Drug treatments for Parkinson`s
... For these reasons, drug treatment for Parkinson’s is often started at low doses and increased gradually, stepping up the doses, the frequency, or adding new drugs, until symptom control is achieved. Anyone with Parkinson’s can aim for a healthier lifestyle by focusing on exercise, relaxation and di ...
... For these reasons, drug treatment for Parkinson’s is often started at low doses and increased gradually, stepping up the doses, the frequency, or adding new drugs, until symptom control is achieved. Anyone with Parkinson’s can aim for a healthier lifestyle by focusing on exercise, relaxation and di ...
Teratogenicity as a Consequence of Drug-Induced
... Drugs prolonging the repolarisation phase of the myocardial action potential, via inhibition of the rapid component of the delayed-rectifying potassium channel (IKr), may cause death due to arrhythmia. Selective IKr-blockers are also embryotoxic in rats. The aim of this thesis was to determine if dr ...
... Drugs prolonging the repolarisation phase of the myocardial action potential, via inhibition of the rapid component of the delayed-rectifying potassium channel (IKr), may cause death due to arrhythmia. Selective IKr-blockers are also embryotoxic in rats. The aim of this thesis was to determine if dr ...
A multiparameter test of clot formation and fibrinolysis for in
... of the studies evaluating the ASA effect on fibrinolysis, however, are ambiguous. The impact of ASA activity is thought to be dependent on the initial plasma fibrinolytic activity, the dose, and the time of its administration [6]. Despite the fact that all the mechanisms by which ASA affects hemosta ...
... of the studies evaluating the ASA effect on fibrinolysis, however, are ambiguous. The impact of ASA activity is thought to be dependent on the initial plasma fibrinolytic activity, the dose, and the time of its administration [6]. Despite the fact that all the mechanisms by which ASA affects hemosta ...
Modifying effects of boswellia carteri on clarithromycine action: In
... Serials Publication, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Article History:-----------------------Date of Submission: 04-06-2012 Date of Acceptance: 13-06-2012 Conflict of Interest: NIL Source of Support: NONE ...
... Serials Publication, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Article History:-----------------------Date of Submission: 04-06-2012 Date of Acceptance: 13-06-2012 Conflict of Interest: NIL Source of Support: NONE ...
ULTRACET C IV
... concentration was delayed for approximately 35 minutes for tramadol and almost one hour for acetaminophen. However, peak plasma concentrations, and the extents of ...
... concentration was delayed for approximately 35 minutes for tramadol and almost one hour for acetaminophen. However, peak plasma concentrations, and the extents of ...
Strategies for in vitro Transporter Testing and
... Huang, et al. New Era in Drug Interaction Evaluation: US FDA Update on CYP Enzymes, Transporters, and the Guidance Process. J. Clin. Pharmacol. 48:662-670 (2008) ...
... Huang, et al. New Era in Drug Interaction Evaluation: US FDA Update on CYP Enzymes, Transporters, and the Guidance Process. J. Clin. Pharmacol. 48:662-670 (2008) ...
Chapter_35
... maintenance of primary and secondary male sex characteristics Development of bone and muscle tissue Inhibition of protein catabolism (metabolic breakdown) Retention of various electrolytes ...
... maintenance of primary and secondary male sex characteristics Development of bone and muscle tissue Inhibition of protein catabolism (metabolic breakdown) Retention of various electrolytes ...
Averrhoa Carambola: An Updated Review
... general debility. It is also used in traditional medicines in countries like India, China, Phillipines, Brazil for various ailments. Although review articles on this plant are already published, but the present attempt is to review and compile all the updated information on botany, phytochemical and ...
... general debility. It is also used in traditional medicines in countries like India, China, Phillipines, Brazil for various ailments. Although review articles on this plant are already published, but the present attempt is to review and compile all the updated information on botany, phytochemical and ...
Safety and Efficacy of Galactogogues
... secrete PRL releasing hormone. In addition, as dopamine is a physiologic inhibitor of PRL release, some galactagogues act either by blocking hypothalamic dopaminergic receptors (e.g metoclopramide and domperidone) or by inhibiting dopamine-producing neurons (6). The mechanism of breast milk producti ...
