Caenorhabditis elegans: A versatile platform for drug discovery
... In the past decades, small-molecule drug discovery has been mostly based on target-specific approaches, where an identified target protein is purified and used for in vitro screening of inhibitors of its biochemical activity using cell extracts or cultured cells. Once hits are identified they need t ...
... In the past decades, small-molecule drug discovery has been mostly based on target-specific approaches, where an identified target protein is purified and used for in vitro screening of inhibitors of its biochemical activity using cell extracts or cultured cells. Once hits are identified they need t ...
Analysis Reveals that CPX-351 Shifts the Exposure of Cytarabine
... improvements in patient outcomes, most notably in elderly newly diagnosed high risk (secondary) AML and in unfavorable risk first relapse adult AML where statistically significant increases in overall survival where observed in two randomized, controlled Phase 2 studies. In patients, CPX-351 display ...
... improvements in patient outcomes, most notably in elderly newly diagnosed high risk (secondary) AML and in unfavorable risk first relapse adult AML where statistically significant increases in overall survival where observed in two randomized, controlled Phase 2 studies. In patients, CPX-351 display ...
pharmacology basic principles
... Coupling: the transduction process between occupying receptors and drug response; effect of full agonists are more efficiently coupled to receptor occupancy than partial agonists; also determined by biochemical events that transduce receptor occupancy cellular response Spare receptors: When max re ...
... Coupling: the transduction process between occupying receptors and drug response; effect of full agonists are more efficiently coupled to receptor occupancy than partial agonists; also determined by biochemical events that transduce receptor occupancy cellular response Spare receptors: When max re ...
STABILITY INDICATING HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF DROTAVERINE AND ACECLOFENAC Research Article
... HPTLC7,8 methods have been reported for the estimation of DRO in combination with other drugs. Spectrofluorometric9 measurement of DRO also has been reported. HPLC method has been reported for estimation of ACE in formulations in combination with other drugs10. Few spectrophoto ...
... HPTLC7,8 methods have been reported for the estimation of DRO in combination with other drugs. Spectrofluorometric9 measurement of DRO also has been reported. HPLC method has been reported for estimation of ACE in formulations in combination with other drugs10. Few spectrophoto ...
Neurobiological mechanisms in the transition from drug use to drug
... from experimental psychology, social psychology and neurobiology can be superimposed on these three stages which are conceptualized as feeding into each other, becoming more intense, and ultimately leading to the pathological state known as addiction [23]. The purpose of current neuroscience researc ...
... from experimental psychology, social psychology and neurobiology can be superimposed on these three stages which are conceptualized as feeding into each other, becoming more intense, and ultimately leading to the pathological state known as addiction [23]. The purpose of current neuroscience researc ...
Master-Thesis
... also show their deficiencies. An example of existing but insufficient regulations is given by the Ukraine. Here import and export of counterfeit goods is prohibited under the Customs code, however their destruction is not regulated and the goods, including counterfeit medicines, often find their way ...
... also show their deficiencies. An example of existing but insufficient regulations is given by the Ukraine. Here import and export of counterfeit goods is prohibited under the Customs code, however their destruction is not regulated and the goods, including counterfeit medicines, often find their way ...
Pharmacokinetic and pharmacodynamic profile of oral and
... 3,4-methylenedioxymethamphetamine (MDMA) is a widely used drug of abuse chemically related to both the amphetamines and mescaline. Laboratory animal studies have shown that MDMA is a potent re-uptake inhibitor and releaser of dopamine and serotonin. Although the subjective and physiological effects ...
... 3,4-methylenedioxymethamphetamine (MDMA) is a widely used drug of abuse chemically related to both the amphetamines and mescaline. Laboratory animal studies have shown that MDMA is a potent re-uptake inhibitor and releaser of dopamine and serotonin. Although the subjective and physiological effects ...
Taste Masking: A Novel Approach for Bitter and Obnoxious Drugs
... as a mean for taste masking of slightly bitter tasting drug. Granulation lowers the effective surface area of the bitter substance that come in contact with the tongue upon oral intake. Liquid and low melting point waxes such as glycerol palmitostearate, glyceryl behenate and hydrogenated castor oil ...
... as a mean for taste masking of slightly bitter tasting drug. Granulation lowers the effective surface area of the bitter substance that come in contact with the tongue upon oral intake. Liquid and low melting point waxes such as glycerol palmitostearate, glyceryl behenate and hydrogenated castor oil ...
