Genetic studies of psoriasis and psoriatic arthritis
... The studies in this thesis aimed at refining two susceptibility loci for psoriasis identified with linkage analysis, 3q21 and 5q31-32, with a special emphasis on the PSORS5 region on chromosome 3q21. Another purpose was to investigate whether several autoimmuneassociating genes and genomic regions a ...
... The studies in this thesis aimed at refining two susceptibility loci for psoriasis identified with linkage analysis, 3q21 and 5q31-32, with a special emphasis on the PSORS5 region on chromosome 3q21. Another purpose was to investigate whether several autoimmuneassociating genes and genomic regions a ...
International Conflicts over Patenting Human DNA Sequences in the
... fit the AIDS virus. The virus binds to the receptor, then fuses to the cell, and fusion allows 1IV to work its way inside. Chartrand, supra note 4. 11 Smaglik, supra note 4, at 322. HGS filed its patent application for the CCR5 gene as a so-called "homologous sequence," Le., a gene sequence of unkno ...
... fit the AIDS virus. The virus binds to the receptor, then fuses to the cell, and fusion allows 1IV to work its way inside. Chartrand, supra note 4. 11 Smaglik, supra note 4, at 322. HGS filed its patent application for the CCR5 gene as a so-called "homologous sequence," Le., a gene sequence of unkno ...
The Arabidopsis STICHEL Gene Is a Regulator of Trichome Branch
... (ECTOPIC ROOT HAIR3) gene appears to be involved in the regulation microtubule assembly and disassembly. In fra2/erh3 mutants trichomes are underbranched; also, other cell types show morphogenesis defects (Burk et al., 2001; Webb et al., 2002). FRA2/ERH3 encodes for a katanin-p60 protein, suggesting ...
... (ECTOPIC ROOT HAIR3) gene appears to be involved in the regulation microtubule assembly and disassembly. In fra2/erh3 mutants trichomes are underbranched; also, other cell types show morphogenesis defects (Burk et al., 2001; Webb et al., 2002). FRA2/ERH3 encodes for a katanin-p60 protein, suggesting ...
Loss of heterozygosity at D8S262: an early genetic event of
... found in cirrhotic liver tissue. Therefore, mounting evidence suggests that SCC represents precursor lesions that are more advanced than LCC in the course of human hepatocarcinogenesis [4]. Foci of altered hepatocyte (FAH) is observed in several animal species in the early stages of hepatocarcinogen ...
... found in cirrhotic liver tissue. Therefore, mounting evidence suggests that SCC represents precursor lesions that are more advanced than LCC in the course of human hepatocarcinogenesis [4]. Foci of altered hepatocyte (FAH) is observed in several animal species in the early stages of hepatocarcinogen ...
Processing the RefSeq and CCDS Annotation Datasets Using the SAS System: Creation of Gene Reference
... in the reference chromosome sequence. It is the same as __POINT, but since __POINT is used in the POINT= option to the SET statement, it is not allowed to be in the output data set. Each time a base is added to the reference gene data set, we increment the value of NN, which is the relative position ...
... in the reference chromosome sequence. It is the same as __POINT, but since __POINT is used in the POINT= option to the SET statement, it is not allowed to be in the output data set. Each time a base is added to the reference gene data set, we increment the value of NN, which is the relative position ...
Searching for Compact Hierarchical Structures in DNA by means of
... The exponential growth of available DNA sequences in recent years is having a fruitful clash with the deep questions underlying information science. Brooks identified in 2003 recent development in biology as the necessary pressure to finally develop a long-time needed quantification of structural infor ...
... The exponential growth of available DNA sequences in recent years is having a fruitful clash with the deep questions underlying information science. Brooks identified in 2003 recent development in biology as the necessary pressure to finally develop a long-time needed quantification of structural infor ...
Visual gene developer: a fully programmable bioinformatics
... California, Davis, 1 Shields Ave, Davis, CA 95616, USA ...
... California, Davis, 1 Shields Ave, Davis, CA 95616, USA ...
Forensic analysis of expirated blood
... analysis and developed a test using PCR analysis to distinguish between the two types of bloodstain patterns to allow for proper bloodstain classification. The current study developed a test involving PCR analysis using DNA from humanspecific oral microbes as a biomarker for the presence of saliva a ...
... analysis and developed a test using PCR analysis to distinguish between the two types of bloodstain patterns to allow for proper bloodstain classification. The current study developed a test involving PCR analysis using DNA from humanspecific oral microbes as a biomarker for the presence of saliva a ...
DNA-mediated transformation of the filamentous fungusAspergillus
... In diploid nuclei mitotic crossing-over may occur, however its frequency is low and consequently, following haploidization, in general not more than one cross-over event is detected in about 200 haploids (Pontecorvo and Käfer 1958). The alternation of haploid and diploid stages in the absence of mei ...
... In diploid nuclei mitotic crossing-over may occur, however its frequency is low and consequently, following haploidization, in general not more than one cross-over event is detected in about 200 haploids (Pontecorvo and Käfer 1958). The alternation of haploid and diploid stages in the absence of mei ...
