Basic Principles of GMP
... What are the problems? 2) Prescription and administration of drug products The drug product prescription is done by Paediatricians (for heavy diseases or long or chronic diseases) or more often by a General Practitioner (for common or acute diseases) The administration of drug products to chi ...
... What are the problems? 2) Prescription and administration of drug products The drug product prescription is done by Paediatricians (for heavy diseases or long or chronic diseases) or more often by a General Practitioner (for common or acute diseases) The administration of drug products to chi ...
Skeletal Muscle Relaxants and Associated Medications for
... of pharmacological therapy for musculoskeletal back pain. The term “muscle relaxant” is very broad and refers to a variety of structurally unrelated medications. Muscle relaxants can be divided into two main categories:7 1. Antispasmodic agents (the primary topic of this article) are used to treat m ...
... of pharmacological therapy for musculoskeletal back pain. The term “muscle relaxant” is very broad and refers to a variety of structurally unrelated medications. Muscle relaxants can be divided into two main categories:7 1. Antispasmodic agents (the primary topic of this article) are used to treat m ...
The hallucinogenic world of tryptamines: an updated review
... they are intentionally marketed as replacements for illegal drugs, being sold legally in certain countries under names such as ‘research chemicals’, ‘legal highs’ or ‘designer drugs’ (Arunotayanun and Gibbons 2012; Kjellgren and Soussan 2011; Musselman and Hampton 2014). These new psychoactive subst ...
... they are intentionally marketed as replacements for illegal drugs, being sold legally in certain countries under names such as ‘research chemicals’, ‘legal highs’ or ‘designer drugs’ (Arunotayanun and Gibbons 2012; Kjellgren and Soussan 2011; Musselman and Hampton 2014). These new psychoactive subst ...
peptic ulcer
... • Ideal drug should be able to maintain pH > 4 for ≥ 16 hr/day • Such level guarantee a consistent response to treatment, & sufficient for most refractory cases of peptic acid disease • Efficacy of the drug would also have to be consistent, so that such potent acid inhibition levels might be achieve ...
... • Ideal drug should be able to maintain pH > 4 for ≥ 16 hr/day • Such level guarantee a consistent response to treatment, & sufficient for most refractory cases of peptic acid disease • Efficacy of the drug would also have to be consistent, so that such potent acid inhibition levels might be achieve ...
CRYSTAL MYTHS œ The BIG LIE drug!!
... derivatives of amphetamine and cook the drugs with other elements to make a potent concentrated white powder. Crystal meth users can then smoke the powder, snort the powder or dilute the powder in water and inject it. Crystal meth stimulates the brains limbic system and dopamine receptors that cause ...
... derivatives of amphetamine and cook the drugs with other elements to make a potent concentrated white powder. Crystal meth users can then smoke the powder, snort the powder or dilute the powder in water and inject it. Crystal meth stimulates the brains limbic system and dopamine receptors that cause ...
Indonesia - K4Health
... 1. In what proportion of deliveries is AMTSL used nationally? 2. What practices are in place that do not conform with the ICM/FIGO definition of AMTSL? 3. What are the facility- and policy-level barriers and facilitators to the use of AMTSL? To answer these questions, a nationally-representative sam ...
... 1. In what proportion of deliveries is AMTSL used nationally? 2. What practices are in place that do not conform with the ICM/FIGO definition of AMTSL? 3. What are the facility- and policy-level barriers and facilitators to the use of AMTSL? To answer these questions, a nationally-representative sam ...
Natural Versus Synthetic Chemicals: Regulation And Toxicology
... they are marketed Firms do not need to provide FDA with information regarding ...
... they are marketed Firms do not need to provide FDA with information regarding ...
STABILITY INDICATING HPTLC METHOD FOR SIMULTANEOUS DETERMINATION OF TELMISARTAN AND RAMIPRIL IN TABLETS
... Chromatographic conditions: The experiment was performed on silica gel 60F254 HPTLC plates using mobile phase comprising of toluene: acetonitrile: formic acid: methanol in the ratio of 5:5:0.3:1(v/v/v/v). The plates were prewashed with methanol and activated in an ...
... Chromatographic conditions: The experiment was performed on silica gel 60F254 HPTLC plates using mobile phase comprising of toluene: acetonitrile: formic acid: methanol in the ratio of 5:5:0.3:1(v/v/v/v). The plates were prewashed with methanol and activated in an ...
