ocena dokumentacji chemicznej, farmaceutycznej i biologicznej
... between nitrendipine and ketoconazole, itraconazole or fluconazole has not been performed. Drugs of this class are known to inhibit the cytochrome P450 3A4 system, and various interactions have been reported for other dihydropyridine calcium antagonists. Therefore, when administered orally together ...
... between nitrendipine and ketoconazole, itraconazole or fluconazole has not been performed. Drugs of this class are known to inhibit the cytochrome P450 3A4 system, and various interactions have been reported for other dihydropyridine calcium antagonists. Therefore, when administered orally together ...
Assessing Drug Substances to Identify “Highly Hazardous
... characteristics of the API such as pharmacologic potency and mechanism of action, which might also trigger specific requirements for safe handling and disposal. Drug manufacturers are often asked by contract manufacturing organizations whether or not APIs are “cytotoxic”, “steroids”, or “hormones.” ...
... characteristics of the API such as pharmacologic potency and mechanism of action, which might also trigger specific requirements for safe handling and disposal. Drug manufacturers are often asked by contract manufacturing organizations whether or not APIs are “cytotoxic”, “steroids”, or “hormones.” ...
Read more. - Griffin Discoveries
... The unique drug development platform consists of medicinal chemistry and molecular pharmacology tools that allow histamine receptors to be studied at an unprecedented level of details. No other company has these capabilities. 30% of all marketed drugs target GPCRs while histamine receptor drugs ...
... The unique drug development platform consists of medicinal chemistry and molecular pharmacology tools that allow histamine receptors to be studied at an unprecedented level of details. No other company has these capabilities. 30% of all marketed drugs target GPCRs while histamine receptor drugs ...
WS0201 - Cat`s TCM Notes
... the means by which drugs are stored in the body and eliminated from it. Bioavailability: ...
... the means by which drugs are stored in the body and eliminated from it. Bioavailability: ...
Topic 9. Clinical-pharmacological characteristics of anti
... World Health Organization (WHO), the rate of Allergy takes the 3rd place among other diseases. According to statistics, now in the world on one or another form of allergic diseases affecting 20-40% of population, that's mean at least every 5th inhabitants for the planet is allergy sufferer. Today >4 ...
... World Health Organization (WHO), the rate of Allergy takes the 3rd place among other diseases. According to statistics, now in the world on one or another form of allergic diseases affecting 20-40% of population, that's mean at least every 5th inhabitants for the planet is allergy sufferer. Today >4 ...
Routes of Administration
... A drug’s effects may be longer and more intense if liver and/or kidney are not functioning up to par. ...
... A drug’s effects may be longer and more intense if liver and/or kidney are not functioning up to par. ...
DRUGS AFFECTING CLOT FORMATION
... time (PT) 1.5 to 2.5 times the control value or ratio of PT to International Normalized Ratio (INR) of 2 to 3— to evaluate the effectiveness of the drug dose. ■ Evaluate for therapeutic effects of heparin—whole blood clotting time (WBCT) 2.5 to 3 times control or activated partial thromboplastin tim ...
... time (PT) 1.5 to 2.5 times the control value or ratio of PT to International Normalized Ratio (INR) of 2 to 3— to evaluate the effectiveness of the drug dose. ■ Evaluate for therapeutic effects of heparin—whole blood clotting time (WBCT) 2.5 to 3 times control or activated partial thromboplastin tim ...
Drug Metabolism
... process, which renders lipid soluble and nonpolar compounds to water soluble and polar compounds so that they are excreted by various processes. Drugs are considered xenobiotics and most are extensively metabolized in humans. Not all drugs are bioavailable, in which this led to the development o ...
... process, which renders lipid soluble and nonpolar compounds to water soluble and polar compounds so that they are excreted by various processes. Drugs are considered xenobiotics and most are extensively metabolized in humans. Not all drugs are bioavailable, in which this led to the development o ...
22Jan2002 PAGE 1
... a. motor vehicle crashes b. value of lost productivity c. direct treatment costs d. crime-related costs e. All of the above contribute to these figures. 9. Which of the following is true about the diagnosis of substance-related dependence and abuse in DSM-IV? a. A person may be diagnosed with both d ...
... a. motor vehicle crashes b. value of lost productivity c. direct treatment costs d. crime-related costs e. All of the above contribute to these figures. 9. Which of the following is true about the diagnosis of substance-related dependence and abuse in DSM-IV? a. A person may be diagnosed with both d ...
Pharmacology Basics
... The user is able to break down and/or excrete the drug more quickly due to repeated exposure. Increased excretion ...
... The user is able to break down and/or excrete the drug more quickly due to repeated exposure. Increased excretion ...
(5-Hydroxytryptamine 3).
... o Transient - lasting only for a short time; impermanent o What does elevation of liver enzymes mean - Any agent that damages the liver may cause elevation of the liver enzymes ...
... o Transient - lasting only for a short time; impermanent o What does elevation of liver enzymes mean - Any agent that damages the liver may cause elevation of the liver enzymes ...