Control of DNA excision efficiency in Paramecium
... micronuclei undergo meiosis, whereas the macronuclei degenerate. The fusion of two gametic nuclei produces a zygotic nucleus. This nucleus divides twice and the daughter nuclei then differentiate into a micronucleus or a macronucleus. In the second case, the whole genome is processed through chromos ...
... micronuclei undergo meiosis, whereas the macronuclei degenerate. The fusion of two gametic nuclei produces a zygotic nucleus. This nucleus divides twice and the daughter nuclei then differentiate into a micronucleus or a macronucleus. In the second case, the whole genome is processed through chromos ...
Genomic variations and distinct evolutionary rate of rare alleles in
... contains the majority of accessions. At a locus, there could be 1, 2 (Fig. 1a-b) or >2 distinct haplotypes (Fig. 1c). When a locus has only one haplotype, it must be a major allele (Fig. 1d). At such locus, the SNPs are randomly (or near randomly) distributed. Because the randomly-distributed SNPs l ...
... contains the majority of accessions. At a locus, there could be 1, 2 (Fig. 1a-b) or >2 distinct haplotypes (Fig. 1c). When a locus has only one haplotype, it must be a major allele (Fig. 1d). At such locus, the SNPs are randomly (or near randomly) distributed. Because the randomly-distributed SNPs l ...
Defining characteristics of Tn5 Transposase non
... recombinases and retroviral integrases. Two of the three domains of the bacteriophage Mu Tnp (MuA) independently bind DNA non-specifically. Filter binding experiments with proteolytic fragments of MuA reveal that the N-terminal 26 amino acids of domain III binds supercoiled DNA nonspecifically (3) a ...
... recombinases and retroviral integrases. Two of the three domains of the bacteriophage Mu Tnp (MuA) independently bind DNA non-specifically. Filter binding experiments with proteolytic fragments of MuA reveal that the N-terminal 26 amino acids of domain III binds supercoiled DNA nonspecifically (3) a ...
Horizontal gene transfer from flowering plants to Gnetum
... base pairs inserted before the GTGCG motif that is typical of the start of group II introns (Tables 3 and 4 and Figs. 1 and 6). Angiosperm-type nad1 exons found in Gnetum share five nucleotide substitutions with angiosperms that are not found in other seed plants. They are also characterized by a fo ...
... base pairs inserted before the GTGCG motif that is typical of the start of group II introns (Tables 3 and 4 and Figs. 1 and 6). Angiosperm-type nad1 exons found in Gnetum share five nucleotide substitutions with angiosperms that are not found in other seed plants. They are also characterized by a fo ...
DNA Methylation Analysis
... Database9 (Genome Build 36). Additional markers provide increased resolution focused on 144 established cancer genes that have shown differential methylation patterns. To ensure the most important loci were represented, Illumina designed markers to cover nearly 1,000 cancer-related genes described i ...
... Database9 (Genome Build 36). Additional markers provide increased resolution focused on 144 established cancer genes that have shown differential methylation patterns. To ensure the most important loci were represented, Illumina designed markers to cover nearly 1,000 cancer-related genes described i ...
Sex differences in the genome-wide DNA
... female X chromosome [8]. Analysis of sex differences in DNA methylation on the autosomal chromosomes have either revealed no, few or small changes [3,4,6,7]. However, in cells found in saliva, females tend to have higher DNA methylation levels on both the X chromosome as well as the autosomes [9]. M ...
... female X chromosome [8]. Analysis of sex differences in DNA methylation on the autosomal chromosomes have either revealed no, few or small changes [3,4,6,7]. However, in cells found in saliva, females tend to have higher DNA methylation levels on both the X chromosome as well as the autosomes [9]. M ...
Brilliant II SYBR® Green QRT-PCR, AffinityScript Master Mix, 2-Step
... The kit includes our QPCR-grade AffinityScript Multiple Temperature Reverse Transcriptase* (RT), a genetically engineered version of Moloney murine leukemia virus RT that is highly thermostable, allowing you to reverse transcribe at your preferred reaction temperature. AffinityScript RT is provided, ...
... The kit includes our QPCR-grade AffinityScript Multiple Temperature Reverse Transcriptase* (RT), a genetically engineered version of Moloney murine leukemia virus RT that is highly thermostable, allowing you to reverse transcribe at your preferred reaction temperature. AffinityScript RT is provided, ...
A TOPRIM Domain in the Crystal Structure of the Catalytic Core of
... Figure 2. Sequence alignment of the catalytic domains of bacterial primases of the DnaG family. Ec, E. coli; St, Salmonella typhimurium; Hi, Haemophilus in¯uenzae; Bs, Bacillus subtilis; Lm, Listeria monocytogenes; Rp, Rickettsia prowazakeii. The residues are highlighted according to their similarit ...
... Figure 2. Sequence alignment of the catalytic domains of bacterial primases of the DnaG family. Ec, E. coli; St, Salmonella typhimurium; Hi, Haemophilus in¯uenzae; Bs, Bacillus subtilis; Lm, Listeria monocytogenes; Rp, Rickettsia prowazakeii. The residues are highlighted according to their similarit ...
