[Product Monograph Template
... geriatric population and virtually no controlled clinical studies on subjects 75 years and over. Of the 306 patients enrolled in the Phase 3 clinical trial utilizing NATESTO, 60 were 65 years of age or older, and 9 were 75 years of age or older. There are insufficient long-term safety data in geriat ...
... geriatric population and virtually no controlled clinical studies on subjects 75 years and over. Of the 306 patients enrolled in the Phase 3 clinical trial utilizing NATESTO, 60 were 65 years of age or older, and 9 were 75 years of age or older. There are insufficient long-term safety data in geriat ...
Combinations of antifungal agents in therapy–what value are they?
... such as miconazole, ketoconazole and itraconazole decreases the fungicidal effects of amphotericin B, wheras fluconazole, a hydrophilic compound, does not. These conflicting results could be explained largely by the technique and the criteria used for evaluating the interaction. Amphotericin–azole c ...
... such as miconazole, ketoconazole and itraconazole decreases the fungicidal effects of amphotericin B, wheras fluconazole, a hydrophilic compound, does not. These conflicting results could be explained largely by the technique and the criteria used for evaluating the interaction. Amphotericin–azole c ...
The use of injectable nonsteroidal anti
... On the other hand, inhibition of COX-1 is thought to produce some of their toxic effects, especially those on the gastrointestinal tract. Most of the NSAID currently available for clinical use inhibit both COX-1 and COX-2 e.g. diclofenac or predominantly COX-1 e.g. ketoprofen.20 They can be administ ...
... On the other hand, inhibition of COX-1 is thought to produce some of their toxic effects, especially those on the gastrointestinal tract. Most of the NSAID currently available for clinical use inhibit both COX-1 and COX-2 e.g. diclofenac or predominantly COX-1 e.g. ketoprofen.20 They can be administ ...
PRODUCT MONOGRAPH PrDEPO-MEDROL* WITH LIDOCAINE
... As sodium retention with resultant edema and potassium loss may occur in patients receiving corticosteroids, these agents should be used with caution, and only if strictly necessary, in patients with congestive heart failure. Corticosteroids should also be used with caution in hypertension, or renal ...
... As sodium retention with resultant edema and potassium loss may occur in patients receiving corticosteroids, these agents should be used with caution, and only if strictly necessary, in patients with congestive heart failure. Corticosteroids should also be used with caution in hypertension, or renal ...
Protective Effect of Ginger oil on Aspirin and Pylorus Ligation
... Aspirin was suspended in 1% CMC solution and administered orally in the dose of 200 mg/kg in non fasted rats once daily for 5 days. Ginger oil and omeprazole were administered orally to the respective treatment groups 30 min before each aspirin treatment where as the control group received only vehi ...
... Aspirin was suspended in 1% CMC solution and administered orally in the dose of 200 mg/kg in non fasted rats once daily for 5 days. Ginger oil and omeprazole were administered orally to the respective treatment groups 30 min before each aspirin treatment where as the control group received only vehi ...
Pediatric Codeine Formularly Restriction
... Fasting or acutely malnourished and/or dehydrated due to vomiting, diarrhea or fever (reduced hepatic glutathione stores) ...
... Fasting or acutely malnourished and/or dehydrated due to vomiting, diarrhea or fever (reduced hepatic glutathione stores) ...
Evolution of medical treatment for endometriosis: back to the roots?
... Experimental evidence is accumulating to suggest that medicinal botanicals have anti-inflammatory and painalleviating properties and hold promise for treatment of endometriosis. Herein, we present a systematic review of clinical and experimental data on the use of medicinal herbs in the treatment of ...
... Experimental evidence is accumulating to suggest that medicinal botanicals have anti-inflammatory and painalleviating properties and hold promise for treatment of endometriosis. Herein, we present a systematic review of clinical and experimental data on the use of medicinal herbs in the treatment of ...
