• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Norepinephrine (Levophed) - the Space Coast EMS Medical
Norepinephrine (Levophed) - the Space Coast EMS Medical

... Few, though at higher doses, symptoms may include:  headache,  palpitations  tachycardia  chest pain  eventual hypertension  Bradycardia can result reflexively from an increase in blood pressure ...
Slide 1
Slide 1

... on living organisms. It is the study of symptoms, mechanisms, treatments and detection of poisoning •Toxicology studies the relationship between dose and its effects on the living organism. The chief criterion regarding the toxicity of a chemical is the dose, the amount of exposure to the substance. ...
Drug binding and investigation of the Michaelis Menten equation
Drug binding and investigation of the Michaelis Menten equation

... where Vmax is the constant of capacity (as a maximum reaction rate for enzyme kinetics); Km is an affinity constant having the same dimension (units) as S and S is the substrate concentration. The units of this equation are most commonly amount/time for velocity and Vmax; and concentration for Km an ...
Lecture 19
Lecture 19

... moment is applied and the spring has a spring constant of 10 lb/ft. Find: The angular velocity of the wheel when point G moves 0.5 ft. The wheel starts from rest and rolls without slipping. The spring is initially un-stretched. Plan: Use the principle of work and energy since distance is the primary ...
Equations - WordPress.com
Equations - WordPress.com

... Solution, or root The numerical value of the unknown that makes the equation true. In the equation X + 7 = 10, for example, 3 is the solution, because 3 + 7 = 10. Coefficient A number or quantity placed before another quantity, indicating multiplication. For example, 4 is the coefficient in the expr ...
Document
Document

... Aerobic activity: a low-intensity, high-endurance activity that requires oxygen for production of energy and continuous work performed over long distances or periods of time. Any type of vigorous activity that uses a continuous supply of oxygen would apply. Benefits:  Increases heart strength  He ...
Drug interaction of plasma protein binding
Drug interaction of plasma protein binding

... Zero-order Elimination Kinetics 零级消除动力学 The character of zero-order kinetics is that the rate of elimination is constant, i.e., independent of drug doses, and that the halflife time is positively relates to the drug doses. When the concentration of drug exceeds the capacity of the metabolism of the ...
Student Background Readings for Bug Dynamics: The Logistic Map
Student Background Readings for Bug Dynamics: The Logistic Map

Pharmacology Basics
Pharmacology Basics

... Rate of elimination is independent of drug concentration. Constant amount eliminated per unit of time. ...
563 kB - recent advances remifentanil mgmc
563 kB - recent advances remifentanil mgmc

PROBLEM SET 4 14.02 Macroeconomics April 5, 2006 Due April 12, 2006
PROBLEM SET 4 14.02 Macroeconomics April 5, 2006 Due April 12, 2006

... typing an equation, you should refer to the cell that contains the value instead of writing down the value directly. For example, if your equation says ut+1 = gmt+1 + (ut − un ), type “= D3 + (B2 − F 3)” instead of “= 3% + (5% − 5%)” in cell B3 (the cell representing for ut+1 ). v. “Copy” B3 and C3 ...
File
File

Mr.  Steve Lee V.  P. Technical  Affairs
Mr. Steve Lee V. P. Technical Affairs

... This is in response to your letter of November 4,2002 to the Food and Drug Administration (FDA) pursuant to 21 U.S.C. 343(r)(6) (section 403(r)(6) of the Federal Food, Drug, and Cosmetic Act (the Act)). In your letter, you notified us about a claim you intend to use for your dietary supplement Promi ...
Motion - RoncalliPhysics
Motion - RoncalliPhysics

... Second law: Law of Acceleration an external unbalance force acting on an object produces an acceleration in the direction of the net force, an acceleration that is directly proportional to the unbalanced force and inversely proportional to the mass of the body Where: F=force m=mass a= acceleration ...
04_Intravenous infusion
04_Intravenous infusion

