PowerPoint プレゼンテーション - 埼玉医科大学総合医療センター 内分泌
... patients experiencing an inadequate response to maximized and stable (_4 weeks at _1500 mg or maximally tolerated dose) metformin therapy. Data Extraction Inclusion/exclusion criteria; duration of patient follow-up; drug, dose, and schedule used; use of concurrent lifestyle modification; and baselin ...
... patients experiencing an inadequate response to maximized and stable (_4 weeks at _1500 mg or maximally tolerated dose) metformin therapy. Data Extraction Inclusion/exclusion criteria; duration of patient follow-up; drug, dose, and schedule used; use of concurrent lifestyle modification; and baselin ...
Examples 11/15
... Examples 11/15 1. (Physiological Processes) Try to explain why the concentration of drugs in the blood stream decays exponentially. 2. (Periodic Drug Doses) It’s common to take a drug (such as aspirin or an antibiotic) repeatedly at fixed time intervals. Suppose that an antibiotic has a half-life of ...
... Examples 11/15 1. (Physiological Processes) Try to explain why the concentration of drugs in the blood stream decays exponentially. 2. (Periodic Drug Doses) It’s common to take a drug (such as aspirin or an antibiotic) repeatedly at fixed time intervals. Suppose that an antibiotic has a half-life of ...
Signal Detection in EudraVigilance
... The nature of the model which will supply the expected cell values against which disproportionality can be assessed will be determined by the information available. Most signal detection processes have started with a basic model of independence between products and adverse events. This makes sense a ...
... The nature of the model which will supply the expected cell values against which disproportionality can be assessed will be determined by the information available. Most signal detection processes have started with a basic model of independence between products and adverse events. This makes sense a ...
Basic Concepts in Medicinal Chemistry - Review
... molecule can also affect its interaction with biological targets. Emphasis is placed on the pharmacological and therapeutic differences that can occur between enantiomers. A chapter is devoted to exploring the metabolism of drug molecules by various enzymes. It identifies the functional groups that ...
... molecule can also affect its interaction with biological targets. Emphasis is placed on the pharmacological and therapeutic differences that can occur between enantiomers. A chapter is devoted to exploring the metabolism of drug molecules by various enzymes. It identifies the functional groups that ...
Side Effects
... The current-day dermatologist is well equipped with an array of therapeutic tools in his/her armamentarium for the successful management of various dermatoses. A better understanding of diseases has resulted in the evolution of drugs that act more specifically with minimal risk to the patient. ...
... The current-day dermatologist is well equipped with an array of therapeutic tools in his/her armamentarium for the successful management of various dermatoses. A better understanding of diseases has resulted in the evolution of drugs that act more specifically with minimal risk to the patient. ...
Autonomic Nervous System Anticholinergic Drugs
... its persistence in the body is increased by : 1- Neostigmine, which inactivate that enzyme. 2- In patient with hepatic disease or severe malnutrition, whose plasma concentration of enzyme may be lower than normal. 3- Procaine also is destroyed by this enzyme and so by competing with suxamethonium fo ...
... its persistence in the body is increased by : 1- Neostigmine, which inactivate that enzyme. 2- In patient with hepatic disease or severe malnutrition, whose plasma concentration of enzyme may be lower than normal. 3- Procaine also is destroyed by this enzyme and so by competing with suxamethonium fo ...
Erythroxylum coca
... Dopamine transporter knockout mice: (1) are hyperactive, (2) show less response to cocaine, (3) self-administer cocaine less 4. Cannabinoid receptors Cannabinoid receptor knockouts have little overt differences to normal mice. They don’t show these effects of THC and anandamide: (1) decreased pain r ...
... Dopamine transporter knockout mice: (1) are hyperactive, (2) show less response to cocaine, (3) self-administer cocaine less 4. Cannabinoid receptors Cannabinoid receptor knockouts have little overt differences to normal mice. They don’t show these effects of THC and anandamide: (1) decreased pain r ...
STATIN THERAPY AND THEIR FORMULATION APPROCHES: A REVIEW Review Article
... disease which has major role as adjunctive therapy with diet for decreasing the total cholesterol level, LDL, triglycerides and Apo-B. Statins are also indicated for mixed dyslipidemia or primary hypercholesterolemia, Fredrickson Type IV and V hyperlipidemia. These diseases are directly or indirectl ...
... disease which has major role as adjunctive therapy with diet for decreasing the total cholesterol level, LDL, triglycerides and Apo-B. Statins are also indicated for mixed dyslipidemia or primary hypercholesterolemia, Fredrickson Type IV and V hyperlipidemia. These diseases are directly or indirectl ...
Atenolol – Interaction with Other drugs
... mainly excreted by kidneys, this interaction is less common with atenolol. 15. Oestrogens cause fluid retention there by blunting the antihypertensive effect of betablockers.13 16. Neuromuscular Blocking Agents: 13 Beta blockers can potentiate and prolong the effect of neuromuscular blocking a ...
