The Angelman syndrome ubiquitin ligase localizes to the synapse
... Cerebellar Purkinje cell number and dendritic branching are not affected by loss of maternal E6-AP We next evaluated cerebellar Purkinje cell number and dendritic branching in Ube3a maternal-deficient mice (AS mice) (9,17). We analyzed the integrity of cerebellar Purkinje cells in WT and AS mice by ...
... Cerebellar Purkinje cell number and dendritic branching are not affected by loss of maternal E6-AP We next evaluated cerebellar Purkinje cell number and dendritic branching in Ube3a maternal-deficient mice (AS mice) (9,17). We analyzed the integrity of cerebellar Purkinje cells in WT and AS mice by ...
Ventromedial Thalamic Neurons Convey Nociceptive Signals from
... apart, could be stimulated independently. A large reference electrode was placed on the skull. Once a unit had been excited, the stimulation thresholds were measured for each of the two electrodes. The stimulation site with the lowest threshold was determined by stimulating at different depths and m ...
... apart, could be stimulated independently. A large reference electrode was placed on the skull. Once a unit had been excited, the stimulation thresholds were measured for each of the two electrodes. The stimulation site with the lowest threshold was determined by stimulating at different depths and m ...
Filamentous contacts: the ultrastructure and three
... differ fundamentally in their composition from other adhering junctions and do not fall into either of the two established categories. Their findings raise the possibility that adhering junctions are in reality a much more heterogeneous family of junctions (in terms of molecular organization and fun ...
... differ fundamentally in their composition from other adhering junctions and do not fall into either of the two established categories. Their findings raise the possibility that adhering junctions are in reality a much more heterogeneous family of junctions (in terms of molecular organization and fun ...
- Warwick WRAP
... densities of both endothermic and ectothermic animals. We formulated a general model to elucidate the key factors that correlate with brain enlargement, and the origin of allometric body-brain size scaling. This framework identified temperature as a critical factor in brain enlargement via temperatu ...
... densities of both endothermic and ectothermic animals. We formulated a general model to elucidate the key factors that correlate with brain enlargement, and the origin of allometric body-brain size scaling. This framework identified temperature as a critical factor in brain enlargement via temperatu ...
Large-scale spatiotemporal spike patterning consistent with
... the number of connections were significantly lower as compared with the unshuffled networks (Supplementary Fig. 6 for monkeys Rs and Mk), suggesting that effective connections reflect singletrial coordination across neurons, rather than overall rate modulations or tuning properties. To place the estima ...
... the number of connections were significantly lower as compared with the unshuffled networks (Supplementary Fig. 6 for monkeys Rs and Mk), suggesting that effective connections reflect singletrial coordination across neurons, rather than overall rate modulations or tuning properties. To place the estima ...
cortical input to the basal forebrain
... *Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, U.S.A. †Department of Pharmacology, Vrije Universiteit, Amsterdam, The Netherlands ‡University of Virginia, Charlottesville, VA 22908, U.S.A. §Department of Basic Health Sciences, Marquette University, Milwaukee ...
... *Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, U.S.A. †Department of Pharmacology, Vrije Universiteit, Amsterdam, The Netherlands ‡University of Virginia, Charlottesville, VA 22908, U.S.A. §Department of Basic Health Sciences, Marquette University, Milwaukee ...
Comprehensive imaging of cortical networks
... into the tissue [65]. The penetration depth is therefore significantly better for red and near-IR fluorophores [36]. Red GECIs with properties comparable to the best green GECIs are on the horizon [66,67] and poised to boost the penetration depth of TPLSM imaging significantly. Three-photon flu ...
... into the tissue [65]. The penetration depth is therefore significantly better for red and near-IR fluorophores [36]. Red GECIs with properties comparable to the best green GECIs are on the horizon [66,67] and poised to boost the penetration depth of TPLSM imaging significantly. Three-photon flu ...
Conduction Velocity and Patellar Reflex Blah A. Blah Partner B
... The purpose of this experiment is to find changes in the conduction velocity based on the patellar reflex as the subject is put through three different conditions: the Jendrassik’s maneuver, mental distraction, and fatigue. The main function of the stretch reflex is to maintain the muscle at a const ...
... The purpose of this experiment is to find changes in the conduction velocity based on the patellar reflex as the subject is put through three different conditions: the Jendrassik’s maneuver, mental distraction, and fatigue. The main function of the stretch reflex is to maintain the muscle at a const ...
From spike frequency to free recall:
... Connections within region CA3 may not be the only synapses being modified. Synapses between region CA3 and the entorhinal cortex may also be modified, forming stronger connections between each element of the memory and the patterns of activity occurring in other cortical areas. Whatever the case, th ...