PARMELIA PERLATA ALLOXAN INDUCED DIABETIC RATS Full Proceeding Paper
... associated with absolute or relative deficiencies in insulin secretion or insulin action. In the present study antihyperlipidemic activity of Parmelia perlata. Ach. has been evaluated in alloxan induced diabetic albino rats. The aqueous extract of the selected plant was administered at dose levels o ...
... associated with absolute or relative deficiencies in insulin secretion or insulin action. In the present study antihyperlipidemic activity of Parmelia perlata. Ach. has been evaluated in alloxan induced diabetic albino rats. The aqueous extract of the selected plant was administered at dose levels o ...
HYPERSENSITIVITY TO LOCAL ANAESTHETICS – 6 FACTS AND
... Local anaesthetics (LAs) are commonly used drugs. In spite of their widespread use, true hypersensitivity appears to be very infrequent. In fact most of the adverse reactions are due to pharmacological, toxic or vasovagal effects of LAs. Our review of the literature has shown that true allergy to LA ...
... Local anaesthetics (LAs) are commonly used drugs. In spite of their widespread use, true hypersensitivity appears to be very infrequent. In fact most of the adverse reactions are due to pharmacological, toxic or vasovagal effects of LAs. Our review of the literature has shown that true allergy to LA ...
Clozapine - Sussex Partnership NHS Foundation Trust
... Treatment Breaks If treatment is stopped for more than 48 hours then it is important to restart gradually from 12.5mg once or twice on the first day. Interactions with Clozapine The following are the most common drug interactions. Drug Bone marrow suppressants eg carbamazepine and long acting depot ...
... Treatment Breaks If treatment is stopped for more than 48 hours then it is important to restart gradually from 12.5mg once or twice on the first day. Interactions with Clozapine The following are the most common drug interactions. Drug Bone marrow suppressants eg carbamazepine and long acting depot ...
protocol - Rajiv Gandhi University of Health Sciences
... been developed which not only improve the taste of molecule but also the formulation and performance of the molecule. The main objective of present review is to explore different method, technologies and evaluations to mask the obnoxious taste of drugs, so that patients can use these drugs without h ...
... been developed which not only improve the taste of molecule but also the formulation and performance of the molecule. The main objective of present review is to explore different method, technologies and evaluations to mask the obnoxious taste of drugs, so that patients can use these drugs without h ...
AGNP Consensus Guidelines for Therapeutic Drug Monitoring in
... with 2- to 40-fold higher levels in brain than in blood ̂ high apparent volume of distribution (about 10–50 L/kg) ̂ low trough plasma concentrations under steady-state (about 0.1–500 ng/mL for psychoactive drugs and up to 20 g/mL for neurological drugs) ̂ slow elimination from plasma (half-life 1 ...
... with 2- to 40-fold higher levels in brain than in blood ̂ high apparent volume of distribution (about 10–50 L/kg) ̂ low trough plasma concentrations under steady-state (about 0.1–500 ng/mL for psychoactive drugs and up to 20 g/mL for neurological drugs) ̂ slow elimination from plasma (half-life 1 ...
Treatment of Childhood PTSD
... by 3 (or more) of the following Efforts to avoid thoughts, feelings, or conversations associated with trauma Efforts to avoid activities, places or people that arouse recollections of the trauma ...
... by 3 (or more) of the following Efforts to avoid thoughts, feelings, or conversations associated with trauma Efforts to avoid activities, places or people that arouse recollections of the trauma ...
Evaluation of analgesic activity of Evodia lunu-ankenda
... Der Pharmacia Sinica, 2010, 1 (1):7-10 ______________________________________________________________________________ From this study, it can be concluded that aqueous extract of root tuber of Evodia lunu-ankenda marked analgesic activity and is equipotent to standard analgesic drugs. The present st ...
... Der Pharmacia Sinica, 2010, 1 (1):7-10 ______________________________________________________________________________ From this study, it can be concluded that aqueous extract of root tuber of Evodia lunu-ankenda marked analgesic activity and is equipotent to standard analgesic drugs. The present st ...