GHB - CAP Members
... traits that make users vulnerable to sexual assault and other criminal acts.GHB abuse became popular among teens and young adults at dance clubs and “raves” in the 1990s and gained notoriety as a date rape drug. GHB is taken alone or in combination with other drugs, such as alcohol (primarily), othe ...
... traits that make users vulnerable to sexual assault and other criminal acts.GHB abuse became popular among teens and young adults at dance clubs and “raves” in the 1990s and gained notoriety as a date rape drug. GHB is taken alone or in combination with other drugs, such as alcohol (primarily), othe ...
Suppression of laser-induced choroidal neovascularization
... subretinal space, subretinal pigment epithelium, or both.6'7 The choroidal neovascular membrane then destroys the macula, which results in visual loss. Although submacular surgery to remove CNV has been advocated, the efficacy of this new therapy has yet to be convincingly demonstrated,8"11 and at p ...
... subretinal space, subretinal pigment epithelium, or both.6'7 The choroidal neovascular membrane then destroys the macula, which results in visual loss. Although submacular surgery to remove CNV has been advocated, the efficacy of this new therapy has yet to be convincingly demonstrated,8"11 and at p ...
Lethal Injection for Execution: Chemical Asphyxiation?
... Task Force, which concluded ‘‘it is not possible to administer so much of it that a lethal effect is guaranteed’’ [23], even in their population of profoundly ill patients. The most compelling evidence that even 5 g of thiopental alone may not be lethal, however, is that some California inmates cont ...
... Task Force, which concluded ‘‘it is not possible to administer so much of it that a lethal effect is guaranteed’’ [23], even in their population of profoundly ill patients. The most compelling evidence that even 5 g of thiopental alone may not be lethal, however, is that some California inmates cont ...
Kwartaalbericht
... PPIs can probably induce tongue discolouration due to their ability to decrease saliva production and increase the pH of the oral mucosa and therefore cause an altered microbial flora. Six cases of tongue discoloration were reported in association with PPIs, including one patient with a positive rec ...
... PPIs can probably induce tongue discolouration due to their ability to decrease saliva production and increase the pH of the oral mucosa and therefore cause an altered microbial flora. Six cases of tongue discoloration were reported in association with PPIs, including one patient with a positive rec ...
Drug interactions involving warfarin
... in the circulation before initiation of the interacting agent must be depleted. An effect on the INR is typically observed within 3 to 5 days for interacting substances with short half-lives. The effect on the INR of drugs with longer half-lives will be even further delayed. Generally, onset and off ...
... in the circulation before initiation of the interacting agent must be depleted. An effect on the INR is typically observed within 3 to 5 days for interacting substances with short half-lives. The effect on the INR of drugs with longer half-lives will be even further delayed. Generally, onset and off ...
Identification of the date-rape drug GHB and its precursor GBL by
... Previous analysis of GHB and GBL (Fig. 1) in a forensic context has been studied by HPLC,[7] GC-MS,[6] NMR[8] and infrared spectroscopy[8] and often involves removing the drug from the liquid matrix prior to analysis. Raman spectroscopy is a suitable method for this type of analysis as it is a non-d ...
... Previous analysis of GHB and GBL (Fig. 1) in a forensic context has been studied by HPLC,[7] GC-MS,[6] NMR[8] and infrared spectroscopy[8] and often involves removing the drug from the liquid matrix prior to analysis. Raman spectroscopy is a suitable method for this type of analysis as it is a non-d ...
Statins Transport, side effects and cytoxicity_Rev2
... rosuvastatin is not significantly metabolized by the CYP enzymes, and is largely excreted unchanged, this situation is complicated by the finding that glucuronidation products of simvastatin acid, cerivastatin acid and rosuvastatin acid all undergo spontaneous cyclization to the lactone form.[7] Oth ...
... rosuvastatin is not significantly metabolized by the CYP enzymes, and is largely excreted unchanged, this situation is complicated by the finding that glucuronidation products of simvastatin acid, cerivastatin acid and rosuvastatin acid all undergo spontaneous cyclization to the lactone form.[7] Oth ...
