• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Concept Questions
Concept Questions

... b) Find an equation for the rate of change of the speed of the rocket in terms mr (t) ,u, and dmr /dt and solve for v. c) Find the differential equation describing the motion of the rocket if it is in a constant gravitational field of magnitude g ...
Targeting Optimal Nutrient Absorption with
Targeting Optimal Nutrient Absorption with

スライド タイトルなし
スライド タイトルなし

Impulse
Impulse

... How to change momentum • Any object that has momentum is going to be hard to stop • To stop an object a force needs to be applied to the object, against the object’s motion and for a certain period of time • It takes a greater force or amount of time to stop an object with a large momentum • The mo ...
Meds and Math for SN
Meds and Math for SN

Modulation of the Partition Coefficient between Octanol and Buffer at
Modulation of the Partition Coefficient between Octanol and Buffer at

RPHPLC DEVELOPMENT AND VALIDATION OF NITAZOXANIDE IN TABLET DOSAGE FORM  Research Article    SONAL BHALE*
RPHPLC DEVELOPMENT AND VALIDATION OF NITAZOXANIDE IN TABLET DOSAGE FORM  Research Article    SONAL BHALE*

... Preparation of standard stock solution  The  standard  stock  solution  of  NTZ  (5mg/ml)  was  prepared  in  methanol and diluted to get working concentration (5‐25 µg/ml).  Preparation of sample stock solution  20  tablets  were  taken,  their  average  weight  was  determined  and  crushed  to  a ...
1 Time-Integrators
1 Time-Integrators

... • Therefore, if we use either high order k with low order N or vice-versa, then we limit the overall accuracy of the scheme • In all previous SLM implementations researchers used low order k (≤ 2) and N (≤ 3)! • However, no one tried to increase both values! It may have been due in part to naivete b ...
The Drugs to Kill the Bugs: Part 1
The Drugs to Kill the Bugs: Part 1

... Percentage of bacteriologic (black bars) and clinical (hatched bars) cures as a function of AUC0-24:MIC in 68 patients with gram-negative infections treated with ciprofloxacin. Note that the bacteriologic and clinical outcomes are better with AUC > 125. ...
Lecture 10a
Lecture 10a

HUGPS268 (acidic and basic solutions)
HUGPS268 (acidic and basic solutions)

... electrons, and two bromide ions lose two electrons. Oxidation and reduction can involve the partial transfer of electrons as well as the complete transfer seen in the preceding example. The oxidation number of an atom is not synonymous with the charge on that atom, so a change in oxidation number do ...
DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR DETERMINATION
DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR DETERMINATION

... An analytically pure sample of Maraviroc was obtained from Hetro L ab, Hyderabad as a gift sample. All the chemicals used were of analytical grade. Triple distilled water was used to prepare Solutions. UV-Visible Spectro-photometer (LABINDIA UV3092 PC and UV 3000+), with wavelength accuracy is 0.5 n ...
Pharma. MCQs
Pharma. MCQs

... ciprofloxacin gave various statements; which of the following statements was rejected by the examiner? a. Clinical antagonism occurs when used with Co-trimoxazole. b. Post-antibiotic effects are similar to aminoglycosides. c. It is active against most of the middle-ear infecting organisms. d. It may ...
Sec 12.1
Sec 12.1

... Another method used to solve a system of two equations is called the elimination method. The elimination method involves adding the two equations together in the attempt to eliminate one of the variables. To accomplish this task, the coefficients of one of the variables must differ only in sign. Thi ...
Prescription_Medications
Prescription_Medications

... A: Choosing a medication to treat obesity is a decision between you and your health care provider. You will consider the drug’s side effects, your family’s medical history, and your current health issues and medicines. Q: How long will I need to take weight-loss drugs? A: The answer depends upon ...
What’s In this Urine?
What’s In this Urine?

