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IN-VITRO STUDIES OF EFAVIRENZ FORMULATION BY RP-HPLC Research Article
IN-VITRO STUDIES OF EFAVIRENZ FORMULATION BY RP-HPLC Research Article

... assay should be stability indicating. Dissolution is considered as one of the most important quality control tests performed on pharmaceutical dosage forms and is now developing into a tool for predicting bioavailability. The profiles obtained from dissolution rate studies, have also been used in an ...
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... (f1= 10 and f1=1) and the chosen significance threshold (α= 0.05), one admits that, at the chosen significance threshold, the corresponding coefficient is significant, therefore the corresponding term will remain in the regression equation. Otherwise, one can neglect the corresponding term. Table 5 ...
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Slajd 1 - Zakład Farmakologii Klinicznej w Poznaniu

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Signaled drug delivery and transport across the blood

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pharm tech 2016-2017 class 7 ch 34 thru 37

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... Consequently, to avoid bone marrow toxicity, the dose of mercaptopurine is usually reduced in patients receiving allopurinol. Cimetidine, a drug used in the treatment of peptic ulcer, has been shown to potentiate the pharmacologic actions of anticoagulants and sedatives. The metabolism of the sedati ...
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Chapter 6 Notes
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Receptor pharmacology

ISSN 1608-2281 2006 6(3):179-181
ISSN 1608-2281 2006 6(3):179-181

... pathophysiology, knockout animals, gender differences and drug-drug interactions. The database also gives a brief description of the experimental methods and all information available in this database is linked to the original references in PubMed. _____ *Correspondence to Yuichi [email protected] ...
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Therapeutic uses: All types of hyperlipidemias.
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... the most potent LDL cholesterol lowering statin drugs, followed by simvastatin, pravastatin and then lovastatin and fluvastatin. Therapeutic uses: All types of hyperlipidemias. Pharmacokinetics: At the doses of 30 to 50 percent of lovastatin and simvastatin are absorbed orally. Pravastatin and fluva ...
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Design fabrication and characterization of controlled

Formulation and in-vitro bioequivalence evaluation of verapamil
Formulation and in-vitro bioequivalence evaluation of verapamil

... retarding behavior of drug in F7 & F8 is much significant as compared to Calan SR but it did not comply with the official limits of USP. As the drug to polymer ratio was increased the similarity between F1 to F4 also increased but the formulation F3 showed some anomalous behavior. Although Formulati ...
The Pigeonhole Principle
The Pigeonhole Principle

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... The I.V. bolus injection method allows rapid drug administration. It can be used in an emergency to provide an immediate drug effect. It can also be used to administer drugs that can’t be given I.M., to achieve peak drug levels in the bloodstream, and to deliver drugs that can’t be diluted, such as ...
Chapter 10
Chapter 10

... - PABA is coenzyme used in nucleotide synthesis – these drugs compete for enzyme active site - Humans use folic acid as coenyzme so these drugs do not effect our cells ...
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Plateau principle

The plateau principle is a mathematical model or scientific law originally developed to explain the time course of drug action The principle has wide applicability in pharmacology, physiology, nutrition, biochemistry and system dynamics. It applies whenever a drug or nutrient is infused or ingested at a relatively constant rate and when a constant fraction is eliminated during each time interval. Under these conditions, any change in the rate of infusion leads to an exponential increase or decrease until a new level is achieved. This behavior is also called an approach to steady state because rather than causing an indefinite increase or decrease, a natural balance is achieved when the rate of infusion or production is balanced by the rate of loss.An especially important use of the plateau principle is to study the renewal of tissue constituents in the human and animal body. In adults, daily synthesis of tissue constituents is nearly constant, and most constituents are removed with a first order reaction rate. Applicability of the plateau principle was recognized during radiotracer studies of protein turnover in the 1940s by Rudolph Schoenheimer and David Rittenberg. Unlike the case with drugs, the initial amount of tissue or tissue protein is not zero because daily synthesis offsets daily elimination. In this case, the model is also said to approach a steady state with exponential or logarithmic kinetics. Constituents that change in this manner are said to have a biological half-life.A practical application of the plateau principle is that most people have experienced ""plateauing"" during regimens for weight management or training for sports. After a few weeks of progress, one seems unable to continue gaining in ability or losing weight. This outcome results from the same underlying quantitative model. This entry will describe the popular concepts as well as development of the plateau principle as a scientific, mathematical model.In the sciences, the broadest application of the plateau principle is creating realistic time signatures for change in kinetic models (see Mathematical model). One example of this principle is the long time required to effectively change human body composition. Theoretical studies have shown that many months of consistent physical training and food restriction are needed to bring about permanent weight stability in people who were previously overweight.
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