Predictors of neonatal abstinence syndrome in
... indicative of the unpredictability of this syndrome following maternal use of buprenorphine. One factor that may contribute to this range includes variability in buprenorphine pharmacokinetics associated with CYP3A and CYP2C8, with heightened variation in CYP3A during pregnancy (Elkader and Sproule ...
... indicative of the unpredictability of this syndrome following maternal use of buprenorphine. One factor that may contribute to this range includes variability in buprenorphine pharmacokinetics associated with CYP3A and CYP2C8, with heightened variation in CYP3A during pregnancy (Elkader and Sproule ...
Beta-agonists • friends or foes? C-G. ofdahl, N .Svedmyr L
... rate among asthmatics in countries where isoprenaline for inhalation in high concentration (Isoprenaline Forte*) was available [19]. The decrease of the epidemic in the sixties occurred when general awareness of the problem increased and patients were better controlled and taken care of in the acute ...
... rate among asthmatics in countries where isoprenaline for inhalation in high concentration (Isoprenaline Forte*) was available [19]. The decrease of the epidemic in the sixties occurred when general awareness of the problem increased and patients were better controlled and taken care of in the acute ...
Niacin - Get Heart Healthy Today
... Niacin is taken in a delayed or extended release form to minimize any side effects. Side effects may include flushing, itching and occasionally palpitations. They usually begin within 15 minutes of taking niacin and lasts 30-60 minutes. The skin may turn red and blotchy, especially around the face a ...
... Niacin is taken in a delayed or extended release form to minimize any side effects. Side effects may include flushing, itching and occasionally palpitations. They usually begin within 15 minutes of taking niacin and lasts 30-60 minutes. The skin may turn red and blotchy, especially around the face a ...
Biochemical Toxicity Induced By Tramadol
... analgesic action is complex. Most reports suggest that the analgesic activity and other clinical effects of tramadol are a result of opioid and non-opioid mechanisms. Tramadol binds to the μ-opioid receptor, although much more weakly than morphine. It also inhibits the neuronal reuptake of norepinep ...
... analgesic action is complex. Most reports suggest that the analgesic activity and other clinical effects of tramadol are a result of opioid and non-opioid mechanisms. Tramadol binds to the μ-opioid receptor, although much more weakly than morphine. It also inhibits the neuronal reuptake of norepinep ...
Product Monograph - AstraZeneca Canada
... Heart Failure: In heart failure patients treated with ATACAND, hyperkalemia may occur. During treatment with ATACAND in patients with heart failure, periodic monitoring of serum potassium is recommended, especially when taken concomitantly with ACE inhibitors and potassium-sparing diuretics such as ...
... Heart Failure: In heart failure patients treated with ATACAND, hyperkalemia may occur. During treatment with ATACAND in patients with heart failure, periodic monitoring of serum potassium is recommended, especially when taken concomitantly with ACE inhibitors and potassium-sparing diuretics such as ...
Biodegradable Janus Nanoparticles for Local Pulmonary Delivery of
... Synthesis of Janus Particles and Loading with Drugs. For the in vitro and in vivo studies, Janus nanoparticles containing DOX and CUR were synthesized using a modified water-in-oil-in-water double emulsion solvent evaporation technique as previously described (Figure 1a).25,28 Briefly, 25 mg DOX were ...
... Synthesis of Janus Particles and Loading with Drugs. For the in vitro and in vivo studies, Janus nanoparticles containing DOX and CUR were synthesized using a modified water-in-oil-in-water double emulsion solvent evaporation technique as previously described (Figure 1a).25,28 Briefly, 25 mg DOX were ...
Advances in Environmental Biology
... Advances in Environmental Biology, 8(1) January 2014, Pages: 108-114 ...
... Advances in Environmental Biology, 8(1) January 2014, Pages: 108-114 ...
QUANTITATIVE ESTIMATION OF MUPIROCIN CALCIUM FROM PHARMACEUTICAL OINTMENT FORMULATION BY UV SPECTROPHOTOMETRY
... phosphate buffer (pH 6.4) solvent system. The calibration curve yielded the linear regression equation as Y = 0.2507 X – 0.0337, where Y is the absorbance and X is the concentration (μg/ml) of pure mupirocin calcium solution having high correlation coefficient r2= 0.999 ...
