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Neurons
Neurons

... Neurotransmitters are an essential part of our everyday functioning. While it is not known exactly how many neurotransmitters exist, scientists have identified more than 100 of these chemical messengers. What effects do each of these neurotransmitters have on the body? What happens when disease or d ...
Chapter 17
Chapter 17

... a. astrocytes are star-shaped cells (with many processes) that perform several functions in support of neurons b. oligodendrocytes have few processes and produce a myelin sheath; each oligodendrocyte can myelinate parts of several axons c. microglia are small, phagocytic neuroglia that protect the n ...
Notes Chapter 50 Nervous and Sensory Systems
Notes Chapter 50 Nervous and Sensory Systems

... nervous system, a complex network of cells that communicate with one another. b) The nervous system includes two major divisions: the central nervous system and the peripheral nervous system. i) The brain and spinal cord make up the central nervous system. ii) The spinal cord carries messages from t ...
The Synaptic Cleft or Synapse
The Synaptic Cleft or Synapse

... A neuron’s axon ends in many small swellings called axon terminals. At the axon terminal the neuron may meet dendrites of another axon or an effector, like a muscle or gland. The space where neurons meet other neurons or effectors is called the synapse. There are presynaptic neurons and postsynaptic ...
Supplemental discussion of modifier gene function
Supplemental discussion of modifier gene function

... kcnl-2 likely encodes a C. elegans SK channel subunit. SK2 channels are small conductance potassium channels activated by calcium entry through voltage-gated calcium channels [93-95]. SK channels have relatively slow calcium influx currents that play a role in repolarization after depolarization and ...
Fundamentals of the Nervous System, Part 2
Fundamentals of the Nervous System, Part 2

... • Repeated use increases the efficiency of neurotransmission • Ca2+ concentration increases in presynaptic terminal and ostsynaptic neuron • Brief high-frequency stimulation partially depolarizes the postsynaptic neuron – Chemically gated channels (NMDA receptors) allow Ca2+ entry – Ca2+ activates k ...
Document
Document

... (like those release by damaged cells) ...
Molecular and Cellular aspects of a Sacred Disease `Epilepsy`
Molecular and Cellular aspects of a Sacred Disease `Epilepsy`

... Figure 2. Structure of voltage dependent potassium channel and cylinder represents helical membrane spanning six domains. Rising phase of the action potential is caused by the fast inactivating and transient current flowing through the sodium channels. Agents that block these fast inactivating chann ...
Na+ - cloudfront.net
Na+ - cloudfront.net

... How do neurons do their jobs? ...
reading guide
reading guide

... 24. There are many different types of neurotransmitters. Each neuron secretes only one type of neurotransmitter. Some neurotransmitters hyperpolarize the postsynaptic membrane. Are these excitatory or inhibitory neurotransmitters? ...
Nervous Systems II PPT
Nervous Systems II PPT

... Most nervous systems are organized into ...
28/03 - Instituto de Psicologia da USP
28/03 - Instituto de Psicologia da USP

... constituent of tobacco smoke, reduces neurogenesis and increases cell loss in both hippocampus and cortex. Accordingly, tobacco smoking has been linked to reduced performance on cognitive paradigms requiring attention and working memory in humans. However, few prior studies have tested for evidence ...
mechanism of action of anxiolytics
mechanism of action of anxiolytics

... CRF acts through two Gs-protein coupled receptors, the CRF-1 and CRF-2 receptor subtypes (9,10). CRF-1 receptors show homology to a number of other neuropeptide receptors, including vasointestinal peptide (VIP) and calcitonin. Three splice variants of the CRF-2 receptor subtype, the CRF-2␣, CRF-2␤, ...
Know Your Neurons: How to Classify Different Types of Neurons in
Know Your Neurons: How to Classify Different Types of Neurons in

... Scientists have classified neurons into four main groups based on differences in shape. Multipolar neurons are the most common neuron in the vertebrate nervous system and their structure most closely matches that of the model neuron: a cell body from which emerges a single long axon as well as a cro ...
Tuberoinfundibular peptid 39 and its receptor in the central nervous
Tuberoinfundibular peptid 39 and its receptor in the central nervous

... 4.2.3. Comparison of PTH2 receptor mRNA expression in the brain of rodents and primates PTH2 receptor expression, demonstrated using RT-PCR in human is very similar to that found in mice. High expression levels were found in the septum, caudate nucleus, medial geniculate body, hypothalamus, pontine ...
Tutorial 10: Temporal and Spatial Summation Figure 10: Temporal
Tutorial 10: Temporal and Spatial Summation Figure 10: Temporal