... concentration of a drug with one compartment PK resulting from the administration of an IV infusion (K0= Css∙Cl ) and a loading bolus (LD= Css∙Vd) that was given at the start of the infusion ...
kinetics of iv bolus: urine data
kinetics of iv bolus: urine data

JJ205 ENGINEERING MECHANICS
JJ205 ENGINEERING MECHANICS

... When a body is taken out in a space craft, the mass will not change but its weight may change due to change in gravitational force. Even the body may become weightless when gravitational force vanishes but the mass remain the same. ...
Psychopharmacology and Other Biologic Treatments
Psychopharmacology and Other Biologic Treatments

... • Used when patients have not responded to ...
4-ANS applied pharm(Lec.1,2,3)
4-ANS applied pharm(Lec.1,2,3)

... Kaplan Pharmacology USMLE Step1 , Lecture notes;2009,p53-67 ; ...
Sect. 8.4
Sect. 8.4

... between them F(r) = -U(r) = -(dU/dr)r • Started with a 6d, 2 body problem. By transforming to CM & relative coordinates (R,r) reduced it to 2, 3d 1 body problems. One (the CM motion, R) is trivial & free particlelike. The 2nd is for a “particle” with mass μ  (m1m2)(m1+m2) = reduced mass interacti ...
Exondys 51
Exondys 51

pharmacokinetics
pharmacokinetics

... 2) Zero-order kinetic Blood concentration of drug is reduced in equal amount or eliminated in continuant shorten half-life (t1/2). C ...
Slides - IIASA
Slides - IIASA

... from the deposition models. - even simple models are non-linear - current preferred parameter choices may not be optimal. Bias is not a problem if - it can be estimated with reasonable accuracy, or - the flux estimate is so far away from a ‘test level’ that it can be ignored. but it is a bigger issu ...
Lesson Plan I: March 17, March 19
Lesson Plan I: March 17, March 19

... specific ways with specific enzymes; metabolism is the most important part of ADME. 3. How do you know how much of a drug to take?  The amount of a drug you take depends on how long your body takes to absorb it. For example, if you have a splitting headache, a doctor might recommend that you take t ...
Reading Material
Reading Material

< 1 ... 133 134 135 136 137 138 139 140 141 ... 157 >

Plateau principle

The plateau principle is a mathematical model or scientific law originally developed to explain the time course of drug action The principle has wide applicability in pharmacology, physiology, nutrition, biochemistry and system dynamics. It applies whenever a drug or nutrient is infused or ingested at a relatively constant rate and when a constant fraction is eliminated during each time interval. Under these conditions, any change in the rate of infusion leads to an exponential increase or decrease until a new level is achieved. This behavior is also called an approach to steady state because rather than causing an indefinite increase or decrease, a natural balance is achieved when the rate of infusion or production is balanced by the rate of loss.An especially important use of the plateau principle is to study the renewal of tissue constituents in the human and animal body. In adults, daily synthesis of tissue constituents is nearly constant, and most constituents are removed with a first order reaction rate. Applicability of the plateau principle was recognized during radiotracer studies of protein turnover in the 1940s by Rudolph Schoenheimer and David Rittenberg. Unlike the case with drugs, the initial amount of tissue or tissue protein is not zero because daily synthesis offsets daily elimination. In this case, the model is also said to approach a steady state with exponential or logarithmic kinetics. Constituents that change in this manner are said to have a biological half-life.A practical application of the plateau principle is that most people have experienced ""plateauing"" during regimens for weight management or training for sports. After a few weeks of progress, one seems unable to continue gaining in ability or losing weight. This outcome results from the same underlying quantitative model. This entry will describe the popular concepts as well as development of the plateau principle as a scientific, mathematical model.In the sciences, the broadest application of the plateau principle is creating realistic time signatures for change in kinetic models (see Mathematical model). One example of this principle is the long time required to effectively change human body composition. Theoretical studies have shown that many months of consistent physical training and food restriction are needed to bring about permanent weight stability in people who were previously overweight.
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report