... phosphate buffer (pH 6.4) solvent system. The calibration curve yielded the linear regression equation as Y = 0.2507 X – 0.0337, where Y is the absorbance and X is the concentration (μg/ml) of pure mupirocin calcium solution having high correlation coefficient r2= 0.999 ...
pharmaceutical calculations in prescription compounding
... The remainder of this chapter will focus on basic pharmaceutical calculations. It is important to recognize the rules involved when adding, subtracting, dividing, and multiplying values. The interrelationships between various units within the different weighing and measuring systems are also importa ...
... The remainder of this chapter will focus on basic pharmaceutical calculations. It is important to recognize the rules involved when adding, subtracting, dividing, and multiplying values. The interrelationships between various units within the different weighing and measuring systems are also importa ...
Saffron (Crocus sativus L.) and morphine
... extracts of flowers can reduce the acquisition of morphine sensitization. So the stigma of saffron flower extracts decreases locomotion activity and the acquisition and expression of behavioral sensitization induced by morphine in male mice (Sahraei H. and Mohammadi M. 2007; Sahraei H. and Shams J. ...
... extracts of flowers can reduce the acquisition of morphine sensitization. So the stigma of saffron flower extracts decreases locomotion activity and the acquisition and expression of behavioral sensitization induced by morphine in male mice (Sahraei H. and Mohammadi M. 2007; Sahraei H. and Shams J. ...
PREPARATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF FINASTERIDE USING CO-PROCESSED EXCIPIENTS
... geriatric and pediatric patients, they are also suitable for the mentally ill, the bedridden and patients who do not have easy access to water and also the bioavailability of drug is significantly greater than those observed from conventional tablet dosage form[3]. Finasteride(FIN) is a synthetic 4- ...
... geriatric and pediatric patients, they are also suitable for the mentally ill, the bedridden and patients who do not have easy access to water and also the bioavailability of drug is significantly greater than those observed from conventional tablet dosage form[3]. Finasteride(FIN) is a synthetic 4- ...
Linköping University Post Print Effects on enantiomeric drug disposition and
... Depression is a common and significant public health problem, and the leading cause of suicide worldwide (Kessler et al. 2009; Moussavi et al. 2007). Pharmacological treatment is one of the cornerstones in clinical practice, but however, it is well known that the result of antidepressant therapy can ...
... Depression is a common and significant public health problem, and the leading cause of suicide worldwide (Kessler et al. 2009; Moussavi et al. 2007). Pharmacological treatment is one of the cornerstones in clinical practice, but however, it is well known that the result of antidepressant therapy can ...
4427 Naltrexone/Carers.NSW
... alcoholic liver disease. The doctor should be informed of any liver conditions that the patient has. • Pregnant and breastfeeding women should seek the advice of their doctor. It has not been established that using naltrexone during pregnancy is completely safe. • There are better outcomes of naltre ...
... alcoholic liver disease. The doctor should be informed of any liver conditions that the patient has. • Pregnant and breastfeeding women should seek the advice of their doctor. It has not been established that using naltrexone during pregnancy is completely safe. • There are better outcomes of naltre ...
Evaluation of the use of static and dynamic models to predict drug
... than Simcyp (84% compared to 58% of the interactions predicted within 2-fold). Differences in the prediction outcomes between the static and dynamic models are attributable to differences in first-pass contribution to DDI. The inclusion of AUCRhfp in static equations leads to systematic overpredicti ...
... than Simcyp (84% compared to 58% of the interactions predicted within 2-fold). Differences in the prediction outcomes between the static and dynamic models are attributable to differences in first-pass contribution to DDI. The inclusion of AUCRhfp in static equations leads to systematic overpredicti ...
Continuous nebulization therapy for asthma with
... Terbutaline sulfate, a b2 agonist, can be administered by oral, inhalation, subcutaneous, or intravenous routes. Undesirable side effects may occur depending upon the serum level. When delivered to the patient via aerosol inhalation, there are fewer side effects compared with oral or parenteral admi ...
... Terbutaline sulfate, a b2 agonist, can be administered by oral, inhalation, subcutaneous, or intravenous routes. Undesirable side effects may occur depending upon the serum level. When delivered to the patient via aerosol inhalation, there are fewer side effects compared with oral or parenteral admi ...
