Topic 4 Proteins as Drug Targets
... • Implications for drug selectivity depending on similarity (evolution) • Membrane bound receptors difficult to crystallise • X-Ray structure of bacteriorhodopsin solved - bacterial protein similar to rhodopsin • Bacteriorhodopsin structure used as ‘template’ for other receptors • Construct model re ...
... • Implications for drug selectivity depending on similarity (evolution) • Membrane bound receptors difficult to crystallise • X-Ray structure of bacteriorhodopsin solved - bacterial protein similar to rhodopsin • Bacteriorhodopsin structure used as ‘template’ for other receptors • Construct model re ...
The peripheral nervous system links the brain to the “real” world
... Receptor Field: An area of the body that when stimulated results in a change in firing rate of a sensory neuron ...
... Receptor Field: An area of the body that when stimulated results in a change in firing rate of a sensory neuron ...
Articular Receptors
... muscle spindles: primary (Ia) and secondary (II). Primary endings are typically seen in virtually all intrafusal fibers. Secondary endings are seen in CF and in static BF, but not in dynamic BF. ...
... muscle spindles: primary (Ia) and secondary (II). Primary endings are typically seen in virtually all intrafusal fibers. Secondary endings are seen in CF and in static BF, but not in dynamic BF. ...
Nervous System
... which has changed a variable from its set point • from eyes, skin, blood vessels, ears, digestive tract, joints, muscles, lungs… • Integration – interpretation of sensory information by the CNS • type, location and magnitude of stimulus • Transmit motor information – propagate APs from the CNS to va ...
... which has changed a variable from its set point • from eyes, skin, blood vessels, ears, digestive tract, joints, muscles, lungs… • Integration – interpretation of sensory information by the CNS • type, location and magnitude of stimulus • Transmit motor information – propagate APs from the CNS to va ...
Nervous System
... which has changed a variable from its set point • from eyes, skin, blood vessels, ears, digestive tract, joints, muscles, lungs… • Integration – interpretation of sensory information by the CNS • type, location and magnitude of stimulus • Transmit motor information – propagate APs from the CNS to va ...
... which has changed a variable from its set point • from eyes, skin, blood vessels, ears, digestive tract, joints, muscles, lungs… • Integration – interpretation of sensory information by the CNS • type, location and magnitude of stimulus • Transmit motor information – propagate APs from the CNS to va ...
Gene Section GRPR (Gastrin-Releasing Peptide Receptor) Atlas of Genetics and Cytogenetics
... The GRP-R is localized to the normal brain especially the periventricular nucleus (PVN) of the hypothalamus (Wolf et al., 1983) where activation by BB causes satiety (Gibbs et al., 1979). The GRPR, which regulates insulin secretion, is present in the pancreatic islets (Persson et al., 2002). The GRP ...
... The GRP-R is localized to the normal brain especially the periventricular nucleus (PVN) of the hypothalamus (Wolf et al., 1983) where activation by BB causes satiety (Gibbs et al., 1979). The GRPR, which regulates insulin secretion, is present in the pancreatic islets (Persson et al., 2002). The GRP ...
Powerpoint - Oregon State University
... RAS is a protein that plays a role in the signaling process, a protooncogene. RAS is involved in EGF signaling. The signaling complex that forms after EGF binding and activation of the EGF receptor activates RAS by causing it to release GDP and replace it with GTP. (When bound to GDP, it is inacti ...
... RAS is a protein that plays a role in the signaling process, a protooncogene. RAS is involved in EGF signaling. The signaling complex that forms after EGF binding and activation of the EGF receptor activates RAS by causing it to release GDP and replace it with GTP. (When bound to GDP, it is inacti ...
15. Nervous System: Autonomic Nervous System
... NE to these alpha receptors causes vasoconstriction. Beta receptors are found in bronchioles of the lungs and blood vessels that serve the heart and skeletal muscles. Binding of NE to these beta receptors causes dilation. Beta receptors on cardiac muscle cause increases in heart rate and strength of ...
