Bulletin #106
... “the Canadian Asthma Consensus Guidelines discourage the use of wet nebulized drugs because more effective and less expensive drugpowdered forms of the same medications are available.” The Saskatchewan drug review committees support these findings and following a discussion of the literature, a revi ...
... “the Canadian Asthma Consensus Guidelines discourage the use of wet nebulized drugs because more effective and less expensive drugpowdered forms of the same medications are available.” The Saskatchewan drug review committees support these findings and following a discussion of the literature, a revi ...
CP47,497-C8 and JWH073, commonly found in `Spice` herbal
... stereoisomer at each of the concentrations tested. Each stereoisomer's suppressive effects were reversed by 1 μM rimonabant treatment. Fig. 5C and D shows example time courses of recordings from autaptic neurons treated with increasing concentrations of cis-CP47,497-C8 and trans-CP47,497-C8, respect ...
... stereoisomer at each of the concentrations tested. Each stereoisomer's suppressive effects were reversed by 1 μM rimonabant treatment. Fig. 5C and D shows example time courses of recordings from autaptic neurons treated with increasing concentrations of cis-CP47,497-C8 and trans-CP47,497-C8, respect ...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF DONEPEZIL HYDROCHLORIDE TABLETS BY RPHPLC Research Article T. SENTHIL KUMAR
... was achieved with a keystone phenyl RP 250 × 4.6 mm i.d., 5 µM particle size analytical column using mixture of methanol, 0.02M phosphate Buffer (pH 7.5 ± 0.1) and triethylamine in the ratio 60: 40: 0.5 v/v as the mobile phase by Reverse phase isocratic mode. The instrumental settings are at a flo ...
... was achieved with a keystone phenyl RP 250 × 4.6 mm i.d., 5 µM particle size analytical column using mixture of methanol, 0.02M phosphate Buffer (pH 7.5 ± 0.1) and triethylamine in the ratio 60: 40: 0.5 v/v as the mobile phase by Reverse phase isocratic mode. The instrumental settings are at a flo ...
Rapid and Sensitive HPLC Method for the Determination of
... Sirolimus and Ketoconazole are used in organ transplantation regimen and potential metabolic interactions of these drugs were reported when administered concomitantly. An analytical method based on high-performance liquid chromatography (HPLC) with photo diode array (PDA) detection was developed for ...
... Sirolimus and Ketoconazole are used in organ transplantation regimen and potential metabolic interactions of these drugs were reported when administered concomitantly. An analytical method based on high-performance liquid chromatography (HPLC) with photo diode array (PDA) detection was developed for ...
ASSIST - World Health Organization
... Thank you for agreeing to take part in this brief interview about alcohol, tobacco products and other drugs. I am going to ask you some questions about your experience of using these substances across your lifetime and in the past three months. These substances can be smoked, swallowed, snorted, inh ...
... Thank you for agreeing to take part in this brief interview about alcohol, tobacco products and other drugs. I am going to ask you some questions about your experience of using these substances across your lifetime and in the past three months. These substances can be smoked, swallowed, snorted, inh ...
micronor - Janssen
... It is important to ascertain all drugs that a patient is taking, both prescription and nonprescription, including herbal preparations/remedies, before oral contraceptives are prescribed. Some anti-epileptic drugs are known to induce or inhibit a number of hepatic enzymes in the cytochrome P450 syste ...
... It is important to ascertain all drugs that a patient is taking, both prescription and nonprescription, including herbal preparations/remedies, before oral contraceptives are prescribed. Some anti-epileptic drugs are known to induce or inhibit a number of hepatic enzymes in the cytochrome P450 syste ...
File - Ms. Walajtys` Pharmacy Tech Class Sidekick
... Two Goals of Antiepileptic Therapy • Seizure control or lessen the frequency • Prevent emotional and behavioral changes that may result from seizures ...
... Two Goals of Antiepileptic Therapy • Seizure control or lessen the frequency • Prevent emotional and behavioral changes that may result from seizures ...
Neurobiological substrates for the dark side of compulsivity in
... individuals can evolve into an opioid-like situation in which they must have alcohol available at all times to avoid the negative consequences of abstinence. Tobacco addiction contrasts with the above patternsdthe binge/intoxication stage forms a minor component of nicotine dependence. The pattern o ...
... individuals can evolve into an opioid-like situation in which they must have alcohol available at all times to avoid the negative consequences of abstinence. Tobacco addiction contrasts with the above patternsdthe binge/intoxication stage forms a minor component of nicotine dependence. The pattern o ...