Unit 3 Resource
... Real-World Biology: Lab, Kernel Color in Corn continued Part B: Looking at Corn Now that you have determined the predicted phenotypic and genotypic ratios, you will examine an ear of corn resulting from a monohybrid (heterozygous × heterozygous) cross and compare the observed phenotypic ratio to th ...
... Real-World Biology: Lab, Kernel Color in Corn continued Part B: Looking at Corn Now that you have determined the predicted phenotypic and genotypic ratios, you will examine an ear of corn resulting from a monohybrid (heterozygous × heterozygous) cross and compare the observed phenotypic ratio to th ...
Properties of Mitotic and Meiotic Recombination in the
... Homologous recombination (HR) is an important mechanism for the repair of doublestranded DNA breaks (DSBs) in yeast (Symington et al., 2014) and in higher eukaryotes (Liang et al., 1998). Saccharomyces cerevisiae strains that lack HR are very sensitive to DNA damaging agents such as X-rays (Resnick ...
... Homologous recombination (HR) is an important mechanism for the repair of doublestranded DNA breaks (DSBs) in yeast (Symington et al., 2014) and in higher eukaryotes (Liang et al., 1998). Saccharomyces cerevisiae strains that lack HR are very sensitive to DNA damaging agents such as X-rays (Resnick ...
Review Synthetic oligonucleotides as RNA mimetics
... dichroism (CD) spectra of phosphoramidate DNA duplexes were consistent with formation of an RNA-like A-form conformation [17]. This change in the helix geometry compared with DNA is likely due to N-type sugar puckering of 3%-aminonucleosides. These findings were confirmed by the X-ray analysis of cr ...
... dichroism (CD) spectra of phosphoramidate DNA duplexes were consistent with formation of an RNA-like A-form conformation [17]. This change in the helix geometry compared with DNA is likely due to N-type sugar puckering of 3%-aminonucleosides. These findings were confirmed by the X-ray analysis of cr ...
Fulltext - Jultika
... characterized here. It was found to consist of 68 exons and span 160 kb, excluding introns 1 and 4. Over 50 kb of new intronic sequences were defined. The exon-intron organization coding for the major triple helical domain was found to be identical to that of the human COL11A2 gene, which codes for ...
... characterized here. It was found to consist of 68 exons and span 160 kb, excluding introns 1 and 4. Over 50 kb of new intronic sequences were defined. The exon-intron organization coding for the major triple helical domain was found to be identical to that of the human COL11A2 gene, which codes for ...
Document
... • Adenine must pair with Thymine • Guanine must pair with Cytosine • Their amounts in a given DNA molecule will be about the same. ...
... • Adenine must pair with Thymine • Guanine must pair with Cytosine • Their amounts in a given DNA molecule will be about the same. ...
Specialized Transduction by Bacteriophage P22 in Salmonella typhimurium: Genetic and Physical Structure of the Transducing Genomes and the Prophage Attachment Site.
... The electron microscopy of P22Tc-10 DNA seemed to confirm this notion: TYE,CHANand BOTSTEIN(1974) found that the ends of the Tc-10 insertion contained an inverted repeat which was apparently identical to the inverted repeat SHARP,COHENand DAVIDSON (1973) had found associated with the tetRgene (s) on ...
... The electron microscopy of P22Tc-10 DNA seemed to confirm this notion: TYE,CHANand BOTSTEIN(1974) found that the ends of the Tc-10 insertion contained an inverted repeat which was apparently identical to the inverted repeat SHARP,COHENand DAVIDSON (1973) had found associated with the tetRgene (s) on ...
Flexibility of centromere and kinetochore structures
... Not only does centromere DNA differ dramatically between organisms [12], it differs between centromeres within a given organism [15,16]. For example, different chicken centromeres vary in length from 30 to 500 kb, and contain either nonrepetitive or highly repetitive DNA [15]. By contrast, human cen ...
... Not only does centromere DNA differ dramatically between organisms [12], it differs between centromeres within a given organism [15,16]. For example, different chicken centromeres vary in length from 30 to 500 kb, and contain either nonrepetitive or highly repetitive DNA [15]. By contrast, human cen ...
Microsatellite
A microsatellite is a tract of repetitive DNA in which certain DNA motifs (ranging in length from 2–5 base pairs) are repeated, typically 5-50 times. Microsatellites occur at thousands of locations in the human genome and they are notable for their high mutation rate and high diversity in the population. Microsatellites and their longer cousins, the minisatellites, together are classified as VNTR (variable number of tandem repeats) DNA. The name ""satellite"" refers to the early observation that centrifugation of genomic DNA in a test tube separates a prominent layer of bulk DNA from accompanying ""satellite"" layers of repetitive DNA. Microsatellites are often referred to as short tandem repeats (STRs) by forensic geneticists, or as simple sequence repeats (SSRs) by plant geneticists.They are widely used for DNA profiling in kinship analysis and in forensic identification. They are also used in genetic linkage analysis/marker assisted selection to locate a gene or a mutation responsible for a given trait or disease.