DEVELOPMENT AND VALIDATION OF HPTLC METHOD FOR SIMULTANEOUS
... Development and validation of simple, rapid, precise, accurate and sensitive HPTLC method for the simultaneous estimation of Rosuvastatin calcium and Aspirin in bulk and in capsule dosage form. The mobile phase consisting of Ethyl acetate:Toluene:Glacial acetic acid (6:3:1 v/v/v) and wavelength of d ...
... Development and validation of simple, rapid, precise, accurate and sensitive HPTLC method for the simultaneous estimation of Rosuvastatin calcium and Aspirin in bulk and in capsule dosage form. The mobile phase consisting of Ethyl acetate:Toluene:Glacial acetic acid (6:3:1 v/v/v) and wavelength of d ...
CHB_Prescribe_012_ EPR clinical checking and supply requests
... Select ACCEPT to denote this medication is clinically suitable for this patient. ...
... Select ACCEPT to denote this medication is clinically suitable for this patient. ...
contents - Health Sciences Authority
... holders to update the package inserts of all azithromycin products to strengthen the warnings regarding the risk of abnormal cardiac rhythms. Apart from azithromycin, other macrolides such as erythromycin and clarithromycin or non-macrolides such as the fluoroquinolones, are known to have the potent ...
... holders to update the package inserts of all azithromycin products to strengthen the warnings regarding the risk of abnormal cardiac rhythms. Apart from azithromycin, other macrolides such as erythromycin and clarithromycin or non-macrolides such as the fluoroquinolones, are known to have the potent ...
Inappropriate long-term use of antipsychotic drugs is
... over 6–8 weeks was associated with a decline in cognition measured using the Mini-Mental State Examination (MMSE) [9]. However, one study showed that the MMSE score did not worsen after treatment with risperidone among people with dementia [10], which might be due to the lack of anticholinergic acti ...
... over 6–8 weeks was associated with a decline in cognition measured using the Mini-Mental State Examination (MMSE) [9]. However, one study showed that the MMSE score did not worsen after treatment with risperidone among people with dementia [10], which might be due to the lack of anticholinergic acti ...
HO • 5/2H2O
... phenothiazines, other tranquilizers, sedative hypnotics or other CNS depressants (including alcohol) concomitantly with hydrocodone may exhibit an additive CNS depression. When such combined therapy is contemplated, the dose of one or both agents should be reduced (see WARNINGS). Laboratory Interact ...
... phenothiazines, other tranquilizers, sedative hypnotics or other CNS depressants (including alcohol) concomitantly with hydrocodone may exhibit an additive CNS depression. When such combined therapy is contemplated, the dose of one or both agents should be reduced (see WARNINGS). Laboratory Interact ...
... minimize bone resorption. The important outcomes are the effects on bone mineral density and prevalence of vertebral fracture. In Toogood's patients there was a reduction in bone mineral density associated with an intermediate dose (1–2 mg·day-1) of inhaled corticosteroids, but the opposite was true ...
Pharmacology Tutoring for Sedative Hypnotics and Antiemetics
... benzodiazepines in terms of GABA channel opening? a. Barbiturates increase frequency while benzodiazepines increase duration of channel opening b. Barbiturates increase duration while benzodiazepines increase frequency of channel opening c. Barbiturates and benzodiazepines both increase frequency of ...
... benzodiazepines in terms of GABA channel opening? a. Barbiturates increase frequency while benzodiazepines increase duration of channel opening b. Barbiturates increase duration while benzodiazepines increase frequency of channel opening c. Barbiturates and benzodiazepines both increase frequency of ...
Hydrocortisone Lacticare-HC Lotion
... Therapy with Hydrocortisone (Lacticare-HC) should be gradually discontinued once control is achieved and an emollient continued as maintenance therapy. Rebound of pre-existing dermatoses can occur with abrupt discontinuation of topical corticosteroids. ...
... Therapy with Hydrocortisone (Lacticare-HC) should be gradually discontinued once control is achieved and an emollient continued as maintenance therapy. Rebound of pre-existing dermatoses can occur with abrupt discontinuation of topical corticosteroids. ...
