• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Radiolabeled ADME studies
Radiolabeled ADME studies

Physical and Cognitive Development in Middle
Physical and Cognitive Development in Middle

... fine motor skills improve-writing (starts off larger ad gradually decreases in size) drawings show gains in organization, detail ad representation of depth games with rules are more common-children have a better concept of fairness, and justice PE classes very important-builds self esteem, and physi ...
The head of a drop hammer is raised 2m and then falls
The head of a drop hammer is raised 2m and then falls

... Both results are very similar (their difference is about 0.2%) so I assume I can use as many known variables as needed and forget about the redundant one. If you are not familiar with formulas in equations (1,2) here is how to get them: ...
VT PowerPoint Template5
VT PowerPoint Template5

...  Metabolites MAY be more important than the drug  Absorption may have the longest half-life. ...
The theoretical model
The theoretical model

Nutrients in Food: Have our Veggies and Fruits become less healthy?
Nutrients in Food: Have our Veggies and Fruits become less healthy?

Population Pharmacokinetic Evaluation of Eslicarbazepine Acetate
Population Pharmacokinetic Evaluation of Eslicarbazepine Acetate

...  Data were obtained from adult subjects enrolled in 11 densely sampled Phase 1 studies and 3 sparsely sampled Phase 3 studies; analysis included only multiple 400-mg to 1200-mg doses administered once daily.  Subjects randomized to treatment in the Phase 3 trials had at least 4 partial-onset seizu ...
Lecture 1
Lecture 1

... distribution, metabolism and elimination (ADME) Pharmacokinetic data is very usefull in optimization of the disage form design and establishing the dosage interval Describes the relationship between the dose and the pharmacological effect at the site of action The medicine which containing identical ...
Biopharmaceutics is a science which studies dependence of
Biopharmaceutics is a science which studies dependence of

... distribution, metabolism and elimination (ADME) Pharmacokinetic data is very usefull in optimization of the disage form design and establishing the dosage interval Describes the relationship between the dose and the pharmacological effect at the site of action The medicine which containing identical ...
Unit 4 Problem Set KEY unit4_problemset_key
Unit 4 Problem Set KEY unit4_problemset_key

... Antagonist ...
4. Mathematics and Statistics
4. Mathematics and Statistics

Integrated Modeling and Analysis of within-host Infection
Integrated Modeling and Analysis of within-host Infection

Mathematical versus physical meaning of classical
Mathematical versus physical meaning of classical

Done By: Sanaa Otoom Advanced Technology Lecture# 2 Last
Done By: Sanaa Otoom Advanced Technology Lecture# 2 Last

... Last lecture we discussed the problems that affect bioavailability, which are solubility, stability and permeability, and how we can solve them. The solutions for solubility problem was the simplest since we can change the physiochemical properties of drug or provide our drug in a form that is avail ...
Slide 1
Slide 1

... Ask patients to complete the Visual Analog Scales (VAS*): Global Well-being and Dyspnea at specific intervals: 6 hrs and 12 hrs after initiation of study drug infusion and daily for 4 days Only 1 IV line necessary; both drugs can run through same IV *Found in patient’s chart box. ...
Sample Lesson on Exponential Functions
Sample Lesson on Exponential Functions

... Population in 2002 Since all calculations are near , we can conclude the population grew by about between 2000 and 2001, between 2001 and 2002, and between 2002 and 2003. Whenever we have we have . The population can be modeled by the function where the base , also called the , represents the factor ...
L8 Pharmacology PPt - Moodle
L8 Pharmacology PPt - Moodle

Background PLASMA PROTEIN BINDING Protocol
Background PLASMA PROTEIN BINDING Protocol

Introduction to Pharmacology
Introduction to Pharmacology

... – Described as “what the body does to the drug” – Includes the processes of absorption, distribution, metabolism and elimination ...
Math 2214, Fall 2014, Form A
Math 2214, Fall 2014, Form A

... 8. An aquarium containing 20 gallons of water is connected to a pump which drives water through a filter and then pumps it back into the aquarium. The filter removes 90% of the pollutants passing through it. Water in the aquarium is pumped out at a rate of 0.2 gallons per minute through the filter ...
1. Recall: tan(x) = sin(x) cos(x) cot(x) = cos(x) sin(x) sec(x) = 1 cos(x
1. Recall: tan(x) = sin(x) cos(x) cot(x) = cos(x) sin(x) sec(x) = 1 cos(x

numbers - Kalvirs
numbers - Kalvirs

Chronotropic Effects of Select Cardiovascular Drugs on the
Chronotropic Effects of Select Cardiovascular Drugs on the

Fad Diets and Eating Disorders
Fad Diets and Eating Disorders

7. Laplace equation...the basis of potential theory
7. Laplace equation...the basis of potential theory

< 1 ... 136 137 138 139 140 141 142 143 144 ... 157 >

Plateau principle

The plateau principle is a mathematical model or scientific law originally developed to explain the time course of drug action The principle has wide applicability in pharmacology, physiology, nutrition, biochemistry and system dynamics. It applies whenever a drug or nutrient is infused or ingested at a relatively constant rate and when a constant fraction is eliminated during each time interval. Under these conditions, any change in the rate of infusion leads to an exponential increase or decrease until a new level is achieved. This behavior is also called an approach to steady state because rather than causing an indefinite increase or decrease, a natural balance is achieved when the rate of infusion or production is balanced by the rate of loss.An especially important use of the plateau principle is to study the renewal of tissue constituents in the human and animal body. In adults, daily synthesis of tissue constituents is nearly constant, and most constituents are removed with a first order reaction rate. Applicability of the plateau principle was recognized during radiotracer studies of protein turnover in the 1940s by Rudolph Schoenheimer and David Rittenberg. Unlike the case with drugs, the initial amount of tissue or tissue protein is not zero because daily synthesis offsets daily elimination. In this case, the model is also said to approach a steady state with exponential or logarithmic kinetics. Constituents that change in this manner are said to have a biological half-life.A practical application of the plateau principle is that most people have experienced ""plateauing"" during regimens for weight management or training for sports. After a few weeks of progress, one seems unable to continue gaining in ability or losing weight. This outcome results from the same underlying quantitative model. This entry will describe the popular concepts as well as development of the plateau principle as a scientific, mathematical model.In the sciences, the broadest application of the plateau principle is creating realistic time signatures for change in kinetic models (see Mathematical model). One example of this principle is the long time required to effectively change human body composition. Theoretical studies have shown that many months of consistent physical training and food restriction are needed to bring about permanent weight stability in people who were previously overweight.
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report