Chapter 7 Body Systems
... Using the Physicians’ Drug Reference® (PDR®) or other drug reference guide to list brand and generic names, drug classifications, product identification by shape and color, major precautions, available forms, dosage, and manufacturer. Identifying and describing drug forms. ...
... Using the Physicians’ Drug Reference® (PDR®) or other drug reference guide to list brand and generic names, drug classifications, product identification by shape and color, major precautions, available forms, dosage, and manufacturer. Identifying and describing drug forms. ...
03_Intravenous infusion and Laplace
... seven half-lives • This can constitute a problem when immediate drug effect is required and immediate achievement of therapeutic drug concentrations is necessary such as in emergency situations • In this ease, administration of a loading dose will be necessary. The loading dose is an IV holus dose a ...
... seven half-lives • This can constitute a problem when immediate drug effect is required and immediate achievement of therapeutic drug concentrations is necessary such as in emergency situations • In this ease, administration of a loading dose will be necessary. The loading dose is an IV holus dose a ...
Liposomes in drug delivery
... would be difficult to retain inside liposomes. However, these type of drugs can be encapsulated into preformed liposomes with high efficiency (up to 90%) using the 'active loading' technique (Clerc and Barenholz, 1995). In the 'active loading' method, the pH in the liposome interior is such that the ...
... would be difficult to retain inside liposomes. However, these type of drugs can be encapsulated into preformed liposomes with high efficiency (up to 90%) using the 'active loading' technique (Clerc and Barenholz, 1995). In the 'active loading' method, the pH in the liposome interior is such that the ...
Making sense of itraconazole pharmacokinetics
... therefore continuous and superior bioavailability at sites of tissue infection.8 Very little drug is found in aqueous body solutions such as the tears, saliva and CSF but any bodily fluid rich in organic matter, such as sputum, bronchial exudates and even pus, will contain high concentrations. These ...
... therefore continuous and superior bioavailability at sites of tissue infection.8 Very little drug is found in aqueous body solutions such as the tears, saliva and CSF but any bodily fluid rich in organic matter, such as sputum, bronchial exudates and even pus, will contain high concentrations. These ...
Valproic acid metabolism and its effects on mitochondrial fatty acid
... the organ that is also the dominant target organ of valproate toxicity. The minor contribution of VPA biotransformation in extrahepatic tissues (e.g. skin, gastrointestinal tract, lung and kidney) is not known with certainty. In principle the elimination of a xenobiotic depends on its conversion int ...
... the organ that is also the dominant target organ of valproate toxicity. The minor contribution of VPA biotransformation in extrahepatic tissues (e.g. skin, gastrointestinal tract, lung and kidney) is not known with certainty. In principle the elimination of a xenobiotic depends on its conversion int ...
drugs and cosmetics (iind amendment) rules, 2005
... determine the common short-term side-effects and risks associated with the drug. Studies in Phase II should be conducted in a group of patients who are selected by relatively narrow criteria leading to a relatively homogeneous population. These studies should be closely monitored. An important goal ...
... determine the common short-term side-effects and risks associated with the drug. Studies in Phase II should be conducted in a group of patients who are selected by relatively narrow criteria leading to a relatively homogeneous population. These studies should be closely monitored. An important goal ...
International Editorial Board
... Preliminary data suggest losartan administration is associated with regression of left ventricular hypertrophy in patients,[2] but the other effects have yet to be demonstrated in humans, ...
... Preliminary data suggest losartan administration is associated with regression of left ventricular hypertrophy in patients,[2] but the other effects have yet to be demonstrated in humans, ...
How much do you know about marijuana?
... achieve the same level of drug high. When marijuana users become dependent, they can suffer from nausea, diarrhea, insomnia, irritability, weight loss, loss of appetite and sweating when denied access to the drug. ...
... achieve the same level of drug high. When marijuana users become dependent, they can suffer from nausea, diarrhea, insomnia, irritability, weight loss, loss of appetite and sweating when denied access to the drug. ...
Dosage Patenting in Personalized Medicine
... metabolism, or elimination.15 Drug responses could also be affected by extrinsic factors associated with environment or culture such as medical practice, diet, or alcohol use.16 However, there are currently no known biomarkers or methods that can predict which group of patients will respond positive ...