Questions and answers on NPS
... Responses in this area are likely to be most effective if they are coordinated across countries and regions. NPS are also a challenge for prevention and treatment. Instead of moral panic, objective and credible information is needed. In this respect, it is particularly important to create risk awar ...
... Responses in this area are likely to be most effective if they are coordinated across countries and regions. NPS are also a challenge for prevention and treatment. Instead of moral panic, objective and credible information is needed. In this respect, it is particularly important to create risk awar ...
Drug Testing - Mayo Medical Laboratories
... *These are approximate detection times for the drug or metabolites in urine. The actual detection time depends on dose, frequency of use, and individual metabolism. Note: These tests do not differentiate between dextro (+) amphetamines (eg, dexamphetamine) and racemic mixtures of dextro (+) and levo ...
... *These are approximate detection times for the drug or metabolites in urine. The actual detection time depends on dose, frequency of use, and individual metabolism. Note: These tests do not differentiate between dextro (+) amphetamines (eg, dexamphetamine) and racemic mixtures of dextro (+) and levo ...
54 What does “off-label use” mean?
... Unfortunately, there have been far too many tragic situations leading to serious injuries as a result of prescribing medications when there was no evidence that giving the medication would result in a therapeutic benefit to the patient. Is it possible that benefits and harms differ when drugs are us ...
... Unfortunately, there have been far too many tragic situations leading to serious injuries as a result of prescribing medications when there was no evidence that giving the medication would result in a therapeutic benefit to the patient. Is it possible that benefits and harms differ when drugs are us ...
Potential Part D Drug-Drug Interactions
... muscle movement, psychosis, hypotension, coma and death have been associated with combination. CoAdministration is contraindicated. Sympathomimetic drugs with indirect activity can release large quantities of norepinephrine, which accumulates during monoamine oxidase inhibition and produces excessiv ...
... muscle movement, psychosis, hypotension, coma and death have been associated with combination. CoAdministration is contraindicated. Sympathomimetic drugs with indirect activity can release large quantities of norepinephrine, which accumulates during monoamine oxidase inhibition and produces excessiv ...
Guidelines on Choice and Selection of Antipsychotics
... used to reduce symptoms in the acute psychotic phase of the illness and also as maintenance treatment to reduce the likelihood of psychotic relapses in stable patients. The National Institute of Health and Care Excellence (NICE) Clinical Guidelines 178 for Psychosis and Schizophrenia in Adults recom ...
... used to reduce symptoms in the acute psychotic phase of the illness and also as maintenance treatment to reduce the likelihood of psychotic relapses in stable patients. The National Institute of Health and Care Excellence (NICE) Clinical Guidelines 178 for Psychosis and Schizophrenia in Adults recom ...
Sustained release microspheres of ropinirole hydrochloride: Effect of
... be satisfactory in preventing agglomeration during the stirring process, which resulted in increased production yield (Table III) as well as in obtaining perfectly smooth spherical microspheres (Fig. 1a). DCM was initially employed as polar internal organic solvent phase for preparation of microsphe ...
... be satisfactory in preventing agglomeration during the stirring process, which resulted in increased production yield (Table III) as well as in obtaining perfectly smooth spherical microspheres (Fig. 1a). DCM was initially employed as polar internal organic solvent phase for preparation of microsphe ...
Product Monograph - Paladin Labs Inc.
... Hepatic Function: Hepatotoxicity, a rare adverse reaction, has an estimated frequency of 0.10.2% in patients treated with propylthiouracil. Propylthiouracil-induced hepatotoxicity is not dose-related and is thought to be idiosyncratic with an autoimmune component. Hepatocellular necrosis and fulmina ...
... Hepatic Function: Hepatotoxicity, a rare adverse reaction, has an estimated frequency of 0.10.2% in patients treated with propylthiouracil. Propylthiouracil-induced hepatotoxicity is not dose-related and is thought to be idiosyncratic with an autoimmune component. Hepatocellular necrosis and fulmina ...
Guideline on Fixed Combinations - EMA
... each active substance makes a contribution to the claimed effect. The product should be formulated so that the dose and proportion of each substance present is appropriate for the intended use. An indication must be a well-recognised disease state, modification of a physiological state, dysfunctiona ...