... NE to these alpha receptors causes vasoconstriction. Beta receptors are found in bronchioles of the lungs and blood vessels that serve the heart and skeletal muscles. Binding of NE to these beta receptors causes dilation. Beta receptors on cardiac muscle cause increases in heart rate and strength of ...
CHAPTER 14: THE AUTONOMIC NERVOUS SYSTEM AND
... Effects on cellular metabolism: during times of sympathetic activation, nearly all cells, especially skeletal muscle, require higher amounts of ATP; to meet this higher energy demand norepinephrine has three effects when it binds to: Beta-3 receptors on adipocytes; triggers breakdown of lipids; re ...
... Effects on cellular metabolism: during times of sympathetic activation, nearly all cells, especially skeletal muscle, require higher amounts of ATP; to meet this higher energy demand norepinephrine has three effects when it binds to: Beta-3 receptors on adipocytes; triggers breakdown of lipids; re ...
LTP
... Synaptic Plasticity Synaptic efficacy (strength) is changing with time. Many of these changes are activity-dependent, i.e. the magnitude and direction of change depend on the activity of pre- and post-synaptic neuron. Some of the mechanisms involved: ...
... Synaptic Plasticity Synaptic efficacy (strength) is changing with time. Many of these changes are activity-dependent, i.e. the magnitude and direction of change depend on the activity of pre- and post-synaptic neuron. Some of the mechanisms involved: ...
Chapter 2: The synapse – regulating communication and
... neurotransmission is somewhat different than excitatory. Many inhibitory neurotransmitters are known. In the central nervous system the most important is Gamma-aminobutyric acid, more commonly referred to as GABA. GABA regulates many functions including controlling movement by regulating input to th ...
... neurotransmission is somewhat different than excitatory. Many inhibitory neurotransmitters are known. In the central nervous system the most important is Gamma-aminobutyric acid, more commonly referred to as GABA. GABA regulates many functions including controlling movement by regulating input to th ...
The Sensory System * Ear/Nose/Tongue/Skin
... Papilla contain taste buds for sweet, sour, salty, and bitter Receptors of taste buds send stimuli through three cranial nerves to the cerebral cortex for interpretation. ...
... Papilla contain taste buds for sweet, sour, salty, and bitter Receptors of taste buds send stimuli through three cranial nerves to the cerebral cortex for interpretation. ...
Lecture 10 Thurs 4-27-06
... B. Plasmodium-infected red blood cells (IRBCs): 1. Adhesion to vascular endothelium is a key factor in pathogenicity and is dependent on the Plasmodium protein PfEMP1 and endothelial receptors including CD36. 2. Evidence that binding of IRBCs to CD36 on endothelial cells activates a signaling pathwa ...
... B. Plasmodium-infected red blood cells (IRBCs): 1. Adhesion to vascular endothelium is a key factor in pathogenicity and is dependent on the Plasmodium protein PfEMP1 and endothelial receptors including CD36. 2. Evidence that binding of IRBCs to CD36 on endothelial cells activates a signaling pathwa ...
Somatosensory system
... The somatosensory system is a diverse sensory system composed of the receptors and processing centres to produce the sensory modalities such as touch, temperature, proprioception (body position), and nociception (pain). The sensory receptors cover the skin and epithelia, skeletal muscles, bones and ...
... The somatosensory system is a diverse sensory system composed of the receptors and processing centres to produce the sensory modalities such as touch, temperature, proprioception (body position), and nociception (pain). The sensory receptors cover the skin and epithelia, skeletal muscles, bones and ...
![Acetylcholine Acetylcholine IUPAC name[hide] 2-Acetoxy](http://s1.studyres.com/store/data/001757659_1-dd3a11ed2d1408ee2f9aa2f256cd3204-300x300.png)
Acetylcholine Acetylcholine IUPAC name[hide] 2-Acetoxy
... Medial septal nucleus acts mainly on M1 receptors in the hippocampus and neocortex. ...