Pentazocine - e-SAFE
... 0.4-2 mg is sufficient in most cases although higher doses of 15-20 mg have been known to be required. An infusion of naloxone may be required. ...
... 0.4-2 mg is sufficient in most cases although higher doses of 15-20 mg have been known to be required. An infusion of naloxone may be required. ...
Pharma-Data 2012
... The world is not as simple as it is often presented in the media by pharma critics. The pharmaceutical industry is not an homogenous industry. There is no such thing as THE pharmaceutical industry. Nearly 900 companies are listed in Germany. In addition, not all drugs are the same. There are highly ...
... The world is not as simple as it is often presented in the media by pharma critics. The pharmaceutical industry is not an homogenous industry. There is no such thing as THE pharmaceutical industry. Nearly 900 companies are listed in Germany. In addition, not all drugs are the same. There are highly ...
Update and trends on pharmacokinetic studies in patients
... 2.2. Role of modeling in lieu of renal impairment studies In certain drug development scenarios, the conduct of a dedicated phase I renal impairment investigation with otherwise healthy, renal impaired subjects and healthy-matched control subjects is deemed not feasible; perhaps due to safety concer ...
... 2.2. Role of modeling in lieu of renal impairment studies In certain drug development scenarios, the conduct of a dedicated phase I renal impairment investigation with otherwise healthy, renal impaired subjects and healthy-matched control subjects is deemed not feasible; perhaps due to safety concer ...
ANTIBACTERIAL AND SYNERGISTIC ACTIVITY OF ETHANOLIC AJWAIN (TRACHYSPERMUM
... A time kill analysis was carried out by performing a viable count of test pathogens in the presence of MBC and 1/2 MBC concentrations of ajwain extract in terms of CFU/ml. The surviving pathogens were estimated over a period of 4h. The time kill analysis was performed using method described by Carso ...
... A time kill analysis was carried out by performing a viable count of test pathogens in the presence of MBC and 1/2 MBC concentrations of ajwain extract in terms of CFU/ml. The surviving pathogens were estimated over a period of 4h. The time kill analysis was performed using method described by Carso ...
Fixed combination of arthemether and lumefantrine
... Malaria continues to be a major health problem in the world today. Between 300-500 people become ill from the disease and approximately 1 million, mainly children dies from it each year. The prevalence of drug resistant falciparum malaria has increased so that, in some countries, resistance to all o ...
... Malaria continues to be a major health problem in the world today. Between 300-500 people become ill from the disease and approximately 1 million, mainly children dies from it each year. The prevalence of drug resistant falciparum malaria has increased so that, in some countries, resistance to all o ...
Ibogaine as an Alternative and Efficacious Treatment for Heroin
... from when one ingests an illicit substance to achieve a high. The nucleus accumbens is called the reward center of the brain and addicts feel a mental and emotional reward for ingesting illicit drugs, particularly opioids. Heroin is a powerful and highly addictive opioid that exerts activity in the ...
... from when one ingests an illicit substance to achieve a high. The nucleus accumbens is called the reward center of the brain and addicts feel a mental and emotional reward for ingesting illicit drugs, particularly opioids. Heroin is a powerful and highly addictive opioid that exerts activity in the ...
Clinician`s Resource Paper
... Benloucif S, Burgess HJ, Klerman EB, et al. Measuring melatonin in humans. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. Feb 15 2008; 4 (1): 66-69. Mahmood A, FitzGerald AJ, Marchbank T, et al. Zinc carnosine, a health food supplement tha ...
... Benloucif S, Burgess HJ, Klerman EB, et al. Measuring melatonin in humans. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. Feb 15 2008; 4 (1): 66-69. Mahmood A, FitzGerald AJ, Marchbank T, et al. Zinc carnosine, a health food supplement tha ...
Scintigraphic comparison of budesonide deposition from two dry powder inhalers
... The Montreal protocol banning the use of CFC propellants has been a major stimulus to the development of novel inhaler technologies for asthma therapy, including many new DPIs [14]. Each of these new devices is unique in its drug delivery characteristics. These differences between products, and espe ...
... The Montreal protocol banning the use of CFC propellants has been a major stimulus to the development of novel inhaler technologies for asthma therapy, including many new DPIs [14]. Each of these new devices is unique in its drug delivery characteristics. These differences between products, and espe ...
