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Synaptic and extrasynaptic traces of long-term memory
Synaptic and extrasynaptic traces of long-term memory

... Experimental induction of LTP usually involves dramatic application of surprising input to the cells of interest, such as 100 or more repetitions of intense electrical stimulation. Probably the least extreme of the experiments successfully inducing LTP have been those of Remy and Spruston (2007), wi ...
An Introduction to Sensory Pathways and the Somatic Nervous System
An Introduction to Sensory Pathways and the Somatic Nervous System

... • 15-1 Specify the components of the afferent and efferent divisions of the nervous system, and explain what is meant by the somatic nervous system. • 15-2 Explain why receptors respond to specific stimuli, and how the organization of a receptor affects its sensitivity. • 15-3 Identify the receptors ...
9 Propagated Signaling: The Action Potential
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Nerve cells in the human ciliary muscle: ultrastructural and
Nerve cells in the human ciliary muscle: ultrastructural and

... contact with terminal boutons that form axo-somatic synaptic contacts (arrows). The boutons contain numerous agranular vesicles (40 to 60 nm, asterisk) and some large granular vesicles (60 to 120 nm, arrowheads). Original magnification, X50000. (B, C) Ciliary muscle neurons (N) express spinelike (B, ...
Motor Threshold - McCausland Center For Brain Imaging
Motor Threshold - McCausland Center For Brain Imaging

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Motor Threshold - McCausland Center | Brain Imaging

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The Somatosensory System: Receptors and Central Pathways
The Somatosensory System: Receptors and Central Pathways

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Peripheral Nervous System 1: The Somatic System

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PPT - Ohio University

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The role of nicotinic acetylcholine receptors and GABAergic

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Peripheral Nerve Diseases

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26. Mixed cranial nervest

... • Cranial nerves are part of the peripheral nervous system. • Carry sensory or motor information or a combination and function in parasympathetic nervous system. • Cranial nerves I, II and VIII are purely sensory. • Cranial nerves III, IV, VI, XI and XII are motor (although also function balance) ...
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... • inf. mesent. g. ascend to synapse at ...
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Neuromuscular junction



A neuromuscular junction (sometimes called a myoneural junction) is a junction between nerve and muscle; it is a chemical synapse formed by the contact between the presynaptic terminal of a motor neuron and the postsynaptic membrane of a muscle fiber. It is at the neuromuscular junction that a motor neuron is able to transmit a signal to the muscle fiber, causing muscle contraction.Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy. Synaptic transmission at the neuromuscular junction begins when an action potential reaches the presynaptic terminal of a motor neuron, which activates voltage-dependent calcium channels to allow calcium ions to enter the neuron. Calcium ions bind to sensor proteins (synaptotagmin) on synaptic vesicles, triggering vesicle fusion with the cell membrane and subsequent neurotransmitter release from the motor neuron into the synaptic cleft. In vertebrates, motor neurons release acetylcholine (ACh), a small molecule neurotransmitter, which diffuses across the synaptic cleft and binds to nicotinic acetylcholine receptors (nAChRs) on the cell membrane of the muscle fiber, also known as the sarcolemma. nAChRs are ionotropic receptors, meaning they serve as ligand-gated ion channels. The binding of ACh to the receptor can depolarize the muscle fiber, causing a cascade that eventually results in muscle contraction.Neuromuscular junction diseases can be of genetic and autoimmune origin. Genetic disorders, such as Duchenne muscular dystrophy, can arise from mutated structural proteins that comprise the neuromuscular junction, whereas autoimmune diseases, such as myasthenia gravis, occur when antibodies are produced against nicotinic acetylcholine receptors on the sarcolemma.
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