...  In cases of maintenance treatment for opioid dependence, buprenorphine is monitored for compliance. It is recommended that patients taking buprenorphine should NOT be taking other opioids or methadone.  Metabolized to norbuprenorphine (pharmacologically active) 0 to 21 days after  Target analyte ...
Georgia Department of Education Accelerated Mathematics III Unit 8
Georgia Department of Education Accelerated Mathematics III Unit 8

... Therefore, even when recommending over the counter cold medications, doctors and pharmacist must consider whether the patient is already on medication for high blood pressure. If the patient is on such a medication, then the cold medicine recommend will have to be one that does not affect blood pres ...
The Development of Deuterium-Containing Drugs
The Development of Deuterium-Containing Drugs

... side effects and enhanced efficacy, depending on the particular drug’s pharmacokinetic/pharmacodynamic relationship. The second panel illustrates a predominantly pre-systemic effect of deuteration, which we have observed in a number of instances. In these cases, reduced rates of (usually oxidative) ...
The Development of Deuterium-Containing Drugs
The Development of Deuterium-Containing Drugs

Mathematical model of blood ionized calcium concentration
Mathematical model of blood ionized calcium concentration

... The cells of organs that regulate blood iCa have unique G-protein-linked cell membrane receptors for the calcium ion. This is the only known biological receptor for an ion, which enables the regulator cells to monitor blood iCa concentrations and respond appropriately. The levels and activity and Ca ...
rajiv gandhi university of health sciences
rajiv gandhi university of health sciences

a review on: sustained release technology
a review on: sustained release technology

... retarded release and timed release medication. Over the past 30 years, as the expense and complication involved in marketing new entities have increased with concomitant recognition of the therapeutics advantages of controlled drug delivery, greater attention has been focused on development of susta ...
Validation of an UPLC-MS/MS method for simultaneous
Validation of an UPLC-MS/MS method for simultaneous

... The stability of analyte was assessed by determining QC samples at three concentrations (six samples each). The stability studies included: (a) stability at room temperature (22–25°C) for 4 h; (b) stability after two freeze–thaw cycles; (c) stability of the extracted samples at room temperature (22– ...
PHARMACODYNAMIC AND PHARMACOKINETIC DRUG INTERACTION OF GLICLAZIDE AND  Research Article
PHARMACODYNAMIC AND PHARMACOKINETIC DRUG INTERACTION OF GLICLAZIDE AND Research Article

... for sulphonylureas activity is ATP sensitive K+ channels (K+ATP channels). The sulphonylureas and related drugs used in type II diabetes stimulate insulin release by closing K+ATP channels in pancreatic β cells. The sulphonylureas target the SUR (sulphonylurea receptor) subunit of K+ATP channels, wh ...
Alfuzosin Stada prolonged
Alfuzosin Stada prolonged

... multiple dose phase and food effect phase. In the 5 mg study on day 1, a single oral dose was given after overnight fasting, and 14 blood samples were collected up to 30 h after administration. From day 3 to 7, twice daily dosing was performed. From day 3 to 6, pre-dose blood sampling was performed ...
< 1 ... 79 80 81 82 83 84 85 86 87 ... 157 >

Plateau principle

The plateau principle is a mathematical model or scientific law originally developed to explain the time course of drug action The principle has wide applicability in pharmacology, physiology, nutrition, biochemistry and system dynamics. It applies whenever a drug or nutrient is infused or ingested at a relatively constant rate and when a constant fraction is eliminated during each time interval. Under these conditions, any change in the rate of infusion leads to an exponential increase or decrease until a new level is achieved. This behavior is also called an approach to steady state because rather than causing an indefinite increase or decrease, a natural balance is achieved when the rate of infusion or production is balanced by the rate of loss.An especially important use of the plateau principle is to study the renewal of tissue constituents in the human and animal body. In adults, daily synthesis of tissue constituents is nearly constant, and most constituents are removed with a first order reaction rate. Applicability of the plateau principle was recognized during radiotracer studies of protein turnover in the 1940s by Rudolph Schoenheimer and David Rittenberg. Unlike the case with drugs, the initial amount of tissue or tissue protein is not zero because daily synthesis offsets daily elimination. In this case, the model is also said to approach a steady state with exponential or logarithmic kinetics. Constituents that change in this manner are said to have a biological half-life.A practical application of the plateau principle is that most people have experienced ""plateauing"" during regimens for weight management or training for sports. After a few weeks of progress, one seems unable to continue gaining in ability or losing weight. This outcome results from the same underlying quantitative model. This entry will describe the popular concepts as well as development of the plateau principle as a scientific, mathematical model.In the sciences, the broadest application of the plateau principle is creating realistic time signatures for change in kinetic models (see Mathematical model). One example of this principle is the long time required to effectively change human body composition. Theoretical studies have shown that many months of consistent physical training and food restriction are needed to bring about permanent weight stability in people who were previously overweight.
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report