... Medial septal nucleus acts mainly on M1 receptors in the hippocampus and neocortex. ...
neural control of respiration
... during inspiration, these receptors initiate impulses that reflexively inhibit the inspiratory drive, reinforcing the actions of the pneumotaxic center and protecting the lungs from overexpansion. This response is called a Haring-Breuer reflex. In humans, it does not appear to be activated until the ...
... during inspiration, these receptors initiate impulses that reflexively inhibit the inspiratory drive, reinforcing the actions of the pneumotaxic center and protecting the lungs from overexpansion. This response is called a Haring-Breuer reflex. In humans, it does not appear to be activated until the ...
Pain Physiology
... Segmental inhibition consists of activation of large afferent fibres subserving epicritic sensation, inhibitory WDR neurones and spinothalamic activity. Glycine and γ-amino butyric acid (GABA) are amino acids that function as inhibitory neurotransmitters. Segmental inhibition appears to be mediated ...
... Segmental inhibition consists of activation of large afferent fibres subserving epicritic sensation, inhibitory WDR neurones and spinothalamic activity. Glycine and γ-amino butyric acid (GABA) are amino acids that function as inhibitory neurotransmitters. Segmental inhibition appears to be mediated ...
Regulation of Neurosteroid Biosynthesis by Neurotransmitters and
... These observations prompted us to investigate the possible effects of NPY on the biosynthesis of sulfated neurosteroids. Double labeling of frog brain sections revealed the existence of NPYimmunoreactive varicosities in close proximity to HST-containing perikarya (Beaujean et al. 2002). Partial sequ ...
... These observations prompted us to investigate the possible effects of NPY on the biosynthesis of sulfated neurosteroids. Double labeling of frog brain sections revealed the existence of NPYimmunoreactive varicosities in close proximity to HST-containing perikarya (Beaujean et al. 2002). Partial sequ ...
Chapter 3
... • The components of the brain interact to receive sensory input, integrate and store the information, and transmit motor responses. • To accomplish the primary functions of the nervous system there are neural pathways to transmit impulses from receptors to the circuitry of the brain, which manipulat ...
... • The components of the brain interact to receive sensory input, integrate and store the information, and transmit motor responses. • To accomplish the primary functions of the nervous system there are neural pathways to transmit impulses from receptors to the circuitry of the brain, which manipulat ...
Photoreception: Functional Anatomy of Photoreceptors
... • The organ of smell is the _____________________________________, which covers the superior nasal concha • Olfactory receptor cells are _____________________________________ with radiating olfactory cilia • Basal cells lie at the base of the epithelium ...
... • The organ of smell is the _____________________________________, which covers the superior nasal concha • Olfactory receptor cells are _____________________________________ with radiating olfactory cilia • Basal cells lie at the base of the epithelium ...
Probing the Role of a Conserved M1 Proline Residue in 5
... therefore may be a physical link between the binding sites and the pore. Membrane-buried Pro residues are far more common in ion channels or transporter proteins than structural membrane proteins, and it has been suggested that this bias reflects an important functional role for Pro in proteins that ...
... therefore may be a physical link between the binding sites and the pore. Membrane-buried Pro residues are far more common in ion channels or transporter proteins than structural membrane proteins, and it has been suggested that this bias reflects an important functional role for Pro in proteins that ...
Serotonin synaptic receptors in the mammalian central
... of the development of the 5-HT norvoussystem by theintracerebralinjection of 40/_g of 5,7-dihydroxytryptamine does not affect the postnatal development of binding sites for d-[3H] LSD or [3H ]5-HT (6). The subcellular distributions of both d-[aH]LSD and [aH]5-HT binding are nearly identical, with en ...
... of the development of the 5-HT norvoussystem by theintracerebralinjection of 40/_g of 5,7-dihydroxytryptamine does not affect the postnatal development of binding sites for d-[3H] LSD or [3H ]5-HT (6). The subcellular distributions of both d-[aH]LSD and [aH]5-HT binding are nearly identical, with en ...