... mainly excreted by kidneys, this interaction is less common with atenolol. 15. Oestrogens cause fluid retention there by blunting the antihypertensive effect of betablockers.13 16. Neuromuscular Blocking Agents: 13 Beta blockers can potentiate and prolong the effect of neuromuscular blocking a ...
designer drugs - Maryland Addictions Directors Council
... • Crushed non-psychoactive herbal plant matter treated with one or more synthetic cannabinoids ...
... • Crushed non-psychoactive herbal plant matter treated with one or more synthetic cannabinoids ...
Maryland Corrections Sara Monnen
... • Crushed non-psychoactive herbal plant matter treated with one or more synthetic cannabinoids ...
... • Crushed non-psychoactive herbal plant matter treated with one or more synthetic cannabinoids ...
moini_ch01_lecture_revised2016
... cells, known as receptors. • Binding of drugs to a particular receptor type produces pharmacologic effect— either agonist or antagonist actions. ...
... cells, known as receptors. • Binding of drugs to a particular receptor type produces pharmacologic effect— either agonist or antagonist actions. ...
1 Lecture Pharmacology Dr. nahlah Pharmacology of the Autonomic
... Therapeutic uses: 1) The drug increases intestinal and bladder motility, which serves as its therapeutic action in atony of either organ. 2) Physostigmineis also used in the treatment of overdoses of drugs with anticholinergic actions, such as atropine. Adverse effects: on the CNS may lead to conv ...
... Therapeutic uses: 1) The drug increases intestinal and bladder motility, which serves as its therapeutic action in atony of either organ. 2) Physostigmineis also used in the treatment of overdoses of drugs with anticholinergic actions, such as atropine. Adverse effects: on the CNS may lead to conv ...
The National Association of Health lJnderwriters is an organization of individuals
... “The official (FDA) position is money doesn’t matter,” Pinto says. “But below the radar, they take into account the financial repercussions of their decisions. They have to take money into account. Otherwise, it would bastardize the economics underlying the pharmaceutical industry. ” Insurance compa ...
... “The official (FDA) position is money doesn’t matter,” Pinto says. “But below the radar, they take into account the financial repercussions of their decisions. They have to take money into account. Otherwise, it would bastardize the economics underlying the pharmaceutical industry. ” Insurance compa ...
Acute kidney injury and sick day rules
... sick day rules/guidance. The premise here is that interventions directed towards these high risk patients will improve their clinical outcome. Inevitably such pathways will have an impact on the management of patients with chronic heart failure. The Board of the British Society for Heart Failure (BS ...
... sick day rules/guidance. The premise here is that interventions directed towards these high risk patients will improve their clinical outcome. Inevitably such pathways will have an impact on the management of patients with chronic heart failure. The Board of the British Society for Heart Failure (BS ...
Effects of Drugs on the Brain
... inhaling the smoke. Smoking cigarettes produces a rapid distribution of nicotine throughout the body, and reaching the brain within ten seconds of inhalation. The nicotine causes a release of dopamine, neurotransmitters that carry information across synaptic clefts, in the dopamine circuit. This cir ...
... inhaling the smoke. Smoking cigarettes produces a rapid distribution of nicotine throughout the body, and reaching the brain within ten seconds of inhalation. The nicotine causes a release of dopamine, neurotransmitters that carry information across synaptic clefts, in the dopamine circuit. This cir ...
UNIT 3: Introduction to Pharmacology
... Are the factors that make a drug "less safe" than it would be under other conditions, e.g. 1. Presence/use/administration of other interacting drugs 2. Changes in drug absorption, distribution, metabolism, excretion VII. Pharmacologic antagonists (also generally called receptor blockers) These are d ...
... Are the factors that make a drug "less safe" than it would be under other conditions, e.g. 1. Presence/use/administration of other interacting drugs 2. Changes in drug absorption, distribution, metabolism, excretion VII. Pharmacologic antagonists (also generally called receptor blockers) These are d ...
A New Assault on Addiction
... naltrexone poses hazards of its own. The common side effects are minor, ranging from nausea to joint pain, but it can cause liver damage at just five times the recommended dose. ReVia's package insert warns repeated1y that the drug should not be used by anyone currently dependent on opioids” such as ...
... naltrexone poses hazards of its own. The common side effects are minor, ranging from nausea to joint pain, but it can cause liver damage at just five times the recommended dose. ReVia's package insert warns repeated1y that the drug should not be used by anyone currently dependent on opioids” such as ...
How to spot illicit drug abuse in your patients
... short duration followed by a strong dysphoric crash. Because the cocaine salt is broken down at high temperatures, cocaine hydrochloride first must be made into its freebase form (cocaine). Freebasing cocaine results in a very intense rush (reportedly more powerful than that from an intravenous inje ...
... short duration followed by a strong dysphoric crash. Because the cocaine salt is broken down at high temperatures, cocaine hydrochloride first must be made into its freebase form (cocaine). Freebasing cocaine results in a very intense rush (reportedly more powerful than that from an intravenous inje ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.