... each active substance makes a contribution to the claimed effect. The product should be formulated so that the dose and proportion of each substance present is appropriate for the intended use. An indication must be a well-recognised disease state, modification of a physiological state, dysfunctiona ...
Adrenergic Agonists
... • Epinephrine enhances cardiovascular actions in these patients. • The dose of epinephrine must be reduced. ...
... • Epinephrine enhances cardiovascular actions in these patients. • The dose of epinephrine must be reduced. ...
CNS Drug Design: Balancing Physicochemical
... ionic composition that may occur, e.g., during a meal or physical activity. The majority of CNS drugs are small molecules that cross the BBB via the transcellular passive diffusion route.12 Designing molecules that can achieve optimal concentration at the desired therapeutic target in the brain is a ...
... ionic composition that may occur, e.g., during a meal or physical activity. The majority of CNS drugs are small molecules that cross the BBB via the transcellular passive diffusion route.12 Designing molecules that can achieve optimal concentration at the desired therapeutic target in the brain is a ...
Abstract - Earth Journals publisher
... The precision of the method was studied as intra-day, inter-day and repeatability of sample injections. Intra-day precision was determined by analysis of the solution three times on the same day. Inter-day precision was assessed by analysis of the solution on three different days over a period of on ...
... The precision of the method was studied as intra-day, inter-day and repeatability of sample injections. Intra-day precision was determined by analysis of the solution three times on the same day. Inter-day precision was assessed by analysis of the solution on three different days over a period of on ...
ANTI-ANXIETY DRUGS
... • Often prescribed for problems that are more effectively managed with non-drug therapies. • Temazepam in 10 most frequently prescribed up until 2001. ...
... • Often prescribed for problems that are more effectively managed with non-drug therapies. • Temazepam in 10 most frequently prescribed up until 2001. ...
Rodent motor and neuropsychological behaviour measured
... speed between the two systems (F1,30 = 10.8, P = 0.02). The SmartCageTM system allows for continuous recording over a much longer period compared with video recordings. In the example shown in Fig. 1c, the animals’ activity levels were recorded for 5 days. As expected, animals were most active durin ...
... speed between the two systems (F1,30 = 10.8, P = 0.02). The SmartCageTM system allows for continuous recording over a much longer period compared with video recordings. In the example shown in Fig. 1c, the animals’ activity levels were recorded for 5 days. As expected, animals were most active durin ...
Antimalarial drugs for preventing malaria weight: a systematic review and meta-analysis
... which are both known risk factors for LBW. This may explain the high LBW prevalence observed in regions where malaria is endemic, and hence making the disease a potentially modifiable necessary cause of LBW. Therefore, the use of antimalarial drugs appears to be one of the most appropriate intervent ...
... which are both known risk factors for LBW. This may explain the high LBW prevalence observed in regions where malaria is endemic, and hence making the disease a potentially modifiable necessary cause of LBW. Therefore, the use of antimalarial drugs appears to be one of the most appropriate intervent ...
PEVISONE Janssen
... be discontinued. Corticosteroids applied to the skin can be absorbed in sufficient amounts to produce systemic effects, including adrenal suppression. Systemic absorption may be increased by various factors such as application over a large skin surface area, application to damaged skin, application ...
... be discontinued. Corticosteroids applied to the skin can be absorbed in sufficient amounts to produce systemic effects, including adrenal suppression. Systemic absorption may be increased by various factors such as application over a large skin surface area, application to damaged skin, application ...
Temperature and pH stimuli-responsive polymers
... therapeutic agents, as drugs, cells or proteins can be mixed with the polymer when this is on its liquid state (temperature below the transition temperature) being able to be injected in the human body on the subcutaneous layer or in the damaged area and forming a gel deposit on the area where it wa ...
... therapeutic agents, as drugs, cells or proteins can be mixed with the polymer when this is on its liquid state (temperature below the transition temperature) being able to be injected in the human body on the subcutaneous layer or in the damaged area and forming a gel deposit on the area where it wa ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.