Patterns of Drug-induced Liver Injury
... damage may be caused by drugs (2) Histological distinction from other causes of liver damage is frequently difficult or impossible • Drug-induced liver injury therefore diagnosed by exclusion (3) For some patterns of liver injury drugs should be considered near the top of the differential diagnosis ...
... damage may be caused by drugs (2) Histological distinction from other causes of liver damage is frequently difficult or impossible • Drug-induced liver injury therefore diagnosed by exclusion (3) For some patterns of liver injury drugs should be considered near the top of the differential diagnosis ...
Reversible Disulfide Formation of the Glutamate Carboxypeptidase
... nM) and efficacy in several animal models of disease after oral administration (Ghadge et al., 2003; Majer et al., 2003), was the first GCP II inhibitor to advance to the clinic where doses up to 1 g were found to be safe and well tolerated in healthy and diabetic subjects after acute and 14-day adm ...
... nM) and efficacy in several animal models of disease after oral administration (Ghadge et al., 2003; Majer et al., 2003), was the first GCP II inhibitor to advance to the clinic where doses up to 1 g were found to be safe and well tolerated in healthy and diabetic subjects after acute and 14-day adm ...
Pharmaceutical legislation and regulation
... Whether or not a national drug policy exists, countries need effective, enforceable legislation and regulation. These legislative acts may take the form of a single national drug law that deals with all the issues or a series of complementary laws, each introduced when the time is right. In some cou ...
... Whether or not a national drug policy exists, countries need effective, enforceable legislation and regulation. These legislative acts may take the form of a single national drug law that deals with all the issues or a series of complementary laws, each introduced when the time is right. In some cou ...
Pharmacological Treatment of Urinary Incontinence
... published rate of effectiveness, different doses, and way of administration. The prevalence of the most common adverse effects and overall compliance had also been pointed out, with cost evaluation after 1 month of treatment for each class of drug. Moreover, we describe those newer agents whose effi ...
... published rate of effectiveness, different doses, and way of administration. The prevalence of the most common adverse effects and overall compliance had also been pointed out, with cost evaluation after 1 month of treatment for each class of drug. Moreover, we describe those newer agents whose effi ...
The effects of green tea polyphenols on drug metabolism
... metabolism and elimination of different drugs. Expert opinion: Tea catechins may bind to certain drugs to affect their absorption and bioactivities. Tea catechins may inhibit the activities of drug-metabolizing enzymes and drug transporters or affect the expression of these proteins, either upregula ...
... metabolism and elimination of different drugs. Expert opinion: Tea catechins may bind to certain drugs to affect their absorption and bioactivities. Tea catechins may inhibit the activities of drug-metabolizing enzymes and drug transporters or affect the expression of these proteins, either upregula ...
Cannabinoid Abuse and Addiction
... acid amide hydrolase genes have been linked to cannabis addiction phenotypes.19 In a recent study, functional connectivity magnetic resonance imaging demonstrated that cannabis users with genetic variation in CNR1 (rs1406977 G carriers) had greater functional connectivity in the left ventrolateral p ...
... acid amide hydrolase genes have been linked to cannabis addiction phenotypes.19 In a recent study, functional connectivity magnetic resonance imaging demonstrated that cannabis users with genetic variation in CNR1 (rs1406977 G carriers) had greater functional connectivity in the left ventrolateral p ...
Core-Shell Type Lipid-Polymer Hybrid Nanoparticles as
... lipoparticles or lipid/polymer particle assemblies were first synthesized for various biotechnological and biomedical applications such as immunological kits and biosensors for amplifying biomolecular recognition. 17,19 The special features of lipoparticles are imparted by their method of preparatio ...
... lipoparticles or lipid/polymer particle assemblies were first synthesized for various biotechnological and biomedical applications such as immunological kits and biosensors for amplifying biomolecular recognition. 17,19 The special features of lipoparticles are imparted by their method of preparatio ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... Diabetes mellitus is a global disease, found in all nations of the world with high prevalence rate. It is characterized by inability to regulate blood glucose caused by relative or absolute deficiency in insulin. The disease may occur as a result of pancreatic β-cells impairment, leading to reductio ...
... Diabetes mellitus is a global disease, found in all nations of the world with high prevalence rate. It is characterized by inability to regulate blood glucose caused by relative or absolute deficiency in insulin. The disease may occur as a result of pancreatic β-cells impairment, leading to reductio ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.