SELECTION OF EXCIPIENTS FOR DRY POWDER INHALERS
... and fumaryl diketopiperazine (FDKP) have been investigated as carriers for use in DPI drugs.3,4 Some of these excipients are hygroscopic and are therefore not suitable for combination with every drug.3 Most formulations in the market use alpha-monohydrate lactose, which has been widely accepted by r ...
... and fumaryl diketopiperazine (FDKP) have been investigated as carriers for use in DPI drugs.3,4 Some of these excipients are hygroscopic and are therefore not suitable for combination with every drug.3 Most formulations in the market use alpha-monohydrate lactose, which has been widely accepted by r ...
The serotonin RECEPTOR antagonists NAN
... Some aspects of locomotor activity and the stereotyped behavior induced by methamphetamine, a known drug of abuse worldwide, are probably a consequence of the release of dopamine from dopaminergic nerve terminals, particularly in the neostriatum. With higher doses of methamphetamine, disturbances of ...
... Some aspects of locomotor activity and the stereotyped behavior induced by methamphetamine, a known drug of abuse worldwide, are probably a consequence of the release of dopamine from dopaminergic nerve terminals, particularly in the neostriatum. With higher doses of methamphetamine, disturbances of ...
NAUSEA What`s the Problem, and How Do You Diagnose It
... intestine, and colon from toxins. In non-HIV research, it has shown some effectiveness as a treatment for colitis, or inflammatory bowel disease. Thus, it may also provide some protection against the damage to the intestines commonly caused by inflammation and pathogen-produced toxins. This could he ...
... intestine, and colon from toxins. In non-HIV research, it has shown some effectiveness as a treatment for colitis, or inflammatory bowel disease. Thus, it may also provide some protection against the damage to the intestines commonly caused by inflammation and pathogen-produced toxins. This could he ...
02/12/14 - Magellan Rx Management
... Lamictal® (swallow) tab start kit (green), #84-25 mg and #14-100 mg; EAC = $661.93 Kit; Lamictal® ODT start kit (orange), #14-25 mg, #14-50 mg, #7-100 mg; EAC = $312.80 Kit; Lamictal® (swallow) tablet start kit (orange); #42-25 mg and #7-100 mg; EAC = $330.96 Kit; Lamictal® ODT start kit (blue); #21 ...
... Lamictal® (swallow) tab start kit (green), #84-25 mg and #14-100 mg; EAC = $661.93 Kit; Lamictal® ODT start kit (orange), #14-25 mg, #14-50 mg, #7-100 mg; EAC = $312.80 Kit; Lamictal® (swallow) tablet start kit (orange); #42-25 mg and #7-100 mg; EAC = $330.96 Kit; Lamictal® ODT start kit (blue); #21 ...
Theranostics Polysaccharide Nanosystems for Future Progress in
... binding and phagocytosis.[15] As an additional example, polysaccharides such as hyaluronic acid are known to interact with macrophages. Polysaccharides may also be used as therapeutic agents. Certain polysaccharides are immunomodulators, affecting the regulation of immune responses during the progre ...
... binding and phagocytosis.[15] As an additional example, polysaccharides such as hyaluronic acid are known to interact with macrophages. Polysaccharides may also be used as therapeutic agents. Certain polysaccharides are immunomodulators, affecting the regulation of immune responses during the progre ...
Research Article PRELIMINARY PHYTOCHEMICAL ANALYSIS, HPTLC STUDIES AND ANTIPYRETIC ACTIVITY HELICTERES ISORA
... available the substrate for the enzyme. In these activities, synthesis of prostaglandin E, especially PGE1 is thought to be increased in the hypothalamus. Antipyretics compete with arachidonic acid at the active site of cyclooxygenase. During fever, arachidonic acid synthesis ma ...
... available the substrate for the enzyme. In these activities, synthesis of prostaglandin E, especially PGE1 is thought to be increased in the hypothalamus. Antipyretics compete with arachidonic acid at the active site of cyclooxygenase. During fever, arachidonic acid synthesis ma ...
Resveratrol
... Drinking large quantities of red wine, which contains resveratrol, may have adverse effects on the liver. Preliminary evidence suggests that resveratrol may weakly inhibit the way that the liver breaks down certain drugs, herbs, and supplements (inhibits multiple cytochrome P450 enzymes). ...
... Drinking large quantities of red wine, which contains resveratrol, may have adverse effects on the liver. Preliminary evidence suggests that resveratrol may weakly inhibit the way that the liver breaks down certain drugs, herbs, and supplements (inhibits multiple cytochrome P450 enzymes). ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.