Depressants
... • it’s odorless, (initially) colorless, tasteless and produces drunkenness, stupor, and blackout • Federal law, since 1996, dictates a 20-year sentence for use of this drug in connection with sexual assault or other violence used ...
... • it’s odorless, (initially) colorless, tasteless and produces drunkenness, stupor, and blackout • Federal law, since 1996, dictates a 20-year sentence for use of this drug in connection with sexual assault or other violence used ...
Depressants
... • Dangers: cross tolerance and potentiation what are the clinical implications of treating anxiety with drugs? difficult to estimate non-medical misuse or abuse of sedatives and tranquilizers NHSDA 2001: (9.6, 2.0, .7%) ...
... • Dangers: cross tolerance and potentiation what are the clinical implications of treating anxiety with drugs? difficult to estimate non-medical misuse or abuse of sedatives and tranquilizers NHSDA 2001: (9.6, 2.0, .7%) ...
Session 7 - Teaching Slides
... The process of transforming active drugs into inactive metabolites that can be more readily excreted from the body. ...
... The process of transforming active drugs into inactive metabolites that can be more readily excreted from the body. ...
When Is an Interaction Likely to Cause Harm?
... Once the mean change in the concentration of the object drug is determined, one needs to consider how that degree of change relates to the usual therapeutic range of the drug. For many drugs, a change in dose of 30% to 50% will produce a change in response. For this reason, a decrease in clearance e ...
... Once the mean change in the concentration of the object drug is determined, one needs to consider how that degree of change relates to the usual therapeutic range of the drug. For many drugs, a change in dose of 30% to 50% will produce a change in response. For this reason, a decrease in clearance e ...
DRUG RECEPTOR INTERACTIONS
... Interaction of drug (agonist) with another chemical (antagonist) outside of receptor to form an inactive complex. ...
... Interaction of drug (agonist) with another chemical (antagonist) outside of receptor to form an inactive complex. ...
chapter 4 psychopharmacology
... – In response to an action potential, the substance is released in sufficient quantities to produce an effect in the postsynaptic cell – We should be able to duplicate the action of a suspected neurotransmitter experimentally on a postsynaptic cell – Some mechanism exists that ends the interaction b ...
... – In response to an action potential, the substance is released in sufficient quantities to produce an effect in the postsynaptic cell – We should be able to duplicate the action of a suspected neurotransmitter experimentally on a postsynaptic cell – Some mechanism exists that ends the interaction b ...
anti-anxiety medications
... benzodiazepines can produce a dangerous level of sedation. Some benzodiazepines are metabolized and eliminated slowly from the body, causing a build-up. Elderly persons are particularly sensitive to the effects of high levels of these drugs. Falls and other accidents can occur due to dizziness and u ...
... benzodiazepines can produce a dangerous level of sedation. Some benzodiazepines are metabolized and eliminated slowly from the body, causing a build-up. Elderly persons are particularly sensitive to the effects of high levels of these drugs. Falls and other accidents can occur due to dizziness and u ...
Library Of Rare CNS Drugs Available For Collaboration
... structure, clinical status, and CNS bioavailability of each molecule selected, as well as QC of the library to ensure that each hit found is actionable. About 40% of the drugs are ex-‐US ...
... structure, clinical status, and CNS bioavailability of each molecule selected, as well as QC of the library to ensure that each hit found is actionable. About 40% of the drugs are ex-‐US ...
Slide 1
... delivery of the drug to the body under normal and pathologic conditions (impaired physiological function). ...
... delivery of the drug to the body under normal and pathologic conditions (impaired physiological function). ...
Lithium - Wellington ICU
... element of the alkali metal group exact mechanism of action in mania is unknown ? alters Na+ transport in muscle and nerves cells ? alters intraneuronal metabolism of catecholamines ...
... element of the alkali metal group exact mechanism of action in mania is unknown ? alters Na+ transport in muscle and nerves cells ? alters intraneuronal metabolism of catecholamines ...
Names
... "Neutralize up to 66 percent of the starch consumed in a meal." "This advanced dietary-fat inhibitor helps block the absorption of fat calories." "Take 3 capsules before bedtime. Watch the fat disappear!" "Guaranteed to block the breakdown of carbohydrates and simple sugars from being converted into ...
... "Neutralize up to 66 percent of the starch consumed in a meal." "This advanced dietary-fat inhibitor helps block the absorption of fat calories." "Take 3 capsules before bedtime. Watch the fat disappear!" "Guaranteed to block the breakdown of carbohydrates and simple sugars from being converted into ...
Intravascular Dosing, Clearance, and Volume of Distribution
... What are the two types? Distribution: Acidic drugs bind to ___________, while basic drugs bind to _________________ True or False: A drug that has a high Volume of distribution (Vd) means that it is very hydrophilic. ...
... What are the two types? Distribution: Acidic drugs bind to ___________, while basic drugs bind to _________________ True or False: A drug that has a high Volume of distribution (Vd) means that it is very hydrophilic. ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.