... Sherrington noted the difference between the motor neurons and sensory neurons, which he called proprioceptors. With this distinction, the role of the nervous system in the integration of information emerged. The knee jerk reflex, he noted, was the result of interaction between two reciprocal forces ...
Nervous tissues
Nervous tissues

... All living cells have the ability to react to stimuli. Nervous tissue is specialised to react to stimuli and to conduct impulses to various organs in the body which bring about a response to the stimulus. Nerve tissue (as in the brain, spinal cord and peripheral nerves that branch throughout the bod ...
The Nervous System
The Nervous System

... why action potentials can only move forward from the point of stimulation. Increased permeability of the sodium channel occurs when there is a deficit of calcium ions. when there is a deficit of calcium ions (Ca+2) in the interstitial fluid the sodium channels are activated (opened) by very little i ...
How are axons guided to their targets?
How are axons guided to their targets?

... • Same guidance cues are used over and over for targeting axons • Guidance molecules are conserved in many organisms ...
The Senses - Poudre School District
The Senses - Poudre School District

... • Highly modified neurons with elongated cilia (between 10-20 million receptors in an area 5 sq. cm) • Canines have 72 times greater surface area than humans in their olfactory organs = better smellers ...
Spinal Cord/ Reflex Action mainly
Spinal Cord/ Reflex Action mainly

... interneuron and this synapses with the motor neuron, An impulse is sent along the motor neuron, out the ventral root into muscles that respond by contracting and pulling your hand from the flame. Only now does the brain become aware of what has happened ...
Monitoring the activity of G protein-coupled receptors
Monitoring the activity of G protein-coupled receptors

... amplification in the pathway, weak agonists can appear as potent agonists (9–11). To address these issues, other functional assays have emerged (5,12,13). ...
chapter 43 mechanisms of action of antiepileptic drugs
chapter 43 mechanisms of action of antiepileptic drugs

... calcium channels have confirmed that ethosuximide blocks all three channel types (18). The block increases when the current is activated from more depolarized potentials and when T-type calcium channels are inactivated as especially occurs during high-frequency activation, so that the drug has selec ...
NERVOUS SYSTEM1.ppt [Recovered]
NERVOUS SYSTEM1.ppt [Recovered]

... These cells are linked together by tight gap junctions, thus forming the blood-brain barrier and permitting only certain substances to enter from the hemolymph. Cells of the perineurium secrete the thick basal lamina known as the neural lamella. ...
Ch. 3 S. 1
Ch. 3 S. 1

... hand, yawns, or thinks about a friend, neurotransmitters are involved. Some diseases and psychological disorders may also be caused by the presence of too much or too little of various neurotransmitters. Researchers have identified dozens of neurotransmitters and their functions. Examples: noradrena ...
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Endocannabinoid system

The endocannabinoid system is a group of neuromodulatory lipids and their receptors in the brain that are involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory; it mediates the psychoactive effects of cannabis and, broadly speaking, includes: The endogenous arachidonate-based lipids, anandamide (N-arachidonoylethanolamide, AEA) and 2-arachidonoylglycerol (2-AG); these are known as ""endocannabinoids"" and are physiological ligands for the cannabinoid receptors. Endocannabinoids are all eicosanoids. The enzymes that synthesize and degrade the endocannabinoids, such as fatty acid amide hydrolase or monoacylglycerol lipase. The cannabinoid receptors CB1 and CB2, two G protein-coupled receptors that are located in the central and peripheral nervous systems.The neurons, neural pathways, and other cells where these molecules, enzymes, and one or both cannabinoid receptor types are all colocalized form the endocannabinoid system.The endocannabinoid system has been studied using genetic and pharmacological methods. These studies have revealed that cannabinoids act as neuromodulators for a variety of processes, including motor learning, appetite, and pain sensation, among other cognitive and physical processes. The localization of the CB1 receptor in the endocannabinoid system has a very large degree of overlap with the orexinergic projection system, which mediates many of the same functions, both physical and cognitive. Moreover, CB1 is colocalized on orexin projection neurons in the lateral hypothalamus and many output structures of the orexin system, where the CB1 and orexin receptor 1 (OX1) receptors physically and functionally join together to form the CB1–OX1 receptor heterodimer.
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