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Pharmacokinetic interaction studies of atosiban with labetalol
Pharmacokinetic interaction studies of atosiban with labetalol

... fact that some antihypertensives, such as diuretics and angiotensin converting enzyme (ACE) inhibitors, are contraindicated during pregnancy due to fetal toxicity or side effects.9 Therefore, due to the frequent co-administration of atosiban and labetalol, it is important to assess the risk of a pha ...
Metabolic Acidosis Stimulates Protein Degradation in Rat
Metabolic Acidosis Stimulates Protein Degradation in Rat

Scintigraphic comparison of budesonide deposition from two dry powder inhalers
Scintigraphic comparison of budesonide deposition from two dry powder inhalers

... the exhalation filter following any of the dosing regimens. Discussion This scintigraphic study has shown that a novel multidose dry powder inhaler (AM-MDPI) deposits at least as much budesonide in the lungs as a Turbuhaler, when used at similar peak inhaled flow rates. The Montreal protocol banning ...
problem #1
problem #1

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ASSAY AND DISSOLUTION... METOPROLOL SUCCINATE EXTENDED RELEASE TABLETS
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ASSAY AND DISSOLUTION... METOPROLOL SUCCINATE EXTENDED RELEASE TABLETS

... profiling of Metoprolol Succinate in extended release tablet dosage forms. Methods: As per official records, the dissolution media for ER Tablets is 6.8 PO4 Buffer and for 20 hours time duration, on USP II (Paddle) Dissolution apparatus, at 50 RPM and at 37.0oC ± 0.5 oC. The chromatographic developm ...
Renal hemodynamics and reduction of proteinuria by a vasodilating
Renal hemodynamics and reduction of proteinuria by a vasodilating

RP-HPLC method for the estimation loratadine [LRD]
RP-HPLC method for the estimation loratadine [LRD]

INTRODUCTION: - PharmaStreet
INTRODUCTION: - PharmaStreet

... 1 . Atypical pneumonia caused by Mycoplasma pneumoniae 2. Whooping cough:- treatment for eradicating B. pertussis from upper ...
Part 3: DIFFERENTIAL EQUATIONS
Part 3: DIFFERENTIAL EQUATIONS

LoNgER DuRAtIoN. gREAtER RoI.
LoNgER DuRAtIoN. gREAtER RoI.

... BRD – In a multi-location field study, 314 calves with naturally occurring BRD were treated with DRAXXIN. Responses to treatment were compared to saline-treated controls. A cure was defined as a calf with normal attitude/activity, normal respiration, and a rectal temperature of ≤104°F on Day 14. The ...
DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR DETERMINATION
DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR DETERMINATION

... Precision of the method was demonstrated by intra-day and interday variation studies. In intra-day variation study, 6 different solutions of same concentration that is 90μg/ml were prepared and analysed three times in a day i.e. morning, afternoon and evening and the absorbances were noted. The resu ...
2 nR , n
2 nR , n

... • Given a set {ˆX(w)} of reconstruction points, the distortion is minimized by mapping a source random variable X to the representation ˆX(w) that is closest to it. The set of regions of  defined by this mapping is called a Voronoi or Dirichlet partition defined by the reconstruction points. • The ...
  FORMULATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE FLOATING TABLET OF  CEPHALEXIN USING HYDROPHILIC POLYMERS 
  FORMULATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE FLOATING TABLET OF  CEPHALEXIN USING HYDROPHILIC POLYMERS 

... tract  infections,  respiratory  tract  infections,  skin  and  soft  tissue  infections.11  Pharmacokinetic  parameters  of  cephalexin  such  as  absorption from the gastrointestinal tract, protein binding 14 %, and  metabolism  90%  excreted  unchanged  in  the  urine,  half‐life  is  1  hour.12  ...
Yanyan Cui, Mona I. Churchwell, Letha H. Couch, Daniel
Yanyan Cui, Mona I. Churchwell, Letha H. Couch, Daniel

... (2000) have listed many of these pigments, which include yellow, orange, blue, green, and red pigments commonly used in the paint and commercial printing industries. Little or no toxicity data have been reported for many of these pigments, even though they contain structural alerts for mutagenicity ...
Pharmacokinetics, toxicity, and cytochrome P450
Pharmacokinetics, toxicity, and cytochrome P450

... nM, respectively. The mean IC50 values of the standard antimalarial drugs artesunate, mefloquine, quinine and chloroquine against K1 and 3D7 P. falciparum clones are 1.5 vs. 2 nM, 12 vs. 10 nM, 133- vs. 52 nM and 130 vs. 8 nM, respectively [5]. The activity against P. falciparum enzyme succinate deh ...
“muscle builder” supplements
“muscle builder” supplements