... Connections within region CA3 may not be the only synapses being modified. Synapses between region CA3 and the entorhinal cortex may also be modified, forming stronger connections between each element of the memory and the patterns of activity occurring in other cortical areas. Whatever the case, th ...
Conduction Velocity and Patellar Reflex Blah A. Blah Parter 1
... The purpose of this experiment is to find changes in the conduction velocity based on the patellar reflex as the subject is put through three different conditions: the Jendrassik’s maneuver, mental distraction, and fatigue. The main function of the stretch reflex is to maintain the muscle at a const ...
... The purpose of this experiment is to find changes in the conduction velocity based on the patellar reflex as the subject is put through three different conditions: the Jendrassik’s maneuver, mental distraction, and fatigue. The main function of the stretch reflex is to maintain the muscle at a const ...
Disruption of the Blood-Brain Barrier and Neuronal Cell Death in
... den Bercken, 1990). Its insecticidal activity persists for several weeks following a single application. Permethrin intoxication results as a consequence of the sustained opening of sodium channels leading to repetitive discharges after a single stimulus (Narahashi, 1985). This repetitive nerve acti ...
... den Bercken, 1990). Its insecticidal activity persists for several weeks following a single application. Permethrin intoxication results as a consequence of the sustained opening of sodium channels leading to repetitive discharges after a single stimulus (Narahashi, 1985). This repetitive nerve acti ...
development and plasticity of cortical areas and networks
... Other evidence indicates that gradients of gene expression in the neuroepithelium of different cortical areas might regulate the initial arealization of the neocortex. For example, Pax6 is usually expressed in a lowcaudomedial–high-rostrolateral gradient28,29. In Pax6 homozygous mutants, caudolatera ...
... Other evidence indicates that gradients of gene expression in the neuroepithelium of different cortical areas might regulate the initial arealization of the neocortex. For example, Pax6 is usually expressed in a lowcaudomedial–high-rostrolateral gradient28,29. In Pax6 homozygous mutants, caudolatera ...
development and plasticity of cortical areas and networks
... Other evidence indicates that gradients of gene expression in the neuroepithelium of different cortical areas might regulate the initial arealization of the neocortex. For example, Pax6 is usually expressed in a lowcaudomedial–high-rostrolateral gradient28,29. In Pax6 homozygous mutants, caudolatera ...
... Other evidence indicates that gradients of gene expression in the neuroepithelium of different cortical areas might regulate the initial arealization of the neocortex. For example, Pax6 is usually expressed in a lowcaudomedial–high-rostrolateral gradient28,29. In Pax6 homozygous mutants, caudolatera ...
Temporal Plasticity Involved in Recovery from Manual Dexterity
... factors to be controlled, provide information essential for understanding the underlying brain mechanisms of functional recovery from brain damage. In particular, in the field of motor recovery, lesioning of the primary motor cortex (M1) in nonhuman primates is a well-established experimental techni ...
... factors to be controlled, provide information essential for understanding the underlying brain mechanisms of functional recovery from brain damage. In particular, in the field of motor recovery, lesioning of the primary motor cortex (M1) in nonhuman primates is a well-established experimental techni ...
Central nervous System Lesions Leading to Disability
... afferent fibers bifurcate and travel in rostral and caudal directions, sending off terminals at various segmental levels. The motor neurons lie in the ventral horn. Those innervating a single muscle are collectively called a motor neuron pool. The motor neuron pools are segregated into longitudinal ...
... afferent fibers bifurcate and travel in rostral and caudal directions, sending off terminals at various segmental levels. The motor neurons lie in the ventral horn. Those innervating a single muscle are collectively called a motor neuron pool. The motor neuron pools are segregated into longitudinal ...
final scientific program
... Anthony DeCostanzo (RIKEN) Competitive neuronal turnover reduces the dimensionality of the dentate gyrus population code to enhance pattern separation, 61 Alexander Ecker (MPI Biological Cybernetics) State dependence of noise correlations in macaque primary visual cortex, 64 Farzad Farkhooi (Freie U ...
... Anthony DeCostanzo (RIKEN) Competitive neuronal turnover reduces the dimensionality of the dentate gyrus population code to enhance pattern separation, 61 Alexander Ecker (MPI Biological Cybernetics) State dependence of noise correlations in macaque primary visual cortex, 64 Farzad Farkhooi (Freie U ...
Circadian Plasticity of Mammalian Inhibitory Interneurons
... Many aspects of mammalian behavior and physiology show circadian rhythmicity. The circadian rhythms, with a period about a day (circa, around and dies, day), are generated by the central clock or pacemaker that in mammals is located in suprachiasmatic nuclei (SCN) of the hypothalamus. Under day/nigh ...
