• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Metaraminol Bitartrate Separated Using an Acclaim Trinity
Metaraminol Bitartrate Separated Using an Acclaim Trinity

... Metaraminol is an alpha-adrenergic agonist used to treat low blood pressure. The molecule is both hydrophilic and basic, making it difficult to analyze with conventional C18 columns. Since this drug molecule is often formulated as the bitartrate salt, the tartrate content needs to be determined to a ...


... mention but a few. The effective treatment of the disease mostly involves the use of a combination of drugs for a period of 6 to 9 months [2, 3]. Non – adherence to the treatment of the disease results in the resurgence of the resistant strains of the disease making it even more difficult to cure. T ...
Information Geometry and the Wright
Information Geometry and the Wright

... To solve them, we use generalized hypergeometric functions (see [4, 5]). To know more about what will happen after the first exit time, or more general, the behavior of whole process, in joint work with J. Hofrichter, we define the global solution by moment conditions, calculate the component soluti ...
HICA - A Fórmula
HICA - A Fórmula

Physics 111
Physics 111

... The center of mass of a body or a system of bodies moves as though all of the mass were concentrated there and all external forces were applied there. 2 bodies, 1 dimension n bodies, 3 dimensions ...
Title
Title

... Sometimes the benefits of change may not be ...
Stimulants and Depressants
Stimulants and Depressants

...  Prolonged stimulant use/abuse can lead to psychosis, ...
Ideas for Progress: Mathematics, Range 16–19
Ideas for Progress: Mathematics, Range 16–19

... To enhance their skills in each mathematics-related strand, students who score in the 16–19 score range on the ACT college readiness assessment may benefit from activities that encourage them to do the ...
Clinical pharmacokinetic equations and calculations
Clinical pharmacokinetic equations and calculations

... head and neck areas. Additionally, vancomycin distributes slowly to tissues with a 1/2–1 hour distribution phase. Because the half-life of vancomycin in patients with normal renal function is approximately 8 hours, a one compartment model intravenous bolus equation can be used to compute concentrati ...
Transport Equations: An Attempt of Analytical Solution and Application
Transport Equations: An Attempt of Analytical Solution and Application

Boehringer Ingelheim Vetmedica, Inc. Buscopan InjectableSolution
Boehringer Ingelheim Vetmedica, Inc. Buscopan InjectableSolution

... There were no signs of toxicity or adverse reactions. The pharmacological effects seen in these studies were consistent with those of anticholinergic drugs (see above). In a target animal safety study, Buscopan was evaluated in two phases. In the first phase, the drug was administered intravenously ...
Pharmacokinetics
Pharmacokinetics

... eliminated by a number of processes. Polar drugs are easily filtered from the blood in the kidneys and removed into urine. However non polar material is generally reabsorbed from the kidney or distributed into fat tissue. The liver however is capable of metabolizing many drugs, generally producing c ...
Pharmacokinetic introduction
Pharmacokinetic introduction

... eliminated by a number of processes. Polar drugs are easily filtered from the blood in the kidneys and removed into urine. However non polar material is generally reabsorbed from the kidney or distributed into fat tissue. The liver however is capable of metabolizing many drugs, generally producing c ...
+ y = 0, if we compare this to equation
+ y = 0, if we compare this to equation

... MATH 2930 HW#14 Solution ...
Lecture Notes for Sections 18-1 - 18
Lecture Notes for Sections 18-1 - 18

kinetic energy
kinetic energy

... do work. Why don’t forces FB and NB do any work? Since the spring is attached to the top of the wheel, it will stretch twice the amount of displacement of G, or 1 ft. ...
Acetylsalicylic acid
Acetylsalicylic acid

Welchol, Protonix, TNKase - Turner White Communications
Welchol, Protonix, TNKase - Turner White Communications

... 50 to 75 seconds. TNKase dosage was based on actual or estimated patient weight. The study’s primary endpoint was 30-day mortality rate with nonparametric adjustment for the covariates of age, Killip class, heart rate, systolic blood pressure, and infarct location. The mortality rate for patients in ...
Chapter 2 Functions and Graphs
Chapter 2 Functions and Graphs

... ƒ The obvious answer to the question is to take the number of pennies on December 31 and not a lump sum payment of $10,000,000 (although I would not mind having either amount!) ƒ This example shows how an exponential function grows extremely rapidly. In this case, the exponential function ...
Simplify and Evaluate Algebraic Expressions, November 15, 2011
Simplify and Evaluate Algebraic Expressions, November 15, 2011

... ...
CHE 230
CHE 230

Pharmacokinetics and Metabolism
Pharmacokinetics and Metabolism

“Applied” Homework: Data Description and General Guidelines The
“Applied” Homework: Data Description and General Guidelines The

Modelling Homeostatic Responses
Modelling Homeostatic Responses

Forensics Toxicology PPT
Forensics Toxicology PPT

... substance that can cause severe harm or death if ingested, inhaled, or absorbed through the skin ...
< 1 ... 137 138 139 140 141 142 143 144 145 ... 157 >

Plateau principle

The plateau principle is a mathematical model or scientific law originally developed to explain the time course of drug action The principle has wide applicability in pharmacology, physiology, nutrition, biochemistry and system dynamics. It applies whenever a drug or nutrient is infused or ingested at a relatively constant rate and when a constant fraction is eliminated during each time interval. Under these conditions, any change in the rate of infusion leads to an exponential increase or decrease until a new level is achieved. This behavior is also called an approach to steady state because rather than causing an indefinite increase or decrease, a natural balance is achieved when the rate of infusion or production is balanced by the rate of loss.An especially important use of the plateau principle is to study the renewal of tissue constituents in the human and animal body. In adults, daily synthesis of tissue constituents is nearly constant, and most constituents are removed with a first order reaction rate. Applicability of the plateau principle was recognized during radiotracer studies of protein turnover in the 1940s by Rudolph Schoenheimer and David Rittenberg. Unlike the case with drugs, the initial amount of tissue or tissue protein is not zero because daily synthesis offsets daily elimination. In this case, the model is also said to approach a steady state with exponential or logarithmic kinetics. Constituents that change in this manner are said to have a biological half-life.A practical application of the plateau principle is that most people have experienced ""plateauing"" during regimens for weight management or training for sports. After a few weeks of progress, one seems unable to continue gaining in ability or losing weight. This outcome results from the same underlying quantitative model. This entry will describe the popular concepts as well as development of the plateau principle as a scientific, mathematical model.In the sciences, the broadest application of the plateau principle is creating realistic time signatures for change in kinetic models (see Mathematical model). One example of this principle is the long time required to effectively change human body composition. Theoretical studies have shown that many months of consistent physical training and food restriction are needed to bring about permanent weight stability in people who were previously overweight.
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report