... metabolism, or elimination.15 Drug responses could also be affected by extrinsic factors associated with environment or culture such as medical practice, diet, or alcohol use.16 However, there are currently no known biomarkers or methods that can predict which group of patients will respond positive ...
Pethidine FAQs
... hyperreflexia, diaphoresis, shivering, tremor, diarrhoea, or fever 15 Clinically, serotonin syndrome may range in severity and is usually self limiting when appropriate supportive care has been instituted. Symptoms commonly resolve over 12 to 24 hours when the offending drugs are discontinued 16 – S ...
... hyperreflexia, diaphoresis, shivering, tremor, diarrhoea, or fever 15 Clinically, serotonin syndrome may range in severity and is usually self limiting when appropriate supportive care has been instituted. Symptoms commonly resolve over 12 to 24 hours when the offending drugs are discontinued 16 – S ...
National Conference on Nanoscience and Nanotechnology (NCNN
... such as plants, insects, animals and minerals. Several synthetic colorants have been banned because they cause allergy like symptoms or are carcinogens. Among all natural dyes, plant based pigments have wide range of medicinal values. Although known for a long time for dyeing as well as medicinal pr ...
... such as plants, insects, animals and minerals. Several synthetic colorants have been banned because they cause allergy like symptoms or are carcinogens. Among all natural dyes, plant based pigments have wide range of medicinal values. Although known for a long time for dyeing as well as medicinal pr ...
PDF - Innovare Academic Sciences
... Microemulsions are dynamic systems in which the interface is continuously and spontaneously fluctuating [15]. Structurally, they are divided into oil-in-water (o/w), water in-oil (w/o) and bicontinuous microemulsions. In w/o microemulsion, water droplets are dispersed in the continuous oil phase whi ...
... Microemulsions are dynamic systems in which the interface is continuously and spontaneously fluctuating [15]. Structurally, they are divided into oil-in-water (o/w), water in-oil (w/o) and bicontinuous microemulsions. In w/o microemulsion, water droplets are dispersed in the continuous oil phase whi ...
JAP Mar. 86/3 - Journal of Applied Physiology
... ANTITUSSIVE DRUGS, such as codeine and dextromethorphan, are among the most commonly used prescription and over-the-counter drugs in the world (12). These drugs are broadly classified into two groups based on their site of action: peripheral or central. Peripheral antitussive drugs act outside the c ...
... ANTITUSSIVE DRUGS, such as codeine and dextromethorphan, are among the most commonly used prescription and over-the-counter drugs in the world (12). These drugs are broadly classified into two groups based on their site of action: peripheral or central. Peripheral antitussive drugs act outside the c ...
Full Text Article - European Journal of Pharmaceutical and Medical
... Omeprazole competes with other drugs through their enzymes, e.g. CYP2C19 which drugs like diazepam, phenytoin and warfarin depends for their activities hence concomonitant administration would delay their activities, (Stedman, 2000). It also affects the absorption of other drugs that are acid-enviro ...
... Omeprazole competes with other drugs through their enzymes, e.g. CYP2C19 which drugs like diazepam, phenytoin and warfarin depends for their activities hence concomonitant administration would delay their activities, (Stedman, 2000). It also affects the absorption of other drugs that are acid-enviro ...
Genvoya - Gilead
... ----------------------DOSAGE FORMS AND STRENGTHS--------------------Tablets: 150 mg of elvitegravir, 150 mg of cobicistat, 200 mg of emtricitabine, and 10 mg of tenofovir alafenamide. (3) -------------------------------CONTRAINDICATIONS------------------------------Coadministration of GENVOYA is con ...
... ----------------------DOSAGE FORMS AND STRENGTHS--------------------Tablets: 150 mg of elvitegravir, 150 mg of cobicistat, 200 mg of emtricitabine, and 10 mg of tenofovir alafenamide. (3) -------------------------------CONTRAINDICATIONS------------------------------Coadministration of GENVOYA is con ...
APRI 7149$
... In the late 1970’s and 1980’s, ephedrine controlled substances. was found in many stimulant “look-alike” products, which resulted in serious health problems. In recent years, FDA has received reports of young people abusing OTC ephedrine drug products for “kicks” and as an “upper” or “energizer” . M ...
... In the late 1970’s and 1980’s, ephedrine controlled substances. was found in many stimulant “look-alike” products, which resulted in serious health problems. In recent years, FDA has received reports of young people abusing OTC ephedrine drug products for “kicks” and as an “upper” or “energizer” . M ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.