Cocaine Abuse
... all other activities and will use the drug until the user or the supply is exhausted. These persons will exhibit behavior entirely different from their previous lifestyle. Cocaine-driven humans will compel themselves to perform unusual acts compared with their former standards of conduct. There are ...
... all other activities and will use the drug until the user or the supply is exhausted. These persons will exhibit behavior entirely different from their previous lifestyle. Cocaine-driven humans will compel themselves to perform unusual acts compared with their former standards of conduct. There are ...
GNRS4DiabetesMellitus
... • Both diabetes and pre-diabetes are important to identify and address • Because of the great heterogeneity in older population, treatment goals for diabetes must be individualized • Although the target is debated, attempts to lower BP, as tolerated, are important for older hypertensive patients wit ...
... • Both diabetes and pre-diabetes are important to identify and address • Because of the great heterogeneity in older population, treatment goals for diabetes must be individualized • Although the target is debated, attempts to lower BP, as tolerated, are important for older hypertensive patients wit ...
Antimalarial Drug Combination Therapy
... The concept of combination therapy is based on the synergistic or additive potential of two or more drugs, to improve therapeutic efficacy and also delay the development of resistance to the individual components of the combination. Combination therapy (CT) with antimalarial drugs is the simultaneou ...
... The concept of combination therapy is based on the synergistic or additive potential of two or more drugs, to improve therapeutic efficacy and also delay the development of resistance to the individual components of the combination. Combination therapy (CT) with antimalarial drugs is the simultaneou ...
a printable PDF of the Clinical
... Biological safety data from 144 children and adults were available from eight datasets of broad-spectrum micronutrient formulas substantially similar to DEN which were administered at comparable therapeutic dosages. In these reports, there was not a single reported occurrence of a clinically meaning ...
... Biological safety data from 144 children and adults were available from eight datasets of broad-spectrum micronutrient formulas substantially similar to DEN which were administered at comparable therapeutic dosages. In these reports, there was not a single reported occurrence of a clinically meaning ...
Mosapride citrate
... (5) The minimum dose of Mosapride citrate Tablet is one 2.5 mg tablet or half a 5 mg tablet. It should therefore not be used in dogs weighing less than 2.5 kg because overdosing will occur when administered to such dogs. 2. Adverse reactions (1) If adverse reactions are observed, promptly seek advic ...
... (5) The minimum dose of Mosapride citrate Tablet is one 2.5 mg tablet or half a 5 mg tablet. It should therefore not be used in dogs weighing less than 2.5 kg because overdosing will occur when administered to such dogs. 2. Adverse reactions (1) If adverse reactions are observed, promptly seek advic ...
Alcohol-related Drug Interactions
... liver by several enzymes. The most important enzymes are aldehyde dehydrogenase and CYP2E1. In people consuming alcohol only occasionally, CYP2E1 metabolizes only a small fraction of the ingested alcohol. In contrast, chronic heavy drinking can increase CYP2E1 activity up to ten-fold, resulting in h ...
... liver by several enzymes. The most important enzymes are aldehyde dehydrogenase and CYP2E1. In people consuming alcohol only occasionally, CYP2E1 metabolizes only a small fraction of the ingested alcohol. In contrast, chronic heavy drinking can increase CYP2E1 activity up to ten-fold, resulting in h ...
Can Drugs Cause Depression? A Review of the Evidence
... likely to become depressed. However, these findings do not necessarily invalidate those of previous studies and may be in need of replication. In particular, this study measured ten potential confounders or response-modifying variables and, on the basis of the analysis, determined that the three var ...
... likely to become depressed. However, these findings do not necessarily invalidate those of previous studies and may be in need of replication. In particular, this study measured ten potential confounders or response-modifying variables and, on the basis of the analysis, determined that the three var ...
First Amendment--Drug Paraphernalia Statutes and the Constitution
... not regulated or prohibited.3 1 Therefore, the Court stated the ordinance did not proscribe noncommercial speech. Justice Marshall reasoned that although drug-related designs or names on cigarette papers may subject them to regulation, the ordinance does not regulate speech, but simply regulates the ...
... not regulated or prohibited.3 1 Therefore, the Court stated the ordinance did not proscribe noncommercial speech. Justice Marshall reasoned that although drug-related designs or names on cigarette papers may subject them to regulation, the ordinance does not regulate speech, but simply regulates the ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.