Adrenergic-Blocking Drugs
... prevent or minimize postural hypotension Avoid caffeine (excessive irritability) Avoid alcohol ingestion and hazardous activities until blood levels become stable Patients should notify their physician if palpitations, dyspnea, nausea, or vomiting occurs ...
... prevent or minimize postural hypotension Avoid caffeine (excessive irritability) Avoid alcohol ingestion and hazardous activities until blood levels become stable Patients should notify their physician if palpitations, dyspnea, nausea, or vomiting occurs ...
Opioid Receptors and Legal Highs - The Salvia divinorum Research
... Salvia divinorum and Mitragyna speciosa (“Kratom”), two unscheduled dietary supplements whose active agents are opioid receptor agonists, have discrete psychoactive effects that have contributed to their increasing popularity. Salvia divinorum contains the highly selective kappa- opioid receptor ago ...
... Salvia divinorum and Mitragyna speciosa (“Kratom”), two unscheduled dietary supplements whose active agents are opioid receptor agonists, have discrete psychoactive effects that have contributed to their increasing popularity. Salvia divinorum contains the highly selective kappa- opioid receptor ago ...
SINGLE RP-HPLC METHOD FOR THE QUANTIFICATION OF
... rate of 1.0 ml min-.The detection wavelength was set at 272 nm with a runtime of 10 min. The mobile phase was prepared freshly and it was degassed by sonicating for 5 min before use. The column was equilibrated for at least 30min with the mobile phase flowing through the system. The column and the H ...
... rate of 1.0 ml min-.The detection wavelength was set at 272 nm with a runtime of 10 min. The mobile phase was prepared freshly and it was degassed by sonicating for 5 min before use. The column was equilibrated for at least 30min with the mobile phase flowing through the system. The column and the H ...
Pralidoxime Iodide Injection
... Intravenous administration of Pralidoxime Iodide Injection should be carried out slowly and, preferably, by infusion, since certain side effects, such as tachycardia, laryngospasm, and muscle rigidity, have been attributed in a few cases to a too rapid rate of injection (see Dosage and Administratio ...
... Intravenous administration of Pralidoxime Iodide Injection should be carried out slowly and, preferably, by infusion, since certain side effects, such as tachycardia, laryngospasm, and muscle rigidity, have been attributed in a few cases to a too rapid rate of injection (see Dosage and Administratio ...
midazolam sedation in paediatrics: comparative study of intranasal
... psychological consequences in children.2 The unfamiliar faces and the environment inside MRI, compound a sense of insecurity in children.3 In a busy radiology department time taken for the procedure becomes an important factor when choosing the technique used for sedation. Pharmacological agents are ...
... psychological consequences in children.2 The unfamiliar faces and the environment inside MRI, compound a sense of insecurity in children.3 In a busy radiology department time taken for the procedure becomes an important factor when choosing the technique used for sedation. Pharmacological agents are ...
Drug Formulary
... immobility in response to a painful stimulation. Drugs that produce anesthesia may or may not provide analgesia (1, 2). • Analgesia: The absence of pain in response to stimulation that would normally be painful. An analgesic drug can provide analgesia by acting at the level of the central nervous sy ...
... immobility in response to a painful stimulation. Drugs that produce anesthesia may or may not provide analgesia (1, 2). • Analgesia: The absence of pain in response to stimulation that would normally be painful. An analgesic drug can provide analgesia by acting at the level of the central nervous sy ...
focusing in on adderall - Institute for Food Laws and Regulations
... students a day that ask for Adderall prescriptions.34 Later on in this paper, we will investigate whether or not there is sufficient evidence to suggest that doctors prescribing Adderall for students who do not have ADHD is a significant problem. II. INVESTIGATING ADDERALL’S HEALTH RISKS We already ...
... students a day that ask for Adderall prescriptions.34 Later on in this paper, we will investigate whether or not there is sufficient evidence to suggest that doctors prescribing Adderall for students who do not have ADHD is a significant problem. II. INVESTIGATING ADDERALL’S HEALTH RISKS We already ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.