... Many aspects of mammalian behavior and physiology show circadian rhythmicity. The circadian rhythms, with a period about a day (circa, around and dies, day), are generated by the central clock or pacemaker that in mammals is located in suprachiasmatic nuclei (SCN) of the hypothalamus. Under day/nigh ...
A hitchhiker`s guide to the nervous system: the - IGMM
... Axonal retrograde transport also allows peripheral signals to be translated into nuclear responses. For example, receptors that are activated by target‑derived neurotrophins during development create ‘signalling endosomes’, which contain neurotrophin receptor complexes as well as downstream‑activate ...
... Axonal retrograde transport also allows peripheral signals to be translated into nuclear responses. For example, receptors that are activated by target‑derived neurotrophins during development create ‘signalling endosomes’, which contain neurotrophin receptor complexes as well as downstream‑activate ...
Antioxidant Enzymes in Brain Cortex of Rats
... activity, along with increased lipid peroxidation and decreased oxidized/reduced GSH ratio, causing redox disturbances (MÖLLER et al. 2011). The recent study of SHAO et al. (2015) indicated opposite effects of social isolation after 8 weeks, in which SOD, CAT, GPx activities and total AO capacity de ...
... activity, along with increased lipid peroxidation and decreased oxidized/reduced GSH ratio, causing redox disturbances (MÖLLER et al. 2011). The recent study of SHAO et al. (2015) indicated opposite effects of social isolation after 8 weeks, in which SOD, CAT, GPx activities and total AO capacity de ...
Imitation, mirror neurons and autism
... This demonstrates input from the sight of movements to the neural system involved in motor control of the same movements. Several functional imaging studies have noted that the sight of hand actions produces activity in frontal regions (premotor cortex and Broca's area) [53,54], which may be homolog ...
... This demonstrates input from the sight of movements to the neural system involved in motor control of the same movements. Several functional imaging studies have noted that the sight of hand actions produces activity in frontal regions (premotor cortex and Broca's area) [53,54], which may be homolog ...
Neuroscience - Thermo Fisher Scientific
... Synapse formation during nervous system development and degeneration in the pathogenesis of human neurological diseases are highly regulated processes. Subtle changes in the environment of the complex neuronal network may cause either breakdown or creation of synaptic connections. Drug discovery scr ...
... Synapse formation during nervous system development and degeneration in the pathogenesis of human neurological diseases are highly regulated processes. Subtle changes in the environment of the complex neuronal network may cause either breakdown or creation of synaptic connections. Drug discovery scr ...
Aalborg Universitet Brain plasticity Wang, Li
... EEG/SEP between experimental conditions can reflect brain dynamic shortterm synaptic changes in response to the peripheral stimulation which are different from the structural long-term synaptic plasticity (Valeriani et al., 2003; Flor, 2003). 1.1. What’s cortical plasticity? Recent studies have show ...
... EEG/SEP between experimental conditions can reflect brain dynamic shortterm synaptic changes in response to the peripheral stimulation which are different from the structural long-term synaptic plasticity (Valeriani et al., 2003; Flor, 2003). 1.1. What’s cortical plasticity? Recent studies have show ...
High acetylcholine sets circuit dynamics for attention and
... responses had cell bodies in oriens and projected to lacunosum-moleculare, while another set of neurons were depolarized by only alpha-7 receptors and appeared spread through many layers (McQuiston and Madison, 1999a). The direct depolarization of interneurons is consistent with the fact that nicoti ...
... responses had cell bodies in oriens and projected to lacunosum-moleculare, while another set of neurons were depolarized by only alpha-7 receptors and appeared spread through many layers (McQuiston and Madison, 1999a). The direct depolarization of interneurons is consistent with the fact that nicoti ...
Chapter 08: The Chemical Senses
... Multiple projections (from OB) to many brain structures Direct and widespread influence on odor discrimination, emotion, motivation, memory.. • OB-OT-Medial dorsal nucleus of thalamus pathway may be responsible for the conscious perception of smell, while connections to amygdala and entorhinal corte ...
... Multiple projections (from OB) to many brain structures Direct and widespread influence on odor discrimination, emotion, motivation, memory.. • OB-OT-Medial dorsal nucleus of thalamus pathway may be responsible for the conscious perception of smell, while connections to amygdala and entorhinal corte ...
Chapter 13 Stress and Glucocorticoid Contributions to Normal and
... maintenance of the immune system, and inhibition of nonessential processes such as reproductive function. Collectively, these functions enable “fight or flight” behaviors to remove the organism from immediate danger, while later restoring bodily homeostasis. Although many hormones are released in re ...
... maintenance of the immune system, and inhibition of nonessential processes such as reproductive function. Collectively, these functions enable “fight or flight” behaviors to remove the organism from immediate danger, while later restoring bodily homeostasis. Although many hormones are released in re ...