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Genetic basis of human brain evolution
Genetic basis of human brain evolution

... expansion in primates and, interestingly, the number of genes in the family increases as one moves across the primate phylogeny toward the human lineage, with the greatest copy number found in humans. The function of this gene family (or its DUF1220 domain) is not known, but it is prominently expres ...
Can regenerating axons recapitulate developmental
Can regenerating axons recapitulate developmental

... An evolutionarily economical mechanism for generating a broad range of position-dependent signalling cues from a limited set of molecules is gradient formation32. The membrane-associated signalling family of ephrin ligands and Eph receptors has diverse roles in both the developing and adult CNS33,34 ...
cerebral cortex - krigolson teaching
cerebral cortex - krigolson teaching

... the thalamus. Major projections from other cortical areas include those from the parietal cortex and certain frontal areas. MA: Primary motor area; SMA: supplementary motor area; PMA: premotor area. ...
The Chemical Senses: Smell and Taste How does the nose and
The Chemical Senses: Smell and Taste How does the nose and

... solution that come into contact with receptors inside the mouth. ...
PDF file
PDF file

... receptive fields, where staggered distance is set to be 1 pixel in both horizontal and vertical directions. A connection falls outside of the neuronal plane is not allowed. Given an input image with dimension 40 × 40, V2’ L4 contains 3 depths of (40 − 21 + 1) × (40 − 21 + 1) neurons. It indicates th ...
proposal2000a.doc
proposal2000a.doc

... ’71, ’76; Simons, ’78; Simons and Woolsey, ’79) of whisker stimulation and/or deprivation. Furthermore, at birth a rodent’s brain is very immature. This allows to closely follow developmental events, such as transience of synapses (Micheva and Beaulieu, ’96), neurotransmitters (Micheva and Beaulieu, ...
Protracted Synaptogenesis after Activity
Protracted Synaptogenesis after Activity

... 100 Hz, repeated five times every 10 s. The tip of the electrode was positioned in the vicinity of the section of apical dendrite that was selected for time-lapse imaging. The minimal distance between the tip of the electrode and the dendrite was kept between 10 and 20 ␮m. In separate experiments, w ...
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File

... Application: Secretion and reabsorption of acetylcholine by neurons at synapses.  Acetylcholine is a neurotransmitter  It is largely used at the neuromuscular junction, meaning it is released by motor neurons and binds to receptors on muscles  It is also used in the autonomic nervous system  Ace ...
Joint maps for orientation, eye, and direction preference in a self
Joint maps for orientation, eye, and direction preference in a self

... that vary over time [5]. The functional properties of these cells form a mosaic across V1, with patches of nearby cells preferring the left or right eye (or both), and similar directions and orientations [3, 6, 9]. In addition to their afferent input from the LGN, neurons in these maps are connected ...
P312 Ch05_PerceivingObjectsII
P312 Ch05_PerceivingObjectsII

... 1) There is some evidence of the existence of neurons that respond to specific volumetric shapes and respond about the same regardless of the perspective or changes in properties that would usually accompany rotation. (Kayaert, Biederman, & Vogels, 2003). These neurons could be the geon detectors. 2 ...
Regents Biology
Regents Biology

...  Axon- Single long fiber that carries impulses away from the cell body. Regents Biology ...
Code-specific policy gradient rules for spiking neurons
Code-specific policy gradient rules for spiking neurons

... We test the learning rule on a 2-armed bandit task (Figure 1A). An agent has the choice between two actions. Depending on which of two states the agent is in, action a1 or action a2 is rewarded (R = 1), while the other action is punished (R = −1). The state information is encoded in the rate pattern ...
The Adenosine Story Goes Ionic: CaV2.1
The Adenosine Story Goes Ionic: CaV2.1

... of a functionally responsive Ca2+ channel with preserved expression levels, but compromised primarily in G-protein-mediated inhibition.22 The hypothesis to be tested by Deboer et al.7 was clear: if CaV2.1 channels mediate some of adenosinergic actions on sleep, then these animals should show attenua ...
Synapse Formation in the Absence of Cell Bodies Requires Protein
Synapse Formation in the Absence of Cell Bodies Requires Protein

... These results support the idea that distal neuritic processes contain stable mRNAs and the macromolecular machinery for protein synthesis that are required for the formation of new synaptic connections. ...
Basic Parts and Organization of the Brain
Basic Parts and Organization of the Brain