... secrete PRL releasing hormone. In addition, as dopamine is a physiologic inhibitor of PRL release, some galactagogues act either by blocking hypothalamic dopaminergic receptors (e.g metoclopramide and domperidone) or by inhibiting dopamine-producing neurons (6). The mechanism of breast milk producti ...
Full Text Article
... measures could be taken for their prevention in future. These reports should be circulated widely so that the regulatory authorities can take necessary steps for modifying the drug labels, package inserts, issue warnings or for reconsideration of marketing approval. There are several methods of ADR ...
... measures could be taken for their prevention in future. These reports should be circulated widely so that the regulatory authorities can take necessary steps for modifying the drug labels, package inserts, issue warnings or for reconsideration of marketing approval. There are several methods of ADR ...
Gastrointestinal Disorders: Nausea in Adults
... Combination therapy may be required and has been found to be most useful in chemotherapyinduced nausea. If management of a nauseated patient fails to provide some symptomatic relief, reassess the patient and look for other causes. Know a few medications well. If one medication fails, try a differen ...
... Combination therapy may be required and has been found to be most useful in chemotherapyinduced nausea. If management of a nauseated patient fails to provide some symptomatic relief, reassess the patient and look for other causes. Know a few medications well. If one medication fails, try a differen ...
Fixed Combinations – Concept of Use
... Mechanism of action: Ocular hypotensive FDCs are products that include two active agents in the same bottle. All currently available FDCs include timolol – a nonselective beta-blocker at the concentration of 5 mg per ml (0.5%). The other drug is a PGA, including bimatoprost, latanoprost or travopros ...
... Mechanism of action: Ocular hypotensive FDCs are products that include two active agents in the same bottle. All currently available FDCs include timolol – a nonselective beta-blocker at the concentration of 5 mg per ml (0.5%). The other drug is a PGA, including bimatoprost, latanoprost or travopros ...
Menthol inhibiting parasympathetic function of tracheal smooth muscle
... response observed in this study was probably an aggregate of the responses of various types of muscle tissue. Secondly, the isolated tracheal preparations used in our experiments were excised from rats without damaging the endothelium or smooth muscle. Therefore, it is reasonable to assume that trac ...
... response observed in this study was probably an aggregate of the responses of various types of muscle tissue. Secondly, the isolated tracheal preparations used in our experiments were excised from rats without damaging the endothelium or smooth muscle. Therefore, it is reasonable to assume that trac ...
The Effects of Caffeine on the Human Metabolism
... The Effects of Caffeine on the Human Metabolism Caffeine is the most commonly used mind altering drug in the world (Moret 1). Caffeine is found in food, drinks, and drug formations, but most products do not list the caffeine content (Sepkowitz 243). It is estimated that people consume 16 to 70 mg of ...
... The Effects of Caffeine on the Human Metabolism Caffeine is the most commonly used mind altering drug in the world (Moret 1). Caffeine is found in food, drinks, and drug formations, but most products do not list the caffeine content (Sepkowitz 243). It is estimated that people consume 16 to 70 mg of ...
Meperidine - Home - KSU Faculty Member websites
... shivering and shaking chills induced by amphotericin B. • it comes in both tablet and liquid form for oral administration. The drug can also be administered by injection into a large muscle or added to an intravenous fluid. ...
... shivering and shaking chills induced by amphotericin B. • it comes in both tablet and liquid form for oral administration. The drug can also be administered by injection into a large muscle or added to an intravenous fluid. ...
Guidance for the use of substitute prescribing in the
... statement on recovery from substance misuse provides a useful guide for the aims of substance misuse treatment: Recovery is a process, characterised by voluntarily maintained control over substance use, leading towards health and well-being and participation in the responsibilities and benefits of s ...
... statement on recovery from substance misuse provides a useful guide for the aims of substance misuse treatment: Recovery is a process, characterised by voluntarily maintained control over substance use, leading towards health and well-being and participation in the responsibilities and benefits of s ...
THERAPEUTIC MDMA (ECSTASY): THE FEDERAL GOVERNMENT
... in rats with damage to nerve terminals which use serotonin as a neurotransmitter.30 While the DEA presented the MDA studies as their rationale behind the emergency scheduling, the ALJ presented various findings of fact drawing distinctions between the two chemical compounds31 . It should also be not ...
