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Direct cortical control of muscle activation in voluntary arm movements
Direct cortical control of muscle activation in voluntary arm movements

... managed to decode the mixed MI signal in real time. The other extreme is to question whether “movement parameters are recognizably coded in the activity of single neurons” in the first place22. It is argued that they are not and do not need to be, as all that matters is the population average of the ...
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A hitchhiker`s guide to the nervous system: the - IGMM

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Localization of the GABA, Receptor in the Rat Brain with a
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Full version (PDF file)

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2011 CSH - Harvard University

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... control the contraction of muscle fibers actuating movement. Damage to motor neurons caused by either injury or disease can result in paralysis or death; consequently, there is significant interest in understanding how motor neurons regenerate after nerve injury and why they are selective targets of ...
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Neuromuscular junction



A neuromuscular junction (sometimes called a myoneural junction) is a junction between nerve and muscle; it is a chemical synapse formed by the contact between the presynaptic terminal of a motor neuron and the postsynaptic membrane of a muscle fiber. It is at the neuromuscular junction that a motor neuron is able to transmit a signal to the muscle fiber, causing muscle contraction.Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy. Synaptic transmission at the neuromuscular junction begins when an action potential reaches the presynaptic terminal of a motor neuron, which activates voltage-dependent calcium channels to allow calcium ions to enter the neuron. Calcium ions bind to sensor proteins (synaptotagmin) on synaptic vesicles, triggering vesicle fusion with the cell membrane and subsequent neurotransmitter release from the motor neuron into the synaptic cleft. In vertebrates, motor neurons release acetylcholine (ACh), a small molecule neurotransmitter, which diffuses across the synaptic cleft and binds to nicotinic acetylcholine receptors (nAChRs) on the cell membrane of the muscle fiber, also known as the sarcolemma. nAChRs are ionotropic receptors, meaning they serve as ligand-gated ion channels. The binding of ACh to the receptor can depolarize the muscle fiber, causing a cascade that eventually results in muscle contraction.Neuromuscular junction diseases can be of genetic and autoimmune origin. Genetic disorders, such as Duchenne muscular dystrophy, can arise from mutated structural proteins that comprise the neuromuscular junction, whereas autoimmune diseases, such as myasthenia gravis, occur when antibodies are produced against nicotinic acetylcholine receptors on the sarcolemma.
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