... through to the brain.  The brain is one of the few organs that can only use glucose to get ATP as its energy source. Therefore, without some sugar in our bloodstream, the brain will die. That’s one reason why proper nutrition is so important. ...
Nervous System - An-Najah Staff - An
Nervous System - An-Najah Staff - An

... • G protein–coupled receptors that oversee slow synaptic responses mediated by G proteins and intracellular second messengers.  Second messengers most often activate kinases, which in turn act on ion channels or activate other proteins. ...
Name: PID: SPRING 2013 COGS 1 Midterm 2 – Form B 1. Which of
Name: PID: SPRING 2013 COGS 1 Midterm 2 – Form B 1. Which of

... a. Prior probability b. Posterior probability c. Marginal probability d. Likelihood e. Evidence 42. Referring to an object's location as being ""due north"" is an example of a(n): a. Relative frame of reference b. Centric frame of reference c. Absolute frame of reference d. Intrinsic frame of refere ...
download file
download file

... their activation can be achieved by a variety of combinations of muscles. The situation is even more complex at the level of individual muscles: eventually the nervous system must specify the activation of each motor unit. What are the implications for the formation of representations? A key feature ...
Sample pages 2 PDF
Sample pages 2 PDF

... remain a curiosity. However, during recent years, ample evidence has shown that co-release is in fact not that uncommon, and it is now known to occur in a variety of neural systems. In addition, although many populations of adult neurons may not release two classical neurotransmitters under basal co ...
Tau pathology does not affect experience-driven single
Tau pathology does not affect experience-driven single

... Intraneuronal neurofibrillary tangles (NFTs) – a characteristic pathological feature of Alzheimer’s and several other neurodegenerative diseases – are considered a major target for drug development. Tangle load correlates well with the severity of cognitive symptoms and mouse models of tauopathy are ...
Neurotransmission in the rat amygdala related to fear and anxiety
Neurotransmission in the rat amygdala related to fear and anxiety

... equal number of the weak and strong inputs are presented in an unpaired fashion. In the CAI region of the hippocampus, activation of the weak input releases excitatory amino acids, such as glutamate, which bind to both NMDA and AMPA! kainate receptors on the postsynaptic neuron (for review see Ref. ...
3-Morpholinylsydnonimine Inhibits Glutamatergic Transmission in
3-Morpholinylsydnonimine Inhibits Glutamatergic Transmission in

... In a previous study, we found that the regulation of sympathetic vasomotor outflow by the endogenous NO is determined by a balance between sympathoexcitation and sympathoinhibition induced by the tonically active nNOS and iNOS (Chan et al., 2001). More importantly, we showed that the prevalence of n ...
Neurons and Nervous Systems
Neurons and Nervous Systems

... Concept 34.3 Neurons Communicate with Other Cells at Synapses ...
Ch03.pps
Ch03.pps

... Axons gather impulses from dendrites and carry them to other neurons. ...
2 neurons in parasympathetic nervous syste
2 neurons in parasympathetic nervous syste

... continue through the trunk and synapse with the postganglionic neurons at the target tissue. What is the function of visceral afferent neurons? Provide sensory information from viscera. Sense distension of viscera. Cause sensing of visceral pain. How do visceral afferent neurons reach the CNS? They ...
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Activity-dependent plasticity

A defining feature of the brain is its capacity to undergo changes based on activity-dependent functions, also called activity-dependent plasticity. Its ability to remodel itself forms the basis of the brain’s capacity to retain memories, improve motor function, and enhance comprehension and speech amongst other things. It is this trait to retain and form memories that is functionally linked to plasticity and therefore many of the functions individuals perform on a daily basis. This plasticity is the result of changed gene expression that occurs because of organized cellular mechanisms.The brain’s ability to adapt toward active functions has allowed humans to specialize in specific processes based on relative use and activity. For example, a right-handed person may perform any movement poorly with his/her left hand but continuous practice with the less dominant hand can make both hands just as able. Another example is if someone was born with a neurological disorder such as autism or had a stroke that resulted in a disorder, then they are capable of retrieving much of their lost function by practicing and “rewiring” the brain in order to incorporate these lost manners. Thanks to the pioneers within this field, many of these advances have become available to most people and many more will continue to arrive as new features of plasticity are discovered.
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