... in rats with damage to nerve terminals which use serotonin as a neurotransmitter.30 While the DEA presented the MDA studies as their rationale behind the emergency scheduling, the ALJ presented various findings of fact drawing distinctions between the two chemical compounds31 . It should also be not ...
Inhibitory Effects of Fruit Juices on Cytochrome P450
... activities observed with 0.25 ml (0.05% v/v) of pineapple juice at preincubation periods of 0, 5, 15, and 30 min were 79.4%, 72.4%, 64.9%, and 55.1% respectively. These data suggest that pineapple juice causes irreversible inhibition of human CYP2C9 activity. Thus, we discovered that pineapple juice ...
... activities observed with 0.25 ml (0.05% v/v) of pineapple juice at preincubation periods of 0, 5, 15, and 30 min were 79.4%, 72.4%, 64.9%, and 55.1% respectively. These data suggest that pineapple juice causes irreversible inhibition of human CYP2C9 activity. Thus, we discovered that pineapple juice ...
Stability Testing of Pharmaceutical Products
... Journal of Applied Pharmaceutical Science 02 (03); 2012: 129-138 ...
... Journal of Applied Pharmaceutical Science 02 (03); 2012: 129-138 ...
Drug formulary - Johns Hopkins University
... anesthesia (unconsciousness) and analgesia (absence of pain) they may also have profound effects on the biologic parameters that you intend to study. Drug dosages are usually based on body weight-be sure that you weigh the animals before you administer the drugs. As a general rule, when a dosage ran ...
... anesthesia (unconsciousness) and analgesia (absence of pain) they may also have profound effects on the biologic parameters that you intend to study. Drug dosages are usually based on body weight-be sure that you weigh the animals before you administer the drugs. As a general rule, when a dosage ran ...
GPAT 2010 Question Paper
... Q.88 Many xenobiotics are oxidized by cytochrome P450 in order to (A) increase their biological activity (B) increase their disposition in lipophilic compartments of the body (C) increase their aqueous solubility (D) all of the above Ans. Q.89 The following protein / polypeptide has a quaternary str ...
... Q.88 Many xenobiotics are oxidized by cytochrome P450 in order to (A) increase their biological activity (B) increase their disposition in lipophilic compartments of the body (C) increase their aqueous solubility (D) all of the above Ans. Q.89 The following protein / polypeptide has a quaternary str ...
POTENTIAL ANTIDIABETIC, HYPOLIPIDAEMIC AND ANTIOXIDANT EFFECTS OF XANTHOSOMA SAGITTIFOLIUM Research Article
... rats for a period of 14 days. The effect of ethanol extract of Xanthosoma sagittifolium corm extract on blood glucose, plasma insulin, urea creatinine, glycosylated haemoglobin, serum lipid profile [total cholesterol (TC), triglyceride (TG), low density lipoprotein- cholesterol (LDL-C), very low den ...
... rats for a period of 14 days. The effect of ethanol extract of Xanthosoma sagittifolium corm extract on blood glucose, plasma insulin, urea creatinine, glycosylated haemoglobin, serum lipid profile [total cholesterol (TC), triglyceride (TG), low density lipoprotein- cholesterol (LDL-C), very low den ...
Liposomal drug delivery systems: From concept to clinical applications
... drugs such as doxorubicin precipitate readily inside liposomes following accumulation and have excellent retention properties, whereas other drugs such as ciprofloxacin, which do not readily precipitate, are more difficult to retain [55]. Drug retention can be improved by loading drugs to achieve high ...
... drugs such as doxorubicin precipitate readily inside liposomes following accumulation and have excellent retention properties, whereas other drugs such as ciprofloxacin, which do not readily precipitate, are more difficult to retain [55]. Drug retention can be improved by loading drugs to achieve high ...
The human cardiac K2P3.1 (TASK-1) potassium leak channel is a
... drug concentration, n is the Hill coefficient, and IC50 is the concentration necessary for half-maximal block. Data are expressed as mean±SEM. We used Student’s t tests (twotailed tests) to compare statistical significance of the results: p<0.05 was considered statistically significant. When more th ...
... drug concentration, n is the Hill coefficient, and IC50 is the concentration necessary for half-maximal block. Data are expressed as mean±SEM. We used Student’s t tests (twotailed tests) to compare statistical significance of the results: p<0.05 was considered statistically significant. When more th ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.