequence. Consistent w ...
Induction of c-fos Expression in Hypothalamic Magnocellular
Induction of c-fos Expression in Hypothalamic Magnocellular

... Since an increase in the intracellular concentration of calcium following influx through voltage-sensitive calcium channels is a known stimulus for c-fos expression and since the action potentials of these neurons have a large calcium component, we hypothesized that c-fos induction in these neurons ...
Sympathetic nervous system
Sympathetic nervous system

... The Endocrine System Composed of a number of glands that release hormones. Hormones travel through the bloodstream and affect different body organs. Endocrine system provides an additional means of communication in the nervous system. The pituitary gland – ‘the Master Gland’ which controls other g ...
the neural impulse
the neural impulse

... The soma (or cell body) is the neuron’s control centre. It contains the nucleus and other organelles which are necessary for the neuron’s survival. Dendrites are branched structures specialized to receive information from other neurons or cells. Therefore, the dendrites are the neuron's information ...
a few sensory concepts, 100416
a few sensory concepts, 100416

... 2011, and 2014). I don’t claim authorship. Other sources are noted when they are used. The lecture slides are mapped to the three editions of the textbook based on the color-coded key below. ...
Lecture_30_2014
Lecture_30_2014

... Schwann cells (glia) wrap around axon, forming myelin sheath ...
ph16neuro lectures
ph16neuro lectures

... 2. Major characteristics of action potentials: they are large, brief, invariant (amplitude does not change) signals that propagate along axons without decrement. They are called "all or none" because once they are initiated; their amplitude is independent of the stimulus that caused them. The action ...
HYPOTHALAMUS and EPITHALAMUS
HYPOTHALAMUS and EPITHALAMUS

... During reproductive life, GnRH neurons in the medial basal hypothalamus secrete circhoral pulses of GnRH into the portal system to elicit LH and FSH secretion. Feedback of gonadal steroids occurs at both the hypo-thalamic and pituitary levels to influence the frequency and the amplitude of the pulse ...
Umami, a taste unto itself
Umami, a taste unto itself

... Taste buds, taste cells, and the sensory organs of taste Before proceeding further, it is important to describe how tastes, generally, are sensed. Chemical compounds in foodstuffs (salts, sugars, proteins, amino acids, etc.) are dissolved in saliva and interact and aqueous solutions with peripheral ...
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Endocannabinoid system

The endocannabinoid system is a group of neuromodulatory lipids and their receptors in the brain that are involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory; it mediates the psychoactive effects of cannabis and, broadly speaking, includes: The endogenous arachidonate-based lipids, anandamide (N-arachidonoylethanolamide, AEA) and 2-arachidonoylglycerol (2-AG); these are known as ""endocannabinoids"" and are physiological ligands for the cannabinoid receptors. Endocannabinoids are all eicosanoids. The enzymes that synthesize and degrade the endocannabinoids, such as fatty acid amide hydrolase or monoacylglycerol lipase. The cannabinoid receptors CB1 and CB2, two G protein-coupled receptors that are located in the central and peripheral nervous systems.The neurons, neural pathways, and other cells where these molecules, enzymes, and one or both cannabinoid receptor types are all colocalized form the endocannabinoid system.The endocannabinoid system has been studied using genetic and pharmacological methods. These studies have revealed that cannabinoids act as neuromodulators for a variety of processes, including motor learning, appetite, and pain sensation, among other cognitive and physical processes. The localization of the CB1 receptor in the endocannabinoid system has a very large degree of overlap with the orexinergic projection system, which mediates many of the same functions, both physical and cognitive. Moreover, CB1 is colocalized on orexin projection neurons in the lateral hypothalamus and many output structures of the orexin system, where the CB1 and orexin receptor 1 (OX1) receptors physically and functionally join together to form the CB1–OX1 receptor heterodimer.
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