... lack of any ergogenic effect of androstenedione during resistance training is therefore not surprising. When consumed at maximal doses typically recommended by manufacturers, androstenedione should not be considered to be an anabolic agent, at least in men, because it has no anabolic properties, eit ...
Distribution of Triazolam and α-Hydroxytriazolam in a Fatal
Distribution of Triazolam and α-Hydroxytriazolam in a Fatal

t.5
t.5

...  They bind to α1-acid lipoproteins (AAG) with relatively high affinity but low capacity. *AAG concentration are elevated in response to certain inflammatory process and this will alter plasma binding & potential therapeutic range for TCAs.  its difficult to determine the alternation of blood prot ...
International Journal of Pharmacy
International Journal of Pharmacy

... is based upon determination of OLME at 256.5 nm and METO at 222.0 nm. Preparation of standard solutions: Standard stock solution of OLME and METO were prepared by transferring accurately weighed OLME (10 mg) and METO (10 mg) to a 100 mL volumetric flask separately, dissolved and diluted to a mark wi ...
Synthesis and Characterization of Nano-encapsulated Drug Delivery System for Bone Loss
Synthesis and Characterization of Nano-encapsulated Drug Delivery System for Bone Loss

... appendicular skeleton at a rate approaching 2% per month [4-5]. Similar results were found in the bed rest study. In a -6 degrees head-down tilt 7-day bed rest model for microgravity, it was observed that there was a decreased bone formation rate in the iliac crest [6]. To effectively countermeasure ...
Intravenous Anesthesia 1991
Intravenous Anesthesia 1991

... responds to 5-10 mg of ephedrine, and is a sign of relative hypovolemia. Fluid administration will usually resolve the hypotension. Patients in hypovolemic shock should not be induced with propofol. Premedication with opioids decreases the propofol dose necessary for induction of anesthesia, decrea ...
Central Nervous System Mechanisms Involving GABA
Central Nervous System Mechanisms Involving GABA

... 2 hours for the larger doses). In terms of timeaction, arterial pressure began to fall within a minute or two after injection and the nadir was reached nearly always by 10 minutes after injection. Intervals between doses of muscimol therefore were approximately 10 minutes. The baseline mean blood pr ...
Group 1 - Random Sampling
Group 1 - Random Sampling

... mean. Standard Deviation on the other hand, is the square root of the variance. Coefficient of Variation measures of relative dispersion which expresses the standard deviation as a percentage of the mean. Standard error of the mean is the measure of how far your sample mean is likely to be from the ...
Central Nervous System Mechanisms Involving GABA Influence
Central Nervous System Mechanisms Involving GABA Influence

... 2 hours for the larger doses). In terms of timeaction, arterial pressure began to fall within a minute or two after injection and the nadir was reached nearly always by 10 minutes after injection. Intervals between doses of muscimol therefore were approximately 10 minutes. The baseline mean blood pr ...
Review Sheets
Review Sheets

... 49. Determine the number of solutions of this linear system. 7x – 3y = 43 7x – 3y = 13 50. Determine the number of solutions of this linear system. 15x + 30y = –240 17x + 21y = 53 ...
< 1 ... 28 29 30 31 32 33 34 35 36 ... 157 >

Plateau principle

The plateau principle is a mathematical model or scientific law originally developed to explain the time course of drug action The principle has wide applicability in pharmacology, physiology, nutrition, biochemistry and system dynamics. It applies whenever a drug or nutrient is infused or ingested at a relatively constant rate and when a constant fraction is eliminated during each time interval. Under these conditions, any change in the rate of infusion leads to an exponential increase or decrease until a new level is achieved. This behavior is also called an approach to steady state because rather than causing an indefinite increase or decrease, a natural balance is achieved when the rate of infusion or production is balanced by the rate of loss.An especially important use of the plateau principle is to study the renewal of tissue constituents in the human and animal body. In adults, daily synthesis of tissue constituents is nearly constant, and most constituents are removed with a first order reaction rate. Applicability of the plateau principle was recognized during radiotracer studies of protein turnover in the 1940s by Rudolph Schoenheimer and David Rittenberg. Unlike the case with drugs, the initial amount of tissue or tissue protein is not zero because daily synthesis offsets daily elimination. In this case, the model is also said to approach a steady state with exponential or logarithmic kinetics. Constituents that change in this manner are said to have a biological half-life.A practical application of the plateau principle is that most people have experienced ""plateauing"" during regimens for weight management or training for sports. After a few weeks of progress, one seems unable to continue gaining in ability or losing weight. This outcome results from the same underlying quantitative model. This entry will describe the popular concepts as well as development of the plateau principle as a scientific, mathematical model.In the sciences, the broadest application of the plateau principle is creating realistic time signatures for change in kinetic models (see Mathematical model). One example of this principle is the long time required to effectively change human body composition. Theoretical studies have shown that many months of consistent physical training and food restriction are needed to bring about permanent weight stability in people who were previously overweight.
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